Incidental Mutation 'R7633:Slco1a6'
ID 589752
Institutional Source Beutler Lab
Gene Symbol Slco1a6
Ensembl Gene ENSMUSG00000079262
Gene Name solute carrier organic anion transporter family, member 1a6
Synonyms Slc21a13, organic anion-transporting polypeptide, 4930422F19Rik, Oatp-5
MMRRC Submission 045721-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R7633 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 142085761-142208521 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 142145755 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 73 (I73N)
Ref Sequence ENSEMBL: ENSMUSP00000107458 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111827]
AlphaFold Q99J94
Predicted Effect probably damaging
Transcript: ENSMUST00000111827
AA Change: I73N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000107458
Gene: ENSMUSG00000079262
AA Change: I73N

DomainStartEndE-ValueType
Pfam:MFS_1 21 421 7.8e-26 PFAM
Pfam:OATP 21 597 1.3e-163 PFAM
Pfam:Kazal_2 445 486 2.7e-11 PFAM
transmembrane domain 600 619 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (52/52)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930504O13Rik C A 11: 58,447,478 (GRCm38) M29I probably benign Het
A530084C06Rik G T 13: 31,558,995 (GRCm38) R92S unknown Het
Acaca A G 11: 84,372,639 (GRCm38) I2029V probably benign Het
Anks1b A C 10: 90,948,584 (GRCm38) D1138A probably damaging Het
Atr T A 9: 95,947,118 (GRCm38) V2508E probably damaging Het
C4b C T 17: 34,729,399 (GRCm38) probably null Het
C530008M17Rik A G 5: 76,857,520 (GRCm38) E576G unknown Het
Cd46 A T 1: 195,083,619 (GRCm38) M146K probably null Het
Chp1 A G 2: 119,560,745 (GRCm38) I28V probably benign Het
Chrnb1 T A 11: 69,792,873 (GRCm38) R216W probably damaging Het
Clmn G A 12: 104,782,112 (GRCm38) T392M probably benign Het
Dcxr A C 11: 120,726,453 (GRCm38) L88R probably benign Het
Dedd C T 1: 171,338,910 (GRCm38) P138L probably benign Het
Degs1 A G 1: 182,279,698 (GRCm38) S35P probably damaging Het
Ehmt1 T C 2: 24,815,780 (GRCm38) D851G possibly damaging Het
Fam117b A G 1: 59,981,534 (GRCm38) D521G probably damaging Het
Fam26d G A 10: 34,043,908 (GRCm38) T121M possibly damaging Het
Gm14085 A T 2: 122,486,680 (GRCm38) R7S probably null Het
Gm21731 G A 13: 120,240,840 (GRCm38) W57* probably null Het
Gm6882 A G 7: 21,427,652 (GRCm38) V97A probably damaging Het
Hgs A T 11: 120,474,302 (GRCm38) Q172L probably damaging Het
Hormad2 T C 11: 4,346,662 (GRCm38) Q274R probably benign Het
Igkv8-19 C T 6: 70,341,399 (GRCm38) probably benign Het
Ikbkb T C 8: 22,671,741 (GRCm38) N377S probably benign Het
Intu G A 3: 40,654,253 (GRCm38) G232S probably damaging Het
Mov10 A G 3: 104,797,065 (GRCm38) S806P possibly damaging Het
Mrgprb1 A G 7: 48,447,583 (GRCm38) F194L probably benign Het
Notch3 A T 17: 32,158,622 (GRCm38) I160K probably benign Het
Nup155 C G 15: 8,109,453 (GRCm38) S3W probably damaging Het
Olfr1287 A G 2: 111,449,622 (GRCm38) I161V probably benign Het
Olfr284 A G 15: 98,340,086 (GRCm38) I301T probably damaging Het
Plxdc1 A T 11: 97,956,151 (GRCm38) F147L possibly damaging Het
Ppfia1 T C 7: 144,552,436 (GRCm38) D33G possibly damaging Het
Prdm11 G A 2: 92,980,654 (GRCm38) A200V probably damaging Het
Qrich2 A T 11: 116,456,629 (GRCm38) I1123K unknown Het
Rgs1 A G 1: 144,248,477 (GRCm38) probably null Het
Skint7 T A 4: 111,984,140 (GRCm38) V259E probably benign Het
Slc25a3 A T 10: 91,118,042 (GRCm38) probably null Het
Sltm C G 9: 70,586,673 (GRCm38) P802R possibly damaging Het
Smc4 CTA CTATA 3: 69,018,067 (GRCm38) probably benign Het
Spock2 G A 10: 60,126,180 (GRCm38) D206N probably damaging Het
Stard3nl T G 13: 19,367,838 (GRCm38) R185S probably damaging Het
Supt16 A G 14: 52,197,099 (GRCm38) Y18H probably benign Het
Synpo G A 18: 60,603,428 (GRCm38) T482I probably damaging Het
Tmc6 G T 11: 117,769,220 (GRCm38) T694K probably benign Het
Trim59 T A 3: 69,037,926 (GRCm38) H27L probably damaging Het
Trpv2 G A 11: 62,591,006 (GRCm38) probably null Het
Tyw5 A T 1: 57,393,485 (GRCm38) D117E probably benign Het
Usp17la T C 7: 104,861,147 (GRCm38) Y320H probably damaging Het
Usp31 T C 7: 121,658,962 (GRCm38) D694G probably damaging Het
Vmn1r159 T A 7: 22,843,023 (GRCm38) T195S probably damaging Het
Vmn2r57 C T 7: 41,425,089 (GRCm38) V517M possibly damaging Het
Yipf1 A G 4: 107,318,996 (GRCm38) N29S probably benign Het
Zfp954 A T 7: 7,115,824 (GRCm38) F240L possibly damaging Het
Other mutations in Slco1a6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Slco1a6 APN 6 142,161,017 (GRCm38) missense probably benign 0.00
IGL00430:Slco1a6 APN 6 142,101,651 (GRCm38) nonsense probably null
IGL00541:Slco1a6 APN 6 142,096,299 (GRCm38) missense possibly damaging 0.67
IGL01340:Slco1a6 APN 6 142,109,383 (GRCm38) missense possibly damaging 0.71
IGL01693:Slco1a6 APN 6 142,133,209 (GRCm38) nonsense probably null
IGL01713:Slco1a6 APN 6 142,086,567 (GRCm38) missense possibly damaging 0.87
IGL01828:Slco1a6 APN 6 142,096,411 (GRCm38) missense probably damaging 1.00
IGL02049:Slco1a6 APN 6 142,101,583 (GRCm38) splice site probably benign
IGL02085:Slco1a6 APN 6 142,086,474 (GRCm38) missense probably benign 0.00
IGL02245:Slco1a6 APN 6 142,109,424 (GRCm38) missense probably damaging 1.00
IGL02549:Slco1a6 APN 6 142,096,415 (GRCm38) splice site probably benign
IGL02698:Slco1a6 APN 6 142,103,011 (GRCm38) nonsense probably null
IGL02948:Slco1a6 APN 6 142,133,235 (GRCm38) splice site probably null
IGL03075:Slco1a6 APN 6 142,103,149 (GRCm38) splice site probably benign
PIT4585001:Slco1a6 UTSW 6 142,109,520 (GRCm38) missense probably damaging 0.99
R0008:Slco1a6 UTSW 6 142,157,222 (GRCm38) unclassified probably benign
R0106:Slco1a6 UTSW 6 142,157,390 (GRCm38) unclassified probably benign
R0106:Slco1a6 UTSW 6 142,157,390 (GRCm38) unclassified probably benign
R0173:Slco1a6 UTSW 6 142,103,122 (GRCm38) missense probably benign 0.10
R1642:Slco1a6 UTSW 6 142,086,434 (GRCm38) missense probably benign 0.00
R1939:Slco1a6 UTSW 6 142,133,230 (GRCm38) missense probably damaging 1.00
R2256:Slco1a6 UTSW 6 142,091,016 (GRCm38) missense probably benign 0.04
R2257:Slco1a6 UTSW 6 142,091,016 (GRCm38) missense probably benign 0.04
R2696:Slco1a6 UTSW 6 142,112,936 (GRCm38) missense probably damaging 1.00
R2902:Slco1a6 UTSW 6 142,096,320 (GRCm38) missense probably damaging 1.00
R4602:Slco1a6 UTSW 6 142,101,652 (GRCm38) missense probably benign 0.00
R4611:Slco1a6 UTSW 6 142,101,652 (GRCm38) missense probably benign 0.00
R4958:Slco1a6 UTSW 6 142,145,705 (GRCm38) missense probably damaging 1.00
R5256:Slco1a6 UTSW 6 142,132,701 (GRCm38) missense probably benign 0.39
R5347:Slco1a6 UTSW 6 142,086,599 (GRCm38) missense probably damaging 0.98
R6130:Slco1a6 UTSW 6 142,086,429 (GRCm38) missense probably benign 0.26
R6384:Slco1a6 UTSW 6 142,109,379 (GRCm38) missense probably benign 0.01
R6543:Slco1a6 UTSW 6 142,133,146 (GRCm38) missense probably benign 0.00
R6662:Slco1a6 UTSW 6 142,133,215 (GRCm38) missense probably damaging 0.97
R6687:Slco1a6 UTSW 6 142,099,350 (GRCm38) missense possibly damaging 0.91
R6702:Slco1a6 UTSW 6 142,103,100 (GRCm38) missense probably damaging 0.99
R7012:Slco1a6 UTSW 6 142,086,561 (GRCm38) missense probably benign 0.02
R7140:Slco1a6 UTSW 6 142,103,019 (GRCm38) missense probably benign 0.00
R7392:Slco1a6 UTSW 6 142,157,277 (GRCm38) missense probably benign 0.00
R7399:Slco1a6 UTSW 6 142,091,068 (GRCm38) missense probably benign 0.01
R7476:Slco1a6 UTSW 6 142,103,001 (GRCm38) missense possibly damaging 0.71
R7621:Slco1a6 UTSW 6 142,161,017 (GRCm38) missense probably damaging 0.96
R8139:Slco1a6 UTSW 6 142,089,900 (GRCm38) missense probably damaging 1.00
R8177:Slco1a6 UTSW 6 142,101,734 (GRCm38) missense probably damaging 1.00
R8768:Slco1a6 UTSW 6 142,133,171 (GRCm38) missense probably benign 0.01
R8957:Slco1a6 UTSW 6 142,145,767 (GRCm38) missense probably damaging 0.99
R9090:Slco1a6 UTSW 6 142,089,849 (GRCm38) missense probably damaging 1.00
R9271:Slco1a6 UTSW 6 142,089,849 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCCAGAGAGGAAATTCAGAGCTTC -3'
(R):5'- AGCAGTCCAGGAGGGTTATAATGTC -3'

Sequencing Primer
(F):5'- GAGAGGAAATTCAGAGCTTCATTTCC -3'
(R):5'- CCAGGAGGGTTATAATGTCTGGAC -3'
Posted On 2019-10-24