Mutagenetix > Incidental Mutation

Incidental Mutation 'R7633:Vmn1r159'

589755

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r159

Ensembl Gene

ENSMUSG00000095931

Gene Name

vomeronasal 1 receptor 159

Synonyms

Gm16507

MMRRC Submission

045721-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R7633 (G1)

Quality Score

208.009

Status

Not validated

Chromosome

Chromosomal Location

22842688-22843605 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 22843023 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 195 (T195S)

Ref Sequence

ENSEMBL: ENSMUSP00000129692 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167871]

AlphaFold

K7N701

Predicted Effect

probably damaging
Transcript: ENSMUST00000167871
AA Change: T195S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000129692
Gene: ENSMUSG00000095931
AA Change: T195S

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	297	1.8e-16	PFAM
Pfam:7tm_1	31	288	7e-8	PFAM
Pfam:V1R	41	296	6.3e-16	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (52/52)

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930504O13Rik	C	A	11: 58,447,478	M29I	probably benign	Het
A530084C06Rik	G	T	13: 31,558,995	R92S	unknown	Het
Acaca	A	G	11: 84,372,639	I2029V	probably benign	Het
Anks1b	A	C	10: 90,948,584	D1138A	probably damaging	Het
Atr	T	A	9: 95,947,118	V2508E	probably damaging	Het
C4b	C	T	17: 34,729,399		probably null	Het
C530008M17Rik	A	G	5: 76,857,520	E576G	unknown	Het
Cd46	A	T	1: 195,083,619	M146K	probably null	Het
Chp1	A	G	2: 119,560,745	I28V	probably benign	Het
Chrnb1	T	A	11: 69,792,873	R216W	probably damaging	Het
Clmn	G	A	12: 104,782,112	T392M	probably benign	Het
Dcxr	A	C	11: 120,726,453	L88R	probably benign	Het
Dedd	C	T	1: 171,338,910	P138L	probably benign	Het
Degs1	A	G	1: 182,279,698	S35P	probably damaging	Het
Ehmt1	T	C	2: 24,815,780	D851G	possibly damaging	Het
Fam117b	A	G	1: 59,981,534	D521G	probably damaging	Het
Fam26d	G	A	10: 34,043,908	T121M	possibly damaging	Het
Gm14085	A	T	2: 122,486,680	R7S	probably null	Het
Gm21731	G	A	13: 120,240,840	W57*	probably null	Het
Gm6882	A	G	7: 21,427,652	V97A	probably damaging	Het
Hgs	A	T	11: 120,474,302	Q172L	probably damaging	Het
Hormad2	T	C	11: 4,346,662	Q274R	probably benign	Het
Igkv8-19	C	T	6: 70,341,399		probably benign	Het
Ikbkb	T	C	8: 22,671,741	N377S	probably benign	Het
Intu	G	A	3: 40,654,253	G232S	probably damaging	Het
Mov10	A	G	3: 104,797,065	S806P	possibly damaging	Het
Mrgprb1	A	G	7: 48,447,583	F194L	probably benign	Het
Notch3	A	T	17: 32,158,622	I160K	probably benign	Het
Nup155	C	G	15: 8,109,453	S3W	probably damaging	Het
Olfr1287	A	G	2: 111,449,622	I161V	probably benign	Het
Olfr284	A	G	15: 98,340,086	I301T	probably damaging	Het
Plxdc1	A	T	11: 97,956,151	F147L	possibly damaging	Het
Ppfia1	T	C	7: 144,552,436	D33G	possibly damaging	Het
Prdm11	G	A	2: 92,980,654	A200V	probably damaging	Het
Qrich2	A	T	11: 116,456,629	I1123K	unknown	Het
Rgs1	A	G	1: 144,248,477		probably null	Het
Skint7	T	A	4: 111,984,140	V259E	probably benign	Het
Slc25a3	A	T	10: 91,118,042		probably null	Het
Slco1a6	A	T	6: 142,145,755	I73N	probably damaging	Het
Sltm	C	G	9: 70,586,673	P802R	possibly damaging	Het
Smc4	CTA	CTATA	3: 69,018,067		probably benign	Het
Spock2	G	A	10: 60,126,180	D206N	probably damaging	Het
Stard3nl	T	G	13: 19,367,838	R185S	probably damaging	Het
Supt16	A	G	14: 52,197,099	Y18H	probably benign	Het
Synpo	G	A	18: 60,603,428	T482I	probably damaging	Het
Tmc6	G	T	11: 117,769,220	T694K	probably benign	Het
Trim59	T	A	3: 69,037,926	H27L	probably damaging	Het
Trpv2	G	A	11: 62,591,006		probably null	Het
Tyw5	A	T	1: 57,393,485	D117E	probably benign	Het
Usp17la	T	C	7: 104,861,147	Y320H	probably damaging	Het
Usp31	T	C	7: 121,658,962	D694G	probably damaging	Het
Vmn2r57	C	T	7: 41,425,089	V517M	possibly damaging	Het
Yipf1	A	G	4: 107,318,996	N29S	probably benign	Het
Zfp954	A	T	7: 7,115,824	F240L	possibly damaging	Het

Other mutations in Vmn1r159

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
ANU23:Vmn1r159	UTSW	7	22,843,163 (GRCm38)	missense	probably damaging	0.99
R1183:Vmn1r159	UTSW	7	22,843,594 (GRCm38)	missense	probably null	0.80
R1522:Vmn1r159	UTSW	7	22,843,268 (GRCm38)	missense	probably damaging	0.98
R1700:Vmn1r159	UTSW	7	22,842,965 (GRCm38)	missense	probably damaging	1.00
R2570:Vmn1r159	UTSW	7	22,842,882 (GRCm38)	missense	probably benign	0.07
R3620:Vmn1r159	UTSW	7	22,842,833 (GRCm38)	missense	possibly damaging	0.89
R4939:Vmn1r159	UTSW	7	22,842,891 (GRCm38)	missense	probably damaging	1.00
R4985:Vmn1r159	UTSW	7	22,843,534 (GRCm38)	missense	probably damaging	1.00
R6161:Vmn1r159	UTSW	7	22,843,187 (GRCm38)	missense	possibly damaging	0.63
R6365:Vmn1r159	UTSW	7	22,843,401 (GRCm38)	missense	probably damaging	1.00
R7033:Vmn1r159	UTSW	7	22,842,864 (GRCm38)	missense	probably damaging	1.00
R7817:Vmn1r159	UTSW	7	22,843,062 (GRCm38)	missense	possibly damaging	0.47
R7846:Vmn1r159	UTSW	7	22,843,271 (GRCm38)	missense	probably benign	0.01
R8008:Vmn1r159	UTSW	7	22,843,240 (GRCm38)	missense	possibly damaging	0.56
R8019:Vmn1r159	UTSW	7	22,842,823 (GRCm38)	missense	probably benign	0.01
R8222:Vmn1r159	UTSW	7	22,843,183 (GRCm38)	nonsense	probably null
R8291:Vmn1r159	UTSW	7	22,842,830 (GRCm38)	missense	possibly damaging	0.94
R8817:Vmn1r159	UTSW	7	22,843,134 (GRCm38)	missense	probably benign	0.04
R9170:Vmn1r159	UTSW	7	22,843,340 (GRCm38)	missense	probably damaging	1.00
R9242:Vmn1r159	UTSW	7	22,843,487 (GRCm38)	missense	probably benign	0.00
R9467:Vmn1r159	UTSW	7	22,842,716 (GRCm38)	missense	possibly damaging	0.90
R9525:Vmn1r159	UTSW	7	22,842,992 (GRCm38)	missense	probably damaging	0.96
R9601:Vmn1r159	UTSW	7	22,843,191 (GRCm38)	missense	probably damaging	1.00
R9699:Vmn1r159	UTSW	7	22,843,250 (GRCm38)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- ACCTCACTGACAAGCCTTATGAAG -3'
(R):5'- CAGAGCAAGTGTCCCAAATTTG -3'

Sequencing Primer
(F):5'- CACTGACAAGCCTTATGAAGAAATG -3'
(R):5'- AATTTGGTGAGTTATTCTTGTTACGG -3'

Posted On

2019-10-24