Incidental Mutation 'R7633:Vmn2r57'
ID 589756
Institutional Source Beutler Lab
Gene Symbol Vmn2r57
Ensembl Gene ENSMUSG00000066537
Gene Name vomeronasal 2, receptor 57
Synonyms EG269902
MMRRC Submission 045721-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.113) question?
Stock # R7633 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 41399732-41448641 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 41425089 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 517 (V517M)
Ref Sequence ENSEMBL: ENSMUSP00000125817 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094532] [ENSMUST00000165029]
AlphaFold L7N269
Predicted Effect probably benign
Transcript: ENSMUST00000094532
Predicted Effect possibly damaging
Transcript: ENSMUST00000165029
AA Change: V517M

PolyPhen 2 Score 0.764 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000125817
Gene: ENSMUSG00000066537
AA Change: V517M

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 471 1.4e-44 PFAM
Pfam:NCD3G 514 567 2.7e-23 PFAM
Pfam:7tm_3 600 835 1.8e-52 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (52/52)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930504O13Rik C A 11: 58,447,478 (GRCm38) M29I probably benign Het
A530084C06Rik G T 13: 31,558,995 (GRCm38) R92S unknown Het
Acaca A G 11: 84,372,639 (GRCm38) I2029V probably benign Het
Anks1b A C 10: 90,948,584 (GRCm38) D1138A probably damaging Het
Atr T A 9: 95,947,118 (GRCm38) V2508E probably damaging Het
C4b C T 17: 34,729,399 (GRCm38) probably null Het
C530008M17Rik A G 5: 76,857,520 (GRCm38) E576G unknown Het
Cd46 A T 1: 195,083,619 (GRCm38) M146K probably null Het
Chp1 A G 2: 119,560,745 (GRCm38) I28V probably benign Het
Chrnb1 T A 11: 69,792,873 (GRCm38) R216W probably damaging Het
Clmn G A 12: 104,782,112 (GRCm38) T392M probably benign Het
Dcxr A C 11: 120,726,453 (GRCm38) L88R probably benign Het
Dedd C T 1: 171,338,910 (GRCm38) P138L probably benign Het
Degs1 A G 1: 182,279,698 (GRCm38) S35P probably damaging Het
Ehmt1 T C 2: 24,815,780 (GRCm38) D851G possibly damaging Het
Fam117b A G 1: 59,981,534 (GRCm38) D521G probably damaging Het
Fam26d G A 10: 34,043,908 (GRCm38) T121M possibly damaging Het
Gm14085 A T 2: 122,486,680 (GRCm38) R7S probably null Het
Gm21731 G A 13: 120,240,840 (GRCm38) W57* probably null Het
Gm6882 A G 7: 21,427,652 (GRCm38) V97A probably damaging Het
Hgs A T 11: 120,474,302 (GRCm38) Q172L probably damaging Het
Hormad2 T C 11: 4,346,662 (GRCm38) Q274R probably benign Het
Igkv8-19 C T 6: 70,341,399 (GRCm38) probably benign Het
Ikbkb T C 8: 22,671,741 (GRCm38) N377S probably benign Het
Intu G A 3: 40,654,253 (GRCm38) G232S probably damaging Het
Mov10 A G 3: 104,797,065 (GRCm38) S806P possibly damaging Het
Mrgprb1 A G 7: 48,447,583 (GRCm38) F194L probably benign Het
Notch3 A T 17: 32,158,622 (GRCm38) I160K probably benign Het
Nup155 C G 15: 8,109,453 (GRCm38) S3W probably damaging Het
Olfr1287 A G 2: 111,449,622 (GRCm38) I161V probably benign Het
Olfr284 A G 15: 98,340,086 (GRCm38) I301T probably damaging Het
Plxdc1 A T 11: 97,956,151 (GRCm38) F147L possibly damaging Het
Ppfia1 T C 7: 144,552,436 (GRCm38) D33G possibly damaging Het
Prdm11 G A 2: 92,980,654 (GRCm38) A200V probably damaging Het
Qrich2 A T 11: 116,456,629 (GRCm38) I1123K unknown Het
Rgs1 A G 1: 144,248,477 (GRCm38) probably null Het
Skint7 T A 4: 111,984,140 (GRCm38) V259E probably benign Het
Slc25a3 A T 10: 91,118,042 (GRCm38) probably null Het
Slco1a6 A T 6: 142,145,755 (GRCm38) I73N probably damaging Het
Sltm C G 9: 70,586,673 (GRCm38) P802R possibly damaging Het
Smc4 CTA CTATA 3: 69,018,067 (GRCm38) probably benign Het
Spock2 G A 10: 60,126,180 (GRCm38) D206N probably damaging Het
Stard3nl T G 13: 19,367,838 (GRCm38) R185S probably damaging Het
Supt16 A G 14: 52,197,099 (GRCm38) Y18H probably benign Het
Synpo G A 18: 60,603,428 (GRCm38) T482I probably damaging Het
Tmc6 G T 11: 117,769,220 (GRCm38) T694K probably benign Het
Trim59 T A 3: 69,037,926 (GRCm38) H27L probably damaging Het
Trpv2 G A 11: 62,591,006 (GRCm38) probably null Het
Tyw5 A T 1: 57,393,485 (GRCm38) D117E probably benign Het
Usp17la T C 7: 104,861,147 (GRCm38) Y320H probably damaging Het
Usp31 T C 7: 121,658,962 (GRCm38) D694G probably damaging Het
Vmn1r159 T A 7: 22,843,023 (GRCm38) T195S probably damaging Het
Yipf1 A G 4: 107,318,996 (GRCm38) N29S probably benign Het
Zfp954 A T 7: 7,115,824 (GRCm38) F240L possibly damaging Het
Other mutations in Vmn2r57
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00159:Vmn2r57 APN 7 41,428,785 (GRCm38) missense probably benign
IGL01108:Vmn2r57 APN 7 41,427,584 (GRCm38) missense probably benign 0.01
IGL01112:Vmn2r57 APN 7 41,425,043 (GRCm38) missense probably damaging 1.00
IGL01516:Vmn2r57 APN 7 41,399,946 (GRCm38) missense probably damaging 1.00
IGL01880:Vmn2r57 APN 7 41,400,195 (GRCm38) missense possibly damaging 0.73
IGL02117:Vmn2r57 APN 7 41,400,450 (GRCm38) missense probably benign 0.00
IGL02500:Vmn2r57 APN 7 41,428,226 (GRCm38) missense probably benign
IGL02801:Vmn2r57 APN 7 41,448,632 (GRCm38) missense probably benign 0.13
IGL02993:Vmn2r57 APN 7 41,428,074 (GRCm38) missense probably benign 0.04
IGL02996:Vmn2r57 APN 7 41,399,741 (GRCm38) missense probably benign 0.02
R0008:Vmn2r57 UTSW 7 41,400,652 (GRCm38) missense probably damaging 1.00
R0032:Vmn2r57 UTSW 7 41,399,733 (GRCm38) splice site probably null
R0305:Vmn2r57 UTSW 7 41,427,543 (GRCm38) missense probably benign 0.00
R0469:Vmn2r57 UTSW 7 41,427,792 (GRCm38) missense possibly damaging 0.58
R0510:Vmn2r57 UTSW 7 41,427,792 (GRCm38) missense possibly damaging 0.58
R0847:Vmn2r57 UTSW 7 41,428,801 (GRCm38) missense probably benign 0.00
R1025:Vmn2r57 UTSW 7 41,427,804 (GRCm38) missense probably benign 0.24
R1081:Vmn2r57 UTSW 7 41,428,211 (GRCm38) missense possibly damaging 0.47
R1479:Vmn2r57 UTSW 7 41,427,830 (GRCm38) missense possibly damaging 0.45
R1579:Vmn2r57 UTSW 7 41,400,124 (GRCm38) missense probably benign 0.38
R1764:Vmn2r57 UTSW 7 41,400,643 (GRCm38) missense probably damaging 1.00
R1848:Vmn2r57 UTSW 7 41,428,107 (GRCm38) missense probably damaging 1.00
R2006:Vmn2r57 UTSW 7 41,448,577 (GRCm38) missense probably benign 0.00
R2197:Vmn2r57 UTSW 7 41,428,825 (GRCm38) critical splice acceptor site probably null
R2242:Vmn2r57 UTSW 7 41,428,074 (GRCm38) missense probably benign 0.00
R2394:Vmn2r57 UTSW 7 41,400,195 (GRCm38) missense possibly damaging 0.73
R3937:Vmn2r57 UTSW 7 41,428,130 (GRCm38) missense probably damaging 0.97
R4193:Vmn2r57 UTSW 7 41,428,239 (GRCm38) missense probably benign
R4423:Vmn2r57 UTSW 7 41,426,640 (GRCm38) missense probably damaging 1.00
R4865:Vmn2r57 UTSW 7 41,400,468 (GRCm38) missense probably damaging 1.00
R4947:Vmn2r57 UTSW 7 41,400,495 (GRCm38) missense probably damaging 1.00
R5042:Vmn2r57 UTSW 7 41,428,662 (GRCm38) missense probably benign 0.06
R5084:Vmn2r57 UTSW 7 41,426,550 (GRCm38) critical splice donor site probably null
R5177:Vmn2r57 UTSW 7 41,400,240 (GRCm38) missense probably benign 0.31
R5192:Vmn2r57 UTSW 7 41,427,939 (GRCm38) missense probably damaging 0.96
R5289:Vmn2r57 UTSW 7 41,399,974 (GRCm38) missense probably damaging 0.99
R5745:Vmn2r57 UTSW 7 41,448,471 (GRCm38) missense possibly damaging 0.51
R6051:Vmn2r57 UTSW 7 41,448,472 (GRCm38) missense probably benign 0.00
R6155:Vmn2r57 UTSW 7 41,428,690 (GRCm38) missense probably benign 0.14
R6248:Vmn2r57 UTSW 7 41,399,860 (GRCm38) missense probably benign
R6381:Vmn2r57 UTSW 7 41,428,818 (GRCm38) missense probably benign 0.08
R7019:Vmn2r57 UTSW 7 41,428,665 (GRCm38) missense probably damaging 1.00
R7126:Vmn2r57 UTSW 7 41,399,794 (GRCm38) missense possibly damaging 0.93
R7146:Vmn2r57 UTSW 7 41,448,471 (GRCm38) missense possibly damaging 0.51
R7215:Vmn2r57 UTSW 7 41,400,286 (GRCm38) missense probably benign 0.00
R7432:Vmn2r57 UTSW 7 41,426,724 (GRCm38) missense probably benign 0.01
R7811:Vmn2r57 UTSW 7 41,425,015 (GRCm38) nonsense probably null
R8025:Vmn2r57 UTSW 7 41,426,759 (GRCm38) missense probably benign 0.00
R8332:Vmn2r57 UTSW 7 41,400,253 (GRCm38) missense probably benign 0.01
R8345:Vmn2r57 UTSW 7 41,427,544 (GRCm38) missense possibly damaging 0.81
R8360:Vmn2r57 UTSW 7 41,400,216 (GRCm38) missense probably damaging 1.00
R8738:Vmn2r57 UTSW 7 41,427,596 (GRCm38) missense probably benign 0.00
R8758:Vmn2r57 UTSW 7 41,428,739 (GRCm38) missense probably damaging 1.00
R8955:Vmn2r57 UTSW 7 41,400,147 (GRCm38) missense possibly damaging 0.64
R8985:Vmn2r57 UTSW 7 41,399,835 (GRCm38) missense probably benign
R9108:Vmn2r57 UTSW 7 41,428,768 (GRCm38) missense possibly damaging 0.87
R9160:Vmn2r57 UTSW 7 41,426,735 (GRCm38) missense possibly damaging 0.48
R9354:Vmn2r57 UTSW 7 41,400,239 (GRCm38) missense probably benign 0.01
R9566:Vmn2r57 UTSW 7 41,427,665 (GRCm38) missense probably benign 0.32
R9633:Vmn2r57 UTSW 7 41,426,582 (GRCm38) missense probably benign 0.00
X0026:Vmn2r57 UTSW 7 41,428,561 (GRCm38) missense possibly damaging 0.91
X0026:Vmn2r57 UTSW 7 41,428,125 (GRCm38) missense probably benign 0.03
X0065:Vmn2r57 UTSW 7 41,427,971 (GRCm38) missense probably benign 0.09
Z1176:Vmn2r57 UTSW 7 41,400,498 (GRCm38) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TAACTACTGGGCAAGAGCTTATCTC -3'
(R):5'- GCATGGTATTGGGCCAAAATG -3'

Sequencing Primer
(F):5'- GAGCTTATCTCTTACTTATCTCCAGG -3'
(R):5'- CATGGTATTGGGCCAAAATGTAAAC -3'
Posted On 2019-10-24