|Institutional Source||Beutler Lab|
|Gene Name||transient receptor potential cation channel, subfamily V, member 2|
|Synonyms||Vrl1, OTRPC2, VRL-1|
|Is this an essential gene?||Possibly essential (E-score: 0.678)|
|Stock #||R7633 (G1)|
|Chromosomal Location||62574486-62600515 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (1 bp from exon)|
|DNA Base Change (assembly)||G to A at 62591006 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000018651 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000018651] [ENSMUST00000102643]|
|Coding Region Coverage||
|Validation Efficiency||100% (52/52)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired macrophage migration, binding, and phagocytosis with increased susceptiblity and mortality following bacterial infection. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Trpv2||
(F):5'- TCGTGGGCAGCTAGTTACTG -3'
(R):5'- CTGCAGTGCCAGAAACACAG -3'
(F):5'- CAGCTAGTTACTGGGGATGGGAC -3'
(R):5'- TCATAGCAGTAAGTGTGCCAG -3'