Incidental Mutation 'R7634:Tars3'
ID 589815
Institutional Source Beutler Lab
Gene Symbol Tars3
Ensembl Gene ENSMUSG00000030515
Gene Name threonyl-tRNA synthetase 3
Synonyms A530046H20Rik, Tarsl2
MMRRC Submission 045693-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.178) question?
Stock # R7634 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 65294646-65341839 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 65325760 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 445 (Y445N)
Ref Sequence ENSEMBL: ENSMUSP00000032728 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032728]
AlphaFold Q8BLY2
Predicted Effect probably damaging
Transcript: ENSMUST00000032728
AA Change: Y445N

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000032728
Gene: ENSMUSG00000030515
AA Change: Y445N

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
coiled coil region 44 68 N/A INTRINSIC
Pfam:TGS 151 210 8.8e-14 PFAM
tRNA_SAD 316 365 1.26e-16 SMART
Pfam:tRNA-synt_2b 464 675 2.2e-35 PFAM
Pfam:HGTP_anticodon 687 778 1.1e-20 PFAM
Meta Mutation Damage Score 0.7288 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (58/58)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadat A T 8: 60,969,102 (GRCm39) M116L probably benign Het
Adam25 A G 8: 41,207,883 (GRCm39) D383G probably benign Het
Adam26b T A 8: 43,974,034 (GRCm39) M323L probably benign Het
Adgrf3 T C 5: 30,407,245 (GRCm39) H227R probably benign Het
Antxr1 G A 6: 87,114,273 (GRCm39) T498I probably benign Het
Arg1 T A 10: 24,791,627 (GRCm39) T285S possibly damaging Het
Arhgdig T C 17: 26,418,365 (GRCm39) D206G probably damaging Het
Asb10 C A 5: 24,745,875 (GRCm39) C17F possibly damaging Het
Atg2b T C 12: 105,618,379 (GRCm39) D891G probably damaging Het
Cacna1h A T 17: 25,611,083 (GRCm39) S572T possibly damaging Het
Cenpj T C 14: 56,780,257 (GRCm39) T985A probably benign Het
Cfap65 G T 1: 74,941,593 (GRCm39) N1780K probably damaging Het
Cyp26c1 T C 19: 37,681,447 (GRCm39) Y417H probably damaging Het
Dnajb13 G T 7: 100,152,393 (GRCm39) Q308K probably benign Het
Fam107b T C 2: 3,771,777 (GRCm39) S3P possibly damaging Het
Gm3127 A G 14: 15,425,787 (GRCm39) N64S probably damaging Het
Gm4847 A C 1: 166,460,249 (GRCm39) N412K probably benign Het
Gtf3c3 A T 1: 54,458,800 (GRCm39) probably null Het
Guf1 T C 5: 69,721,887 (GRCm39) S349P probably damaging Het
Hvcn1 A G 5: 122,371,586 (GRCm39) Y42C probably damaging Het
Insm1 A G 2: 146,065,027 (GRCm39) Y281C probably damaging Het
Lrrc71 A G 3: 87,650,281 (GRCm39) I264T probably damaging Het
Lrriq1 T C 10: 103,036,462 (GRCm39) N897S probably damaging Het
Mtmr6 T A 14: 60,533,596 (GRCm39) F375I probably damaging Het
Mtor G C 4: 148,536,807 (GRCm39) S27T possibly damaging Het
Mylk4 T A 13: 32,892,891 (GRCm39) K387N possibly damaging Het
Nadk2 T G 15: 9,092,935 (GRCm39) D247E probably benign Het
Nfya T C 17: 48,699,445 (GRCm39) T213A probably damaging Het
Nlrp1a A G 11: 70,990,354 (GRCm39) V1067A probably benign Het
Nrbp2 C T 15: 75,959,257 (GRCm39) R206Q possibly damaging Het
Oas2 A G 5: 120,871,293 (GRCm39) V722A probably benign Het
Odad4 G A 11: 100,452,731 (GRCm39) probably null Het
Or4c108 G T 2: 88,804,001 (GRCm39) P78Q probably damaging Het
Pcdhb2 G T 18: 37,428,000 (GRCm39) probably benign Het
Pdpr T A 8: 111,852,317 (GRCm39) H561Q probably damaging Het
Plcz1 A G 6: 139,961,853 (GRCm39) F233L probably damaging Het
Ppp1r3d A G 2: 178,055,165 (GRCm39) I279T probably damaging Het
Psg17 A G 7: 18,548,416 (GRCm39) Y452H probably damaging Het
Reg4 T C 3: 98,140,428 (GRCm39) probably null Het
Rint1 A G 5: 24,010,477 (GRCm39) T229A probably benign Het
Robo1 T G 16: 72,839,866 (GRCm39) probably null Het
Slc22a26 A C 19: 7,779,952 (GRCm39) probably null Het
Slc22a7 C T 17: 46,749,156 (GRCm39) A54T probably benign Het
Slc52a3 C A 2: 151,846,534 (GRCm39) T165N possibly damaging Het
Slc7a11 C T 3: 50,378,486 (GRCm39) probably null Het
Smap2 T C 4: 120,873,996 (GRCm39) N18S probably benign Het
Spag6l T C 16: 16,595,278 (GRCm39) E369G probably damaging Het
Tmem161b C A 13: 84,370,537 (GRCm39) probably benign Het
Tmprss7 C T 16: 45,483,637 (GRCm39) G579D probably benign Het
Tpi1 T A 6: 124,789,817 (GRCm39) K109* probably null Het
Ttn T C 2: 76,628,856 (GRCm39) E14466G possibly damaging Het
Usp40 A T 1: 87,890,152 (GRCm39) C903* probably null Het
Vinac1 T A 2: 128,880,192 (GRCm39) D578V Het
Vmn2r104 T A 17: 20,261,971 (GRCm39) L386F possibly damaging Het
Vmn2r54 G A 7: 12,349,630 (GRCm39) P651S probably damaging Het
Wnk4 C A 11: 101,153,721 (GRCm39) T261K probably damaging Het
Wnt2b T C 3: 104,854,432 (GRCm39) Y342C probably damaging Het
Zbtb8b A G 4: 129,326,755 (GRCm39) Y137H probably damaging Het
Other mutations in Tars3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Tars3 APN 7 65,302,007 (GRCm39) critical splice acceptor site probably null
IGL00470:Tars3 APN 7 65,338,656 (GRCm39) missense probably benign 0.03
IGL00594:Tars3 APN 7 65,325,880 (GRCm39) critical splice donor site probably null
IGL01352:Tars3 APN 7 65,308,658 (GRCm39) missense possibly damaging 0.80
IGL01519:Tars3 APN 7 65,313,634 (GRCm39) missense probably damaging 1.00
IGL01726:Tars3 APN 7 65,332,566 (GRCm39) missense possibly damaging 0.46
IGL02370:Tars3 APN 7 65,310,913 (GRCm39) missense probably benign 0.17
IGL02729:Tars3 APN 7 65,332,567 (GRCm39) missense probably damaging 0.97
IGL03234:Tars3 APN 7 65,302,026 (GRCm39) missense probably benign 0.06
gary UTSW 7 65,338,700 (GRCm39) critical splice donor site probably null
R8254_tarsl2_650 UTSW 7 65,325,809 (GRCm39) missense probably benign
smart_money UTSW 7 65,327,890 (GRCm39) missense probably damaging 1.00
R0127:Tars3 UTSW 7 65,314,717 (GRCm39) missense probably benign 0.19
R0153:Tars3 UTSW 7 65,333,829 (GRCm39) missense probably damaging 1.00
R0605:Tars3 UTSW 7 65,327,819 (GRCm39) missense probably damaging 1.00
R1070:Tars3 UTSW 7 65,305,444 (GRCm39) missense probably damaging 1.00
R1450:Tars3 UTSW 7 65,297,244 (GRCm39) missense probably benign 0.01
R1467:Tars3 UTSW 7 65,305,444 (GRCm39) missense probably damaging 1.00
R1467:Tars3 UTSW 7 65,305,444 (GRCm39) missense probably damaging 1.00
R2142:Tars3 UTSW 7 65,308,645 (GRCm39) missense probably benign
R2143:Tars3 UTSW 7 65,305,539 (GRCm39) missense possibly damaging 0.57
R2144:Tars3 UTSW 7 65,305,539 (GRCm39) missense possibly damaging 0.57
R2145:Tars3 UTSW 7 65,305,539 (GRCm39) missense possibly damaging 0.57
R2208:Tars3 UTSW 7 65,332,596 (GRCm39) missense probably damaging 1.00
R3713:Tars3 UTSW 7 65,338,700 (GRCm39) critical splice donor site probably null
R3715:Tars3 UTSW 7 65,338,700 (GRCm39) critical splice donor site probably null
R3914:Tars3 UTSW 7 65,333,556 (GRCm39) missense probably benign 0.05
R3929:Tars3 UTSW 7 65,333,791 (GRCm39) splice site probably null
R4008:Tars3 UTSW 7 65,327,876 (GRCm39) missense probably damaging 1.00
R4064:Tars3 UTSW 7 65,302,018 (GRCm39) missense possibly damaging 0.90
R4367:Tars3 UTSW 7 65,332,567 (GRCm39) missense probably damaging 0.97
R4652:Tars3 UTSW 7 65,339,717 (GRCm39) missense probably damaging 1.00
R4825:Tars3 UTSW 7 65,297,302 (GRCm39) missense probably benign 0.38
R4901:Tars3 UTSW 7 65,341,042 (GRCm39) missense probably benign 0.05
R4999:Tars3 UTSW 7 65,308,683 (GRCm39) missense probably damaging 0.99
R5423:Tars3 UTSW 7 65,333,567 (GRCm39) missense probably benign 0.00
R5756:Tars3 UTSW 7 65,325,724 (GRCm39) missense probably benign 0.22
R5772:Tars3 UTSW 7 65,333,873 (GRCm39) missense probably damaging 1.00
R6160:Tars3 UTSW 7 65,332,527 (GRCm39) missense probably benign 0.32
R6230:Tars3 UTSW 7 65,336,184 (GRCm39) splice site probably null
R6424:Tars3 UTSW 7 65,305,487 (GRCm39) missense probably damaging 1.00
R6615:Tars3 UTSW 7 65,327,890 (GRCm39) missense probably damaging 1.00
R6792:Tars3 UTSW 7 65,312,051 (GRCm39) missense probably damaging 1.00
R7350:Tars3 UTSW 7 65,308,672 (GRCm39) missense probably damaging 1.00
R7549:Tars3 UTSW 7 65,297,341 (GRCm39) missense probably damaging 0.96
R7592:Tars3 UTSW 7 65,308,619 (GRCm39) missense probably benign 0.01
R7710:Tars3 UTSW 7 65,314,717 (GRCm39) missense probably benign 0.19
R7808:Tars3 UTSW 7 65,302,009 (GRCm39) missense probably benign 0.01
R7875:Tars3 UTSW 7 65,327,899 (GRCm39) missense probably benign 0.05
R8254:Tars3 UTSW 7 65,325,809 (GRCm39) missense probably benign
R8793:Tars3 UTSW 7 65,294,673 (GRCm39) start gained probably benign
R9162:Tars3 UTSW 7 65,332,518 (GRCm39) missense probably benign 0.01
R9200:Tars3 UTSW 7 65,302,013 (GRCm39) missense probably benign
R9461:Tars3 UTSW 7 65,339,719 (GRCm39) missense possibly damaging 0.68
R9533:Tars3 UTSW 7 65,333,808 (GRCm39) critical splice acceptor site probably null
Z1177:Tars3 UTSW 7 65,302,012 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CTGTCACCTGAGGAACCATG -3'
(R):5'- ACTCTTCCCATTCCAGAGAATC -3'

Sequencing Primer
(F):5'- CACCTGAGGAACCATGAATTAATAG -3'
(R):5'- ACGTGAACAGCTGATTCTGATGC -3'
Posted On 2019-10-24