Incidental Mutation 'R7636:Or2w3b'
ID 589971
Institutional Source Beutler Lab
Gene Symbol Or2w3b
Ensembl Gene ENSMUSG00000060030
Gene Name olfactory receptor family 2 subfamily W member 3B
Synonyms Olfr317, GA_x6K02T2NKPP-680866-681849, MOR256-47
MMRRC Submission 045722-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R7636 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 58622922-58624049 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 58623273 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 239 (N239K)
Ref Sequence ENSEMBL: ENSMUSP00000150575 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075607] [ENSMUST00000215513] [ENSMUST00000216196]
AlphaFold Q5NCD6
Predicted Effect possibly damaging
Transcript: ENSMUST00000075607
AA Change: N239K

PolyPhen 2 Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000075034
Gene: ENSMUSG00000060030
AA Change: N239K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.4e-50 PFAM
Pfam:7tm_1 41 290 5.8e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215513
AA Change: N239K

PolyPhen 2 Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216196
AA Change: N239K

PolyPhen 2 Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610318N02Rik C T 16: 16,935,701 (GRCm39) E199K possibly damaging Het
Akap13 C A 7: 75,259,621 (GRCm39) N748K probably benign Het
Aldh16a1 G T 7: 44,796,955 (GRCm39) P58T unknown Het
Amhr2 T A 15: 102,360,893 (GRCm39) C343S probably damaging Het
Ankrd17 A T 5: 90,380,239 (GRCm39) M2483K possibly damaging Het
Ano3 A T 2: 110,513,048 (GRCm39) L649* probably null Het
Apob T C 12: 8,059,516 (GRCm39) I2666T possibly damaging Het
C1ql3 A T 2: 13,015,621 (GRCm39) V13E probably benign Het
Casp12 A G 9: 5,358,344 (GRCm39) I384V probably benign Het
Cimip2a A T 2: 25,108,832 (GRCm39) H7L probably damaging Het
Clcn1 A T 6: 42,268,268 (GRCm39) K147* probably null Het
Ctnna1 T A 18: 35,356,526 (GRCm39) N398K possibly damaging Het
Dcdc2a A T 13: 25,286,605 (GRCm39) K176M probably damaging Het
Depdc5 T A 5: 33,075,327 (GRCm39) S502T probably benign Het
Fam83e G A 7: 45,376,450 (GRCm39) D388N probably damaging Het
Fbxl15 G A 19: 46,317,614 (GRCm39) E99K probably benign Het
Fbxw2 T C 2: 34,702,956 (GRCm39) T186A probably benign Het
Frem2 T A 3: 53,560,668 (GRCm39) M1280L probably benign Het
Gbgt1 T A 2: 28,395,326 (GRCm39) D321E probably damaging Het
Gsdmc2 T A 15: 63,700,041 (GRCm39) T244S probably benign Het
Heatr5a C A 12: 51,934,979 (GRCm39) G1675W probably damaging Het
Heatr5a G A 12: 51,999,341 (GRCm39) L287F probably damaging Het
Hfm1 C A 5: 107,065,332 (GRCm39) A116S probably benign Het
Insr A G 8: 3,308,709 (GRCm39) I109T probably damaging Het
Itga4 A G 2: 79,144,176 (GRCm39) I688V probably benign Het
Lipe A G 7: 25,088,042 (GRCm39) M49T probably benign Het
Lrriq3 A G 3: 154,893,787 (GRCm39) Y496C probably damaging Het
Lyst T C 13: 13,791,332 (GRCm39) probably null Het
Megf10 T A 18: 57,410,061 (GRCm39) I614N possibly damaging Het
Mkx A G 18: 7,000,630 (GRCm39) I104T possibly damaging Het
Mrgpra4 C A 7: 47,630,721 (GRCm39) L293F possibly damaging Het
Olfm2 A G 9: 20,579,593 (GRCm39) V386A possibly damaging Het
Or4a15 A T 2: 89,193,583 (GRCm39) Y63* probably null Het
Or52s6 C A 7: 103,092,040 (GRCm39) D97Y probably damaging Het
Pkd2l1 G T 19: 44,179,870 (GRCm39) D113E possibly damaging Het
Rab11fip2 A T 19: 59,931,317 (GRCm39) I39K possibly damaging Het
Rab1b A T 19: 5,150,810 (GRCm39) V99E probably damaging Het
Rad54l2 A T 9: 106,597,586 (GRCm39) L140Q probably damaging Het
Repin1 T C 6: 48,573,299 (GRCm39) F76S probably benign Het
Robo1 A G 16: 72,360,615 (GRCm39) D9G Het
Scn3a A G 2: 65,328,033 (GRCm39) L819P probably damaging Het
Scn7a A T 2: 66,574,172 (GRCm39) N150K possibly damaging Het
Sh2d3c T C 2: 32,615,023 (GRCm39) S38P probably benign Het
Sin3b A T 8: 73,474,362 (GRCm39) K549* probably null Het
Sorl1 A G 9: 42,003,630 (GRCm39) F222S possibly damaging Het
Spata31h1 T A 10: 82,130,973 (GRCm39) D679V probably benign Het
Tmem147 A T 7: 30,427,726 (GRCm39) probably null Het
Tmem161b C A 13: 84,370,537 (GRCm39) probably benign Het
Tmem179 C T 12: 112,477,177 (GRCm39) probably null Het
Tubg2 A T 11: 101,050,913 (GRCm39) I213F probably damaging Het
Zfhx3 T C 8: 109,673,441 (GRCm39) I1497T probably benign Het
Zfp128 A T 7: 12,624,039 (GRCm39) M136L probably benign Het
Zzz3 G A 3: 152,133,289 (GRCm39) A116T probably benign Het
Other mutations in Or2w3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02692:Or2w3b APN 11 58,623,343 (GRCm39) missense probably benign 0.07
IGL03330:Or2w3b APN 11 58,623,745 (GRCm39) missense probably damaging 1.00
R0554:Or2w3b UTSW 11 58,623,865 (GRCm39) missense probably damaging 1.00
R1109:Or2w3b UTSW 11 58,623,742 (GRCm39) missense probably benign 0.03
R2012:Or2w3b UTSW 11 58,623,214 (GRCm39) missense possibly damaging 0.60
R2243:Or2w3b UTSW 11 58,623,271 (GRCm39) missense probably damaging 1.00
R2253:Or2w3b UTSW 11 58,623,821 (GRCm39) missense probably benign 0.23
R5400:Or2w3b UTSW 11 58,623,146 (GRCm39) missense possibly damaging 0.74
R6551:Or2w3b UTSW 11 58,623,583 (GRCm39) missense probably damaging 0.99
R6944:Or2w3b UTSW 11 58,623,068 (GRCm39) missense possibly damaging 0.93
R7144:Or2w3b UTSW 11 58,623,571 (GRCm39) missense probably damaging 1.00
R7985:Or2w3b UTSW 11 58,623,532 (GRCm39) missense possibly damaging 0.49
R8201:Or2w3b UTSW 11 58,623,940 (GRCm39) missense probably damaging 1.00
R8374:Or2w3b UTSW 11 58,623,724 (GRCm39) missense probably damaging 0.97
R8692:Or2w3b UTSW 11 58,623,595 (GRCm39) missense probably damaging 1.00
R9006:Or2w3b UTSW 11 58,623,188 (GRCm39) nonsense probably null
Z1186:Or2w3b UTSW 11 58,624,048 (GRCm39) intron probably benign
Z1186:Or2w3b UTSW 11 58,623,200 (GRCm39) missense probably benign 0.02
Z1186:Or2w3b UTSW 11 58,623,475 (GRCm39) missense probably benign
Z1187:Or2w3b UTSW 11 58,624,048 (GRCm39) intron probably benign
Z1187:Or2w3b UTSW 11 58,623,200 (GRCm39) missense probably benign 0.02
Z1187:Or2w3b UTSW 11 58,623,295 (GRCm39) missense probably benign 0.04
Z1187:Or2w3b UTSW 11 58,623,475 (GRCm39) missense probably benign
Z1188:Or2w3b UTSW 11 58,623,475 (GRCm39) missense probably benign
Z1188:Or2w3b UTSW 11 58,623,295 (GRCm39) missense probably benign 0.04
Z1188:Or2w3b UTSW 11 58,623,200 (GRCm39) missense probably benign 0.02
Z1188:Or2w3b UTSW 11 58,624,048 (GRCm39) intron probably benign
Z1189:Or2w3b UTSW 11 58,624,048 (GRCm39) intron probably benign
Z1189:Or2w3b UTSW 11 58,623,475 (GRCm39) missense probably benign
Z1190:Or2w3b UTSW 11 58,623,475 (GRCm39) missense probably benign
Z1190:Or2w3b UTSW 11 58,623,295 (GRCm39) missense probably benign 0.04
Z1190:Or2w3b UTSW 11 58,623,200 (GRCm39) missense probably benign 0.02
Z1190:Or2w3b UTSW 11 58,624,048 (GRCm39) intron probably benign
Z1191:Or2w3b UTSW 11 58,623,475 (GRCm39) missense probably benign
Z1191:Or2w3b UTSW 11 58,623,295 (GRCm39) missense probably benign 0.04
Z1191:Or2w3b UTSW 11 58,623,200 (GRCm39) missense probably benign 0.02
Z1191:Or2w3b UTSW 11 58,624,048 (GRCm39) intron probably benign
Z1192:Or2w3b UTSW 11 58,623,475 (GRCm39) missense probably benign
Z1192:Or2w3b UTSW 11 58,623,295 (GRCm39) missense probably benign 0.04
Z1192:Or2w3b UTSW 11 58,623,200 (GRCm39) missense probably benign 0.02
Z1192:Or2w3b UTSW 11 58,624,048 (GRCm39) intron probably benign
Predicted Primers PCR Primer
(F):5'- CCTTGTTCCTGAGCGTGTAG -3'
(R):5'- ATGTCTCCAGCAACTCTCAGC -3'

Sequencing Primer
(F):5'- AGCGTGTAGATCAGAGGGTTG -3'
(R):5'- GGATCACTTCCTCTGCGAGATG -3'
Posted On 2019-10-24