Incidental Mutation 'R7637:Selenbp1'
ID 590001
Institutional Source Beutler Lab
Gene Symbol Selenbp1
Ensembl Gene ENSMUSG00000068874
Gene Name selenium binding protein 1
Synonyms Lp56, Lpsb
MMRRC Submission 045695-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7637 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 94840394-94852069 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 94844659 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 105 (Y105*)
Ref Sequence ENSEMBL: ENSMUSP00000088349 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090839] [ENSMUST00000134202] [ENSMUST00000140757]
AlphaFold P17563
Predicted Effect probably null
Transcript: ENSMUST00000090839
AA Change: Y105*
SMART Domains Protein: ENSMUSP00000088349
Gene: ENSMUSG00000068874
AA Change: Y105*

DomainStartEndE-ValueType
Pfam:SBP56 6 472 3.2e-225 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000134202
AA Change: Y105*
SMART Domains Protein: ENSMUSP00000120159
Gene: ENSMUSG00000068874
AA Change: Y105*

DomainStartEndE-ValueType
Pfam:SBP56 6 123 4.7e-56 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000140757
AA Change: Y105*
SMART Domains Protein: ENSMUSP00000118563
Gene: ENSMUSG00000068874
AA Change: Y105*

DomainStartEndE-ValueType
Pfam:SBP56 6 123 4.7e-56 PFAM
Meta Mutation Damage Score 0.9756 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (51/51)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit sex-specific changes in organ weights. Mice homozygous for a different allele lack methanethiol oxidase activity and exhibit an increase in dimethylsulfide and dimethyl-sulfone serum levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 T A 11: 110,109,778 (GRCm39) Q651L probably benign Het
Adam8 C T 7: 139,565,343 (GRCm39) V624I probably damaging Het
Cltc T C 11: 86,621,158 (GRCm39) H287R probably damaging Het
Cmya5 T C 13: 93,219,720 (GRCm39) K3243R possibly damaging Het
Dock5 G A 14: 68,023,789 (GRCm39) T1124M possibly damaging Het
Fam8a1 A T 13: 46,824,723 (GRCm39) M237L probably benign Het
Fars2 G T 13: 36,388,758 (GRCm39) K82N probably benign Het
Gm40460 ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG 7: 141,794,450 (GRCm39) probably benign Het
Gm57858 T A 3: 36,101,025 (GRCm39) Q49L probably damaging Het
Gnat3 A G 5: 18,208,770 (GRCm39) D158G Het
Grhl2 A C 15: 37,328,574 (GRCm39) N400T probably damaging Het
Grin2c A T 11: 115,147,085 (GRCm39) probably null Het
Hipk4 A G 7: 27,222,973 (GRCm39) Y11C probably damaging Het
Hspa9 G T 18: 35,071,740 (GRCm39) A620E not run Het
Igkv12-89 A G 6: 68,812,083 (GRCm39) S29P probably benign Het
Itga8 A T 2: 12,113,998 (GRCm39) D1039E probably damaging Het
Itgae A T 11: 73,004,457 (GRCm39) D248V probably damaging Het
Kmt2c T C 5: 25,520,093 (GRCm39) K2006E probably damaging Het
Litafd C T 16: 8,501,510 (GRCm39) P59L unknown Het
Mdga1 C T 17: 30,051,353 (GRCm39) G934R probably benign Het
Mov10 T C 3: 104,703,201 (GRCm39) N896S probably benign Het
Ndufb6 A T 4: 40,273,080 (GRCm39) probably null Het
Nlk T C 11: 78,481,831 (GRCm39) probably null Het
Notch2 T A 3: 98,053,939 (GRCm39) S2201T probably damaging Het
Or5i1 A T 2: 87,613,778 (GRCm39) D298V probably damaging Het
Pank1 A C 19: 34,799,388 (GRCm39) probably null Het
Pdlim3 T C 8: 46,362,102 (GRCm39) F126S probably damaging Het
Pds5a C A 5: 65,795,947 (GRCm39) G648C probably benign Het
Plekhh3 T C 11: 101,055,153 (GRCm39) I567V unknown Het
Ppfia2 T C 10: 106,701,264 (GRCm39) probably null Het
Prl3d1 A G 13: 27,284,052 (GRCm39) D207G probably damaging Het
Prss23 T A 7: 89,159,454 (GRCm39) D205V probably benign Het
Pygl C T 12: 70,244,569 (GRCm39) probably null Het
Qsox2 A G 2: 26,111,032 (GRCm39) F111S probably damaging Het
Sart3 T C 5: 113,909,413 (GRCm39) N95S probably benign Het
Scpep1 A G 11: 88,820,046 (GRCm39) F414S probably damaging Het
Sirpa A G 2: 129,458,365 (GRCm39) D327G probably benign Het
Sowahc G A 10: 59,058,005 (GRCm39) R47H probably damaging Het
Szt2 T C 4: 118,251,025 (GRCm39) Y361C probably damaging Het
Taf3 A G 2: 9,945,804 (GRCm39) V600A probably benign Het
Tie1 T C 4: 118,330,175 (GRCm39) I1042M probably damaging Het
Tmem132e T A 11: 82,325,342 (GRCm39) L114Q probably damaging Het
Tmx3 A G 18: 90,555,233 (GRCm39) T317A probably damaging Het
Tppp3 A G 8: 106,194,924 (GRCm39) V69A probably benign Het
Tpr T C 1: 150,299,267 (GRCm39) Y1156H probably damaging Het
Trank1 A C 9: 111,194,364 (GRCm39) D796A possibly damaging Het
Tsc2 G A 17: 24,826,466 (GRCm39) P928S probably benign Het
Unc80 G T 1: 66,711,843 (GRCm39) V2722F possibly damaging Het
Vmn1r199 G T 13: 22,566,845 (GRCm39) L46F probably benign Het
Vps13a A T 19: 16,727,513 (GRCm39) H196Q probably benign Het
Wnt10a T A 1: 74,832,633 (GRCm39) C75* probably null Het
Zfp335 A G 2: 164,734,459 (GRCm39) probably null Het
Other mutations in Selenbp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01970:Selenbp1 APN 3 94,844,313 (GRCm39) missense probably benign 0.24
IGL03281:Selenbp1 APN 3 94,844,621 (GRCm39) nonsense probably null
PIT4131001:Selenbp1 UTSW 3 94,844,607 (GRCm39) missense probably damaging 0.99
R0415:Selenbp1 UTSW 3 94,844,224 (GRCm39) missense possibly damaging 0.61
R1132:Selenbp1 UTSW 3 94,844,644 (GRCm39) missense probably benign 0.02
R1421:Selenbp1 UTSW 3 94,851,183 (GRCm39) missense probably benign
R1522:Selenbp1 UTSW 3 94,844,669 (GRCm39) missense probably damaging 1.00
R1676:Selenbp1 UTSW 3 94,851,854 (GRCm39) missense probably damaging 1.00
R1701:Selenbp1 UTSW 3 94,844,701 (GRCm39) missense probably damaging 1.00
R2152:Selenbp1 UTSW 3 94,851,441 (GRCm39) missense probably damaging 1.00
R3033:Selenbp1 UTSW 3 94,845,351 (GRCm39) missense probably benign 0.22
R4363:Selenbp1 UTSW 3 94,850,060 (GRCm39) splice site probably null
R4631:Selenbp1 UTSW 3 94,851,879 (GRCm39) makesense probably null
R4798:Selenbp1 UTSW 3 94,851,211 (GRCm39) missense probably benign 0.27
R4935:Selenbp1 UTSW 3 94,845,269 (GRCm39) missense probably benign 0.10
R5464:Selenbp1 UTSW 3 94,851,727 (GRCm39) missense probably benign
R6253:Selenbp1 UTSW 3 94,851,157 (GRCm39) missense possibly damaging 0.95
R6314:Selenbp1 UTSW 3 94,844,576 (GRCm39) missense probably damaging 1.00
R7199:Selenbp1 UTSW 3 94,851,745 (GRCm39) missense possibly damaging 0.79
R7330:Selenbp1 UTSW 3 94,847,021 (GRCm39) missense probably benign
R7658:Selenbp1 UTSW 3 94,851,413 (GRCm39) missense probably benign 0.03
R8739:Selenbp1 UTSW 3 94,844,601 (GRCm39) missense probably damaging 0.99
R8803:Selenbp1 UTSW 3 94,851,821 (GRCm39) missense possibly damaging 0.88
R8987:Selenbp1 UTSW 3 94,847,425 (GRCm39) missense probably benign 0.10
R9145:Selenbp1 UTSW 3 94,851,414 (GRCm39) missense probably benign 0.38
R9209:Selenbp1 UTSW 3 94,847,079 (GRCm39) missense probably benign 0.08
R9747:Selenbp1 UTSW 3 94,844,648 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGAGTCTGTAGAGGCAGGAC -3'
(R):5'- CCATGCTTGAAACTTGCTTGATG -3'

Sequencing Primer
(F):5'- AGGACCTGGGCAATCAGC -3'
(R):5'- AAACTTGCTTGATGGTGCCAG -3'
Posted On 2019-10-24