Incidental Mutation 'R7638:Or8g37'
ID 590071
Institutional Source Beutler Lab
Gene Symbol Or8g37
Ensembl Gene ENSMUSG00000095774
Gene Name olfactory receptor family 8 subfamily G member 37
Synonyms Olfr970, GA_x6K02T2PVTD-33517322-33518257, MOR171-16
MMRRC Submission 045696-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.318) question?
Stock # R7638 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 39730937-39731872 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 39731189 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Valine at position 85 (F85V)
Ref Sequence ENSEMBL: ENSMUSP00000150325 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071132] [ENSMUST00000213975] [ENSMUST00000215922]
AlphaFold Q8VFN3
Predicted Effect probably damaging
Transcript: ENSMUST00000071132
AA Change: F85V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000071132
Gene: ENSMUSG00000095774
AA Change: F85V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.2e-53 PFAM
Pfam:7tm_1 41 290 1.6e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213975
AA Change: F85V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000215922
AA Change: F85V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (71/71)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abo T G 2: 26,733,855 (GRCm39) T115P probably damaging Het
Aggf1 G A 13: 95,492,921 (GRCm39) R563* probably null Het
Amdhd1 A T 10: 93,370,360 (GRCm39) Y159* probably null Het
Camp T C 9: 109,677,461 (GRCm39) E124G Het
Casq2 A G 3: 101,994,016 (GRCm39) E21G possibly damaging Het
Cbln1 A T 8: 88,198,357 (GRCm39) F116Y probably damaging Het
Cklf A T 8: 104,989,996 (GRCm39) K143* probably null Het
Clca3a1 A G 3: 144,457,723 (GRCm39) I387T probably damaging Het
Cndp1 T A 18: 84,654,174 (GRCm39) D130V probably benign Het
Cyp4a12a T A 4: 115,184,670 (GRCm39) M317K possibly damaging Het
Dmxl2 A T 9: 54,365,078 (GRCm39) I138K unknown Het
Eapp A G 12: 54,720,508 (GRCm39) S236P probably benign Het
Efcab3 T A 11: 104,927,625 (GRCm39) M4798K probably benign Het
Efnb3 T C 11: 69,448,046 (GRCm39) H132R possibly damaging Het
Fam243 A G 16: 92,117,805 (GRCm39) V161A probably damaging Het
Fbn2 A T 18: 58,238,208 (GRCm39) N596K probably damaging Het
Fzd9 A G 5: 135,279,484 (GRCm39) W134R probably damaging Het
Gga2 A G 7: 121,603,157 (GRCm39) S180P probably damaging Het
Golga3 A G 5: 110,353,694 (GRCm39) T911A probably benign Het
Gstm1 C T 3: 107,921,866 (GRCm39) probably null Het
Heg1 A G 16: 33,547,867 (GRCm39) T909A probably damaging Het
Herc2 T C 7: 55,807,186 (GRCm39) S2455P probably benign Het
Herc2 C T 7: 55,870,273 (GRCm39) R4349W probably damaging Het
Hivep2 T G 10: 14,019,595 (GRCm39) M2122R possibly damaging Het
Itga10 T A 3: 96,564,707 (GRCm39) probably null Het
Kbtbd13 G T 9: 65,298,605 (GRCm39) C110* probably null Het
Krt78 T C 15: 101,859,318 (GRCm39) E293G probably damaging Het
Lgals3bp C T 11: 118,288,995 (GRCm39) V110M possibly damaging Het
Lrp2 A G 2: 69,307,352 (GRCm39) probably null Het
Lrrc14 A G 15: 76,598,173 (GRCm39) D301G probably benign Het
Lrrc71 C A 3: 87,649,113 (GRCm39) G352W probably damaging Het
Map3k9 A G 12: 81,771,506 (GRCm39) V694A probably benign Het
Mboat2 T C 12: 24,989,325 (GRCm39) S162P probably damaging Het
Megf11 C A 9: 64,586,535 (GRCm39) N422K probably damaging Het
Miga1 C T 3: 151,982,324 (GRCm39) S584N probably benign Het
Mindy2 A G 9: 70,524,141 (GRCm39) Y403H probably damaging Het
Mmd C T 11: 90,167,583 (GRCm39) A204V possibly damaging Het
Mta3 A T 17: 84,107,572 (GRCm39) Y262F probably benign Het
Ncoa7 G A 10: 30,598,794 (GRCm39) S43F probably benign Het
Nhsl3 T C 4: 129,115,734 (GRCm39) T1022A probably benign Het
Nphp4 T C 4: 152,638,991 (GRCm39) V874A probably benign Het
Nsd1 A G 13: 55,460,141 (GRCm39) T2226A probably benign Het
Nt5dc1 T C 10: 34,190,792 (GRCm39) H302R probably benign Het
Odc1 A G 12: 17,600,003 (GRCm39) Y389C probably damaging Het
Or52p2 A G 7: 102,237,125 (GRCm39) I275T probably damaging Het
Or5k8 G A 16: 58,644,958 (GRCm39) T38I probably damaging Het
Pcare T C 17: 72,057,880 (GRCm39) D599G probably damaging Het
Pcdhb10 A C 18: 37,545,365 (GRCm39) Q147P probably benign Het
Pdcl2 A C 5: 76,465,675 (GRCm39) C182G probably damaging Het
Pigv T C 4: 133,392,762 (GRCm39) D136G possibly damaging Het
Polr1h A C 17: 37,268,722 (GRCm39) probably null Het
Pramel5 T C 4: 143,998,010 (GRCm39) E411G possibly damaging Het
Prkce T C 17: 86,476,028 (GRCm39) V3A probably benign Het
Pth1r T C 9: 110,551,461 (GRCm39) N546S probably benign Het
Qrich2 C T 11: 116,346,148 (GRCm39) V1559I probably benign Het
Rbm20 A C 19: 53,802,764 (GRCm39) D424A possibly damaging Het
Rbm26 C T 14: 105,388,284 (GRCm39) D393N probably damaging Het
Sf3b3 G A 8: 111,547,445 (GRCm39) R728C probably damaging Het
Spata31e1 G T 13: 49,940,451 (GRCm39) Q420K probably benign Het
Srcap A G 7: 127,137,920 (GRCm39) N1090S probably benign Het
Syt4 A T 18: 31,576,875 (GRCm39) S160T probably benign Het
Tcstv6 A T 13: 120,304,224 (GRCm39) probably null Het
Tfap2e C T 4: 126,615,727 (GRCm39) V236M probably damaging Het
Thsd4 G A 9: 60,301,755 (GRCm39) T180M probably damaging Het
Tlr4 T A 4: 66,758,443 (GRCm39) M412K probably damaging Het
Tmem67 T A 4: 12,079,883 (GRCm39) H136L probably benign Het
Tnpo2 T A 8: 85,771,044 (GRCm39) I110N probably benign Het
Trav13d-3 A G 14: 53,270,870 (GRCm39) M111V probably benign Het
Tubb3 A T 8: 124,147,900 (GRCm39) S278C probably benign Het
Ugcg T A 4: 59,220,299 (GRCm39) F364Y probably benign Het
Usp17lc T C 7: 103,067,706 (GRCm39) S334P probably damaging Het
Vps13c A G 9: 67,852,791 (GRCm39) D2357G probably damaging Het
Zfp157 T C 5: 138,454,172 (GRCm39) Y125H probably benign Het
Zfp747 A T 7: 126,973,819 (GRCm39) M117K probably benign Het
Zscan4c A T 7: 10,743,658 (GRCm39) N419I possibly damaging Het
Other mutations in Or8g37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01388:Or8g37 APN 9 39,731,298 (GRCm39) missense probably damaging 1.00
IGL02674:Or8g37 APN 9 39,730,934 (GRCm39) splice site probably null
R0659:Or8g37 UTSW 9 39,731,112 (GRCm39) missense possibly damaging 0.78
R0686:Or8g37 UTSW 9 39,730,964 (GRCm39) missense probably damaging 0.98
R1952:Or8g37 UTSW 9 39,731,363 (GRCm39) missense probably benign 0.09
R2068:Or8g37 UTSW 9 39,731,846 (GRCm39) missense probably benign 0.00
R4472:Or8g37 UTSW 9 39,731,870 (GRCm39) makesense probably null
R4798:Or8g37 UTSW 9 39,731,193 (GRCm39) missense probably benign 0.13
R5035:Or8g37 UTSW 9 39,731,390 (GRCm39) missense possibly damaging 0.82
R5339:Or8g37 UTSW 9 39,731,229 (GRCm39) missense probably damaging 0.97
R6751:Or8g37 UTSW 9 39,731,193 (GRCm39) missense probably benign 0.13
R7211:Or8g37 UTSW 9 39,731,154 (GRCm39) missense possibly damaging 0.76
R7471:Or8g37 UTSW 9 39,731,423 (GRCm39) missense probably benign 0.00
R7609:Or8g37 UTSW 9 39,731,583 (GRCm39) missense probably benign
R7890:Or8g37 UTSW 9 39,731,310 (GRCm39) missense probably damaging 0.99
R7918:Or8g37 UTSW 9 39,731,406 (GRCm39) missense probably damaging 0.98
R8548:Or8g37 UTSW 9 39,731,537 (GRCm39) missense probably benign 0.00
R8817:Or8g37 UTSW 9 39,730,939 (GRCm39) start codon destroyed probably null 0.40
R8868:Or8g37 UTSW 9 39,731,252 (GRCm39) missense probably benign
R9689:Or8g37 UTSW 9 39,731,801 (GRCm39) missense possibly damaging 0.95
Z1176:Or8g37 UTSW 9 39,731,651 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGTGACTGAGTTCATCCTCGC -3'
(R):5'- AACAGACTTGAAAGGACATTACAGC -3'

Sequencing Primer
(F):5'- TCCTCGCTGGGTTAACAAAC -3'
(R):5'- TACAGCATTGTAAAGCAAGGGGTTAC -3'
Posted On 2019-10-24