|Institutional Source||Beutler Lab|
|Gene Name||cathelicidin antimicrobial peptide|
|Synonyms||Cnlp, MCLP, CAP18, FALL39, Cramp|
|Is this an essential gene?||Probably non essential (E-score: 0.067)|
|Stock #||R7638 (G1)|
|Chromosomal Location||109847379-109849617 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 109848393 bp|
|Amino Acid Change||Glutamic Acid to Glycine at position 124 (E124G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000107653 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000112022]|
AA Change: E124G
|Coding Region Coverage||
|Validation Efficiency||100% (71/71)|
FUNCTION: This gene encodes a member of the cathelicidin family of antimicrobial peptides that play an important role in the defense against microbial infection. The encoded preproprotein undergoes proteolytic processing to generate a mature polypeptide before secretion by host cells such as neutrophils, epithelial cells and macrophages. Mice lacking the encoded protein exhibit increased susceptibility to group A streptococcus and Escherichia coli infections. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a knock-out allele are more susceptible to necrotic skin infection caused by Group A Streptococcus and urinary tract infection caused by uropathogenic E. coli and F. solani-induced keratitis. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Camp||
(F):5'- GAATCGCTACTTTAAGGGATGAC -3'
(R):5'- CTGAGCAATGTGCCTTCAAG -3'
(F):5'- TCGCTACTTTAAGGGATGACAGAACC -3'
(R):5'- GTCCCTCTTGTGGAACTAGTCAAG -3'