Incidental Mutation 'R7640:Drc3'
ID 590202
Institutional Source Beutler Lab
Gene Symbol Drc3
Ensembl Gene ENSMUSG00000056598
Gene Name dynein regulatory complex subunit 3
Synonyms Lrrc48, m6Bei, 4930449E07Rik
MMRRC Submission 045698-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R7640 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 60244155-60285167 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 60279730 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 432 (M432V)
Ref Sequence ENSEMBL: ENSMUSP00000104363 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108722] [ENSMUST00000108723]
AlphaFold Q9D5E4
Predicted Effect probably benign
Transcript: ENSMUST00000108722
AA Change: M432V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000104362
Gene: ENSMUSG00000056598
AA Change: M432V

DomainStartEndE-ValueType
low complexity region 66 75 N/A INTRINSIC
LRR 86 106 9.24e1 SMART
LRR 108 129 1.71e1 SMART
LRR 130 153 1.49e1 SMART
low complexity region 216 235 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108723
AA Change: M432V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000104363
Gene: ENSMUSG00000056598
AA Change: M432V

DomainStartEndE-ValueType
low complexity region 66 75 N/A INTRINSIC
LRR 86 106 9.24e1 SMART
LRR 108 129 1.71e1 SMART
LRR 130 153 1.49e1 SMART
low complexity region 216 235 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 99% (68/69)
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik A T 4: 137,181,905 (GRCm39) N20I probably damaging Het
4930558K02Rik A G 1: 161,784,718 (GRCm39) S74P probably benign Het
Abcb6 A T 1: 75,151,489 (GRCm39) probably null Het
Adamts14 C A 10: 61,081,836 (GRCm39) A234S probably benign Het
Ankrd42 A G 7: 92,268,843 (GRCm39) S167P probably benign Het
Ap3m1 T C 14: 21,088,243 (GRCm39) I272V probably benign Het
Armt1 T C 10: 4,403,572 (GRCm39) F219S probably damaging Het
Atr T G 9: 95,789,346 (GRCm39) probably null Het
Cep72 G A 13: 74,206,607 (GRCm39) Q72* probably null Het
Clock G T 5: 76,396,225 (GRCm39) L175M possibly damaging Het
Cnmd T A 14: 79,898,974 (GRCm39) Y26F possibly damaging Het
Col6a6 A T 9: 105,662,943 (GRCm39) M198K possibly damaging Het
Cuta C T 17: 27,157,396 (GRCm39) V135I probably benign Het
Ddx41 A T 13: 55,682,052 (GRCm39) M241K possibly damaging Het
Dnajc22 A G 15: 98,998,995 (GRCm39) N60S probably damaging Het
Dync2i2 T G 2: 29,921,780 (GRCm39) D527A probably benign Het
Eef1d C A 15: 75,774,556 (GRCm39) G368C probably damaging Het
En2 A T 5: 28,375,164 (GRCm39) K236* probably null Het
Fas A G 19: 34,284,564 (GRCm39) T24A possibly damaging Het
Golga2 T C 2: 32,196,251 (GRCm39) V930A probably benign Het
Gprin2 G T 14: 33,917,710 (GRCm39) A20D probably benign Het
Ighv14-4 A T 12: 114,140,064 (GRCm39) C115* probably null Het
Impdh2 T C 9: 108,442,380 (GRCm39) Y459H possibly damaging Het
Klhdc7b G T 15: 89,271,463 (GRCm39) V124L possibly damaging Het
L2hgdh A T 12: 69,768,131 (GRCm39) Y122* probably null Het
Lamc2 A T 1: 153,012,550 (GRCm39) I708N possibly damaging Het
Large2 T C 2: 92,205,050 (GRCm39) M1V probably null Het
Lrit2 T C 14: 36,794,081 (GRCm39) W382R probably damaging Het
Mcee T A 7: 64,061,716 (GRCm39) V173E probably damaging Het
Mcph1 T A 8: 18,682,342 (GRCm39) V493E probably benign Het
Mfap4 A G 11: 61,377,913 (GRCm39) N118D probably damaging Het
Mknk2 T C 10: 80,504,400 (GRCm39) S301G probably benign Het
Mlf1 G A 3: 67,300,266 (GRCm39) M94I possibly damaging Het
Mrc2 T A 11: 105,223,121 (GRCm39) S455T possibly damaging Het
Mrgprb5 T G 7: 47,818,007 (GRCm39) I243L probably benign Het
Muc4 C A 16: 32,580,479 (GRCm39) P360T Het
Nat10 G A 2: 103,573,435 (GRCm39) A354V probably damaging Het
Nscme3l T A 19: 5,553,035 (GRCm39) S249C probably damaging Het
Nts T C 10: 102,326,165 (GRCm39) Q7R possibly damaging Het
Oas1b T C 5: 120,959,479 (GRCm39) L288P probably damaging Het
Or4a66 T A 2: 88,531,230 (GRCm39) I148L probably benign Het
Or51k2 A T 7: 103,596,150 (GRCm39) I126F probably damaging Het
Or5w11 A G 2: 87,459,436 (GRCm39) I94V probably benign Het
Or8k30 A G 2: 86,339,287 (GRCm39) I161M possibly damaging Het
Otoa A G 7: 120,744,849 (GRCm39) E869G probably damaging Het
Pcdhac2 T C 18: 37,277,578 (GRCm39) L186P probably damaging Het
Plekhh2 A G 17: 84,918,204 (GRCm39) E1271G possibly damaging Het
Pmepa1 C T 2: 173,117,956 (GRCm39) A8T probably benign Het
Pramel24 T C 4: 143,453,276 (GRCm39) V128A probably benign Het
Rc3h2 A G 2: 37,267,861 (GRCm39) probably null Het
Rlf T A 4: 121,003,998 (GRCm39) M1771L possibly damaging Het
Rpap1 G A 2: 119,594,891 (GRCm39) P1372L possibly damaging Het
Rragd A T 4: 32,983,527 (GRCm39) D22V probably benign Het
Sema3f A T 9: 107,560,774 (GRCm39) S644R probably benign Het
Sp110 G A 1: 85,506,813 (GRCm39) R417C probably benign Het
Spata31h1 T A 10: 82,130,490 (GRCm39) N840I probably damaging Het
Specc1l T A 10: 75,093,703 (GRCm39) N717K probably damaging Het
Sphkap C T 1: 83,256,649 (GRCm39) D367N possibly damaging Het
Tbc1d21 C T 9: 58,268,544 (GRCm39) V272M probably damaging Het
Tlcd4 A G 3: 121,028,690 (GRCm39) probably null Het
Tmem132c A G 5: 127,640,070 (GRCm39) D747G probably damaging Het
Trim2 C A 3: 84,098,213 (GRCm39) V372F probably benign Het
Ttc34 A G 4: 154,945,841 (GRCm39) T292A probably benign Het
Ube3b A G 5: 114,553,384 (GRCm39) T919A probably benign Het
Zfhx4 T C 3: 5,477,540 (GRCm39) I3385T probably benign Het
Zfp423 T C 8: 88,507,905 (GRCm39) K813R probably damaging Het
Zfp850 T C 7: 27,688,634 (GRCm39) T525A probably benign Het
Zfp873 T C 10: 81,896,109 (GRCm39) I280T possibly damaging Het
Zkscan7 A G 9: 122,725,121 (GRCm39) T697A possibly damaging Het
Other mutations in Drc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01319:Drc3 APN 11 60,255,788 (GRCm39) missense probably null 0.70
IGL01457:Drc3 APN 11 60,249,475 (GRCm39) utr 5 prime probably benign
IGL02329:Drc3 APN 11 60,261,404 (GRCm39) missense probably damaging 1.00
IGL02576:Drc3 APN 11 60,261,377 (GRCm39) missense probably benign 0.01
IGL02610:Drc3 APN 11 60,261,419 (GRCm39) missense probably benign 0.40
IGL02817:Drc3 APN 11 60,275,062 (GRCm39) missense probably benign 0.16
IGL03380:Drc3 APN 11 60,268,731 (GRCm39) missense probably benign 0.01
R0020:Drc3 UTSW 11 60,261,371 (GRCm39) missense probably damaging 1.00
R1221:Drc3 UTSW 11 60,275,052 (GRCm39) missense probably benign
R1394:Drc3 UTSW 11 60,284,545 (GRCm39) missense possibly damaging 0.94
R1483:Drc3 UTSW 11 60,279,715 (GRCm39) missense probably benign 0.00
R2093:Drc3 UTSW 11 60,261,310 (GRCm39) missense probably damaging 1.00
R2151:Drc3 UTSW 11 60,265,983 (GRCm39) missense probably benign 0.15
R4631:Drc3 UTSW 11 60,255,734 (GRCm39) missense probably benign 0.02
R4796:Drc3 UTSW 11 60,254,354 (GRCm39) missense probably damaging 1.00
R4841:Drc3 UTSW 11 60,261,361 (GRCm39) missense probably benign 0.00
R4842:Drc3 UTSW 11 60,261,361 (GRCm39) missense probably benign 0.00
R5739:Drc3 UTSW 11 60,265,956 (GRCm39) missense possibly damaging 0.89
R5766:Drc3 UTSW 11 60,284,647 (GRCm39) missense probably benign 0.18
R6143:Drc3 UTSW 11 60,261,406 (GRCm39) missense possibly damaging 0.82
R6298:Drc3 UTSW 11 60,284,596 (GRCm39) missense possibly damaging 0.74
R6558:Drc3 UTSW 11 60,255,718 (GRCm39) missense probably damaging 1.00
R6611:Drc3 UTSW 11 60,255,773 (GRCm39) missense probably damaging 0.99
R6938:Drc3 UTSW 11 60,284,949 (GRCm39) critical splice acceptor site probably null
R7013:Drc3 UTSW 11 60,278,129 (GRCm39) missense probably benign 0.00
R7108:Drc3 UTSW 11 60,261,380 (GRCm39) missense probably benign 0.13
R7713:Drc3 UTSW 11 60,261,386 (GRCm39) missense probably benign
R9188:Drc3 UTSW 11 60,249,615 (GRCm39) missense probably damaging 1.00
R9500:Drc3 UTSW 11 60,261,334 (GRCm39) missense probably benign 0.19
Predicted Primers PCR Primer
(F):5'- GGTCTTGAACCCTGAGACTCTAAG -3'
(R):5'- TCTGTCTCGTCGAGAAGGAAG -3'

Sequencing Primer
(F):5'- TGAACCCTGAGACTCTAAGACTTAG -3'
(R):5'- AGGAAGCCTCCAGGAGCTTG -3'
Posted On 2019-10-24