Incidental Mutation 'R7643:Olfr298'
ID 590350
Institutional Source Beutler Lab
Gene Symbol Olfr298
Ensembl Gene ENSMUSG00000062878
Gene Name olfactory receptor 298
Synonyms GA_x6K02T2NHDJ-9619796-9620794, MOR219-4
MMRRC Submission 045700-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # R7643 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 86486322-86492484 bp(-) (GRCm38)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) C to T at 86489568 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000150228 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077800] [ENSMUST00000213223] [ENSMUST00000213223] [ENSMUST00000216968] [ENSMUST00000216968] [ENSMUST00000217110] [ENSMUST00000217110]
AlphaFold Q7TS06
Predicted Effect probably benign
Transcript: ENSMUST00000077800
SMART Domains Protein: ENSMUSP00000076973
Gene: ENSMUSG00000062878

Pfam:7tm_4 29 306 4.2e-37 PFAM
Pfam:7tm_1 39 288 8.4e-19 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213223
Predicted Effect probably null
Transcript: ENSMUST00000213223
Predicted Effect probably null
Transcript: ENSMUST00000216968
Predicted Effect probably null
Transcript: ENSMUST00000216968
Predicted Effect probably null
Transcript: ENSMUST00000217110
Predicted Effect probably null
Transcript: ENSMUST00000217110
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930435E12Rik A G 16: 38,827,863 (GRCm38) Y295H probably benign Het
4931406C07Rik A G 9: 15,297,860 (GRCm38) F46S probably damaging Het
Acaca T C 11: 84,338,356 (GRCm38) Y1670H probably damaging Het
Acrbp G A 6: 125,053,832 (GRCm38) R272Q possibly damaging Het
Adcy6 T A 15: 98,593,568 (GRCm38) Q1050L probably benign Het
Amn1 C T 6: 149,185,031 (GRCm38) M44I probably benign Het
Ankrd13b A G 11: 77,473,085 (GRCm38) V395A probably benign Het
Ap3b2 T C 7: 81,477,072 (GRCm38) K310R probably benign Het
Bnc2 T C 4: 84,506,574 (GRCm38) D123G probably benign Het
Bst1 G A 5: 43,840,449 (GRCm38) M263I probably benign Het
Ccdc7a C T 8: 128,889,811 (GRCm38) G937E probably damaging Het
Cep290 A G 10: 100,537,553 (GRCm38) M1232V probably benign Het
Cfhr1 A G 1: 139,553,585 (GRCm38) Y186H possibly damaging Het
Dnah7c A T 1: 46,602,813 (GRCm38) H1203L probably benign Het
Emc7 A G 2: 112,455,279 (GRCm38) E71G probably benign Het
Exoc3l4 G A 12: 111,421,935 (GRCm38) probably benign Het
Fam83c A G 2: 155,831,004 (GRCm38) F278L possibly damaging Het
Gabpb2 C A 3: 95,200,225 (GRCm38) V180L probably benign Het
Gbp2b G T 3: 142,603,609 (GRCm38) Q160H probably benign Het
Gm19965 C G 1: 116,822,229 (GRCm38) Q547E unknown Het
Gon4l T A 3: 88,902,807 (GRCm38) D1774E probably damaging Het
Gpr15 A C 16: 58,717,816 (GRCm38) Y303* probably null Het
Greb1 T C 12: 16,711,996 (GRCm38) D461G probably damaging Het
Gria4 T C 9: 4,793,950 (GRCm38) N36S probably benign Het
Hacd1 T C 2: 14,044,791 (GRCm38) I119V probably damaging Het
Ing5 T A 1: 93,812,433 (GRCm38) D101E probably damaging Het
Irak4 T A 15: 94,558,828 (GRCm38) N297K probably benign Het
Itga7 A G 10: 128,953,501 (GRCm38) D971G probably benign Het
Klf5 A G 14: 99,313,178 (GRCm38) E397G possibly damaging Het
Krtap29-1 C T 11: 99,978,198 (GRCm38) G286S probably damaging Het
Lrp2bp A T 8: 46,020,527 (GRCm38) probably null Het
March4 T G 1: 72,447,220 (GRCm38) Q266H probably damaging Het
Med23 A G 10: 24,905,965 (GRCm38) T1056A probably benign Het
Megf11 T C 9: 64,706,632 (GRCm38) L1079P probably damaging Het
Mycbp2 G T 14: 103,346,265 (GRCm38) L85I probably benign Het
Nlgn2 G T 11: 69,827,885 (GRCm38) Q290K probably damaging Het
Nox4 A T 7: 87,323,754 (GRCm38) E323V probably damaging Het
Nup93 T C 8: 94,286,619 (GRCm38) probably null Het
Olfr558 C T 7: 102,709,538 (GRCm38) T93I probably benign Het
Olfr977-ps1 T A 9: 39,974,821 (GRCm38) M1L unknown Het
Otop3 T C 11: 115,339,648 (GRCm38) L117P probably damaging Het
Pde6c C A 19: 38,141,421 (GRCm38) Q260K probably damaging Het
Plb1 C T 5: 32,247,557 (GRCm38) Q20* probably null Het
Qser1 A T 2: 104,786,977 (GRCm38) Y1163* probably null Het
Rbm12 A T 2: 156,098,217 (GRCm38) I45N unknown Het
Rictor T A 15: 6,769,269 (GRCm38) Y332* probably null Het
Rpp14 C A 14: 8,090,325 (GRCm38) S83* probably null Het
Sel1l3 C T 5: 53,123,162 (GRCm38) probably null Het
Setd2 T C 9: 110,567,840 (GRCm38) probably null Het
Spink5 A G 18: 44,010,252 (GRCm38) T759A probably benign Het
Spon2 T A 5: 33,217,456 (GRCm38) E2V probably benign Het
Tdrd1 T C 19: 56,837,708 (GRCm38) S144P probably damaging Het
Tex15 A C 8: 33,575,120 (GRCm38) Y1526S probably damaging Het
Tnfrsf21 T C 17: 43,037,916 (GRCm38) S140P probably benign Het
Trav6-2 T A 14: 52,667,442 (GRCm38) M11K probably benign Het
Trp53bp1 G T 2: 121,247,814 (GRCm38) probably null Het
Ttn T C 2: 76,734,827 (GRCm38) N28352S possibly damaging Het
Uckl1 T C 2: 181,573,106 (GRCm38) I292V probably benign Het
Unc13b T A 4: 43,216,333 (GRCm38) S211T probably benign Het
Zcchc4 T C 5: 52,808,293 (GRCm38) I313T possibly damaging Het
Zfp106 C T 2: 120,512,734 (GRCm38) R1811K probably benign Het
Zfp599 G T 9: 22,249,892 (GRCm38) Q326K probably benign Het
Zscan4e A T 7: 11,309,525 (GRCm38) M108K probably damaging Het
Other mutations in Olfr298
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01517:Olfr298 APN 7 86,489,557 (GRCm38) utr 5 prime probably benign
IGL01603:Olfr298 APN 7 86,488,931 (GRCm38) missense possibly damaging 0.92
IGL02389:Olfr298 APN 7 86,489,128 (GRCm38) missense probably damaging 0.98
IGL03146:Olfr298 APN 7 86,489,194 (GRCm38) missense probably damaging 1.00
R0680:Olfr298 UTSW 7 86,489,337 (GRCm38) missense probably benign
R0834:Olfr298 UTSW 7 86,489,490 (GRCm38) missense probably benign 0.11
R1132:Olfr298 UTSW 7 86,489,217 (GRCm38) missense probably benign 0.03
R1519:Olfr298 UTSW 7 86,489,125 (GRCm38) missense probably damaging 0.99
R1881:Olfr298 UTSW 7 86,489,438 (GRCm38) missense probably benign 0.01
R2170:Olfr298 UTSW 7 86,488,570 (GRCm38) missense probably benign 0.03
R4500:Olfr298 UTSW 7 86,488,919 (GRCm38) missense probably benign 0.00
R4524:Olfr298 UTSW 7 86,488,826 (GRCm38) missense probably damaging 1.00
R5184:Olfr298 UTSW 7 86,489,291 (GRCm38) frame shift probably null
R5521:Olfr298 UTSW 7 86,488,631 (GRCm38) missense probably benign 0.08
R7448:Olfr298 UTSW 7 86,489,209 (GRCm38) missense probably damaging 1.00
R7688:Olfr298 UTSW 7 86,488,975 (GRCm38) missense probably benign 0.01
R8104:Olfr298 UTSW 7 86,489,023 (GRCm38) missense probably damaging 1.00
R8732:Olfr298 UTSW 7 86,488,853 (GRCm38) missense probably damaging 0.96
R8973:Olfr298 UTSW 7 86,489,279 (GRCm38) missense probably damaging 1.00
R9235:Olfr298 UTSW 7 86,489,098 (GRCm38) missense probably benign 0.01
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2019-10-24