|Institutional Source||Beutler Lab|
|Gene Name||fos-like antigen 1|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R7644 (G1)|
|Chromosomal Location||5447703-5455945 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||C to T at 5450304 bp|
|Amino Acid Change||Arginine to Stop codon at position 84 (R84*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000025850 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000025850]|
|Predicted Effect||probably null
AA Change: R84*
AA Change: R84*
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
PHENOTYPE: Homozygous inactivation of this gene leads to in utero lethality. Embryos homozygous for a reporter/null allele are severely growth retarded and display defects in the extra-embryonic compartment, including a highly abnormal yolk sac and a narrow, largely avascular placental labyrinth layer. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Fosl1||
(F):5'- ACAGAAGTCCAGCCTCTGTC -3'
(R):5'- AGACAGTGGAGACATGCTCAC -3'
(F):5'- AGTCCACACAGACCTTATCATTTC -3'
(R):5'- GAAGCCTTCCTTGACTCAAAGGTG -3'