Incidental Mutation 'R7645:Gpr3'
ID 590473
Institutional Source Beutler Lab
Gene Symbol Gpr3
Ensembl Gene ENSMUSG00000049649
Gene Name G-protein coupled receptor 3
Synonyms Gpcr3, Gpcr21
MMRRC Submission 045701-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.244) question?
Stock # R7645 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 132936651-132939847 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 132938640 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 11 (W11R)
Ref Sequence ENSEMBL: ENSMUSP00000062083 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052090] [ENSMUST00000105911] [ENSMUST00000151025]
AlphaFold P35413
Predicted Effect probably damaging
Transcript: ENSMUST00000052090
AA Change: W11R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000062083
Gene: ENSMUSG00000049649
AA Change: W11R

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
Pfam:7tm_1 57 297 2.4e-40 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000105911
AA Change: W11R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000101531
Gene: ENSMUSG00000049649
AA Change: W11R

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
Pfam:7tm_1 57 297 2e-34 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000151025
AA Change: W11R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000116032
Gene: ENSMUSG00000049649
AA Change: W11R

DomainStartEndE-ValueType
SCOP:d1l9ha_ 20 95 3e-3 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 98% (46/47)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]
PHENOTYPE: Mice homozygous for one allele display an increased thermal nociceptive threshold while females homozygous for another allele display age-related reproductive failure due to ovulation of a progressively increasing proportion of developmentally incompetent oocytes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actbl2 T A 13: 111,392,789 (GRCm39) C375S probably benign Het
Adgrg3 A G 8: 95,761,392 (GRCm39) probably benign Het
Amn1 C T 6: 149,086,529 (GRCm39) M44I probably benign Het
Atg2b T C 12: 105,589,689 (GRCm39) Y1854C probably benign Het
Bcat2 T A 7: 45,237,387 (GRCm39) N290K probably benign Het
Ccdc39 T C 3: 33,879,318 (GRCm39) probably null Het
Cnot10 T C 9: 114,442,705 (GRCm39) S501G probably benign Het
Col6a6 A G 9: 105,644,397 (GRCm39) probably null Het
Coq2 A C 5: 100,808,116 (GRCm39) C228W probably damaging Het
Cpt2 A T 4: 107,764,171 (GRCm39) M531K possibly damaging Het
Dennd1a A G 2: 37,911,375 (GRCm39) L204P probably damaging Het
Dock9 C T 14: 121,835,075 (GRCm39) V1305M probably benign Het
Dusp16 A G 6: 134,702,888 (GRCm39) I201T probably damaging Het
Esco2 T C 14: 66,064,630 (GRCm39) D370G probably benign Het
Fbxl4 T C 4: 22,377,037 (GRCm39) S158P probably damaging Het
Fut10 A G 8: 31,726,232 (GRCm39) H329R possibly damaging Het
H2-M3 T A 17: 37,581,620 (GRCm39) I94N probably damaging Het
Krt7 T C 15: 101,310,524 (GRCm39) I57T probably damaging Het
Ltc4s T C 11: 50,129,373 (GRCm39) probably benign Het
Ms4a6b A T 19: 11,501,304 (GRCm39) T105S probably damaging Het
Muc6 T C 7: 141,234,923 (GRCm39) H592R probably benign Het
Ncam1 T C 9: 49,476,303 (GRCm39) E262G probably benign Het
Or4x11 T A 2: 89,868,091 (GRCm39) I276K possibly damaging Het
Or5b108 T C 19: 13,168,937 (GRCm39) V302A probably benign Het
Plxnb1 T A 9: 108,943,480 (GRCm39) S1908T probably damaging Het
Polg2 A T 11: 106,666,419 (GRCm39) M242K probably benign Het
Polr3g T C 13: 81,842,563 (GRCm39) T151A unknown Het
Pramel51 T C 12: 88,143,028 (GRCm39) T392A probably damaging Het
Psmb8 T C 17: 34,419,186 (GRCm39) L160P possibly damaging Het
Rab5b G A 10: 128,517,260 (GRCm39) A176V possibly damaging Het
Rreb1 T C 13: 38,115,010 (GRCm39) C790R probably damaging Het
Rufy3 A G 5: 88,788,476 (GRCm39) T506A probably benign Het
Samd11 T C 4: 156,340,243 (GRCm39) probably benign Het
Slc12a2 T C 18: 58,029,450 (GRCm39) F279L possibly damaging Het
Slc49a4 T A 16: 35,554,438 (GRCm39) probably null Het
Son TCCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCAGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG TCCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG 16: 91,457,183 (GRCm39) probably benign Het
Srgn C T 10: 62,330,757 (GRCm39) W116* probably null Het
Svil A G 18: 5,099,663 (GRCm39) E1733G probably damaging Het
Tbc1d22a C T 15: 86,119,742 (GRCm39) P49S probably benign Het
Tbc1d9 A T 8: 83,969,182 (GRCm39) K490M probably damaging Het
Tcte1 A G 17: 45,845,915 (GRCm39) N173S probably benign Het
Tmco6 C T 18: 36,868,446 (GRCm39) R31W probably damaging Het
Ttn C A 2: 76,730,025 (GRCm39) A5155S unknown Het
Tyro3 T C 2: 119,647,387 (GRCm39) Y839H probably damaging Het
Zc3h12d A G 10: 7,743,340 (GRCm39) D370G probably benign Het
Zc3h7b T C 15: 81,664,803 (GRCm39) L554P probably damaging Het
Zfp352 C T 4: 90,113,014 (GRCm39) P385S probably benign Het
Other mutations in Gpr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02424:Gpr3 APN 4 132,938,405 (GRCm39) missense probably damaging 1.00
IGL02974:Gpr3 APN 4 132,938,220 (GRCm39) missense possibly damaging 0.90
R0095:Gpr3 UTSW 4 132,938,597 (GRCm39) missense probably benign 0.01
R0532:Gpr3 UTSW 4 132,937,796 (GRCm39) missense probably damaging 1.00
R1831:Gpr3 UTSW 4 132,938,454 (GRCm39) missense possibly damaging 0.80
R2127:Gpr3 UTSW 4 132,937,932 (GRCm39) missense probably damaging 0.96
R4077:Gpr3 UTSW 4 132,938,226 (GRCm39) missense probably damaging 1.00
R4078:Gpr3 UTSW 4 132,938,226 (GRCm39) missense probably damaging 1.00
R5306:Gpr3 UTSW 4 132,938,490 (GRCm39) missense probably damaging 1.00
R5602:Gpr3 UTSW 4 132,937,805 (GRCm39) missense probably damaging 1.00
R5712:Gpr3 UTSW 4 132,937,719 (GRCm39) missense probably benign 0.01
R5913:Gpr3 UTSW 4 132,938,489 (GRCm39) missense probably damaging 1.00
R7434:Gpr3 UTSW 4 132,938,448 (GRCm39) missense probably benign 0.45
R7709:Gpr3 UTSW 4 132,937,748 (GRCm39) missense probably damaging 1.00
R8043:Gpr3 UTSW 4 132,938,271 (GRCm39) missense probably damaging 1.00
R8818:Gpr3 UTSW 4 132,938,538 (GRCm39) missense possibly damaging 0.95
R9015:Gpr3 UTSW 4 132,938,390 (GRCm39) missense possibly damaging 0.80
R9027:Gpr3 UTSW 4 132,938,209 (GRCm39) nonsense probably null
R9587:Gpr3 UTSW 4 132,937,988 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGTCAGCCGCAAAGTGCAG -3'
(R):5'- CCACAGGACATGAATTGGGG -3'

Sequencing Primer
(F):5'- TCTGCTACGGCCAAGCTAC -3'
(R):5'- CAGGACATGAATTGGGGGTGTG -3'
Posted On 2019-10-24