Incidental Mutation 'R7645:Gpr3'
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ID590473
Institutional Source Beutler Lab
Gene Symbol Gpr3
Ensembl Gene ENSMUSG00000049649
Gene NameG-protein coupled receptor 3
SynonymsGpcr3, Gpcr21
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.194) question?
Stock #R7645 (G1)
Quality Score225.009
Status Validated
Chromosome4
Chromosomal Location133209340-133212536 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 133211329 bp
ZygosityHeterozygous
Amino Acid Change Tryptophan to Arginine at position 11 (W11R)
Ref Sequence ENSEMBL: ENSMUSP00000062083 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052090] [ENSMUST00000105911] [ENSMUST00000151025]
Predicted Effect probably damaging
Transcript: ENSMUST00000052090
AA Change: W11R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000062083
Gene: ENSMUSG00000049649
AA Change: W11R

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
Pfam:7tm_1 57 297 2.4e-40 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000105911
AA Change: W11R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000101531
Gene: ENSMUSG00000049649
AA Change: W11R

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
Pfam:7tm_1 57 297 2e-34 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000151025
AA Change: W11R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000116032
Gene: ENSMUSG00000049649
AA Change: W11R

DomainStartEndE-ValueType
SCOP:d1l9ha_ 20 95 3e-3 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 98% (46/47)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]
PHENOTYPE: Mice homozygous for one allele display an increased thermal nociceptive threshold while females homozygous for another allele display age-related reproductive failure due to ovulation of a progressively increasing proportion of developmentally incompetent oocytes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actbl2 T A 13: 111,256,255 C375S probably benign Het
Adgrg3 A G 8: 95,034,764 probably benign Het
Amn1 C T 6: 149,185,031 M44I probably benign Het
Atg2b T C 12: 105,623,430 Y1854C probably benign Het
Bcat2 T A 7: 45,587,963 N290K probably benign Het
Ccdc39 T C 3: 33,825,169 probably null Het
Cnot10 T C 9: 114,613,637 S501G probably benign Het
Col6a6 A G 9: 105,767,198 probably null Het
Coq2 A C 5: 100,660,250 C228W probably damaging Het
Cpt2 A T 4: 107,906,974 M531K possibly damaging Het
Dennd1a A G 2: 38,021,363 L204P probably damaging Het
Dirc2 T A 16: 35,734,068 probably null Het
Dock9 C T 14: 121,597,663 V1305M probably benign Het
Dusp16 A G 6: 134,725,925 I201T probably damaging Het
Esco2 T C 14: 65,827,181 D370G probably benign Het
Fbxl4 T C 4: 22,377,037 S158P probably damaging Het
Fut10 A G 8: 31,236,204 H329R possibly damaging Het
Gm10436 T C 12: 88,176,258 T392A probably damaging Het
H2-M3 T A 17: 37,270,729 I94N probably damaging Het
Krt7 T C 15: 101,412,643 I57T probably damaging Het
Ltc4s T C 11: 50,238,546 probably benign Het
Ms4a6b A T 19: 11,523,940 T105S probably damaging Het
Muc6 T C 7: 141,648,658 H592R probably benign Het
Ncam1 T C 9: 49,565,003 E262G probably benign Het
Olfr1265 T A 2: 90,037,747 I276K possibly damaging Het
Olfr1462 T C 19: 13,191,573 V302A probably benign Het
Plxnb1 T A 9: 109,114,412 S1908T probably damaging Het
Polg2 A T 11: 106,775,593 M242K probably benign Het
Polr3g T C 13: 81,694,444 T151A unknown Het
Psmb8 T C 17: 34,200,212 L160P possibly damaging Het
Rab5b G A 10: 128,681,391 A176V possibly damaging Het
Rreb1 T C 13: 37,931,034 C790R probably damaging Het
Rufy3 A G 5: 88,640,617 T506A probably benign Het
Samd11 T C 4: 156,255,183 probably benign Het
Slc12a2 T C 18: 57,896,378 F279L possibly damaging Het
Son TCCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCAGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG TCCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG 16: 91,660,295 probably benign Het
Srgn C T 10: 62,494,978 W116* probably null Het
Svil A G 18: 5,099,663 E1733G probably damaging Het
Tbc1d22a C T 15: 86,235,541 P49S probably benign Het
Tbc1d9 A T 8: 83,242,553 K490M probably damaging Het
Tcte1 A G 17: 45,534,989 N173S probably benign Het
Tmco6 C T 18: 36,735,393 R31W probably damaging Het
Ttn C A 2: 76,899,681 A5155S unknown Het
Tyro3 T C 2: 119,816,906 Y839H probably damaging Het
Zc3h12d A G 10: 7,867,576 D370G probably benign Het
Zc3h7b T C 15: 81,780,602 L554P probably damaging Het
Zfp352 C T 4: 90,224,777 P385S probably benign Het
Other mutations in Gpr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02424:Gpr3 APN 4 133211094 missense probably damaging 1.00
IGL02974:Gpr3 APN 4 133210909 missense possibly damaging 0.90
R0095:Gpr3 UTSW 4 133211286 missense probably benign 0.01
R0532:Gpr3 UTSW 4 133210485 missense probably damaging 1.00
R1831:Gpr3 UTSW 4 133211143 missense possibly damaging 0.80
R2127:Gpr3 UTSW 4 133210621 missense probably damaging 0.96
R4077:Gpr3 UTSW 4 133210915 missense probably damaging 1.00
R4078:Gpr3 UTSW 4 133210915 missense probably damaging 1.00
R5306:Gpr3 UTSW 4 133211179 missense probably damaging 1.00
R5602:Gpr3 UTSW 4 133210494 missense probably damaging 1.00
R5712:Gpr3 UTSW 4 133210408 missense probably benign 0.01
R5913:Gpr3 UTSW 4 133211178 missense probably damaging 1.00
R7434:Gpr3 UTSW 4 133211137 missense probably benign 0.45
R7709:Gpr3 UTSW 4 133210437 missense probably damaging 1.00
R8043:Gpr3 UTSW 4 133210960 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGTCAGCCGCAAAGTGCAG -3'
(R):5'- CCACAGGACATGAATTGGGG -3'

Sequencing Primer
(F):5'- TCTGCTACGGCCAAGCTAC -3'
(R):5'- CAGGACATGAATTGGGGGTGTG -3'
Posted On2019-10-24