Incidental Mutation 'R7645:Fut10'
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ID590481
Institutional Source Beutler Lab
Gene Symbol Fut10
Ensembl Gene ENSMUSG00000046152
Gene Namefucosyltransferase 10
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.079) question?
Stock #R7645 (G1)
Quality Score225.009
Status Validated
Chromosome8
Chromosomal Location31187331-31261738 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 31236204 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Arginine at position 329 (H329R)
Ref Sequence ENSEMBL: ENSMUSP00000069816 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066173] [ENSMUST00000110527] [ENSMUST00000161502] [ENSMUST00000161788]
Predicted Effect possibly damaging
Transcript: ENSMUST00000066173
AA Change: H329R

PolyPhen 2 Score 0.916 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000069816
Gene: ENSMUSG00000046152
AA Change: H329R

DomainStartEndE-ValueType
transmembrane domain 9 31 N/A INTRINSIC
Pfam:Glyco_tran_10_N 79 184 5e-13 PFAM
Pfam:Glyco_transf_10 209 410 7.9e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110527
SMART Domains Protein: ENSMUSP00000106156
Gene: ENSMUSG00000046152

DomainStartEndE-ValueType
Pfam:Glyco_transf_10 7 134 3e-9 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000161502
AA Change: H329R

PolyPhen 2 Score 0.916 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000125265
Gene: ENSMUSG00000046152
AA Change: H329R

DomainStartEndE-ValueType
Pfam:Glyco_transf_10 7 412 4.1e-92 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000161788
AA Change: H329R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000124437
Gene: ENSMUSG00000046152
AA Change: H329R

DomainStartEndE-ValueType
Pfam:Glyco_transf_10 7 411 1.3e-92 PFAM
low complexity region 418 429 N/A INTRINSIC
Meta Mutation Damage Score 0.3448 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 98% (46/47)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actbl2 T A 13: 111,256,255 C375S probably benign Het
Adgrg3 A G 8: 95,034,764 probably benign Het
Amn1 C T 6: 149,185,031 M44I probably benign Het
Atg2b T C 12: 105,623,430 Y1854C probably benign Het
Bcat2 T A 7: 45,587,963 N290K probably benign Het
Ccdc39 T C 3: 33,825,169 probably null Het
Cnot10 T C 9: 114,613,637 S501G probably benign Het
Col6a6 A G 9: 105,767,198 probably null Het
Coq2 A C 5: 100,660,250 C228W probably damaging Het
Cpt2 A T 4: 107,906,974 M531K possibly damaging Het
Dennd1a A G 2: 38,021,363 L204P probably damaging Het
Dirc2 T A 16: 35,734,068 probably null Het
Dock9 C T 14: 121,597,663 V1305M probably benign Het
Dusp16 A G 6: 134,725,925 I201T probably damaging Het
Esco2 T C 14: 65,827,181 D370G probably benign Het
Fbxl4 T C 4: 22,377,037 S158P probably damaging Het
Gm10436 T C 12: 88,176,258 T392A probably damaging Het
Gpr3 A G 4: 133,211,329 W11R probably damaging Het
H2-M3 T A 17: 37,270,729 I94N probably damaging Het
Krt7 T C 15: 101,412,643 I57T probably damaging Het
Ltc4s T C 11: 50,238,546 probably benign Het
Ms4a6b A T 19: 11,523,940 T105S probably damaging Het
Muc6 T C 7: 141,648,658 H592R probably benign Het
Ncam1 T C 9: 49,565,003 E262G probably benign Het
Olfr1265 T A 2: 90,037,747 I276K possibly damaging Het
Olfr1462 T C 19: 13,191,573 V302A probably benign Het
Plxnb1 T A 9: 109,114,412 S1908T probably damaging Het
Polg2 A T 11: 106,775,593 M242K probably benign Het
Polr3g T C 13: 81,694,444 T151A unknown Het
Psmb8 T C 17: 34,200,212 L160P possibly damaging Het
Rab5b G A 10: 128,681,391 A176V possibly damaging Het
Rreb1 T C 13: 37,931,034 C790R probably damaging Het
Rufy3 A G 5: 88,640,617 T506A probably benign Het
Samd11 T C 4: 156,255,183 probably benign Het
Slc12a2 T C 18: 57,896,378 F279L possibly damaging Het
Son TCCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCAGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG TCCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG 16: 91,660,295 probably benign Het
Srgn C T 10: 62,494,978 W116* probably null Het
Svil A G 18: 5,099,663 E1733G probably damaging Het
Tbc1d22a C T 15: 86,235,541 P49S probably benign Het
Tbc1d9 A T 8: 83,242,553 K490M probably damaging Het
Tcte1 A G 17: 45,534,989 N173S probably benign Het
Tmco6 C T 18: 36,735,393 R31W probably damaging Het
Ttn C A 2: 76,899,681 A5155S unknown Het
Tyro3 T C 2: 119,816,906 Y839H probably damaging Het
Zc3h12d A G 10: 7,867,576 D370G probably benign Het
Zc3h7b T C 15: 81,780,602 L554P probably damaging Het
Zfp352 C T 4: 90,224,777 P385S probably benign Het
Other mutations in Fut10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Fut10 APN 8 31195291 critical splice donor site probably null
IGL00566:Fut10 APN 8 31235684 missense probably damaging 1.00
IGL00858:Fut10 APN 8 31235705 missense probably damaging 0.97
IGL00861:Fut10 APN 8 31235705 missense probably damaging 0.97
IGL00862:Fut10 APN 8 31235705 missense probably damaging 0.97
IGL01916:Fut10 APN 8 31235706 missense probably benign 0.01
IGL02030:Fut10 APN 8 31235978 nonsense probably null
IGL02318:Fut10 APN 8 31236258 missense probably damaging 1.00
IGL02354:Fut10 APN 8 31201370 missense probably damaging 0.99
IGL02361:Fut10 APN 8 31201370 missense probably damaging 0.99
IGL02932:Fut10 APN 8 31259937 missense probably damaging 1.00
IGL03345:Fut10 APN 8 31260041 missense probably damaging 1.00
R0234:Fut10 UTSW 8 31236197 missense probably damaging 1.00
R0234:Fut10 UTSW 8 31236197 missense probably damaging 1.00
R1728:Fut10 UTSW 8 31201390 missense probably benign 0.00
R1729:Fut10 UTSW 8 31201390 missense probably benign 0.00
R1845:Fut10 UTSW 8 31236300 missense probably damaging 1.00
R2173:Fut10 UTSW 8 31236131 missense probably damaging 1.00
R2518:Fut10 UTSW 8 31236467 missense probably benign 0.19
R3692:Fut10 UTSW 8 31236020 missense possibly damaging 0.94
R4449:Fut10 UTSW 8 31236257 missense probably damaging 1.00
R5015:Fut10 UTSW 8 31236120 missense probably damaging 0.96
R5942:Fut10 UTSW 8 31201457 missense possibly damaging 0.62
R6497:Fut10 UTSW 8 31236250 missense probably damaging 0.99
R7566:Fut10 UTSW 8 31259922 missense probably benign 0.00
R8127:Fut10 UTSW 8 31194971 start gained probably benign
R8241:Fut10 UTSW 8 31260006 nonsense probably null
Predicted Primers PCR Primer
(F):5'- TCTACAGAGTCATTGCCCAGTATAAG -3'
(R):5'- AGCCTACTGTTTGCCCACAC -3'

Sequencing Primer
(F):5'- GCCCAGTATAAGTTCATCCTGG -3'
(R):5'- ACACTCAAACGAGTCAATGTAGTTG -3'
Posted On2019-10-24