Incidental Mutation 'R7645:Zc3h7b'
ID 590499
Institutional Source Beutler Lab
Gene Symbol Zc3h7b
Ensembl Gene ENSMUSG00000022390
Gene Name zinc finger CCCH type containing 7B
Synonyms Scrg3
MMRRC Submission 045701-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.229) question?
Stock # R7645 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 81629299-81680470 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 81664803 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 554 (L554P)
Ref Sequence ENSEMBL: ENSMUSP00000105181 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109554]
AlphaFold F8VPP8
Predicted Effect probably damaging
Transcript: ENSMUST00000109554
AA Change: L554P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105181
Gene: ENSMUSG00000022390
AA Change: L554P

DomainStartEndE-ValueType
Pfam:TPR_11 34 113 2.3e-12 PFAM
Pfam:TPR_1 82 115 2.4e-6 PFAM
Pfam:TPR_8 82 115 8.2e-4 PFAM
Pfam:TPR_8 116 143 4.8e-3 PFAM
low complexity region 294 309 N/A INTRINSIC
low complexity region 340 354 N/A INTRINSIC
ZnF_C3H1 482 508 2.15e1 SMART
ZnF_C3H1 612 638 2.03e1 SMART
ZnF_C3H1 757 782 8.31e0 SMART
ZnF_C2H2 843 867 2.86e-1 SMART
ZnF_C3H1 889 914 7.81e-1 SMART
low complexity region 959 981 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 98% (46/47)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(9) : Gene trapped(9)

Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actbl2 T A 13: 111,392,789 (GRCm39) C375S probably benign Het
Adgrg3 A G 8: 95,761,392 (GRCm39) probably benign Het
Amn1 C T 6: 149,086,529 (GRCm39) M44I probably benign Het
Atg2b T C 12: 105,589,689 (GRCm39) Y1854C probably benign Het
Bcat2 T A 7: 45,237,387 (GRCm39) N290K probably benign Het
Ccdc39 T C 3: 33,879,318 (GRCm39) probably null Het
Cnot10 T C 9: 114,442,705 (GRCm39) S501G probably benign Het
Col6a6 A G 9: 105,644,397 (GRCm39) probably null Het
Coq2 A C 5: 100,808,116 (GRCm39) C228W probably damaging Het
Cpt2 A T 4: 107,764,171 (GRCm39) M531K possibly damaging Het
Dennd1a A G 2: 37,911,375 (GRCm39) L204P probably damaging Het
Dock9 C T 14: 121,835,075 (GRCm39) V1305M probably benign Het
Dusp16 A G 6: 134,702,888 (GRCm39) I201T probably damaging Het
Esco2 T C 14: 66,064,630 (GRCm39) D370G probably benign Het
Fbxl4 T C 4: 22,377,037 (GRCm39) S158P probably damaging Het
Fut10 A G 8: 31,726,232 (GRCm39) H329R possibly damaging Het
Gpr3 A G 4: 132,938,640 (GRCm39) W11R probably damaging Het
H2-M3 T A 17: 37,581,620 (GRCm39) I94N probably damaging Het
Krt7 T C 15: 101,310,524 (GRCm39) I57T probably damaging Het
Ltc4s T C 11: 50,129,373 (GRCm39) probably benign Het
Ms4a6b A T 19: 11,501,304 (GRCm39) T105S probably damaging Het
Muc6 T C 7: 141,234,923 (GRCm39) H592R probably benign Het
Ncam1 T C 9: 49,476,303 (GRCm39) E262G probably benign Het
Or4x11 T A 2: 89,868,091 (GRCm39) I276K possibly damaging Het
Or5b108 T C 19: 13,168,937 (GRCm39) V302A probably benign Het
Plxnb1 T A 9: 108,943,480 (GRCm39) S1908T probably damaging Het
Polg2 A T 11: 106,666,419 (GRCm39) M242K probably benign Het
Polr3g T C 13: 81,842,563 (GRCm39) T151A unknown Het
Pramel51 T C 12: 88,143,028 (GRCm39) T392A probably damaging Het
Psmb8 T C 17: 34,419,186 (GRCm39) L160P possibly damaging Het
Rab5b G A 10: 128,517,260 (GRCm39) A176V possibly damaging Het
Rreb1 T C 13: 38,115,010 (GRCm39) C790R probably damaging Het
Rufy3 A G 5: 88,788,476 (GRCm39) T506A probably benign Het
Samd11 T C 4: 156,340,243 (GRCm39) probably benign Het
Slc12a2 T C 18: 58,029,450 (GRCm39) F279L possibly damaging Het
Slc49a4 T A 16: 35,554,438 (GRCm39) probably null Het
Son TCCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCAGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG TCCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG 16: 91,457,183 (GRCm39) probably benign Het
Srgn C T 10: 62,330,757 (GRCm39) W116* probably null Het
Svil A G 18: 5,099,663 (GRCm39) E1733G probably damaging Het
Tbc1d22a C T 15: 86,119,742 (GRCm39) P49S probably benign Het
Tbc1d9 A T 8: 83,969,182 (GRCm39) K490M probably damaging Het
Tcte1 A G 17: 45,845,915 (GRCm39) N173S probably benign Het
Tmco6 C T 18: 36,868,446 (GRCm39) R31W probably damaging Het
Ttn C A 2: 76,730,025 (GRCm39) A5155S unknown Het
Tyro3 T C 2: 119,647,387 (GRCm39) Y839H probably damaging Het
Zc3h12d A G 10: 7,743,340 (GRCm39) D370G probably benign Het
Zfp352 C T 4: 90,113,014 (GRCm39) P385S probably benign Het
Other mutations in Zc3h7b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01726:Zc3h7b APN 15 81,656,000 (GRCm39) missense possibly damaging 0.95
IGL01955:Zc3h7b APN 15 81,676,205 (GRCm39) missense probably benign 0.10
IGL02526:Zc3h7b APN 15 81,677,338 (GRCm39) missense probably benign 0.10
IGL02582:Zc3h7b APN 15 81,653,341 (GRCm39) missense probably benign 0.05
IGL02736:Zc3h7b APN 15 81,676,175 (GRCm39) missense probably benign 0.02
F6893:Zc3h7b UTSW 15 81,662,872 (GRCm39) missense possibly damaging 0.94
R0212:Zc3h7b UTSW 15 81,660,529 (GRCm39) missense probably benign 0.00
R0242:Zc3h7b UTSW 15 81,653,031 (GRCm39) splice site probably benign
R0471:Zc3h7b UTSW 15 81,666,169 (GRCm39) missense probably damaging 1.00
R0590:Zc3h7b UTSW 15 81,661,199 (GRCm39) missense possibly damaging 0.74
R1530:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1563:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1565:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1566:Zc3h7b UTSW 15 81,653,035 (GRCm39) missense possibly damaging 0.91
R1670:Zc3h7b UTSW 15 81,661,268 (GRCm39) missense probably benign
R1712:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1727:Zc3h7b UTSW 15 81,652,230 (GRCm39) missense probably damaging 1.00
R2069:Zc3h7b UTSW 15 81,676,529 (GRCm39) missense probably damaging 0.98
R2375:Zc3h7b UTSW 15 81,676,703 (GRCm39) missense probably benign 0.17
R2656:Zc3h7b UTSW 15 81,664,631 (GRCm39) missense probably damaging 1.00
R4660:Zc3h7b UTSW 15 81,676,451 (GRCm39) missense probably benign 0.07
R4764:Zc3h7b UTSW 15 81,653,384 (GRCm39) critical splice donor site probably null
R4815:Zc3h7b UTSW 15 81,677,864 (GRCm39) missense probably damaging 1.00
R4999:Zc3h7b UTSW 15 81,663,334 (GRCm39) missense probably damaging 1.00
R5086:Zc3h7b UTSW 15 81,677,375 (GRCm39) missense probably damaging 0.96
R5169:Zc3h7b UTSW 15 81,657,515 (GRCm39) missense probably benign 0.01
R5395:Zc3h7b UTSW 15 81,656,702 (GRCm39) missense possibly damaging 0.50
R5407:Zc3h7b UTSW 15 81,670,092 (GRCm39) missense probably damaging 0.99
R5587:Zc3h7b UTSW 15 81,656,059 (GRCm39) missense possibly damaging 0.80
R5721:Zc3h7b UTSW 15 81,657,499 (GRCm39) missense probably benign 0.02
R6001:Zc3h7b UTSW 15 81,676,236 (GRCm39) missense possibly damaging 0.89
R6151:Zc3h7b UTSW 15 81,662,911 (GRCm39) critical splice donor site probably null
R6248:Zc3h7b UTSW 15 81,667,386 (GRCm39) missense probably damaging 1.00
R6397:Zc3h7b UTSW 15 81,677,055 (GRCm39) missense probably benign 0.03
R6502:Zc3h7b UTSW 15 81,653,252 (GRCm39) missense probably benign 0.01
R7248:Zc3h7b UTSW 15 81,655,988 (GRCm39) missense possibly damaging 0.46
R7397:Zc3h7b UTSW 15 81,653,354 (GRCm39) missense possibly damaging 0.50
R7450:Zc3h7b UTSW 15 81,667,281 (GRCm39) missense probably benign
R7471:Zc3h7b UTSW 15 81,664,682 (GRCm39) missense probably damaging 1.00
R7575:Zc3h7b UTSW 15 81,662,086 (GRCm39) nonsense probably null
R7650:Zc3h7b UTSW 15 81,677,851 (GRCm39) missense possibly damaging 0.81
R7881:Zc3h7b UTSW 15 81,664,679 (GRCm39) missense probably damaging 1.00
R7918:Zc3h7b UTSW 15 81,653,189 (GRCm39) missense probably damaging 0.98
R8001:Zc3h7b UTSW 15 81,663,461 (GRCm39) nonsense probably null
R8504:Zc3h7b UTSW 15 81,664,719 (GRCm39) missense probably damaging 1.00
R8855:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8856:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8857:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8865:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8866:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8867:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8868:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R9071:Zc3h7b UTSW 15 81,677,964 (GRCm39) makesense probably null
R9136:Zc3h7b UTSW 15 81,653,312 (GRCm39) missense probably damaging 1.00
R9169:Zc3h7b UTSW 15 81,661,184 (GRCm39) missense probably benign 0.19
R9701:Zc3h7b UTSW 15 81,676,505 (GRCm39) missense probably damaging 1.00
R9802:Zc3h7b UTSW 15 81,676,505 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TACGGGGATAACTGCACCTTC -3'
(R):5'- TAAATCCTGCACATTCCGGGC -3'

Sequencing Primer
(F):5'- TCGCCTACCATCAGGAGGAGATC -3'
(R):5'- ATTCCGGGCTCCCAAGGAAG -3'
Posted On 2019-10-24