|List |< first << previous [record 12 of 48] next >> last >||
|Institutional Source||Beutler Lab|
|Gene Name||disrupted in renal carcinoma 2 (human)|
|Is this an essential gene?||Probably essential (E-score: 0.909)|
|Stock #||R7645 (G1)|
|Chromosomal Location||35694062-35769356 bp(-) (GRCm38)|
|Type of Mutation||critical splice acceptor site|
|DNA Base Change (assembly)||T to A at 35734068 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000023554 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000023554] [ENSMUST00000149892]|
|Predicted Effect||probably null
|Predicted Effect||probably benign
|Coding Region Coverage||
|Validation Efficiency||98% (46/47)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Dirc2||
(F):5'- CTTGAACATTAAGAATCAGGGGTGG -3'
(R):5'- ATCTTTGTTCATAGCGCGCC -3'
(F):5'- AGCCTGAGTTTGATCCCTGGAAC -3'
(R):5'- ATAGCGCGCCTCCTACTG -3'