|Institutional Source||Beutler Lab|
|Gene Name||ATPase family, AAA domain containing 2B|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7648 (G1)|
|Chromosomal Location||4917353-5047394 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to A at 5027182 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000047445 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000045664]|
|Meta Mutation Damage Score||0.9497|
|Coding Region Coverage||
|Validation Efficiency||100% (53/53)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit reduced body size and fertility in female mice. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Atad2b||
(F):5'- ATGCAGCTGGGAACATGTAAC -3'
(R):5'- AACACCAAACATGTTTCAAGGG -3'
(F):5'- GCTGGGAACATGTAACTAAGTAGTTC -3'
(R):5'- AAGCTCCTCTCTGGAAAG -3'