Incidental Mutation 'R7649:Or13c3'
ID 590679
Institutional Source Beutler Lab
Gene Symbol Or13c3
Ensembl Gene ENSMUSG00000049648
Gene Name olfactory receptor family 13 subfamily C member 3
Synonyms Olfr273, GA_x6K02T2N78B-7137430-7138383, MOR262-8
MMRRC Submission 045646-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R7649 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 52855558-52856511 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 52855692 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 274 (Q274*)
Ref Sequence ENSEMBL: ENSMUSP00000103297 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051520] [ENSMUST00000107670] [ENSMUST00000215274]
AlphaFold Q8VG87
Predicted Effect probably null
Transcript: ENSMUST00000051520
AA Change: Q274*
SMART Domains Protein: ENSMUSP00000052080
Gene: ENSMUSG00000049648
AA Change: Q274*

DomainStartEndE-ValueType
Pfam:7tm_4 31 314 1.3e-55 PFAM
Pfam:7tm_1 41 296 1.4e-28 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000107670
AA Change: Q274*
SMART Domains Protein: ENSMUSP00000103297
Gene: ENSMUSG00000049648
AA Change: Q274*

DomainStartEndE-ValueType
Pfam:7tm_1 41 296 3.2e-37 PFAM
Pfam:7tm_4 139 289 4e-42 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000215274
AA Change: Q274*
Meta Mutation Damage Score 0.9716 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 98% (57/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr3b T C 5: 26,053,364 (GRCm39) V319A probably benign Het
Adam28 T A 14: 68,872,282 (GRCm39) Y320F probably benign Het
Adam4 T C 12: 81,467,151 (GRCm39) Y490C probably damaging Het
Ampd3 G T 7: 110,377,049 (GRCm39) L13F probably benign Het
Arhgap45 C A 10: 79,866,835 (GRCm39) Q1113K probably benign Het
Arid5b T C 10: 67,954,175 (GRCm39) T370A possibly damaging Het
Arl15 A G 13: 114,104,208 (GRCm39) D115G possibly damaging Het
AW146154 G A 7: 41,130,156 (GRCm39) T320I probably benign Het
Cdh17 C T 4: 11,814,698 (GRCm39) P751L probably damaging Het
Chchd4 C T 6: 91,444,754 (GRCm39) R11Q probably benign Het
Clta T G 4: 44,025,494 (GRCm39) I140R possibly damaging Het
Cnpy1 T C 5: 28,412,282 (GRCm39) T84A probably benign Het
Cpne5 T C 17: 29,445,172 (GRCm39) D44G probably damaging Het
Crkl T C 16: 17,270,366 (GRCm39) S9P unknown Het
Csmd3 T C 15: 47,532,539 (GRCm39) D1641G Het
Ctnnd2 A G 15: 31,027,630 (GRCm39) T1185A probably benign Het
Dlc1 A T 8: 37,049,894 (GRCm39) L607Q probably damaging Het
Dpy19l2 T C 9: 24,607,459 (GRCm39) M1V probably null Het
Dst T C 1: 34,206,778 (GRCm39) V982A probably benign Het
Fam135b T C 15: 71,334,429 (GRCm39) I922V probably benign Het
Fbxl13 T C 5: 21,819,664 (GRCm39) E245G probably benign Het
Fcgbp T C 7: 27,790,928 (GRCm39) S730P possibly damaging Het
Ggt1 T C 10: 75,421,290 (GRCm39) V468A possibly damaging Het
Gja5 A T 3: 96,958,957 (GRCm39) H338L probably benign Het
Herpud2 T C 9: 25,021,902 (GRCm39) E248G possibly damaging Het
Il17rd C A 14: 26,761,167 (GRCm39) A36E probably benign Het
Irf2bpl T C 12: 86,929,572 (GRCm39) Y367C possibly damaging Het
Lama1 T A 17: 68,044,549 (GRCm39) D149E Het
Lipf A T 19: 33,943,098 (GRCm39) E135D possibly damaging Het
Manea T A 4: 26,328,234 (GRCm39) D269V probably damaging Het
Megf6 A G 4: 154,349,542 (GRCm39) Y910C probably damaging Het
Mical3 G A 6: 120,911,909 (GRCm39) R1928W probably damaging Het
Or5b108 T A 19: 13,168,136 (GRCm39) I35N possibly damaging Het
Plch1 G T 3: 63,605,590 (GRCm39) S1438* probably null Het
Por T C 5: 135,763,359 (GRCm39) F595L probably damaging Het
Prkcg G A 7: 3,378,480 (GRCm39) R634H probably benign Het
Prr14l C T 5: 32,985,589 (GRCm39) G1302D probably benign Het
Rcan3 A T 4: 135,139,799 (GRCm39) S135T probably benign Het
Rnf223 A G 4: 156,216,660 (GRCm39) M12V probably benign Het
Rps6kb2 A G 19: 4,207,020 (GRCm39) S483P unknown Het
Sacs T A 14: 61,440,677 (GRCm39) F908I possibly damaging Het
Slc4a9 A G 18: 36,661,430 (GRCm39) Q64R probably benign Het
Slco4c1 T A 1: 96,756,667 (GRCm39) I552F probably benign Het
Sppl2b C T 10: 80,703,253 (GRCm39) P505L probably benign Het
Sptbn4 A G 7: 27,061,002 (GRCm39) S2434P possibly damaging Het
Ssh1 A T 5: 114,088,612 (GRCm39) M395K probably benign Het
Stk10 A T 11: 32,527,764 (GRCm39) I171F Het
Tmx3 C T 18: 90,558,154 (GRCm39) A402V probably damaging Het
Tnfrsf13c T C 15: 82,108,341 (GRCm39) D58G possibly damaging Het
Tnk1 T C 11: 69,744,403 (GRCm39) probably null Het
Trav14n-3 A T 14: 53,607,951 (GRCm39) N94Y probably damaging Het
Trav5-4 A T 14: 53,941,902 (GRCm39) K92* probably null Het
Tsga10 C T 1: 37,874,229 (GRCm39) R190H unknown Het
Zfhx3 T C 8: 109,678,276 (GRCm39) F3109L probably benign Het
Zfhx4 A G 3: 5,307,170 (GRCm39) Y132C probably damaging Het
Zfp521 T C 18: 13,977,413 (GRCm39) E1000G probably damaging Het
Other mutations in Or13c3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02114:Or13c3 APN 4 52,856,144 (GRCm39) missense probably damaging 1.00
R0048:Or13c3 UTSW 4 52,856,196 (GRCm39) missense probably damaging 1.00
R0048:Or13c3 UTSW 4 52,856,196 (GRCm39) missense probably damaging 1.00
R0826:Or13c3 UTSW 4 52,855,566 (GRCm39) missense probably benign
R0831:Or13c3 UTSW 4 52,855,764 (GRCm39) missense possibly damaging 0.46
R1772:Or13c3 UTSW 4 52,855,730 (GRCm39) missense probably benign 0.30
R1774:Or13c3 UTSW 4 52,855,674 (GRCm39) missense probably benign 0.01
R1861:Or13c3 UTSW 4 52,856,373 (GRCm39) missense probably benign 0.00
R2080:Or13c3 UTSW 4 52,855,568 (GRCm39) missense probably benign 0.20
R2242:Or13c3 UTSW 4 52,855,769 (GRCm39) missense probably damaging 1.00
R3777:Or13c3 UTSW 4 52,855,636 (GRCm39) missense probably damaging 1.00
R4492:Or13c3 UTSW 4 52,855,764 (GRCm39) missense probably benign 0.01
R4748:Or13c3 UTSW 4 52,856,076 (GRCm39) missense possibly damaging 0.95
R4880:Or13c3 UTSW 4 52,856,411 (GRCm39) missense probably damaging 1.00
R4905:Or13c3 UTSW 4 52,855,613 (GRCm39) missense probably damaging 0.99
R5856:Or13c3 UTSW 4 52,856,516 (GRCm39) start gained probably benign
R6585:Or13c3 UTSW 4 52,856,192 (GRCm39) missense possibly damaging 0.84
R6862:Or13c3 UTSW 4 52,855,695 (GRCm39) missense probably benign
R7378:Or13c3 UTSW 4 52,856,421 (GRCm39) missense probably benign
R8793:Or13c3 UTSW 4 52,856,490 (GRCm39) missense probably benign
R9169:Or13c3 UTSW 4 52,856,052 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- GTGCTCACAGATTTGCAATTAAGTC -3'
(R):5'- CATATCAAATATGGCCTTCCTGGTTC -3'

Sequencing Primer
(F):5'- CACAGATTTGCAATTAAGTCAATCTC -3'
(R):5'- AATATGGCCTTCCTGGTTCTTCCAC -3'
Posted On 2019-10-24