Mutagenetix > Incidental Mutation

Incidental Mutation 'R7651:Vmn2r72'

590835

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

Vmn2r72-ps, EG244114

MMRRC Submission

045728-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.139) question?

Stock #

R7651 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

85737784-85754981 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 85751938 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Isoleucine at position 91 (N91I)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

AlphaFold

D3Z4N8

Predicted Effect

probably damaging
Transcript: ENSMUST00000063425
AA Change: N91I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: N91I

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930438A08Rik	T	G	11: 58,293,362	V302G		Het
A230072I06Rik	T	C	8: 12,279,689	I48T	unknown	Het
A430089I19Rik	T	C	5: 94,303,377	T297A	probably benign	Het
Ada	T	A	2: 163,732,355	D127V	probably damaging	Het
Alb	G	C	5: 90,467,355	R242P	probably damaging	Het
Ankrd34c	T	C	9: 89,729,410	R293G	possibly damaging	Het
Ap2b1	T	C	11: 83,339,430		probably null	Het
Arhgef16	A	G	4: 154,291,067	S157P	probably damaging	Het
Atp2b1	C	T	10: 99,016,968	L1036F	probably damaging	Het
Ccdc27	A	T	4: 154,028,099	I573N	probably damaging	Het
Cep164	T	C	9: 45,773,852	E869G	probably benign	Het
Colq	A	T	14: 31,528,335	V381D	possibly damaging	Het
Drc1	A	G	5: 30,359,614	E519G	probably benign	Het
Drosha	G	A	15: 12,859,436	V577I	probably benign	Het
Epg5	C	T	18: 77,981,400	Q1157*	probably null	Het
Eqtn	T	C	4: 94,923,707	S150G	possibly damaging	Het
Fam216a	G	A	5: 122,367,382	H172Y	probably damaging	Het
Fbxw19	T	A	9: 109,494,646	D87V	probably damaging	Het
Fgr	A	T	4: 132,995,013	I198F	probably damaging	Het
Flnc	A	G	6: 29,444,050	D621G	probably benign	Het
Flt3	A	C	5: 147,354,922	Y573D	probably damaging	Het
Git2	A	T	5: 114,733,235	I603N	probably damaging	Het
Gm4559	C	T	7: 142,273,816	R183K	unknown	Het
Gnb5	T	C	9: 75,343,571	F326L	probably damaging	Het
Grm8	A	T	6: 27,760,258	W358R	possibly damaging	Het
Grrp1	C	T	4: 134,251,648	R173H	probably damaging	Het
Hoxa3	A	G	6: 52,172,273	V126A	unknown	Het
Hras	T	C	7: 141,192,151	T144A	possibly damaging	Het
Hyal1	G	A	9: 107,578,370	R293H	probably damaging	Het
Ifnlr1	A	G	4: 135,690,608	S49G	possibly damaging	Het
Ighv8-11	C	A	12: 115,567,385	C41F	probably benign	Het
Jakmip1	A	G	5: 37,134,273	T689A	probably damaging	Het
Kcnb1	T	C	2: 167,188,361	H88R	probably damaging	Het
Kcnt2	T	A	1: 140,570,461	M892K	probably benign	Het
Lrba	C	A	3: 86,741,466	S2507*	probably null	Het
Mbp	C	T	18: 82,554,374	T65I	probably damaging	Het
Muc2	A	T	7: 141,704,201	Y12F		Het
Muc4	T	A	16: 32,756,575	S80T		Het
Muc5ac	A	G	7: 141,796,254	D579G	possibly damaging	Het
Muc5b	A	G	7: 141,864,023	T3569A	possibly damaging	Het
Myb	C	T	10: 21,156,374	R36H	probably damaging	Het
Myo6	T	C	9: 80,264,266		probably null	Het
Ogfod1	T	C	8: 94,037,353	V22A	probably benign	Het
Orai3	A	G	7: 127,774,064	I246V	probably damaging	Het
Otog	A	G	7: 46,241,761	M68V	probably benign	Het
Pcdh20	T	A	14: 88,469,153	D237V	probably damaging	Het
Pcdhb18	T	C	18: 37,490,993	F459L	probably benign	Het
Pik3c2g	C	T	6: 139,622,072	T62M	possibly damaging	Het
Plaa	T	C	4: 94,582,639	Y420C	probably damaging	Het
Ppp1r9b	C	T	11: 95,001,942	A656V	probably benign	Het
Prg4	T	A	1: 150,454,945	E659V	unknown	Het
Prlhr	C	A	19: 60,467,145	A328S	probably benign	Het
Prlr	A	T	15: 10,328,378	D313V	probably benign	Het
Prune2	C	T	19: 17,120,408	T1092I	probably damaging	Het
Psme4	T	A	11: 30,837,334	L1043H	probably damaging	Het
Ptprr	T	C	10: 116,251,179	V521A	probably benign	Het
Rab44	A	T	17: 29,148,205	D703V	unknown	Het
Rpl9-ps1	A	T	11: 83,645,085	Y179*	probably null	Het
Scg3	T	A	9: 75,682,050	N107I	probably benign	Het
Sh3bgrl2	T	C	9: 83,548,472	V5A	possibly damaging	Het
Slc7a12	T	C	3: 14,481,449	V218A	probably benign	Het
Sorcs2	A	G	5: 36,027,978	L918P	probably damaging	Het
Sox1	C	A	8: 12,396,686	A109E	probably damaging	Het
Syne1	T	A	10: 5,205,074	M5622L	probably benign	Het
Syne1	A	T	10: 5,343,416	L1305Q	probably damaging	Het
Tacc2	A	T	7: 130,623,154	H523L	probably benign	Het
Tas1r2	A	T	4: 139,669,627	D788V	probably benign	Het
Tcl1b5	T	A	12: 105,176,435	D7E	possibly damaging	Het
Tesc	A	G	5: 118,056,601	D159G	possibly damaging	Het
Tm2d2	G	T	8: 25,017,300		probably benign	Het
Tnfrsf11a	T	A	1: 105,809,446	C93S	probably damaging	Het
Tnfsf4	T	C	1: 161,417,022	V94A	probably benign	Het
Trav13n-3	T	A	14: 53,337,507	Y69N	probably benign	Het
Utp20	T	C	10: 88,754,595	D2339G	probably benign	Het
Vmn1r225	A	G	17: 20,502,349	I17M	possibly damaging	Het
Vmn2r111	T	C	17: 22,559,051	N549S	possibly damaging	Het
Vmn2r114	G	T	17: 23,291,012	Y831*	probably null	Het
Zfp846	T	C	9: 20,588,512	S13P	possibly damaging	Het
Zfp934	G	T	13: 62,518,513	N116K	probably benign	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85749646	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85738334	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85749646	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85738367	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85750711	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85737962	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85750693	missense	probably benign
IGL02514:Vmn2r72	APN	7	85738699	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85738183	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85738671	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85751813	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85752041	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85751176	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85754954	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85750867	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85751836	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85754876	missense	probably benign
R0655:Vmn2r72	UTSW	7	85738111	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85749739	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85751309	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85749188	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85738257	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85749211	missense	probably benign
R1632:Vmn2r72	UTSW	7	85751792	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85738170	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85749161	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85738236	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85738341	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85738256	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85750953	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85751269	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85749642	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85749735	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85751131	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85749809	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85737828	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85737911	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85737861	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85750598	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85751109	missense	probably benign
R4991:Vmn2r72	UTSW	7	85751130	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85738485	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85737853	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85737840	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85738254	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85750897	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85751942	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85737850	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85750539	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85751174	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85749684	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85737996	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85749803	splice site	probably null
R7189:Vmn2r72	UTSW	7	85754917	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85738274	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85750563	missense	probably benign
R7426:Vmn2r72	UTSW	7	85751140	missense	probably benign
R7606:Vmn2r72	UTSW	7	85751154	missense	possibly damaging	0.91
R7688:Vmn2r72	UTSW	7	85754890	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85750626	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85749630	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85751233	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85751019	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85751960	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85738175	missense	probably benign
R8989:Vmn2r72	UTSW	7	85754926	missense	probably benign	0.10
R9015:Vmn2r72	UTSW	7	85749180	missense	probably benign	0.01
R9080:Vmn2r72	UTSW	7	85738256	missense	probably damaging	1.00
R9269:Vmn2r72	UTSW	7	85751203	missense	probably benign	0.03
R9317:Vmn2r72	UTSW	7	85754814	missense	probably benign	0.04
R9509:Vmn2r72	UTSW	7	85754867	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85749191	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- GCTATACATGAACATGAGTGGTC -3'
(R):5'- TCCCTTTTCTGTCAGTTAAAACCAG -3'

Sequencing Primer
(F):5'- CATGAACATGAGTGGTCCTAGTC -3'
(R):5'- GGCTCTTGCTTGTACAGTT -3'

Posted On

2019-10-24