Incidental Mutation 'R7652:Zfp764l1'
ID 590916
Institutional Source Beutler Lab
Gene Symbol Zfp764l1
Ensembl Gene ENSMUSG00000078580
Gene Name zinc finger protein 764 like 1
Synonyms E430018J23Rik
MMRRC Submission 045729-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R7652 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 126988845-126992801 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 126992496 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 38 (C38Y)
Ref Sequence ENSEMBL: ENSMUSP00000073867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074249] [ENSMUST00000106303] [ENSMUST00000165495]
AlphaFold E9PZQ8
Predicted Effect probably null
Transcript: ENSMUST00000074249
AA Change: C38Y

PolyPhen 2 Score 0.876 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000073867
Gene: ENSMUSG00000078580
AA Change: C38Y

DomainStartEndE-ValueType
KRAB 22 79 4.43e-7 SMART
Predicted Effect probably null
Transcript: ENSMUST00000106303
AA Change: C38Y

PolyPhen 2 Score 0.122 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000101910
Gene: ENSMUSG00000078580
AA Change: C38Y

DomainStartEndE-ValueType
KRAB 22 81 9.25e-28 SMART
Predicted Effect probably null
Transcript: ENSMUST00000165495
AA Change: C38Y

PolyPhen 2 Score 0.193 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000126288
Gene: ENSMUSG00000078580
AA Change: C38Y

DomainStartEndE-ValueType
KRAB 22 82 4.09e-29 SMART
ZnF_C2H2 168 190 2.2e-2 SMART
ZnF_C2H2 196 218 4.79e-3 SMART
ZnF_C2H2 224 246 4.3e-5 SMART
ZnF_C2H2 252 274 7.9e-4 SMART
ZnF_C2H2 280 302 9.58e-3 SMART
ZnF_C2H2 308 331 2.36e-2 SMART
ZnF_C2H2 337 359 2.57e-3 SMART
ZnF_C2H2 365 387 1.69e-3 SMART
ZnF_C2H2 393 415 2.2e-2 SMART
Meta Mutation Damage Score 0.3601 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (66/66)
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agrn A G 4: 156,253,675 (GRCm39) probably null Het
Alb G C 5: 90,615,214 (GRCm39) R242P probably damaging Het
Anxa2r2 A T 13: 120,488,529 (GRCm39) S7T possibly damaging Het
Aph1b T C 9: 66,691,823 (GRCm39) T195A probably benign Het
Apoe G T 7: 19,430,535 (GRCm39) R236S possibly damaging Het
Arap3 G T 18: 38,111,505 (GRCm39) T1137K probably damaging Het
Arhgap45 C T 10: 79,864,672 (GRCm39) A908V probably benign Het
Atp13a1 T C 8: 70,258,209 (GRCm39) C965R probably damaging Het
C7 A G 15: 5,041,587 (GRCm39) Y440H probably damaging Het
Cacna2d2 T C 9: 107,401,397 (GRCm39) probably null Het
Ddah2 C A 17: 35,280,026 (GRCm39) R173S possibly damaging Het
Dnajc11 T C 4: 152,058,682 (GRCm39) Y337H probably damaging Het
Dnajc25 A G 4: 59,020,483 (GRCm39) K302R probably benign Het
Dnajc6 A T 4: 101,463,874 (GRCm39) Q209L probably damaging Het
Drosha G A 15: 12,859,522 (GRCm39) V577I probably benign Het
Ebf2 G T 14: 67,628,016 (GRCm39) probably null Het
Epx A G 11: 87,766,160 (GRCm39) probably null Het
Eqtn T C 4: 94,816,574 (GRCm39) Y73C probably damaging Het
Fam107b A G 2: 3,773,884 (GRCm39) N21S probably benign Het
Fasn G A 11: 120,707,154 (GRCm39) S857F probably damaging Het
Fat1 A G 8: 45,406,336 (GRCm39) N1029S probably damaging Het
Gas8 A G 8: 124,253,275 (GRCm39) I208V probably benign Het
Gm3269 T C 14: 16,026,209 (GRCm39) I88T probably benign Het
Gm8005 C A 14: 42,258,919 (GRCm39) L136F Het
Grid2ip C A 5: 143,368,393 (GRCm39) P743Q probably damaging Het
H2-T15 A T 17: 36,367,675 (GRCm39) V221D probably damaging Het
Hbs1l C T 10: 21,240,659 (GRCm39) T626I probably benign Het
Hdac3 T A 18: 38,087,972 (GRCm39) probably benign Het
Hnrnpab T C 11: 51,496,400 (GRCm39) Y94C probably damaging Het
Homer2 T C 7: 81,299,414 (GRCm39) D17G probably damaging Het
Ikbke C T 1: 131,199,569 (GRCm39) R308Q probably damaging Het
Ints10 A G 8: 69,277,771 (GRCm39) T682A possibly damaging Het
Klhl3 G A 13: 58,261,146 (GRCm39) probably benign Het
Klk1b9 A T 7: 43,445,514 (GRCm39) T235S probably benign Het
Kmt2c T C 5: 25,520,717 (GRCm39) T1798A probably benign Het
Kri1 TTCCTCCTCCTCCTCCTCCTCCTCCTCCTC TTCCTCCTCCTCCTCCTCCTCCTCCTC 9: 21,192,352 (GRCm39) probably benign Het
Krtap4-6 T C 11: 99,556,440 (GRCm39) I96V unknown Het
Lef1 A C 3: 130,994,003 (GRCm39) R354S probably damaging Het
Lrp6 A T 6: 134,488,208 (GRCm39) L296* probably null Het
Maml2 T C 9: 13,532,945 (GRCm39) Y720H Het
Mmrn1 A G 6: 60,954,490 (GRCm39) N924D probably benign Het
Myh7b A G 2: 155,474,156 (GRCm39) K1624E probably damaging Het
Nos3 T A 5: 24,588,610 (GRCm39) V1112D probably damaging Het
Or2y14 T C 11: 49,404,512 (GRCm39) F16L probably damaging Het
Or4c111 C T 2: 88,843,893 (GRCm39) V172I probably benign Het
Or5an1b C A 19: 12,299,651 (GRCm39) C180F probably damaging Het
Or5w13 A G 2: 87,523,704 (GRCm39) I174T probably damaging Het
Or6c70 A T 10: 129,710,346 (GRCm39) N93K probably damaging Het
Phospho1 T C 11: 95,721,645 (GRCm39) L105S probably damaging Het
Prss35 T A 9: 86,638,023 (GRCm39) N264K probably benign Het
Ptpn13 A G 5: 103,677,578 (GRCm39) D732G probably benign Het
Rab18 A T 18: 6,783,123 (GRCm39) T64S possibly damaging Het
Rft1 A G 14: 30,399,773 (GRCm39) Q319R probably benign Het
Rgs7 T A 1: 174,921,396 (GRCm39) M220L probably benign Het
Rnf13 A G 3: 57,671,772 (GRCm39) N28S probably benign Het
Setd3 A T 12: 108,078,548 (GRCm39) I311N probably damaging Het
Setd5 G A 6: 113,098,725 (GRCm39) R786H probably damaging Het
Slc26a6 T C 9: 108,733,143 (GRCm39) probably null Het
Slc26a9 A T 1: 131,691,634 (GRCm39) T626S probably benign Het
Stambp A T 6: 83,540,910 (GRCm39) probably null Het
Stom A T 2: 35,206,041 (GRCm39) N229K probably benign Het
Tlr1 A T 5: 65,084,130 (GRCm39) L149* probably null Het
Trpc3 C A 3: 36,692,677 (GRCm39) V772F probably benign Het
Ube3a A G 7: 58,893,102 (GRCm39) probably benign Het
Ugt2b35 T A 5: 87,149,369 (GRCm39) F207I probably damaging Het
Usp53 A T 3: 122,746,884 (GRCm39) D360E possibly damaging Het
Vmn2r96 T G 17: 18,793,832 (GRCm39) S59A probably benign Het
Wdr70 A G 15: 8,108,700 (GRCm39) C149R probably benign Het
Wnt3 A G 11: 103,703,290 (GRCm39) T258A possibly damaging Het
Zfp729b T C 13: 67,739,371 (GRCm39) T965A probably benign Het
Other mutations in Zfp764l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01716:Zfp764l1 APN 7 126,991,208 (GRCm39) missense possibly damaging 0.92
IGL01782:Zfp764l1 APN 7 126,992,476 (GRCm39) missense probably benign 0.02
IGL02174:Zfp764l1 APN 7 126,991,525 (GRCm39) missense possibly damaging 0.54
IGL02882:Zfp764l1 APN 7 126,991,424 (GRCm39) missense probably damaging 1.00
IGL03152:Zfp764l1 APN 7 126,991,469 (GRCm39) missense probably damaging 1.00
R0552:Zfp764l1 UTSW 7 126,991,504 (GRCm39) missense possibly damaging 0.92
R1828:Zfp764l1 UTSW 7 126,991,081 (GRCm39) missense probably damaging 1.00
R1843:Zfp764l1 UTSW 7 126,990,660 (GRCm39) missense probably benign 0.32
R1866:Zfp764l1 UTSW 7 126,992,503 (GRCm39) missense probably damaging 1.00
R3429:Zfp764l1 UTSW 7 126,990,914 (GRCm39) missense possibly damaging 0.79
R4433:Zfp764l1 UTSW 7 126,992,174 (GRCm39) missense possibly damaging 0.75
R4933:Zfp764l1 UTSW 7 126,992,521 (GRCm39) missense probably damaging 1.00
R5292:Zfp764l1 UTSW 7 126,991,659 (GRCm39) missense possibly damaging 0.48
R6218:Zfp764l1 UTSW 7 126,992,581 (GRCm39) missense possibly damaging 0.85
R6667:Zfp764l1 UTSW 7 126,992,595 (GRCm39) missense probably benign 0.35
R6712:Zfp764l1 UTSW 7 126,991,482 (GRCm39) missense probably damaging 1.00
R7108:Zfp764l1 UTSW 7 126,990,695 (GRCm39) missense probably benign 0.05
R7214:Zfp764l1 UTSW 7 126,990,695 (GRCm39) missense probably benign 0.05
R7215:Zfp764l1 UTSW 7 126,990,695 (GRCm39) missense probably benign 0.05
R7216:Zfp764l1 UTSW 7 126,990,695 (GRCm39) missense probably benign 0.05
R7313:Zfp764l1 UTSW 7 126,990,856 (GRCm39) missense probably benign 0.23
R7396:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7397:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7398:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7478:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7479:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7480:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7481:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7512:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7716:Zfp764l1 UTSW 7 126,991,259 (GRCm39) missense probably benign
R7820:Zfp764l1 UTSW 7 126,990,608 (GRCm39) missense possibly damaging 0.84
R7923:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R7999:Zfp764l1 UTSW 7 126,991,600 (GRCm39) missense probably damaging 0.98
R8097:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8098:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8100:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8182:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8184:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8185:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8309:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8389:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8433:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R8436:Zfp764l1 UTSW 7 126,992,496 (GRCm39) missense probably null 0.88
R9196:Zfp764l1 UTSW 7 126,990,761 (GRCm39) missense probably benign 0.02
R9779:Zfp764l1 UTSW 7 126,991,469 (GRCm39) missense probably damaging 1.00
X0022:Zfp764l1 UTSW 7 126,992,442 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGTCGACCCACTTGTTACG -3'
(R):5'- CACGGACCTGATATATGTCCTTTC -3'

Sequencing Primer
(F):5'- ACTTGTTACGACCACCCGTAC -3'
(R):5'- GGCAACCTAGGATCTGGCAG -3'
Posted On 2019-10-24