Incidental Mutation 'R7338:Wnt5b'
ID 591020
Institutional Source Beutler Lab
Gene Symbol Wnt5b
Ensembl Gene ENSMUSG00000030170
Gene Name wingless-type MMTV integration site family, member 5B
Synonyms Wnt-5b
MMRRC Submission 045428-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7338 (G1)
Quality Score 70.0074
Status Validated
Chromosome 6
Chromosomal Location 119409492-119521308 bp(-) (GRCm39)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) C to A at 119425092 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000137065 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117171] [ENSMUST00000118120] [ENSMUST00000119369] [ENSMUST00000178696]
AlphaFold P22726
Predicted Effect probably null
Transcript: ENSMUST00000117171
SMART Domains Protein: ENSMUSP00000113188
Gene: ENSMUSG00000030170

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
WNT1 50 359 3.47e-215 SMART
Predicted Effect probably null
Transcript: ENSMUST00000118120
SMART Domains Protein: ENSMUSP00000112819
Gene: ENSMUSG00000030170

DomainStartEndE-ValueType
WNT1 12 321 3.47e-215 SMART
Predicted Effect probably null
Transcript: ENSMUST00000119369
SMART Domains Protein: ENSMUSP00000112448
Gene: ENSMUSG00000030170

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
WNT1 63 372 3.47e-215 SMART
Predicted Effect probably null
Transcript: ENSMUST00000178696
SMART Domains Protein: ENSMUSP00000137065
Gene: ENSMUSG00000030170

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
WNT1 50 359 3.47e-215 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 T C 17: 24,595,717 (GRCm39) S357P possibly damaging Het
Arhgap28 T C 17: 68,203,106 (GRCm39) R166G probably damaging Het
Bcan T A 3: 87,901,550 (GRCm39) E384V probably damaging Het
Bcl9l A G 9: 44,420,005 (GRCm39) N1137S probably benign Het
Caprin1 A G 2: 103,609,768 (GRCm39) L170S probably benign Het
Card6 C T 15: 5,129,354 (GRCm39) E681K probably benign Het
Catsperb G A 12: 101,447,243 (GRCm39) V248I probably benign Het
Ccnj T A 19: 40,825,477 (GRCm39) H62Q probably damaging Het
Cd180 A C 13: 102,842,936 (GRCm39) I661L probably benign Het
Cdk11b A G 4: 155,732,008 (GRCm39) R473G unknown Het
Cep126 T C 9: 8,099,799 (GRCm39) T912A possibly damaging Het
Chek2 T A 5: 111,021,380 (GRCm39) V530E probably benign Het
Chga G T 12: 102,529,100 (GRCm39) S359I probably damaging Het
Cnrip1 T C 11: 17,004,657 (GRCm39) V69A probably damaging Het
Cyp2a5 A T 7: 26,542,372 (GRCm39) Q458L probably damaging Het
Cyp2j11 T A 4: 96,195,524 (GRCm39) T391S possibly damaging Het
Dhx16 T C 17: 36,199,036 (GRCm39) L794P probably damaging Het
Dscaml1 A G 9: 45,585,802 (GRCm39) T580A probably benign Het
Elmo1 A T 13: 20,464,982 (GRCm39) I184L probably benign Het
Gabra1 C T 11: 42,073,121 (GRCm39) G51S unknown Het
Gabrr3 C A 16: 59,268,439 (GRCm39) L351I possibly damaging Het
Gbp7 A T 3: 142,243,786 (GRCm39) N111I probably damaging Het
Gjd2 C T 2: 113,841,583 (GRCm39) R298H probably damaging Het
Gm5930 T C 14: 44,573,914 (GRCm39) Y141C probably damaging Het
Grin3a G T 4: 49,771,238 (GRCm39) N511K probably benign Het
Hdac7 T C 15: 97,707,903 (GRCm39) D122G probably benign Het
Ifi204 G A 1: 173,587,703 (GRCm39) T152I possibly damaging Het
Lrrc9 C T 12: 72,510,305 (GRCm39) probably null Het
Med21 T A 6: 146,544,082 (GRCm39) probably benign Het
Mmp19 A T 10: 128,634,952 (GRCm39) T523S probably benign Het
Nav3 G A 10: 109,605,073 (GRCm39) T1000I probably benign Het
Nherf2 T A 17: 24,869,182 (GRCm39) probably benign Het
Nin T C 12: 70,090,838 (GRCm39) D859G Het
Nip7 T G 8: 107,783,916 (GRCm39) L52R possibly damaging Het
Or10d1c A G 9: 38,893,816 (GRCm39) Y175H probably damaging Het
Or5al5 A T 2: 85,961,726 (GRCm39) F94I probably damaging Het
Or6b13 A T 7: 139,782,446 (GRCm39) V79E probably benign Het
Otop1 T A 5: 38,457,547 (GRCm39) Y435* probably null Het
Pak4 A G 7: 28,264,381 (GRCm39) S174P probably benign Het
Pcsk7 G A 9: 45,837,287 (GRCm39) R537Q probably benign Het
Podxl G A 6: 31,505,941 (GRCm39) S34F unknown Het
Prr36 G A 8: 4,266,212 (GRCm39) R113C probably damaging Het
Ptk7 T C 17: 46,890,525 (GRCm39) I436V probably benign Het
Slc13a5 C T 11: 72,157,310 (GRCm39) V28I probably benign Het
Slco6d1 A T 1: 98,349,097 (GRCm39) D56V probably benign Het
Spg11 G A 2: 121,885,858 (GRCm39) R2317W probably damaging Het
Stom T A 2: 35,213,760 (GRCm39) probably null Het
Svs5 T C 2: 164,174,728 (GRCm39) L8P possibly damaging Het
Tmem141 C A 2: 25,511,626 (GRCm39) V39F probably damaging Het
Tmprss6 A G 15: 78,344,019 (GRCm39) L181P probably damaging Het
Tnni3 A G 7: 4,524,379 (GRCm39) S40P probably benign Het
Tubgcp4 A G 2: 121,024,465 (GRCm39) I548V probably benign Het
Twf2 A G 9: 106,081,138 (GRCm39) probably benign Het
Wrap73 A G 4: 154,237,043 (GRCm39) D210G probably benign Het
Yipf4 T G 17: 74,796,771 (GRCm39) S21A probably benign Het
Zscan20 A G 4: 128,481,943 (GRCm39) M573T probably benign Het
Other mutations in Wnt5b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01590:Wnt5b APN 6 119,417,515 (GRCm39) missense possibly damaging 0.70
IGL01822:Wnt5b APN 6 119,410,433 (GRCm39) missense probably damaging 1.00
Blizzard UTSW 6 119,423,319 (GRCm39) missense probably damaging 1.00
Invierno UTSW 6 119,417,272 (GRCm39) missense probably damaging 1.00
luftmensch UTSW 6 119,410,813 (GRCm39) missense probably damaging 0.97
R0557:Wnt5b UTSW 6 119,410,779 (GRCm39) missense probably damaging 1.00
R0732:Wnt5b UTSW 6 119,423,543 (GRCm39) nonsense probably null
R1472:Wnt5b UTSW 6 119,410,442 (GRCm39) missense probably damaging 1.00
R1673:Wnt5b UTSW 6 119,423,315 (GRCm39) missense probably benign 0.19
R4202:Wnt5b UTSW 6 119,417,272 (GRCm39) missense probably damaging 1.00
R5100:Wnt5b UTSW 6 119,417,449 (GRCm39) missense probably benign 0.20
R5264:Wnt5b UTSW 6 119,410,813 (GRCm39) missense probably damaging 0.97
R5393:Wnt5b UTSW 6 119,417,394 (GRCm39) missense probably damaging 1.00
R5394:Wnt5b UTSW 6 119,417,283 (GRCm39) missense probably damaging 0.98
R5482:Wnt5b UTSW 6 119,423,392 (GRCm39) missense probably benign 0.19
R5741:Wnt5b UTSW 6 119,410,690 (GRCm39) missense probably damaging 1.00
R5902:Wnt5b UTSW 6 119,425,199 (GRCm39) missense probably benign 0.00
R6005:Wnt5b UTSW 6 119,410,615 (GRCm39) missense probably benign 0.04
R6061:Wnt5b UTSW 6 119,410,603 (GRCm39) missense probably damaging 0.98
R6208:Wnt5b UTSW 6 119,423,473 (GRCm39) missense probably damaging 1.00
R6405:Wnt5b UTSW 6 119,410,457 (GRCm39) missense probably benign 0.06
R6478:Wnt5b UTSW 6 119,410,751 (GRCm39) missense probably damaging 1.00
R6482:Wnt5b UTSW 6 119,410,573 (GRCm39) missense possibly damaging 0.88
R7047:Wnt5b UTSW 6 119,425,217 (GRCm39) start gained probably benign
R8044:Wnt5b UTSW 6 119,423,319 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCATTCACCGCCAGGAGTTG -3'
(R):5'- CCCCAAGTCTGTGGCATTTC -3'

Sequencing Primer
(F):5'- AGTTGGGTCCAGGCTAGAC -3'
(R):5'- ATTTCCATGCTGACTCTCCTTTG -3'
Posted On 2019-11-08