Incidental Mutation 'R7654:Vmn2r65'
| ID |
591069 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r65
|
| Ensembl Gene |
ENSMUSG00000066372 |
| Gene Name |
vomeronasal 2, receptor 65 |
| Synonyms |
ENSMUSG00000070600 |
| MMRRC Submission |
045702-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.071)
|
| Stock # |
R7654 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
84589377-84613217 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 84590261 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 552
(Y552H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000036551
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044583]
|
| AlphaFold |
G3X931 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000044583
AA Change: Y552H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000036551
Gene: ENSMUSG00000066372
AA Change: Y552H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
435 |
5.6e-41 |
PFAM |
|
Pfam:NCD3G
|
501 |
553 |
1.3e-21 |
PFAM |
|
Pfam:7tm_3
|
584 |
821 |
2.3e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
100% (76/76) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc2 |
G |
A |
19: 43,815,032 (GRCm39) |
V1140M |
possibly damaging |
Het |
| Adamtsl3 |
A |
C |
7: 82,223,702 (GRCm39) |
E1161A |
probably benign |
Het |
| Adcy5 |
T |
C |
16: 35,091,317 (GRCm39) |
S587P |
probably damaging |
Het |
| Aebp2 |
T |
A |
6: 140,599,474 (GRCm39) |
|
probably null |
Het |
| Alb |
G |
C |
5: 90,615,214 (GRCm39) |
R242P |
probably damaging |
Het |
| Ankhd1 |
T |
C |
18: 36,727,154 (GRCm39) |
V423A |
probably damaging |
Het |
| Arid1b |
T |
A |
17: 5,341,360 (GRCm39) |
M888K |
possibly damaging |
Het |
| Asl |
C |
A |
5: 130,047,231 (GRCm39) |
R122S |
probably damaging |
Het |
| B3gntl1 |
T |
A |
11: 121,542,439 (GRCm39) |
D109V |
probably damaging |
Het |
| Cat |
G |
A |
2: 103,290,709 (GRCm39) |
P402S |
probably damaging |
Het |
| Ccdc141 |
A |
T |
2: 76,872,822 (GRCm39) |
Y787N |
probably benign |
Het |
| Ccdc78 |
T |
C |
17: 26,009,085 (GRCm39) |
Y405H |
probably damaging |
Het |
| Ces1f |
T |
G |
8: 93,998,562 (GRCm39) |
K145Q |
probably benign |
Het |
| Cfap65 |
A |
T |
1: 74,972,303 (GRCm39) |
C19S |
probably benign |
Het |
| CN725425 |
T |
A |
15: 91,123,638 (GRCm39) |
I118N |
probably benign |
Het |
| Ctc1 |
C |
T |
11: 68,917,041 (GRCm39) |
P312S |
probably damaging |
Het |
| Ctsa |
C |
T |
2: 164,680,853 (GRCm39) |
T442I |
probably benign |
Het |
| Cyp2b9 |
A |
G |
7: 25,886,367 (GRCm39) |
T131A |
possibly damaging |
Het |
| D630045J12Rik |
A |
G |
6: 38,154,636 (GRCm39) |
M1181T |
probably damaging |
Het |
| Dagla |
C |
G |
19: 10,225,570 (GRCm39) |
G865R |
probably benign |
Het |
| Dst |
A |
C |
1: 34,268,058 (GRCm39) |
K3153Q |
probably damaging |
Het |
| Dst |
A |
T |
1: 34,268,059 (GRCm39) |
K3153M |
probably damaging |
Het |
| Dync2h1 |
A |
T |
9: 7,122,664 (GRCm39) |
H2097Q |
probably damaging |
Het |
| Etnppl |
A |
G |
3: 130,423,160 (GRCm39) |
I286M |
probably benign |
Het |
| Flvcr1 |
A |
T |
1: 190,743,802 (GRCm39) |
M418K |
possibly damaging |
Het |
| Fuca1 |
T |
C |
4: 135,657,232 (GRCm39) |
S215P |
probably damaging |
Het |
| Gabrg1 |
T |
C |
5: 70,935,504 (GRCm39) |
K222E |
probably benign |
Het |
| Gdpd5 |
G |
A |
7: 99,073,396 (GRCm39) |
R26H |
probably damaging |
Het |
| Gnptab |
T |
A |
10: 88,281,681 (GRCm39) |
S1229R |
possibly damaging |
Het |
| Gpt |
A |
G |
15: 76,582,530 (GRCm39) |
E256G |
probably benign |
Het |
| Hif3a |
C |
T |
7: 16,783,021 (GRCm39) |
V261I |
probably damaging |
Het |
| Hmcn2 |
A |
G |
2: 31,236,581 (GRCm39) |
T375A |
probably benign |
Het |
| Hspa4 |
C |
A |
11: 53,190,951 (GRCm39) |
V15F |
probably damaging |
Het |
| Il18 |
A |
G |
9: 50,490,701 (GRCm39) |
N112S |
possibly damaging |
Het |
| Inpp4a |
A |
G |
1: 37,413,179 (GRCm39) |
|
probably null |
Het |
| Knop1 |
A |
G |
7: 118,445,032 (GRCm39) |
S525P |
unknown |
Het |
| Leo1 |
A |
T |
9: 75,362,961 (GRCm39) |
Y461F |
possibly damaging |
Het |
| Med1 |
C |
T |
11: 98,060,189 (GRCm39) |
V247I |
possibly damaging |
Het |
| Mpnd |
T |
G |
17: 56,317,489 (GRCm39) |
H159Q |
probably benign |
Het |
| Msl1 |
A |
G |
11: 98,686,937 (GRCm39) |
E94G |
possibly damaging |
Het |
| Mthfd2l |
A |
T |
5: 91,094,665 (GRCm39) |
I45F |
probably damaging |
Het |
| Neurl1b |
T |
A |
17: 26,657,671 (GRCm39) |
L203Q |
probably benign |
Het |
| Or5m12 |
G |
T |
2: 85,734,663 (GRCm39) |
T245N |
possibly damaging |
Het |
| Otoa |
T |
G |
7: 120,746,923 (GRCm39) |
L896R |
probably damaging |
Het |
| Pcdhac2 |
T |
A |
18: 37,278,076 (GRCm39) |
V352E |
probably damaging |
Het |
| Pcsk5 |
T |
A |
19: 17,434,168 (GRCm39) |
K1400I |
possibly damaging |
Het |
| Pcx |
T |
A |
19: 4,565,697 (GRCm39) |
|
probably null |
Het |
| Pds5a |
A |
G |
5: 65,776,324 (GRCm39) |
V90A |
probably damaging |
Het |
| Pgam2 |
T |
C |
11: 5,753,351 (GRCm39) |
K113R |
probably null |
Het |
| Phkb |
G |
T |
8: 86,667,516 (GRCm39) |
R266L |
possibly damaging |
Het |
| Phtf2 |
A |
G |
5: 20,987,459 (GRCm39) |
S346P |
probably damaging |
Het |
| Pkd1l3 |
G |
A |
8: 110,365,049 (GRCm39) |
A1144T |
probably damaging |
Het |
| Plbd1 |
T |
C |
6: 136,628,864 (GRCm39) |
Y68C |
possibly damaging |
Het |
| Polk |
T |
C |
13: 96,633,321 (GRCm39) |
T241A |
probably benign |
Het |
| Ppfibp2 |
T |
A |
7: 107,337,818 (GRCm39) |
D635E |
probably damaging |
Het |
| Ppip5k1 |
G |
A |
2: 121,179,040 (GRCm39) |
R229W |
probably damaging |
Het |
| Ptpn20 |
A |
G |
14: 33,360,281 (GRCm39) |
D386G |
probably benign |
Het |
| Rab22a |
T |
C |
2: 173,529,968 (GRCm39) |
Y49H |
probably benign |
Het |
| Rab3gap1 |
A |
G |
1: 127,837,652 (GRCm39) |
D238G |
probably damaging |
Het |
| Rbp3 |
T |
C |
14: 33,677,797 (GRCm39) |
S582P |
probably benign |
Het |
| Rcbtb2 |
T |
C |
14: 73,411,941 (GRCm39) |
V410A |
probably benign |
Het |
| Sh3rf2 |
A |
G |
18: 42,237,173 (GRCm39) |
E232G |
probably damaging |
Het |
| Shroom1 |
T |
A |
11: 53,357,735 (GRCm39) |
V762E |
probably benign |
Het |
| Speer4f2 |
A |
T |
5: 17,579,413 (GRCm39) |
M71L |
|
Het |
| Sprr2b |
CTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCC |
CTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCC |
3: 92,224,826 (GRCm39) |
|
probably benign |
Het |
| Tgfb1 |
A |
T |
7: 25,387,120 (GRCm39) |
|
probably benign |
Het |
| Tnik |
C |
T |
3: 28,658,334 (GRCm39) |
R540C |
probably damaging |
Het |
| Tti1 |
A |
T |
2: 157,850,474 (GRCm39) |
I255N |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,727,490 (GRCm39) |
S5739G |
unknown |
Het |
| Umad1 |
G |
A |
6: 8,426,995 (GRCm39) |
V57M |
probably damaging |
Het |
| Usp30 |
T |
A |
5: 114,240,506 (GRCm39) |
I49N |
probably damaging |
Het |
| Usp7 |
G |
A |
16: 8,519,907 (GRCm39) |
T398I |
probably benign |
Het |
| Zfp616 |
A |
G |
11: 73,974,013 (GRCm39) |
N185S |
possibly damaging |
Het |
| Zfp804b |
T |
A |
5: 6,819,458 (GRCm39) |
T1202S |
probably damaging |
Het |
| Zfyve28 |
A |
T |
5: 34,400,539 (GRCm39) |
V53D |
probably damaging |
Het |
|
| Other mutations in Vmn2r65 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00942:Vmn2r65
|
APN |
7 |
84,592,761 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01104:Vmn2r65
|
APN |
7 |
84,589,996 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01154:Vmn2r65
|
APN |
7 |
84,592,729 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01453:Vmn2r65
|
APN |
7 |
84,589,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Vmn2r65
|
APN |
7 |
84,596,587 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01748:Vmn2r65
|
APN |
7 |
84,589,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01997:Vmn2r65
|
APN |
7 |
84,589,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02527:Vmn2r65
|
APN |
7 |
84,595,724 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02617:Vmn2r65
|
APN |
7 |
84,589,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02676:Vmn2r65
|
APN |
7 |
84,589,381 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL03084:Vmn2r65
|
APN |
7 |
84,592,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
A4554:Vmn2r65
|
UTSW |
7 |
84,595,791 (GRCm39) |
missense |
probably damaging |
0.96 |
|
PIT4651001:Vmn2r65
|
UTSW |
7 |
84,595,461 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0322:Vmn2r65
|
UTSW |
7 |
84,595,756 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0453:Vmn2r65
|
UTSW |
7 |
84,595,442 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0862:Vmn2r65
|
UTSW |
7 |
84,592,853 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1392:Vmn2r65
|
UTSW |
7 |
84,596,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1392:Vmn2r65
|
UTSW |
7 |
84,596,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1508:Vmn2r65
|
UTSW |
7 |
84,589,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1687:Vmn2r65
|
UTSW |
7 |
84,590,026 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1876:Vmn2r65
|
UTSW |
7 |
84,595,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Vmn2r65
|
UTSW |
7 |
84,592,781 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2259:Vmn2r65
|
UTSW |
7 |
84,590,119 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2338:Vmn2r65
|
UTSW |
7 |
84,590,051 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2880:Vmn2r65
|
UTSW |
7 |
84,613,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3410:Vmn2r65
|
UTSW |
7 |
84,595,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3411:Vmn2r65
|
UTSW |
7 |
84,595,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3770:Vmn2r65
|
UTSW |
7 |
84,589,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3800:Vmn2r65
|
UTSW |
7 |
84,589,738 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3850:Vmn2r65
|
UTSW |
7 |
84,595,859 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4105:Vmn2r65
|
UTSW |
7 |
84,595,691 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4568:Vmn2r65
|
UTSW |
7 |
84,596,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4677:Vmn2r65
|
UTSW |
7 |
84,613,082 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4768:Vmn2r65
|
UTSW |
7 |
84,596,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4778:Vmn2r65
|
UTSW |
7 |
84,592,801 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5057:Vmn2r65
|
UTSW |
7 |
84,589,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5279:Vmn2r65
|
UTSW |
7 |
84,589,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5280:Vmn2r65
|
UTSW |
7 |
84,595,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5394:Vmn2r65
|
UTSW |
7 |
84,595,862 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5487:Vmn2r65
|
UTSW |
7 |
84,595,529 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5580:Vmn2r65
|
UTSW |
7 |
84,596,802 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5638:Vmn2r65
|
UTSW |
7 |
84,590,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5673:Vmn2r65
|
UTSW |
7 |
84,596,615 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5688:Vmn2r65
|
UTSW |
7 |
84,589,900 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5935:Vmn2r65
|
UTSW |
7 |
84,592,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6354:Vmn2r65
|
UTSW |
7 |
84,589,574 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6372:Vmn2r65
|
UTSW |
7 |
84,589,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6924:Vmn2r65
|
UTSW |
7 |
84,613,198 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7021:Vmn2r65
|
UTSW |
7 |
84,596,587 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7195:Vmn2r65
|
UTSW |
7 |
84,592,347 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7422:Vmn2r65
|
UTSW |
7 |
84,595,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7686:Vmn2r65
|
UTSW |
7 |
84,589,744 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7691:Vmn2r65
|
UTSW |
7 |
84,592,851 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7798:Vmn2r65
|
UTSW |
7 |
84,596,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7798:Vmn2r65
|
UTSW |
7 |
84,595,530 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8103:Vmn2r65
|
UTSW |
7 |
84,595,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8272:Vmn2r65
|
UTSW |
7 |
84,596,817 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8303:Vmn2r65
|
UTSW |
7 |
84,589,391 (GRCm39) |
nonsense |
probably null |
|
|
R8354:Vmn2r65
|
UTSW |
7 |
84,589,402 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8454:Vmn2r65
|
UTSW |
7 |
84,589,402 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8489:Vmn2r65
|
UTSW |
7 |
84,589,964 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8554:Vmn2r65
|
UTSW |
7 |
84,595,960 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8680:Vmn2r65
|
UTSW |
7 |
84,589,388 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8731:Vmn2r65
|
UTSW |
7 |
84,589,447 (GRCm39) |
nonsense |
probably null |
|
|
R8839:Vmn2r65
|
UTSW |
7 |
84,595,489 (GRCm39) |
nonsense |
probably null |
|
|
R8847:Vmn2r65
|
UTSW |
7 |
84,590,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8916:Vmn2r65
|
UTSW |
7 |
84,595,665 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9254:Vmn2r65
|
UTSW |
7 |
84,596,650 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9379:Vmn2r65
|
UTSW |
7 |
84,596,650 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9392:Vmn2r65
|
UTSW |
7 |
84,589,718 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9563:Vmn2r65
|
UTSW |
7 |
84,589,880 (GRCm39) |
nonsense |
probably null |
|
|
R9686:Vmn2r65
|
UTSW |
7 |
84,590,084 (GRCm39) |
missense |
probably benign |
0.45 |
|
X0067:Vmn2r65
|
UTSW |
7 |
84,590,113 (GRCm39) |
missense |
probably benign |
0.04 |
|
Z1088:Vmn2r65
|
UTSW |
7 |
84,592,473 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Vmn2r65
|
UTSW |
7 |
84,590,234 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCGCCTTGACAATGGGATTG -3'
(R):5'- ATCGAGTGCTAATTACTTCATAGCG -3'
Sequencing Primer
(F):5'- TGTCTTGGTGTTTCAAAAGGATAC -3'
(R):5'- ATAGCGTTTTTGCCTTCCTAGATAG -3'
|
| Posted On |
2019-11-12 |
Incidental Mutation