Incidental Mutation 'R7655:Gm19410'
| ID |
591139 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gm19410
|
| Ensembl Gene |
ENSMUSG00000109372 |
| Gene Name |
predicted gene, 19410 |
| Synonyms |
|
| MMRRC Submission |
045731-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.092)
|
| Stock # |
R7655 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
35765790-35818047 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 35809099 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 1637
(M1637L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000147162
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000207505]
|
| AlphaFold |
A0A140LJC7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207505
AA Change: M1637L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Meta Mutation Damage Score |
0.0846 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abitram |
A |
G |
4: 56,804,218 (GRCm38) |
I78V |
probably benign |
Het |
| Acot2 |
A |
G |
12: 83,992,917 (GRCm38) |
Y400C |
probably benign |
Het |
| Agbl1 |
A |
G |
7: 76,409,332 (GRCm38) |
M237V |
|
Het |
| Atrnl1 |
C |
A |
19: 57,611,379 (GRCm38) |
S9* |
probably null |
Het |
| BC031181 |
A |
T |
18: 75,009,335 (GRCm38) |
K71* |
probably null |
Het |
| Bmal2 |
A |
G |
6: 146,806,442 (GRCm38) |
T21A |
probably benign |
Het |
| Brpf1 |
A |
T |
6: 113,314,874 (GRCm38) |
M294L |
probably benign |
Het |
| Camk2g |
T |
G |
14: 20,739,342 (GRCm38) |
D382A |
possibly damaging |
Het |
| Ccdc33 |
T |
A |
9: 58,118,465 (GRCm38) |
R94W |
probably damaging |
Het |
| Cd244a |
T |
A |
1: 171,577,255 (GRCm38) |
L225Q |
probably damaging |
Het |
| Chsy1 |
G |
T |
7: 66,171,030 (GRCm38) |
V338F |
probably damaging |
Het |
| Col14a1 |
A |
G |
15: 55,362,450 (GRCm38) |
I170V |
unknown |
Het |
| Col6a2 |
G |
T |
10: 76,607,756 (GRCm38) |
Q492K |
probably benign |
Het |
| Dnah12 |
G |
T |
14: 26,859,316 (GRCm38) |
V3168L |
probably benign |
Het |
| Dnah7a |
T |
C |
1: 53,496,005 (GRCm38) |
S2699G |
possibly damaging |
Het |
| Fsip2 |
A |
G |
2: 82,977,542 (GRCm38) |
K1402E |
possibly damaging |
Het |
| Ghdc |
C |
T |
11: 100,769,667 (GRCm38) |
A127T |
probably benign |
Het |
| Glp1r |
T |
C |
17: 30,930,598 (GRCm38) |
|
probably null |
Het |
| Gm15922 |
T |
C |
7: 3,739,282 (GRCm38) |
E82G |
probably damaging |
Het |
| Grm5 |
T |
G |
7: 88,130,251 (GRCm38) |
D998E |
probably benign |
Het |
| Krtcap3 |
A |
G |
5: 31,252,560 (GRCm38) |
T157A |
probably damaging |
Het |
| Luc7l2 |
A |
G |
6: 38,603,464 (GRCm38) |
R333G |
unknown |
Het |
| Mdc1 |
T |
G |
17: 35,850,881 (GRCm38) |
S895R |
probably benign |
Het |
| Mef2a |
G |
A |
7: 67,295,394 (GRCm38) |
T80M |
probably damaging |
Het |
| Mitd1 |
T |
A |
1: 37,885,275 (GRCm38) |
I65F |
probably benign |
Het |
| Mms19 |
A |
G |
19: 41,944,572 (GRCm38) |
L1026P |
probably damaging |
Het |
| Mtbp |
G |
T |
15: 55,609,526 (GRCm38) |
V629L |
unknown |
Het |
| Ncapd3 |
T |
A |
9: 27,055,505 (GRCm38) |
I545N |
possibly damaging |
Het |
| Nin |
G |
A |
12: 70,042,768 (GRCm38) |
T1291M |
|
Het |
| Or10z1 |
T |
A |
1: 174,250,218 (GRCm38) |
K236N |
probably damaging |
Het |
| Or5b123 |
A |
T |
19: 13,619,833 (GRCm38) |
I181F |
probably damaging |
Het |
| Orc3 |
G |
T |
4: 34,587,032 (GRCm38) |
C352* |
probably null |
Het |
| Oxct2b |
G |
A |
4: 123,117,757 (GRCm38) |
G490D |
probably benign |
Het |
| Pcdhb16 |
A |
T |
18: 37,479,405 (GRCm38) |
T473S |
probably benign |
Het |
| Phkg2 |
G |
A |
7: 127,582,902 (GRCm38) |
G365D |
probably damaging |
Het |
| Ppp2r3a |
A |
T |
9: 101,211,712 (GRCm38) |
F471I |
probably benign |
Het |
| Prl3d1 |
T |
C |
13: 27,100,035 (GRCm38) |
C196R |
possibly damaging |
Het |
| Prmt1 |
A |
T |
7: 44,984,128 (GRCm38) |
F14L |
probably benign |
Het |
| Prox1 |
A |
G |
1: 190,162,221 (GRCm38) |
L9P |
probably damaging |
Het |
| Ptpn13 |
T |
A |
5: 103,540,983 (GRCm38) |
F881I |
probably benign |
Het |
| Rab3ip |
A |
G |
10: 116,914,139 (GRCm38) |
I363T |
probably benign |
Het |
| Rapgef3 |
T |
C |
15: 97,761,209 (GRCm38) |
E134G |
probably damaging |
Het |
| Rapgef6 |
C |
T |
11: 54,694,453 (GRCm38) |
P1559L |
probably benign |
Het |
| Rnf180 |
T |
C |
13: 105,167,588 (GRCm38) |
K507E |
probably damaging |
Het |
| Rpl3l |
T |
C |
17: 24,730,986 (GRCm38) |
I53T |
probably benign |
Het |
| Rtl1 |
T |
C |
12: 109,591,008 (GRCm38) |
I1466V |
unknown |
Het |
| Saxo2 |
A |
G |
7: 82,635,351 (GRCm38) |
Y100H |
probably damaging |
Het |
| Selenoh |
G |
T |
2: 84,670,380 (GRCm38) |
R39S |
probably damaging |
Het |
| Sgsm2 |
A |
G |
11: 74,865,497 (GRCm38) |
V342A |
probably damaging |
Het |
| Slc26a9 |
T |
A |
1: 131,763,244 (GRCm38) |
F587I |
possibly damaging |
Het |
| Smoc1 |
A |
T |
12: 81,105,908 (GRCm38) |
Q91L |
possibly damaging |
Het |
| Spag9 |
A |
C |
11: 93,996,563 (GRCm38) |
H98P |
possibly damaging |
Het |
| Spata31e3 |
T |
G |
13: 50,247,086 (GRCm38) |
K401N |
probably benign |
Het |
| T2 |
T |
A |
17: 8,418,215 (GRCm38) |
C337* |
probably null |
Het |
| Tbc1d19 |
A |
G |
5: 53,897,035 (GRCm38) |
Y455C |
probably damaging |
Het |
| Thbd |
A |
G |
2: 148,407,420 (GRCm38) |
L176P |
probably damaging |
Het |
| Tmem116 |
A |
G |
5: 121,452,189 (GRCm38) |
|
probably null |
Het |
| Tmem25 |
C |
T |
9: 44,798,343 (GRCm38) |
V54I |
possibly damaging |
Het |
| Trpm4 |
C |
T |
7: 45,321,809 (GRCm38) |
V378I |
probably benign |
Het |
| Trrap |
G |
T |
5: 144,842,612 (GRCm38) |
W3129C |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,728,316 (GRCm38) |
D29740E |
probably damaging |
Het |
| Vcan |
C |
T |
13: 89,685,114 (GRCm38) |
C3073Y |
probably damaging |
Het |
| Xrra1 |
T |
A |
7: 99,910,982 (GRCm38) |
D388E |
probably benign |
Het |
|
| Other mutations in Gm19410 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
BB009:Gm19410
|
UTSW |
8 |
35,795,599 (GRCm38) |
missense |
probably damaging |
0.98 |
|
BB019:Gm19410
|
UTSW |
8 |
35,795,599 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0046:Gm19410
|
UTSW |
8 |
35,802,645 (GRCm38) |
missense |
probably benign |
0.31 |
|
R6026:Gm19410
|
UTSW |
8 |
35,812,426 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6039:Gm19410
|
UTSW |
8 |
35,809,364 (GRCm38) |
missense |
probably benign |
0.44 |
|
R6039:Gm19410
|
UTSW |
8 |
35,809,364 (GRCm38) |
missense |
probably benign |
0.44 |
|
R6185:Gm19410
|
UTSW |
8 |
35,807,510 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R6239:Gm19410
|
UTSW |
8 |
35,778,764 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6303:Gm19410
|
UTSW |
8 |
35,807,560 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R6377:Gm19410
|
UTSW |
8 |
35,803,582 (GRCm38) |
nonsense |
probably null |
|
|
R6545:Gm19410
|
UTSW |
8 |
35,790,498 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R6700:Gm19410
|
UTSW |
8 |
35,807,510 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R6720:Gm19410
|
UTSW |
8 |
35,807,576 (GRCm38) |
missense |
probably benign |
0.12 |
|
R6795:Gm19410
|
UTSW |
8 |
35,795,522 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6808:Gm19410
|
UTSW |
8 |
35,772,579 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6810:Gm19410
|
UTSW |
8 |
35,772,579 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6811:Gm19410
|
UTSW |
8 |
35,772,579 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6966:Gm19410
|
UTSW |
8 |
35,817,973 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R7264:Gm19410
|
UTSW |
8 |
35,785,766 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7267:Gm19410
|
UTSW |
8 |
35,814,843 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R7355:Gm19410
|
UTSW |
8 |
35,807,072 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7423:Gm19410
|
UTSW |
8 |
35,804,607 (GRCm38) |
missense |
probably benign |
0.28 |
|
R7494:Gm19410
|
UTSW |
8 |
35,795,530 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7516:Gm19410
|
UTSW |
8 |
35,796,279 (GRCm38) |
missense |
probably benign |
0.30 |
|
R7517:Gm19410
|
UTSW |
8 |
35,773,618 (GRCm38) |
missense |
possibly damaging |
0.45 |
|
R7526:Gm19410
|
UTSW |
8 |
35,790,612 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7527:Gm19410
|
UTSW |
8 |
35,802,232 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7545:Gm19410
|
UTSW |
8 |
35,802,625 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7549:Gm19410
|
UTSW |
8 |
35,799,346 (GRCm38) |
missense |
probably benign |
0.20 |
|
R7564:Gm19410
|
UTSW |
8 |
35,806,997 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7615:Gm19410
|
UTSW |
8 |
35,796,359 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7622:Gm19410
|
UTSW |
8 |
35,810,347 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R7656:Gm19410
|
UTSW |
8 |
35,809,099 (GRCm38) |
missense |
probably benign |
|
|
R7703:Gm19410
|
UTSW |
8 |
35,799,385 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7750:Gm19410
|
UTSW |
8 |
35,807,498 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R7760:Gm19410
|
UTSW |
8 |
35,802,337 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7837:Gm19410
|
UTSW |
8 |
35,808,980 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R7932:Gm19410
|
UTSW |
8 |
35,795,599 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7942:Gm19410
|
UTSW |
8 |
35,771,786 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7970:Gm19410
|
UTSW |
8 |
35,815,647 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8088:Gm19410
|
UTSW |
8 |
35,806,841 (GRCm38) |
missense |
probably benign |
0.45 |
|
R8228:Gm19410
|
UTSW |
8 |
35,785,838 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R8382:Gm19410
|
UTSW |
8 |
35,809,148 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8757:Gm19410
|
UTSW |
8 |
35,808,965 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R8879:Gm19410
|
UTSW |
8 |
35,771,868 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9010:Gm19410
|
UTSW |
8 |
35,814,857 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9060:Gm19410
|
UTSW |
8 |
35,802,326 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9088:Gm19410
|
UTSW |
8 |
35,773,612 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9104:Gm19410
|
UTSW |
8 |
35,780,467 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9186:Gm19410
|
UTSW |
8 |
35,815,475 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R9290:Gm19410
|
UTSW |
8 |
35,802,232 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9334:Gm19410
|
UTSW |
8 |
35,803,568 (GRCm38) |
nonsense |
probably null |
|
|
R9398:Gm19410
|
UTSW |
8 |
35,805,202 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9439:Gm19410
|
UTSW |
8 |
35,781,656 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9445:Gm19410
|
UTSW |
8 |
35,772,498 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R9511:Gm19410
|
UTSW |
8 |
35,790,694 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9520:Gm19410
|
UTSW |
8 |
35,795,483 (GRCm38) |
missense |
probably benign |
0.15 |
|
R9523:Gm19410
|
UTSW |
8 |
35,790,454 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9669:Gm19410
|
UTSW |
8 |
35,780,339 (GRCm38) |
missense |
possibly damaging |
0.45 |
|
R9711:Gm19410
|
UTSW |
8 |
35,812,339 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R9728:Gm19410
|
UTSW |
8 |
35,780,440 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R9759:Gm19410
|
UTSW |
8 |
35,785,784 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
Z1176:Gm19410
|
UTSW |
8 |
35,792,611 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
Z1177:Gm19410
|
UTSW |
8 |
35,808,965 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCACCAGTGTCAAACAGCTG -3'
(R):5'- TCTCCCACTGCCATCCATAGAG -3'
Sequencing Primer
(F):5'- ACAGCTGGCATCAGTGGATTACC -3'
(R):5'- TCCATAGAGGCGCATTCAATG -3'
|
| Posted On |
2019-11-12 |
Incidental Mutation