Mutagenetix > Incidental Mutation

Incidental Mutation 'R7658:Lrrk2'

591392

Institutional Source

Beutler Lab

Gene Symbol

Lrrk2

Ensembl Gene

ENSMUSG00000036273

Gene Name

leucine-rich repeat kinase 2

Synonyms

9330188B09Rik, 4921513O20Rik, LOC381026, cI-46, D630001M17Rik

MMRRC Submission

045703-MU

Accession Numbers

Genbank: NM_025730; MGI: 1913975

Essential gene?

Possibly essential (E-score: 0.520) question?

Stock #

R7658 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

91673175-91816120 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 91700358 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Tyrosine at position 326 (F326Y)

Ref Sequence

ENSEMBL: ENSMUSP00000052584 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060642]

AlphaFold

Q5S006

Predicted Effect

possibly damaging
Transcript: ENSMUST00000060642
AA Change: F326Y

PolyPhen 2 Score 0.914 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000052584
Gene: ENSMUSG00000036273
AA Change: F326Y

Domain	Start	End	E-Value	Type
low complexity region	138	156	N/A	INTRINSIC
low complexity region	332	347	N/A	INTRINSIC
ANK	708	737	3.95e1	SMART
ANK	770	800	4.58e2	SMART
low complexity region	890	901	N/A	INTRINSIC
low complexity region	953	966	N/A	INTRINSIC
low complexity region	971	979	N/A	INTRINSIC
LRR	1010	1033	9.96e-1	SMART
LRR	1034	1057	8.01e0	SMART
LRR	1082	1105	2.45e0	SMART
LRR	1128	1151	9.3e-1	SMART
LRR	1195	1219	3.24e0	SMART
LRR	1244	1266	3.87e1	SMART
LRR	1267	1291	4.98e1	SMART
Pfam:Roc	1336	1456	4.9e-32	PFAM
Pfam:Ras	1336	1489	3.3e-17	PFAM
Pfam:COR	1524	1740	4e-28	PFAM
Pfam:Pkinase	1881	2132	4.7e-40	PFAM
Pfam:Pkinase_Tyr	1882	2132	6.8e-39	PFAM
WD40	2231	2276	3.09e-1	SMART
WD40	2401	2438	1.37e2	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy. [provided by MGI curators]

Allele List at MGI

All alleles(7) : Targeted, knock-out(6) Targeted, other(1)

Other mutations in this stock

Total: 95 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110025L11Rik	G	T	16: 89,063,730 (GRCm38)	S72Y	unknown	Het
6430531B16Rik	T	C	7: 139,976,618 (GRCm38)	N152S	probably benign	Het
Abca8b	T	A	11: 109,935,717 (GRCm38)	K1568N	probably benign	Het
Adcy6	T	A	15: 98,596,067 (GRCm38)	Y865F	probably benign	Het
Adgrf3	A	T	5: 30,197,206 (GRCm38)	V608D	probably benign	Het
Agbl1	G	T	7: 76,766,369 (GRCm38)	A965S	unknown	Het
Agbl3	C	T	6: 34,832,508 (GRCm38)	P690L	probably benign	Het
Akap9	C	G	5: 3,968,745 (GRCm38)	H1109D	probably benign	Het
Amt	A	C	9: 108,297,231 (GRCm38)	H65P	probably damaging	Het
Ankrd11	T	A	8: 122,893,664 (GRCm38)	T1150S	probably benign	Het
Arhgap15	A	C	2: 44,142,268 (GRCm38)	H288P	probably benign	Het
Arhgap39	A	T	15: 76,737,417 (GRCm38)	M328K	probably benign	Het
Arhgef12	T	C	9: 42,992,536 (GRCm38)	K743R	probably damaging	Het
Atg2a	T	G	19: 6,251,263 (GRCm38)	V789G	probably damaging	Het
Ccdc54	T	C	16: 50,590,481 (GRCm38)	T141A	probably benign	Het
Ccng2	C	G	5: 93,273,343 (GRCm38)	S237R	probably benign	Het
Cdh5	T	C	8: 104,129,401 (GRCm38)		probably null	Het
Cdkl3	T	C	11: 52,027,182 (GRCm38)	V404A	not run	Het
Chrm2	A	T	6: 36,523,249 (GRCm38)	I14F	probably benign	Het
Cnbp	T	C	6: 87,845,276 (GRCm38)	K89E	possibly damaging	Het
Cntn6	T	A	6: 104,650,483 (GRCm38)	D92E	probably benign	Het
Col15a1	T	C	4: 47,245,591 (GRCm38)	F114S	possibly damaging	Het
Csrnp1	A	G	9: 119,972,403 (GRCm38)	F530S	probably benign	Het
Dcun1d3	C	T	7: 119,857,668 (GRCm38)	V274M	probably damaging	Het
Dph2	T	A	4: 117,890,281 (GRCm38)	H302L	possibly damaging	Het
Fam162a	A	T	16: 36,046,400 (GRCm38)	Y118*	probably null	Het
Fam186a	A	G	15: 99,939,844 (GRCm38)	Y2840H	unknown	Het
Fto	A	G	8: 91,666,322 (GRCm38)	K466E	probably benign	Het
Gal	T	A	19: 3,413,309 (GRCm38)	Y41F	probably damaging	Het
Gigyf2	A	T	1: 87,419,138 (GRCm38)	L620F	unknown	Het
Git2	C	T	5: 114,766,489 (GRCm38)	R123H	probably damaging	Het
Glud1	A	T	14: 34,311,157 (GRCm38)	E87V	probably benign	Het
Gm21190	T	G	5: 15,527,925 (GRCm38)	E94A	possibly damaging	Het
Gm5592	T	C	7: 41,288,710 (GRCm38)	V472A	probably benign	Het
Gpc5	T	A	14: 115,428,208 (GRCm38)	N481K	possibly damaging	Het
Gpn2	A	G	4: 133,591,376 (GRCm38)	E304G	probably benign	Het
Gsdmc2	T	C	15: 63,825,054 (GRCm38)	T423A	probably damaging	Het
Gucy2e	G	A	11: 69,226,229 (GRCm38)	Q789*	probably null	Het
Gxylt2	T	A	6: 100,783,143 (GRCm38)	V213E	probably damaging	Het
Ighv1-75	G	A	12: 115,834,111 (GRCm38)	L64F	possibly damaging	Het
Il17re	T	C	6: 113,458,982 (GRCm38)	C30R	probably benign	Het
Il7	G	T	3: 7,604,082 (GRCm38)	D31E	probably benign	Het
Ints4	T	C	7: 97,529,253 (GRCm38)	Y687H	possibly damaging	Het
Kdelr1	T	G	7: 45,882,977 (GRCm38)	V202G	probably benign	Het
Khnyn	C	A	14: 55,887,139 (GRCm38)	Y283*	probably null	Het
Klf11	T	C	12: 24,653,671 (GRCm38)	V52A	probably damaging	Het
Klhl7	A	G	5: 24,141,286 (GRCm38)	N310S	probably benign	Het
Krt27	A	T	11: 99,349,486 (GRCm38)	L202Q	possibly damaging	Het
Lce1d	A	G	3: 92,686,047 (GRCm38)	C20R	unknown	Het
Lim2	A	T	7: 43,433,630 (GRCm38)	I80F	possibly damaging	Het
Lyst	A	T	13: 13,730,476 (GRCm38)	Y3246F	possibly damaging	Het
Mafb	T	A	2: 160,366,435 (GRCm38)	H81L	possibly damaging	Het
Mfsd5	G	A	15: 102,280,877 (GRCm38)	R228H	probably benign	Het
Mmp1b	A	T	9: 7,386,675 (GRCm38)	F150I	possibly damaging	Het
Mthfd1	T	A	12: 76,270,435 (GRCm38)	L20Q	probably damaging	Het
Mxra8	A	G	4: 155,842,963 (GRCm38)	T402A	probably benign	Het
Ndc80	A	T	17: 71,508,663 (GRCm38)	L376M	probably damaging	Het
Nsd1	A	T	13: 55,277,639 (GRCm38)	R1536S	probably damaging	Het
Nup210l	C	A	3: 90,211,993 (GRCm38)	H1874Q	probably benign	Het
Nyap1	T	C	5: 137,732,974 (GRCm38)	H776R	probably benign	Het
Patj	C	A	4: 98,688,179 (GRCm38)	H1773Q	probably damaging	Het
Pax8	T	A	2: 24,436,511 (GRCm38)	T280S	probably benign	Het
Pcdhb19	A	G	18: 37,498,981 (GRCm38)	T610A	probably damaging	Het
Pde2a	A	G	7: 101,511,581 (GRCm38)	D919G	possibly damaging	Het
Pdk2	T	A	11: 95,028,965 (GRCm38)	Y240F	probably damaging	Het
Peg3	A	T	7: 6,709,610 (GRCm38)	I871N	probably damaging	Het
Pex1	A	T	5: 3,596,244 (GRCm38)		probably benign	Het
Pgm2l1	C	T	7: 100,250,328 (GRCm38)	R50W	probably damaging	Het
Phkg1	T	A	5: 129,865,923 (GRCm38)	K262N	probably damaging	Het
Pik3r4	A	G	9: 105,644,511 (GRCm38)	E92G	probably damaging	Het
Prmt6	A	T	3: 110,250,385 (GRCm38)	V196E	possibly damaging	Het
Ptprn2	T	G	12: 116,722,119 (GRCm38)	M66R	probably benign	Het
Rai14	C	T	15: 10,593,103 (GRCm38)	G152R	probably damaging	Het
Recql5	A	T	11: 115,923,276 (GRCm38)	S348T	probably damaging	Het
Rfk	T	G	19: 17,398,682 (GRCm38)		probably null	Het
Selenbp1	A	T	3: 94,944,102 (GRCm38)	M389L	probably benign	Het
Sipa1l2	G	A	8: 125,492,290 (GRCm38)	R103C	probably benign	Het
Slc10a6	T	A	5: 103,629,190 (GRCm38)	S15C	probably damaging	Het
Slc12a2	G	T	18: 57,932,524 (GRCm38)	V944L	probably benign	Het
Slc16a11	T	A	11: 70,215,317 (GRCm38)	L127Q	possibly damaging	Het
St6gal1	A	G	16: 23,356,228 (GRCm38)	Y272C	probably damaging	Het
Stab2	C	A	10: 86,981,135 (GRCm38)	V133F	probably benign	Het
Stradb	G	A	1: 58,992,726 (GRCm38)	V266I	probably damaging	Het
Tmem150b	A	G	7: 4,720,759 (GRCm38)	W140R	probably benign	Het
Tnnt3	A	T	7: 142,512,096 (GRCm38)	K157*	probably null	Het
Trove2	T	C	1: 143,770,873 (GRCm38)	T45A	probably damaging	Het
Ttn	T	G	2: 76,723,769 (GRCm38)	K30863N	probably damaging	Het
Vldlr	G	A	19: 27,243,136 (GRCm38)	R592H	probably benign	Het
Vmn1r12	A	T	6: 57,158,898 (GRCm38)		probably benign	Het
Vmn2r63	A	C	7: 42,925,269 (GRCm38)	S519R	probably damaging	Het
Zbtb22	G	C	17: 33,918,497 (GRCm38)	E539Q	probably damaging	Het
Zbtb44	G	A	9: 31,054,079 (GRCm38)	A262T	probably benign	Het
Zfp280d	A	T	9: 72,324,072 (GRCm38)	N455I	probably damaging	Het
Zfp287	T	C	11: 62,725,263 (GRCm38)	N201D	probably damaging	Het
Zfp988	T	C	4: 147,332,294 (GRCm38)	L395P	probably damaging	Het

Other mutations in Lrrk2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Lrrk2	APN	15	91,747,799 (GRCm38)	missense	possibly damaging	0.90
IGL00542:Lrrk2	APN	15	91,699,943 (GRCm38)	missense	probably benign
IGL00770:Lrrk2	APN	15	91,801,833 (GRCm38)	splice site	probably benign
IGL00774:Lrrk2	APN	15	91,801,833 (GRCm38)	splice site	probably benign
IGL00791:Lrrk2	APN	15	91,779,841 (GRCm38)	missense	probably damaging	1.00
IGL00827:Lrrk2	APN	15	91,755,790 (GRCm38)	missense	probably damaging	1.00
IGL00843:Lrrk2	APN	15	91,757,058 (GRCm38)	missense	possibly damaging	0.58
IGL01109:Lrrk2	APN	15	91,738,832 (GRCm38)	missense	probably damaging	1.00
IGL01293:Lrrk2	APN	15	91,726,137 (GRCm38)	missense	probably benign	0.21
IGL01296:Lrrk2	APN	15	91,683,142 (GRCm38)	missense	probably benign
IGL01301:Lrrk2	APN	15	91,767,339 (GRCm38)	missense	probably damaging	1.00
IGL01360:Lrrk2	APN	15	91,700,569 (GRCm38)	splice site	probably null
IGL01465:Lrrk2	APN	15	91,728,925 (GRCm38)	missense	probably benign	0.21
IGL01529:Lrrk2	APN	15	91,812,313 (GRCm38)	missense	possibly damaging	0.92
IGL01557:Lrrk2	APN	15	91,699,989 (GRCm38)	missense	probably damaging	1.00
IGL01560:Lrrk2	APN	15	91,774,988 (GRCm38)	missense	probably benign	0.33
IGL01991:Lrrk2	APN	15	91,779,946 (GRCm38)	missense	probably damaging	0.99
IGL02003:Lrrk2	APN	15	91,731,491 (GRCm38)	missense	probably damaging	0.99
IGL02325:Lrrk2	APN	15	91,726,308 (GRCm38)	critical splice donor site	probably null
IGL02711:Lrrk2	APN	15	91,685,822 (GRCm38)	missense	possibly damaging	0.71
IGL02869:Lrrk2	APN	15	91,750,277 (GRCm38)	missense	probably damaging	1.00
IGL03104:Lrrk2	APN	15	91,747,755 (GRCm38)	missense	possibly damaging	0.68
IGL03179:Lrrk2	APN	15	91,700,578 (GRCm38)	missense	probably damaging	1.00
IGL03395:Lrrk2	APN	15	91,797,414 (GRCm38)	splice site	probably null
horned	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R1312_Lrrk2_980	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R4710_lrrk2_232	UTSW	15	91,699,927 (GRCm38)	missense	possibly damaging	0.88
R5245_Lrrk2_127	UTSW	15	91,796,089 (GRCm38)	missense	probably damaging	1.00
spree	UTSW	15	91,702,247 (GRCm38)	missense	probably benign	0.00
Spur	UTSW	15	91,774,995 (GRCm38)	nonsense	probably null
3-1:Lrrk2	UTSW	15	91,801,934 (GRCm38)	missense	probably benign	0.01
ANU18:Lrrk2	UTSW	15	91,767,339 (GRCm38)	missense	probably damaging	1.00
H8562:Lrrk2	UTSW	15	91,673,358 (GRCm38)	missense	probably benign
H8786:Lrrk2	UTSW	15	91,673,358 (GRCm38)	missense	probably benign
IGL02835:Lrrk2	UTSW	15	91,814,660 (GRCm38)	critical splice acceptor site	probably null
R0014:Lrrk2	UTSW	15	91,802,045 (GRCm38)	splice site	probably benign
R0014:Lrrk2	UTSW	15	91,802,045 (GRCm38)	splice site	probably benign
R0078:Lrrk2	UTSW	15	91,734,009 (GRCm38)	missense	probably benign	0.01
R0100:Lrrk2	UTSW	15	91,745,796 (GRCm38)	missense	probably damaging	1.00
R0282:Lrrk2	UTSW	15	91,778,414 (GRCm38)	splice site	probably benign
R0448:Lrrk2	UTSW	15	91,709,305 (GRCm38)	missense	probably damaging	0.99
R0449:Lrrk2	UTSW	15	91,750,275 (GRCm38)	missense	probably damaging	1.00
R0610:Lrrk2	UTSW	15	91,815,416 (GRCm38)	missense	probably benign
R0617:Lrrk2	UTSW	15	91,752,278 (GRCm38)	missense	probably benign	0.00
R0632:Lrrk2	UTSW	15	91,796,028 (GRCm38)	missense	probably damaging	0.98
R0639:Lrrk2	UTSW	15	91,772,996 (GRCm38)	missense	probably benign	0.03
R0661:Lrrk2	UTSW	15	91,787,016 (GRCm38)	missense	probably damaging	1.00
R0666:Lrrk2	UTSW	15	91,757,070 (GRCm38)	critical splice donor site	probably null
R0764:Lrrk2	UTSW	15	91,775,046 (GRCm38)	splice site	probably null
R0766:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R0845:Lrrk2	UTSW	15	91,755,962 (GRCm38)	missense	probably benign	0.22
R0940:Lrrk2	UTSW	15	91,729,081 (GRCm38)	missense	possibly damaging	0.83
R0970:Lrrk2	UTSW	15	91,729,169 (GRCm38)	missense	probably benign	0.22
R1080:Lrrk2	UTSW	15	91,673,689 (GRCm38)	missense	probably benign	0.01
R1114:Lrrk2	UTSW	15	91,700,468 (GRCm38)	nonsense	probably null
R1223:Lrrk2	UTSW	15	91,673,635 (GRCm38)	missense	probably benign	0.00
R1289:Lrrk2	UTSW	15	91,812,360 (GRCm38)	missense	probably benign	0.00
R1296:Lrrk2	UTSW	15	91,728,920 (GRCm38)	missense	probably damaging	1.00
R1312:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R1637:Lrrk2	UTSW	15	91,734,058 (GRCm38)	missense	probably benign
R1773:Lrrk2	UTSW	15	91,779,981 (GRCm38)	missense	possibly damaging	0.96
R1809:Lrrk2	UTSW	15	91,699,892 (GRCm38)	missense	possibly damaging	0.86
R1839:Lrrk2	UTSW	15	91,683,134 (GRCm38)	missense	probably benign	0.00
R1946:Lrrk2	UTSW	15	91,736,661 (GRCm38)	splice site	probably null
R2160:Lrrk2	UTSW	15	91,796,060 (GRCm38)	missense	probably damaging	1.00
R2232:Lrrk2	UTSW	15	91,764,716 (GRCm38)	missense	probably benign	0.05
R2419:Lrrk2	UTSW	15	91,797,526 (GRCm38)	splice site	probably benign
R2516:Lrrk2	UTSW	15	91,755,927 (GRCm38)	missense	probably benign
R3110:Lrrk2	UTSW	15	91,814,695 (GRCm38)	missense	probably benign	0.02
R3112:Lrrk2	UTSW	15	91,814,695 (GRCm38)	missense	probably benign	0.02
R3801:Lrrk2	UTSW	15	91,737,111 (GRCm38)	missense	probably benign
R3842:Lrrk2	UTSW	15	91,755,916 (GRCm38)	missense	probably benign	0.01
R3903:Lrrk2	UTSW	15	91,747,701 (GRCm38)	missense	probably damaging	1.00
R3903:Lrrk2	UTSW	15	91,747,700 (GRCm38)	missense	probably damaging	1.00
R3930:Lrrk2	UTSW	15	91,767,461 (GRCm38)	critical splice donor site	probably null
R3937:Lrrk2	UTSW	15	91,778,504 (GRCm38)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,778,504 (GRCm38)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,712,780 (GRCm38)	missense	possibly damaging	0.69
R3982:Lrrk2	UTSW	15	91,709,284 (GRCm38)	missense	probably benign	0.22
R4125:Lrrk2	UTSW	15	91,815,483 (GRCm38)	missense	probably benign	0.01
R4130:Lrrk2	UTSW	15	91,755,794 (GRCm38)	missense	probably benign	0.19
R4296:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R4465:Lrrk2	UTSW	15	91,747,820 (GRCm38)	missense	probably damaging	0.96
R4478:Lrrk2	UTSW	15	91,723,188 (GRCm38)	missense	probably damaging	1.00
R4517:Lrrk2	UTSW	15	91,705,120 (GRCm38)	missense	probably benign
R4539:Lrrk2	UTSW	15	91,729,142 (GRCm38)	missense	possibly damaging	0.86
R4654:Lrrk2	UTSW	15	91,765,681 (GRCm38)	missense	probably damaging	0.96
R4710:Lrrk2	UTSW	15	91,699,927 (GRCm38)	missense	possibly damaging	0.88
R4722:Lrrk2	UTSW	15	91,688,901 (GRCm38)	missense	probably damaging	1.00
R4723:Lrrk2	UTSW	15	91,764,759 (GRCm38)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,765,747 (GRCm38)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,688,849 (GRCm38)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,765,747 (GRCm38)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,688,849 (GRCm38)	missense	probably damaging	1.00
R4787:Lrrk2	UTSW	15	91,712,828 (GRCm38)	missense	probably benign
R4945:Lrrk2	UTSW	15	91,804,920 (GRCm38)	missense	probably benign	0.02
R4948:Lrrk2	UTSW	15	91,803,389 (GRCm38)	missense	probably benign	0.20
R5000:Lrrk2	UTSW	15	91,749,878 (GRCm38)	missense	probably damaging	1.00
R5031:Lrrk2	UTSW	15	91,700,619 (GRCm38)	missense	possibly damaging	0.50
R5067:Lrrk2	UTSW	15	91,765,790 (GRCm38)	missense	probably benign	0.01
R5245:Lrrk2	UTSW	15	91,796,089 (GRCm38)	missense	probably damaging	1.00
R5341:Lrrk2	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R5460:Lrrk2	UTSW	15	91,814,644 (GRCm38)	splice site	probably null
R5551:Lrrk2	UTSW	15	91,812,350 (GRCm38)	missense	probably benign
R5574:Lrrk2	UTSW	15	91,787,016 (GRCm38)	missense	probably damaging	1.00
R5577:Lrrk2	UTSW	15	91,765,745 (GRCm38)	missense	probably damaging	1.00
R5685:Lrrk2	UTSW	15	91,803,301 (GRCm38)	nonsense	probably null
R5712:Lrrk2	UTSW	15	91,702,222 (GRCm38)	nonsense	probably null
R5728:Lrrk2	UTSW	15	91,774,974 (GRCm38)	missense	probably benign	0.36
R5782:Lrrk2	UTSW	15	91,702,183 (GRCm38)	missense	probably damaging	1.00
R5788:Lrrk2	UTSW	15	91,764,648 (GRCm38)	missense	possibly damaging	0.55
R5821:Lrrk2	UTSW	15	91,709,390 (GRCm38)	critical splice donor site	probably null
R5852:Lrrk2	UTSW	15	91,755,949 (GRCm38)	missense	probably damaging	1.00
R5934:Lrrk2	UTSW	15	91,734,046 (GRCm38)	missense	probably benign	0.00
R5935:Lrrk2	UTSW	15	91,745,831 (GRCm38)	missense	probably benign	0.14
R5979:Lrrk2	UTSW	15	91,772,945 (GRCm38)	missense	possibly damaging	0.47
R6101:Lrrk2	UTSW	15	91,723,135 (GRCm38)	missense	probably benign	0.10
R6114:Lrrk2	UTSW	15	91,747,826 (GRCm38)	missense	probably benign	0.33
R6259:Lrrk2	UTSW	15	91,702,247 (GRCm38)	missense	probably benign	0.00
R6376:Lrrk2	UTSW	15	91,742,266 (GRCm38)	missense	possibly damaging	0.89
R6417:Lrrk2	UTSW	15	91,812,346 (GRCm38)	missense	probably benign	0.03
R6420:Lrrk2	UTSW	15	91,812,346 (GRCm38)	missense	probably benign	0.03
R6737:Lrrk2	UTSW	15	91,723,218 (GRCm38)	missense	possibly damaging	0.50
R7056:Lrrk2	UTSW	15	91,774,995 (GRCm38)	nonsense	probably null
R7072:Lrrk2	UTSW	15	91,801,920 (GRCm38)	missense	probably benign	0.03
R7109:Lrrk2	UTSW	15	91,764,782 (GRCm38)	missense	probably damaging	1.00
R7128:Lrrk2	UTSW	15	91,801,885 (GRCm38)	missense	probably benign
R7144:Lrrk2	UTSW	15	91,734,055 (GRCm38)	missense	possibly damaging	0.54
R7187:Lrrk2	UTSW	15	91,757,001 (GRCm38)	missense	possibly damaging	0.92
R7270:Lrrk2	UTSW	15	91,700,441 (GRCm38)	missense	probably benign	0.01
R7356:Lrrk2	UTSW	15	91,738,744 (GRCm38)	missense	probably benign	0.07
R7360:Lrrk2	UTSW	15	91,731,655 (GRCm38)	critical splice donor site	probably null
R7373:Lrrk2	UTSW	15	91,700,004 (GRCm38)	critical splice donor site	probably null
R7465:Lrrk2	UTSW	15	91,767,340 (GRCm38)	missense	probably damaging	1.00
R7477:Lrrk2	UTSW	15	91,812,325 (GRCm38)	missense	probably damaging	0.98
R7614:Lrrk2	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R7622:Lrrk2	UTSW	15	91,812,323 (GRCm38)	missense	probably damaging	1.00
R7679:Lrrk2	UTSW	15	91,726,186 (GRCm38)	missense	possibly damaging	0.58
R7737:Lrrk2	UTSW	15	91,815,446 (GRCm38)	missense	probably damaging	0.98
R7739:Lrrk2	UTSW	15	91,700,613 (GRCm38)	missense	probably damaging	1.00
R7740:Lrrk2	UTSW	15	91,767,324 (GRCm38)	missense	probably damaging	1.00
R7908:Lrrk2	UTSW	15	91,726,152 (GRCm38)	missense	probably damaging	1.00
R8299:Lrrk2	UTSW	15	91,673,240 (GRCm38)	start gained	probably benign
R8389:Lrrk2	UTSW	15	91,699,991 (GRCm38)	missense	probably damaging	1.00
R8462:Lrrk2	UTSW	15	91,731,477 (GRCm38)	missense	probably benign
R8698:Lrrk2	UTSW	15	91,752,197 (GRCm38)	missense	probably benign	0.38
R8947:Lrrk2	UTSW	15	91,702,270 (GRCm38)	nonsense	probably null
R9084:Lrrk2	UTSW	15	91,750,266 (GRCm38)	missense
R9086:Lrrk2	UTSW	15	91,755,848 (GRCm38)	missense	probably benign	0.01
R9096:Lrrk2	UTSW	15	91,673,256 (GRCm38)	start gained	probably benign
R9097:Lrrk2	UTSW	15	91,673,256 (GRCm38)	start gained	probably benign
R9267:Lrrk2	UTSW	15	91,700,426 (GRCm38)	missense	probably damaging	0.99
R9285:Lrrk2	UTSW	15	91,778,483 (GRCm38)	missense	probably damaging	1.00
R9341:Lrrk2	UTSW	15	91,700,415 (GRCm38)	missense	probably benign	0.18
R9343:Lrrk2	UTSW	15	91,700,415 (GRCm38)	missense	probably benign	0.18
R9371:Lrrk2	UTSW	15	91,723,204 (GRCm38)	missense	probably damaging	1.00
R9424:Lrrk2	UTSW	15	91,752,185 (GRCm38)	nonsense	probably null
R9489:Lrrk2	UTSW	15	91,737,217 (GRCm38)	missense	probably benign	0.37
R9502:Lrrk2	UTSW	15	91,723,162 (GRCm38)	missense	probably damaging	0.98
R9563:Lrrk2	UTSW	15	91,749,840 (GRCm38)	missense	possibly damaging	0.90
R9576:Lrrk2	UTSW	15	91,752,185 (GRCm38)	nonsense	probably null
R9605:Lrrk2	UTSW	15	91,737,217 (GRCm38)	missense	probably benign	0.37
R9635:Lrrk2	UTSW	15	91,812,324 (GRCm38)	missense	probably benign	0.21
R9641:Lrrk2	UTSW	15	91,787,048 (GRCm38)	missense	possibly damaging	0.94
R9660:Lrrk2	UTSW	15	91,734,025 (GRCm38)	missense	probably benign	0.00
R9673:Lrrk2	UTSW	15	91,765,681 (GRCm38)	missense	probably damaging	1.00
R9708:Lrrk2	UTSW	15	91,750,279 (GRCm38)	nonsense	probably null
R9728:Lrrk2	UTSW	15	91,734,025 (GRCm38)	missense	probably benign	0.00
R9757:Lrrk2	UTSW	15	91,811,026 (GRCm38)	missense	probably benign	0.03
RF001:Lrrk2	UTSW	15	91,736,633 (GRCm38)	missense	probably benign	0.11
X0028:Lrrk2	UTSW	15	91,738,851 (GRCm38)	missense	probably benign	0.00
Z1088:Lrrk2	UTSW	15	91,726,240 (GRCm38)	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- GTGTGATATATCAAGAACCAGGCAATC -3'
(R):5'- AGCCTGATCTTACGCCAGTG -3'

Sequencing Primer
(F):5'- GGCAATCACTTCAGATAATCCTTC -3'
(R):5'- GCCTGATCTTACGCCAGTGATTAAC -3'

Posted On

2019-11-12