Incidental Mutation 'R7658:Fam186a'
ID 591394
Institutional Source Beutler Lab
Gene Symbol Fam186a
Ensembl Gene ENSMUSG00000045350
Gene Name family with sequence similarity 186, member A
Synonyms LOC380973, 1700030F18Rik
MMRRC Submission 045703-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R7658 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 99816229-99864942 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 99837725 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 2840 (Y2840H)
Ref Sequence ENSEMBL: ENSMUSP00000097783 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100209]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000100209
AA Change: Y2840H
SMART Domains Protein: ENSMUSP00000097783
Gene: ENSMUSG00000045350
AA Change: Y2840H

DomainStartEndE-ValueType
low complexity region 10 21 N/A INTRINSIC
Blast:FBG 44 222 4e-48 BLAST
coiled coil region 292 340 N/A INTRINSIC
low complexity region 423 443 N/A INTRINSIC
low complexity region 446 458 N/A INTRINSIC
low complexity region 632 644 N/A INTRINSIC
low complexity region 702 713 N/A INTRINSIC
internal_repeat_2 743 1156 1.05e-58 PROSPERO
internal_repeat_1 833 1270 7.71e-59 PROSPERO
low complexity region 1271 1285 N/A INTRINSIC
low complexity region 1289 1300 N/A INTRINSIC
low complexity region 1309 1323 N/A INTRINSIC
low complexity region 1327 1338 N/A INTRINSIC
low complexity region 1347 1361 N/A INTRINSIC
low complexity region 1365 1376 N/A INTRINSIC
low complexity region 1384 1395 N/A INTRINSIC
low complexity region 1403 1414 N/A INTRINSIC
low complexity region 1423 1437 N/A INTRINSIC
low complexity region 1441 1452 N/A INTRINSIC
low complexity region 1460 1471 N/A INTRINSIC
low complexity region 1479 1490 N/A INTRINSIC
low complexity region 1498 1509 N/A INTRINSIC
low complexity region 1518 1532 N/A INTRINSIC
low complexity region 1536 1547 N/A INTRINSIC
low complexity region 1555 1566 N/A INTRINSIC
low complexity region 1574 1585 N/A INTRINSIC
internal_repeat_1 1586 1981 7.71e-59 PROSPERO
internal_repeat_2 1737 2197 1.05e-58 PROSPERO
low complexity region 2367 2378 N/A INTRINSIC
low complexity region 2549 2564 N/A INTRINSIC
low complexity region 2644 2655 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 95 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110025L11Rik G T 16: 88,860,618 (GRCm39) S72Y unknown Het
Abca8b T A 11: 109,826,543 (GRCm39) K1568N probably benign Het
Adcy6 T A 15: 98,493,948 (GRCm39) Y865F probably benign Het
Adgrf3 A T 5: 30,402,204 (GRCm39) V608D probably benign Het
Agbl1 G T 7: 76,416,117 (GRCm39) A965S unknown Het
Agbl3 C T 6: 34,809,443 (GRCm39) P690L probably benign Het
Akap9 C G 5: 4,018,745 (GRCm39) H1109D probably benign Het
Amt A C 9: 108,174,430 (GRCm39) H65P probably damaging Het
Ankrd11 T A 8: 123,620,403 (GRCm39) T1150S probably benign Het
Arhgap15 A C 2: 44,032,280 (GRCm39) H288P probably benign Het
Arhgap39 A T 15: 76,621,617 (GRCm39) M328K probably benign Het
Arhgef12 T C 9: 42,903,832 (GRCm39) K743R probably damaging Het
Atg2a T G 19: 6,301,293 (GRCm39) V789G probably damaging Het
Ccdc54 T C 16: 50,410,844 (GRCm39) T141A probably benign Het
Ccng2 C G 5: 93,421,202 (GRCm39) S237R probably benign Het
Cdh5 T C 8: 104,856,033 (GRCm39) probably null Het
Cdkl3 T C 11: 51,918,009 (GRCm39) V404A not run Het
Chrm2 A T 6: 36,500,184 (GRCm39) I14F probably benign Het
Cnbp T C 6: 87,822,258 (GRCm39) K89E possibly damaging Het
Cntn6 T A 6: 104,627,444 (GRCm39) D92E probably benign Het
Col15a1 T C 4: 47,245,591 (GRCm39) F114S possibly damaging Het
Csrnp1 A G 9: 119,801,469 (GRCm39) F530S probably benign Het
Dcun1d3 C T 7: 119,456,891 (GRCm39) V274M probably damaging Het
Dph2 T A 4: 117,747,478 (GRCm39) H302L possibly damaging Het
Fam162a A T 16: 35,866,770 (GRCm39) Y118* probably null Het
Fto A G 8: 92,392,950 (GRCm39) K466E probably benign Het
Gal T A 19: 3,463,309 (GRCm39) Y41F probably damaging Het
Gigyf2 A T 1: 87,346,860 (GRCm39) L620F unknown Het
Git2 C T 5: 114,904,550 (GRCm39) R123H probably damaging Het
Glud1 A T 14: 34,033,114 (GRCm39) E87V probably benign Het
Gm21190 T G 5: 15,732,923 (GRCm39) E94A possibly damaging Het
Gm5592 T C 7: 40,938,134 (GRCm39) V472A probably benign Het
Gpc5 T A 14: 115,665,620 (GRCm39) N481K possibly damaging Het
Gpn2 A G 4: 133,318,687 (GRCm39) E304G probably benign Het
Gsdmc2 T C 15: 63,696,903 (GRCm39) T423A probably damaging Het
Gucy2e G A 11: 69,117,055 (GRCm39) Q789* probably null Het
Gxylt2 T A 6: 100,760,104 (GRCm39) V213E probably damaging Het
Ighv1-75 G A 12: 115,797,731 (GRCm39) L64F possibly damaging Het
Il17re T C 6: 113,435,943 (GRCm39) C30R probably benign Het
Il7 G T 3: 7,669,142 (GRCm39) D31E probably benign Het
Ints4 T C 7: 97,178,460 (GRCm39) Y687H possibly damaging Het
Kdelr1 T G 7: 45,532,401 (GRCm39) V202G probably benign Het
Khnyn C A 14: 56,124,596 (GRCm39) Y283* probably null Het
Klf11 T C 12: 24,703,670 (GRCm39) V52A probably damaging Het
Klhl7 A G 5: 24,346,284 (GRCm39) N310S probably benign Het
Krt27 A T 11: 99,240,312 (GRCm39) L202Q possibly damaging Het
Lce1d A G 3: 92,593,354 (GRCm39) C20R unknown Het
Lim2 A T 7: 43,083,054 (GRCm39) I80F possibly damaging Het
Lrrk2 T A 15: 91,584,561 (GRCm39) F326Y possibly damaging Het
Lyst A T 13: 13,905,061 (GRCm39) Y3246F possibly damaging Het
Mafb T A 2: 160,208,355 (GRCm39) H81L possibly damaging Het
Mfsd5 G A 15: 102,189,312 (GRCm39) R228H probably benign Het
Mmp1b A T 9: 7,386,675 (GRCm39) F150I possibly damaging Het
Mthfd1 T A 12: 76,317,209 (GRCm39) L20Q probably damaging Het
Mxra8 A G 4: 155,927,420 (GRCm39) T402A probably benign Het
Ndc80 A T 17: 71,815,658 (GRCm39) L376M probably damaging Het
Nsd1 A T 13: 55,425,452 (GRCm39) R1536S probably damaging Het
Nup210l C A 3: 90,119,300 (GRCm39) H1874Q probably benign Het
Nyap1 T C 5: 137,731,236 (GRCm39) H776R probably benign Het
Patj C A 4: 98,576,416 (GRCm39) H1773Q probably damaging Het
Pax8 T A 2: 24,326,523 (GRCm39) T280S probably benign Het
Pcdhb19 A G 18: 37,632,034 (GRCm39) T610A probably damaging Het
Pde2a A G 7: 101,160,788 (GRCm39) D919G possibly damaging Het
Pdk2 T A 11: 94,919,791 (GRCm39) Y240F probably damaging Het
Peg3 A T 7: 6,712,609 (GRCm39) I871N probably damaging Het
Pex1 A T 5: 3,646,244 (GRCm39) probably benign Het
Pgm2l1 C T 7: 99,899,535 (GRCm39) R50W probably damaging Het
Phkg1 T A 5: 129,894,764 (GRCm39) K262N probably damaging Het
Pik3r4 A G 9: 105,521,710 (GRCm39) E92G probably damaging Het
Prmt6 A T 3: 110,157,701 (GRCm39) V196E possibly damaging Het
Ptprn2 T G 12: 116,685,739 (GRCm39) M66R probably benign Het
Rai14 C T 15: 10,593,189 (GRCm39) G152R probably damaging Het
Recql5 A T 11: 115,814,102 (GRCm39) S348T probably damaging Het
Rfk T G 19: 17,376,046 (GRCm39) probably null Het
Ro60 T C 1: 143,646,611 (GRCm39) T45A probably damaging Het
Selenbp1 A T 3: 94,851,413 (GRCm39) M389L probably benign Het
Sipa1l2 G A 8: 126,219,029 (GRCm39) R103C probably benign Het
Slc10a6 T A 5: 103,777,056 (GRCm39) S15C probably damaging Het
Slc12a2 G T 18: 58,065,596 (GRCm39) V944L probably benign Het
Slc16a11 T A 11: 70,106,143 (GRCm39) L127Q possibly damaging Het
Spef1l T C 7: 139,556,531 (GRCm39) N152S probably benign Het
St6gal1 A G 16: 23,174,978 (GRCm39) Y272C probably damaging Het
Stab2 C A 10: 86,816,999 (GRCm39) V133F probably benign Het
Stradb G A 1: 59,031,885 (GRCm39) V266I probably damaging Het
Tmem150b A G 7: 4,723,758 (GRCm39) W140R probably benign Het
Tnnt3 A T 7: 142,065,833 (GRCm39) K157* probably null Het
Ttn T G 2: 76,554,113 (GRCm39) K30863N probably damaging Het
Vldlr G A 19: 27,220,536 (GRCm39) R592H probably benign Het
Vmn1r12 A T 6: 57,135,883 (GRCm39) probably benign Het
Vmn2r63 A C 7: 42,574,693 (GRCm39) S519R probably damaging Het
Zbtb22 G C 17: 34,137,471 (GRCm39) E539Q probably damaging Het
Zbtb44 G A 9: 30,965,375 (GRCm39) A262T probably benign Het
Zfp280d A T 9: 72,231,354 (GRCm39) N455I probably damaging Het
Zfp287 T C 11: 62,616,089 (GRCm39) N201D probably damaging Het
Zfp988 T C 4: 147,416,751 (GRCm39) L395P probably damaging Het
Other mutations in Fam186a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00588:Fam186a APN 15 99,825,572 (GRCm39) splice site probably benign
IGL03047:Fam186a UTSW 15 99,843,589 (GRCm39) missense unknown
R0172:Fam186a UTSW 15 99,852,768 (GRCm39) missense unknown
R0194:Fam186a UTSW 15 99,839,644 (GRCm39) missense possibly damaging 0.92
R0381:Fam186a UTSW 15 99,840,055 (GRCm39) missense probably damaging 0.97
R0799:Fam186a UTSW 15 99,839,893 (GRCm39) missense probably damaging 1.00
R1295:Fam186a UTSW 15 99,837,670 (GRCm39) splice site probably benign
R1366:Fam186a UTSW 15 99,841,270 (GRCm39) missense possibly damaging 0.89
R1519:Fam186a UTSW 15 99,845,536 (GRCm39) missense unknown
R1592:Fam186a UTSW 15 99,838,199 (GRCm39) missense probably benign 0.01
R1636:Fam186a UTSW 15 99,839,539 (GRCm39) missense unknown
R1719:Fam186a UTSW 15 99,840,227 (GRCm39) missense possibly damaging 0.54
R1759:Fam186a UTSW 15 99,864,762 (GRCm39) nonsense probably null
R1856:Fam186a UTSW 15 99,838,183 (GRCm39) missense possibly damaging 0.82
R2131:Fam186a UTSW 15 99,831,557 (GRCm39) unclassified probably benign
R2192:Fam186a UTSW 15 99,838,192 (GRCm39) missense possibly damaging 0.90
R2239:Fam186a UTSW 15 99,852,745 (GRCm39) missense unknown
R2251:Fam186a UTSW 15 99,842,978 (GRCm39) missense probably benign 0.02
R2902:Fam186a UTSW 15 99,843,049 (GRCm39) missense possibly damaging 0.73
R3037:Fam186a UTSW 15 99,841,675 (GRCm39) missense probably damaging 0.99
R3744:Fam186a UTSW 15 99,845,416 (GRCm39) missense unknown
R4021:Fam186a UTSW 15 99,839,680 (GRCm39) missense possibly damaging 0.66
R4183:Fam186a UTSW 15 99,831,566 (GRCm39) unclassified probably benign
R4238:Fam186a UTSW 15 99,841,523 (GRCm39) missense probably benign 0.05
R4667:Fam186a UTSW 15 99,842,413 (GRCm39) missense possibly damaging 0.92
R4817:Fam186a UTSW 15 99,831,419 (GRCm39) unclassified probably benign
R4835:Fam186a UTSW 15 99,843,689 (GRCm39) missense unknown
R4837:Fam186a UTSW 15 99,838,678 (GRCm39) missense unknown
R4897:Fam186a UTSW 15 99,843,158 (GRCm39) missense possibly damaging 0.66
R4902:Fam186a UTSW 15 99,844,723 (GRCm39) missense unknown
R4950:Fam186a UTSW 15 99,839,534 (GRCm39) missense unknown
R4995:Fam186a UTSW 15 99,842,980 (GRCm39) missense probably benign 0.27
R5062:Fam186a UTSW 15 99,842,527 (GRCm39) missense possibly damaging 0.66
R5124:Fam186a UTSW 15 99,840,977 (GRCm39) missense possibly damaging 0.90
R5133:Fam186a UTSW 15 99,853,374 (GRCm39) missense unknown
R5424:Fam186a UTSW 15 99,843,644 (GRCm39) missense unknown
R5624:Fam186a UTSW 15 99,839,628 (GRCm39) missense possibly damaging 0.90
R5628:Fam186a UTSW 15 99,839,628 (GRCm39) missense possibly damaging 0.90
R5637:Fam186a UTSW 15 99,839,628 (GRCm39) missense possibly damaging 0.90
R5639:Fam186a UTSW 15 99,844,931 (GRCm39) missense unknown
R5652:Fam186a UTSW 15 99,843,253 (GRCm39) missense possibly damaging 0.79
R5673:Fam186a UTSW 15 99,839,628 (GRCm39) missense possibly damaging 0.90
R5799:Fam186a UTSW 15 99,864,705 (GRCm39) nonsense probably null
R5965:Fam186a UTSW 15 99,842,978 (GRCm39) missense probably benign 0.37
R6044:Fam186a UTSW 15 99,839,878 (GRCm39) missense probably damaging 0.97
R6077:Fam186a UTSW 15 99,840,584 (GRCm39) missense possibly damaging 0.46
R6120:Fam186a UTSW 15 99,838,244 (GRCm39) missense probably benign 0.00
R6185:Fam186a UTSW 15 99,845,530 (GRCm39) missense unknown
R6186:Fam186a UTSW 15 99,845,206 (GRCm39) missense unknown
R6242:Fam186a UTSW 15 99,837,788 (GRCm39) missense unknown
R6351:Fam186a UTSW 15 99,839,623 (GRCm39) missense probably damaging 0.97
R6368:Fam186a UTSW 15 99,841,198 (GRCm39) missense possibly damaging 0.66
R6369:Fam186a UTSW 15 99,845,212 (GRCm39) missense unknown
R6559:Fam186a UTSW 15 99,842,356 (GRCm39) missense possibly damaging 0.46
R6855:Fam186a UTSW 15 99,852,756 (GRCm39) missense unknown
R6867:Fam186a UTSW 15 99,843,731 (GRCm39) missense unknown
R6957:Fam186a UTSW 15 99,844,357 (GRCm39) missense unknown
R6961:Fam186a UTSW 15 99,838,082 (GRCm39) missense probably benign 0.16
R6994:Fam186a UTSW 15 99,840,347 (GRCm39) missense probably benign 0.35
R6996:Fam186a UTSW 15 99,853,374 (GRCm39) missense unknown
R7062:Fam186a UTSW 15 99,831,521 (GRCm39) unclassified probably benign
R7064:Fam186a UTSW 15 99,839,557 (GRCm39) missense unknown
R7173:Fam186a UTSW 15 99,843,531 (GRCm39) missense unknown
R7244:Fam186a UTSW 15 99,844,273 (GRCm39) missense unknown
R7270:Fam186a UTSW 15 99,842,033 (GRCm39) missense possibly damaging 0.66
R7410:Fam186a UTSW 15 99,844,826 (GRCm39) nonsense probably null
R7437:Fam186a UTSW 15 99,840,775 (GRCm39) missense probably damaging 1.00
R7475:Fam186a UTSW 15 99,845,395 (GRCm39) missense unknown
R7487:Fam186a UTSW 15 99,840,017 (GRCm39) missense possibly damaging 0.66
R7526:Fam186a UTSW 15 99,839,796 (GRCm39) missense possibly damaging 0.83
R7650:Fam186a UTSW 15 99,837,788 (GRCm39) missense unknown
R7663:Fam186a UTSW 15 99,842,950 (GRCm39) missense probably benign 0.00
R7703:Fam186a UTSW 15 99,852,678 (GRCm39) missense unknown
R7814:Fam186a UTSW 15 99,842,545 (GRCm39) missense possibly damaging 0.92
R7958:Fam186a UTSW 15 99,841,189 (GRCm39) missense probably damaging 0.99
R7970:Fam186a UTSW 15 99,831,467 (GRCm39) missense unknown
R8076:Fam186a UTSW 15 99,841,351 (GRCm39) missense possibly damaging 0.83
R8087:Fam186a UTSW 15 99,839,725 (GRCm39) missense possibly damaging 0.46
R8130:Fam186a UTSW 15 99,841,914 (GRCm39) frame shift probably null
R8239:Fam186a UTSW 15 99,839,191 (GRCm39) missense unknown
R8246:Fam186a UTSW 15 99,838,428 (GRCm39) missense unknown
R8446:Fam186a UTSW 15 99,845,335 (GRCm39) missense unknown
R8469:Fam186a UTSW 15 99,845,186 (GRCm39) missense unknown
R8676:Fam186a UTSW 15 99,845,023 (GRCm39) missense unknown
R8790:Fam186a UTSW 15 99,841,024 (GRCm39) missense possibly damaging 0.90
R8808:Fam186a UTSW 15 99,842,604 (GRCm39) missense possibly damaging 0.83
R8848:Fam186a UTSW 15 99,838,034 (GRCm39) missense possibly damaging 0.83
R9083:Fam186a UTSW 15 99,843,079 (GRCm39) missense probably benign 0.27
R9106:Fam186a UTSW 15 99,844,107 (GRCm39) small deletion probably benign
R9116:Fam186a UTSW 15 99,840,472 (GRCm39) missense possibly damaging 0.95
R9156:Fam186a UTSW 15 99,841,159 (GRCm39) missense possibly damaging 0.46
R9227:Fam186a UTSW 15 99,853,384 (GRCm39) missense unknown
R9250:Fam186a UTSW 15 99,845,330 (GRCm39) missense unknown
R9282:Fam186a UTSW 15 99,839,879 (GRCm39) missense probably damaging 0.97
R9495:Fam186a UTSW 15 99,844,766 (GRCm39) missense unknown
R9514:Fam186a UTSW 15 99,844,766 (GRCm39) missense unknown
R9521:Fam186a UTSW 15 99,841,471 (GRCm39) missense probably damaging 0.97
R9553:Fam186a UTSW 15 99,844,561 (GRCm39) missense unknown
R9641:Fam186a UTSW 15 99,838,244 (GRCm39) missense probably benign 0.00
R9655:Fam186a UTSW 15 99,840,973 (GRCm39) missense probably damaging 0.99
R9661:Fam186a UTSW 15 99,842,492 (GRCm39) missense possibly damaging 0.66
R9673:Fam186a UTSW 15 99,841,024 (GRCm39) missense possibly damaging 0.90
R9762:Fam186a UTSW 15 99,842,393 (GRCm39) missense possibly damaging 0.66
X0021:Fam186a UTSW 15 99,843,316 (GRCm39) missense probably benign 0.00
Z1088:Fam186a UTSW 15 99,843,875 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TCCTTCATAAGAGCATGATACAGC -3'
(R):5'- GCCAAGATGATAGTGTCCCC -3'

Sequencing Primer
(F):5'- GGAGATCCAATATCCTCTGTGAGC -3'
(R):5'- GTGTCCCCCACTGATCAGCAC -3'
Posted On 2019-11-12