Mutagenetix > Incidental Mutations

Incidental Mutation 'R7659:Armh1'

591421

Institutional Source

Beutler Lab

Gene Symbol

Armh1

Ensembl Gene

ENSMUSG00000060268

Gene Name

armadillo-like helical domain containing 1

Synonyms

LOC381543, LOC381544, Ncrna00082

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R7659 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

117213333-117252125 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 117213741 bp

Zygosity

Heterozygous

Amino Acid Change

Alanine to Serine at position 396 (A396S)

Ref Sequence

ENSEMBL: ENSMUSP00000128613 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077500] [ENSMUST00000165128]

Predicted Effect

probably benign
Transcript: ENSMUST00000077500

SMART Domains

Protein: ENSMUSP00000076706
Gene: ENSMUSG00000060268

Domain	Start	End	E-Value	Type
SCOP:d1qbkb_	156	272	3e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000165128
AA Change: A396S

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000128613
Gene: ENSMUSG00000060268
AA Change: A396S

Domain	Start	End	E-Value	Type
low complexity region	162	176	N/A	INTRINSIC

Meta Mutation Damage Score

0.0602

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

100% (66/66)

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh2	T	C	5: 121,568,960	E498G	probably damaging	Het
Ankar	T	C	1: 72,690,135	T284A	possibly damaging	Het
Arid5b	C	T	10: 68,098,587	G495E	probably benign	Het
Atp6v0a4	A	G	6: 38,071,972	I452T	probably damaging	Het
Azgp1	G	T	5: 137,987,513	A133S	probably damaging	Het
Bmp2k	T	C	5: 97,074,719	S667P	unknown	Het
C1qtnf9	T	A	14: 60,772,304	I3N	possibly damaging	Het
C530025M09Rik	T	G	2: 149,830,619	T199P	unknown	Het
Casc3	C	G	11: 98,809,873	R4G	unknown	Het
Cass4	A	G	2: 172,427,027	D343G	probably damaging	Het
Ccdc84	T	C	9: 44,413,493	E164G	probably damaging	Het
Col6a3	T	A	1: 90,781,745	T2517S	unknown	Het
Dbr1	A	G	9: 99,576,610	T78A	probably damaging	Het
Dnah9	A	G	11: 65,989,780	F2664L	probably damaging	Het
Eif2ak1	T	C	5: 143,889,462	I431T	probably damaging	Het
Got1	A	G	19: 43,504,639	V281A	probably benign	Het
Gpld1	A	C	13: 24,979,981	R555S	probably benign	Het
Gpr149	T	C	3: 62,603,835	R248G	probably benign	Het
Hps3	G	A	3: 20,022,814	R395*	probably null	Het
Inpp5b	T	C	4: 124,795,426	L833P	probably damaging	Het
Itgb4	A	T	11: 115,979,731	S129C	probably damaging	Het
Kif1a	T	A	1: 93,046,820		probably benign	Het
Lgr4	T	A	2: 109,996,766	V205E	probably damaging	Het
Mbd3	T	C	10: 80,395,185	N96S	probably damaging	Het
Mcam	T	A	9: 44,136,770	C136S	unknown	Het
Mki67	A	G	7: 135,697,426	S1960P	probably damaging	Het
Mogs	G	A	6: 83,116,825		probably null	Het
Muc6	T	C	7: 141,637,060	T2567A	possibly damaging	Het
Mug1	C	A	6: 121,861,220	H470N	possibly damaging	Het
Nae1	A	G	8: 104,516,164	V432A	probably benign	Het
Nav3	T	G	10: 109,766,990	T1233P	probably benign	Het
Nme9	G	A	9: 99,470,857	A287T	possibly damaging	Het
Nmrk1	A	G	19: 18,636,135	I8V	probably benign	Het
Noa1	T	C	5: 77,309,390	N223D	not run	Het
Nr4a3	T	C	4: 48,051,269	Y8H	probably damaging	Het
Olfr1112	T	A	2: 87,192,365	V226E	possibly damaging	Het
Olfr1181	T	C	2: 88,423,926	Y33C	probably damaging	Het
Olfr124	A	T	17: 37,805,163	Q6L	probably benign	Het
Olfr25	T	C	9: 38,329,716	V40A	possibly damaging	Het
Olfr344	T	A	2: 36,568,625	V9E	possibly damaging	Het
Olfr649	T	C	7: 104,190,187	S7G	probably benign	Het
Olfr733	T	C	14: 50,299,241	I23V	probably benign	Het
Olfr847	C	T	9: 19,375,558	A108T	probably benign	Het
Otoa	T	A	7: 121,134,044	H711Q	probably benign	Het
Otogl	T	A	10: 107,777,120	E2048D	probably benign	Het
Paip1	C	T	13: 119,450,770	T390I	possibly damaging	Het
Pcdha3	A	G	18: 36,948,166	T654A	probably benign	Het
Pigg	G	A	5: 108,338,619	V713I	probably benign	Het
Ppt1	T	A	4: 122,836,333	H26Q	probably benign	Het
Prim1	T	C	10: 128,026,589		probably null	Het
Prmt7	G	T	8: 106,237,286	A271S	probably benign	Het
Ptprd	T	C	4: 76,128,916	D124G	probably benign	Het
Rad54l2	T	C	9: 106,713,578	K450E	probably benign	Het
Rasgrp2	G	T	19: 6,401,827	V13L	probably damaging	Het
Sapcd2	A	G	2: 25,375,966		probably null	Het
Siglecf	A	G	7: 43,351,770	Y54C	probably damaging	Het
Stk31	T	A	6: 49,423,406	N388K	probably benign	Het
Timm23	A	C	14: 32,198,978	Y52*	probably null	Het
Tm9sf1	A	T	14: 55,636,335	F569I	probably damaging	Het
Tmprss9	C	A	10: 80,893,009	A592E	probably damaging	Het
Trim30d	A	T	7: 104,472,347	V397E	probably benign	Het
Tshz1	A	T	18: 84,016,075	N69K	probably damaging	Het
Upk2	A	C	9: 44,453,511	S130R	probably damaging	Het
Vmn1r80	A	G	7: 12,193,050	Y29C	probably damaging	Het
Vmn2r96	T	C	17: 18,573,487	I31T	probably benign	Het
Zfp975	T	C	7: 42,662,424	Q255R	probably benign	Het

Other mutations in Armh1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02049:Armh1	APN	4	117237663	missense	probably benign	0.37
R0350:Armh1	UTSW	4	117215556	nonsense	probably null
R0584:Armh1	UTSW	4	117229850	missense	probably damaging	1.00
R1570:Armh1	UTSW	4	117229992	missense	probably damaging	1.00
R4335:Armh1	UTSW	4	117214463	missense	probably damaging	0.99
R4898:Armh1	UTSW	4	117237780	missense	probably damaging	1.00
R5939:Armh1	UTSW	4	117229922	missense	probably damaging	1.00
R6300:Armh1	UTSW	4	117231782	missense	probably damaging	1.00
R6815:Armh1	UTSW	4	117229937	missense	probably damaging	1.00
R7526:Armh1	UTSW	4	117213741	missense	probably benign	0.02
R7529:Armh1	UTSW	4	117213741	missense	probably benign	0.02
R7630:Armh1	UTSW	4	117213741	missense	probably benign	0.02
R7632:Armh1	UTSW	4	117213741	missense	probably benign	0.02
R7660:Armh1	UTSW	4	117213741	missense	probably benign	0.02
R7662:Armh1	UTSW	4	117213741	missense	probably benign	0.02
R7663:Armh1	UTSW	4	117213741	missense	probably benign	0.02
R7665:Armh1	UTSW	4	117213741	missense	probably benign	0.02
R7666:Armh1	UTSW	4	117213741	missense	probably benign	0.02
R7713:Armh1	UTSW	4	117214228	missense	possibly damaging	0.65
R8030:Armh1	UTSW	4	117229987	missense	probably benign	0.31
R8433:Armh1	UTSW	4	117228338	missense	probably benign	0.43
Z1088:Armh1	UTSW	4	117213795	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TTCATATCATTGGAGCCCGTG -3'
(R):5'- AGGTAACCCTTCCTCCCTAG -3'

Sequencing Primer
(F):5'- TATCATTGGAGCCCGTGGAGAAG -3'
(R):5'- AGGGGTGCACTGCTCTG -3'

Posted On

2019-11-12