Incidental Mutation 'R7659:Vmn2r96'
| ID |
591466 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r96
|
| Ensembl Gene |
ENSMUSG00000091679 |
| Gene Name |
vomeronasal 2, receptor 96 |
| Synonyms |
EG433070 |
| MMRRC Submission |
045734-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.156)
|
| Stock # |
R7659 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
18793282-18818419 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 18793749 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 31
(I31T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135095
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000177244]
[ENSMUST00000231261]
[ENSMUST00000231286]
|
| AlphaFold |
E9PZU5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177244
AA Change: I31T
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000135095
Gene: ENSMUSG00000091679
AA Change: I31T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
1 |
245 |
4.2e-19 |
PFAM |
|
Pfam:NCD3G
|
317 |
370 |
6.9e-21 |
PFAM |
|
Pfam:7tm_3
|
400 |
639 |
3.4e-75 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000231261
AA Change: I31T
PolyPhen 2
Score 0.682 (Sensitivity: 0.86; Specificity: 0.92)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231286
AA Change: I31T
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
100% (66/66) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aldh2 |
T |
C |
5: 121,707,023 (GRCm39) |
E498G |
probably damaging |
Het |
| Ankar |
T |
C |
1: 72,729,294 (GRCm39) |
T284A |
possibly damaging |
Het |
| Arid5b |
C |
T |
10: 67,934,417 (GRCm39) |
G495E |
probably benign |
Het |
| Armh1 |
C |
A |
4: 117,070,938 (GRCm39) |
A396S |
probably benign |
Het |
| Atp6v0a4 |
A |
G |
6: 38,048,907 (GRCm39) |
I452T |
probably damaging |
Het |
| Azgp1 |
G |
T |
5: 137,985,775 (GRCm39) |
A133S |
probably damaging |
Het |
| Bmp2k |
T |
C |
5: 97,222,578 (GRCm39) |
S667P |
unknown |
Het |
| C1qtnf9 |
T |
A |
14: 61,009,753 (GRCm39) |
I3N |
possibly damaging |
Het |
| C530025M09Rik |
T |
G |
2: 149,672,539 (GRCm39) |
T199P |
unknown |
Het |
| Casc3 |
C |
G |
11: 98,700,699 (GRCm39) |
R4G |
unknown |
Het |
| Cass4 |
A |
G |
2: 172,268,947 (GRCm39) |
D343G |
probably damaging |
Het |
| Cenatac |
T |
C |
9: 44,324,790 (GRCm39) |
E164G |
probably damaging |
Het |
| Col6a3 |
T |
A |
1: 90,709,467 (GRCm39) |
T2517S |
unknown |
Het |
| Dbr1 |
A |
G |
9: 99,458,663 (GRCm39) |
T78A |
probably damaging |
Het |
| Dnah9 |
A |
G |
11: 65,880,606 (GRCm39) |
F2664L |
probably damaging |
Het |
| Eif2ak1 |
T |
C |
5: 143,826,280 (GRCm39) |
I431T |
probably damaging |
Het |
| Got1 |
A |
G |
19: 43,493,078 (GRCm39) |
V281A |
probably benign |
Het |
| Gpld1 |
A |
C |
13: 25,163,964 (GRCm39) |
R555S |
probably benign |
Het |
| Gpr149 |
T |
C |
3: 62,511,256 (GRCm39) |
R248G |
probably benign |
Het |
| Hps3 |
G |
A |
3: 20,076,978 (GRCm39) |
R395* |
probably null |
Het |
| Inpp5b |
T |
C |
4: 124,689,219 (GRCm39) |
L833P |
probably damaging |
Het |
| Itgb4 |
A |
T |
11: 115,870,557 (GRCm39) |
S129C |
probably damaging |
Het |
| Kif1a |
T |
A |
1: 92,974,542 (GRCm39) |
|
probably benign |
Het |
| Lgr4 |
T |
A |
2: 109,827,111 (GRCm39) |
V205E |
probably damaging |
Het |
| Mbd3 |
T |
C |
10: 80,231,019 (GRCm39) |
N96S |
probably damaging |
Het |
| Mcam |
T |
A |
9: 44,048,067 (GRCm39) |
C136S |
unknown |
Het |
| Mki67 |
A |
G |
7: 135,299,155 (GRCm39) |
S1960P |
probably damaging |
Het |
| Mogs |
G |
A |
6: 83,093,806 (GRCm39) |
|
probably null |
Het |
| Muc6 |
T |
C |
7: 141,216,973 (GRCm39) |
T2567A |
possibly damaging |
Het |
| Mug1 |
C |
A |
6: 121,838,179 (GRCm39) |
H470N |
possibly damaging |
Het |
| Nae1 |
A |
G |
8: 105,242,796 (GRCm39) |
V432A |
probably benign |
Het |
| Nav3 |
T |
G |
10: 109,602,851 (GRCm39) |
T1233P |
probably benign |
Het |
| Nme9 |
G |
A |
9: 99,352,910 (GRCm39) |
A287T |
possibly damaging |
Het |
| Nmrk1 |
A |
G |
19: 18,613,499 (GRCm39) |
I8V |
probably benign |
Het |
| Noa1 |
T |
C |
5: 77,457,237 (GRCm39) |
N223D |
not run |
Het |
| Nr4a3 |
T |
C |
4: 48,051,269 (GRCm39) |
Y8H |
probably damaging |
Het |
| Or12e1 |
T |
A |
2: 87,022,709 (GRCm39) |
V226E |
possibly damaging |
Het |
| Or1j15 |
T |
A |
2: 36,458,637 (GRCm39) |
V9E |
possibly damaging |
Het |
| Or2b4 |
A |
T |
17: 38,116,054 (GRCm39) |
Q6L |
probably benign |
Het |
| Or4n4b |
T |
C |
14: 50,536,698 (GRCm39) |
I23V |
probably benign |
Het |
| Or4p20 |
T |
C |
2: 88,254,270 (GRCm39) |
Y33C |
probably damaging |
Het |
| Or52h2 |
T |
C |
7: 103,839,394 (GRCm39) |
S7G |
probably benign |
Het |
| Or7g29 |
C |
T |
9: 19,286,854 (GRCm39) |
A108T |
probably benign |
Het |
| Or8c9 |
T |
C |
9: 38,241,012 (GRCm39) |
V40A |
possibly damaging |
Het |
| Otoa |
T |
A |
7: 120,733,267 (GRCm39) |
H711Q |
probably benign |
Het |
| Otogl |
T |
A |
10: 107,612,981 (GRCm39) |
E2048D |
probably benign |
Het |
| Paip1 |
C |
T |
13: 119,587,306 (GRCm39) |
T390I |
possibly damaging |
Het |
| Pcdha3 |
A |
G |
18: 37,081,219 (GRCm39) |
T654A |
probably benign |
Het |
| Pigg |
G |
A |
5: 108,486,485 (GRCm39) |
V713I |
probably benign |
Het |
| Ppt1 |
T |
A |
4: 122,730,126 (GRCm39) |
H26Q |
probably benign |
Het |
| Prim1 |
T |
C |
10: 127,862,458 (GRCm39) |
|
probably null |
Het |
| Prmt7 |
G |
T |
8: 106,963,918 (GRCm39) |
A271S |
probably benign |
Het |
| Ptprd |
T |
C |
4: 76,047,153 (GRCm39) |
D124G |
probably benign |
Het |
| Rad54l2 |
T |
C |
9: 106,590,777 (GRCm39) |
K450E |
probably benign |
Het |
| Rasgrp2 |
G |
T |
19: 6,451,857 (GRCm39) |
V13L |
probably damaging |
Het |
| Sapcd2 |
A |
G |
2: 25,265,978 (GRCm39) |
|
probably null |
Het |
| Siglecf |
A |
G |
7: 43,001,194 (GRCm39) |
Y54C |
probably damaging |
Het |
| Stk31 |
T |
A |
6: 49,400,340 (GRCm39) |
N388K |
probably benign |
Het |
| Timm23 |
A |
C |
14: 31,920,935 (GRCm39) |
Y52* |
probably null |
Het |
| Tm9sf1 |
A |
T |
14: 55,873,792 (GRCm39) |
F569I |
probably damaging |
Het |
| Tmprss9 |
C |
A |
10: 80,728,843 (GRCm39) |
A592E |
probably damaging |
Het |
| Trim30d |
A |
T |
7: 104,121,554 (GRCm39) |
V397E |
probably benign |
Het |
| Tshz1 |
A |
T |
18: 84,034,200 (GRCm39) |
N69K |
probably damaging |
Het |
| Upk2 |
A |
C |
9: 44,364,808 (GRCm39) |
S130R |
probably damaging |
Het |
| Vmn1r80 |
A |
G |
7: 11,926,977 (GRCm39) |
Y29C |
probably damaging |
Het |
| Zfp975 |
T |
C |
7: 42,311,848 (GRCm39) |
Q255R |
probably benign |
Het |
|
| Other mutations in Vmn2r96 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00562:Vmn2r96
|
APN |
17 |
18,804,077 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00563:Vmn2r96
|
APN |
17 |
18,804,077 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00769:Vmn2r96
|
APN |
17 |
18,804,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01314:Vmn2r96
|
APN |
17 |
18,803,226 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01983:Vmn2r96
|
APN |
17 |
18,817,527 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02314:Vmn2r96
|
APN |
17 |
18,804,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02600:Vmn2r96
|
APN |
17 |
18,817,829 (GRCm39) |
missense |
probably benign |
|
|
IGL02672:Vmn2r96
|
APN |
17 |
18,818,376 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02750:Vmn2r96
|
APN |
17 |
18,802,851 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03068:Vmn2r96
|
APN |
17 |
18,803,137 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03411:Vmn2r96
|
APN |
17 |
18,806,634 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0316:Vmn2r96
|
UTSW |
17 |
18,802,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0502:Vmn2r96
|
UTSW |
17 |
18,804,262 (GRCm39) |
missense |
probably benign |
|
|
R0580:Vmn2r96
|
UTSW |
17 |
18,802,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0652:Vmn2r96
|
UTSW |
17 |
18,817,830 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0789:Vmn2r96
|
UTSW |
17 |
18,802,738 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1462:Vmn2r96
|
UTSW |
17 |
18,817,660 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1462:Vmn2r96
|
UTSW |
17 |
18,817,660 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1660:Vmn2r96
|
UTSW |
17 |
18,817,988 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1755:Vmn2r96
|
UTSW |
17 |
18,802,915 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1843:Vmn2r96
|
UTSW |
17 |
18,818,183 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1943:Vmn2r96
|
UTSW |
17 |
18,806,664 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1993:Vmn2r96
|
UTSW |
17 |
18,804,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2018:Vmn2r96
|
UTSW |
17 |
18,804,263 (GRCm39) |
missense |
probably benign |
|
|
R2405:Vmn2r96
|
UTSW |
17 |
18,818,102 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3977:Vmn2r96
|
UTSW |
17 |
18,817,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3979:Vmn2r96
|
UTSW |
17 |
18,817,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4059:Vmn2r96
|
UTSW |
17 |
18,818,339 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4693:Vmn2r96
|
UTSW |
17 |
18,803,270 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4709:Vmn2r96
|
UTSW |
17 |
18,803,088 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4776:Vmn2r96
|
UTSW |
17 |
18,817,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4882:Vmn2r96
|
UTSW |
17 |
18,817,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4920:Vmn2r96
|
UTSW |
17 |
18,802,918 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5143:Vmn2r96
|
UTSW |
17 |
18,804,120 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5301:Vmn2r96
|
UTSW |
17 |
18,817,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5507:Vmn2r96
|
UTSW |
17 |
18,818,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6151:Vmn2r96
|
UTSW |
17 |
18,804,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6181:Vmn2r96
|
UTSW |
17 |
18,804,126 (GRCm39) |
missense |
probably benign |
|
|
R6339:Vmn2r96
|
UTSW |
17 |
18,804,124 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6404:Vmn2r96
|
UTSW |
17 |
18,817,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6452:Vmn2r96
|
UTSW |
17 |
18,804,117 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6749:Vmn2r96
|
UTSW |
17 |
18,818,352 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6813:Vmn2r96
|
UTSW |
17 |
18,802,116 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6851:Vmn2r96
|
UTSW |
17 |
18,802,800 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6944:Vmn2r96
|
UTSW |
17 |
18,817,891 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6949:Vmn2r96
|
UTSW |
17 |
18,818,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6962:Vmn2r96
|
UTSW |
17 |
18,818,283 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6990:Vmn2r96
|
UTSW |
17 |
18,804,082 (GRCm39) |
missense |
probably benign |
|
|
R7149:Vmn2r96
|
UTSW |
17 |
18,817,989 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7346:Vmn2r96
|
UTSW |
17 |
18,803,029 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7385:Vmn2r96
|
UTSW |
17 |
18,803,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7442:Vmn2r96
|
UTSW |
17 |
18,793,662 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7509:Vmn2r96
|
UTSW |
17 |
18,802,995 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7652:Vmn2r96
|
UTSW |
17 |
18,793,832 (GRCm39) |
missense |
probably benign |
|
|
R7753:Vmn2r96
|
UTSW |
17 |
18,806,663 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7855:Vmn2r96
|
UTSW |
17 |
18,818,130 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R8166:Vmn2r96
|
UTSW |
17 |
18,802,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8260:Vmn2r96
|
UTSW |
17 |
18,804,243 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8323:Vmn2r96
|
UTSW |
17 |
18,803,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8787:Vmn2r96
|
UTSW |
17 |
18,818,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8837:Vmn2r96
|
UTSW |
17 |
18,802,888 (GRCm39) |
missense |
probably benign |
|
|
R8933:Vmn2r96
|
UTSW |
17 |
18,804,241 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9306:Vmn2r96
|
UTSW |
17 |
18,803,226 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9481:Vmn2r96
|
UTSW |
17 |
18,793,621 (GRCm39) |
start gained |
probably benign |
|
|
R9626:Vmn2r96
|
UTSW |
17 |
18,793,758 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9629:Vmn2r96
|
UTSW |
17 |
18,803,257 (GRCm39) |
missense |
probably benign |
0.15 |
|
Z1088:Vmn2r96
|
UTSW |
17 |
18,817,628 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Z1177:Vmn2r96
|
UTSW |
17 |
18,818,376 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- AATCTGAGTGACAAACTGAGTCATC -3'
(R):5'- GATTACCTTTCCCTCTGAGTGAG -3'
Sequencing Primer
(F):5'- AGTGACAAACTGAGTCATCAATAAAC -3'
(R):5'- TCTAAGAGTGAATTGGCCAAAATC -3'
|
| Posted On |
2019-11-12 |
Incidental Mutation