Incidental Mutation 'R7661:Vmn2r-ps158'
ID 591567
Institutional Source Beutler Lab
Gene Symbol Vmn2r-ps158
Ensembl Gene ENSMUSG00000091528
Gene Name vomeronasal 2, receptor, pseudogene 158
Synonyms Vmn2r126, Gm9268
MMRRC Submission 045736-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R7661 (G1)
Quality Score 163.009
Status Not validated
Chromosome 7
Chromosomal Location 42668222-42697530 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 42672582 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 72 (N72K)
Ref Sequence ENSEMBL: ENSMUSP00000129068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166914] [ENSMUST00000173815]
AlphaFold E9Q0M3
Predicted Effect probably benign
Transcript: ENSMUST00000166914
AA Change: N72K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000129068
Gene: ENSMUSG00000091528
AA Change: N72K

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 473 1.1e-41 PFAM
Pfam:NCD3G 516 569 1.7e-23 PFAM
Pfam:7tm_3 602 837 9.6e-51 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173815
AA Change: N72K

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000134441
Gene: ENSMUSG00000091528
AA Change: N72K

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 467 5.3e-40 PFAM
Pfam:NCD3G 509 562 4.6e-22 PFAM
Pfam:7tm_3 594 831 1.1e-73 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 96% (50/52)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110018I06Rik A T 12: 107,455,215 (GRCm39) K100N unknown Het
Abi3bp T A 16: 56,453,263 (GRCm39) probably null Het
Akr1c20 T C 13: 4,558,218 (GRCm39) D210G probably benign Het
Arid5b C T 10: 67,934,417 (GRCm39) G495E probably benign Het
Ascc1 A C 10: 59,885,629 (GRCm39) N227H probably damaging Het
Atp5f1a G T 18: 77,861,802 (GRCm39) A18S possibly damaging Het
Bcl2l13 A G 6: 120,842,558 (GRCm39) T84A possibly damaging Het
Blmh T A 11: 76,877,341 (GRCm39) V419D probably damaging Het
Cacna1d G A 14: 29,769,177 (GRCm39) P1918S probably benign Het
Calr4 T C 4: 109,110,951 (GRCm39) V339A probably benign Het
Capza3 C A 6: 139,987,498 (GRCm39) D32E probably benign Het
Cilk1 G C 9: 78,074,902 (GRCm39) V586L probably benign Het
Cldn20 T A 17: 3,583,133 (GRCm39) M102K possibly damaging Het
Dennd1a T C 2: 37,734,841 (GRCm39) Q479R probably benign Het
Dpp10 A T 1: 123,312,681 (GRCm39) I432N probably damaging Het
Dst T A 1: 34,295,434 (GRCm39) probably null Het
Efcab3 T A 11: 104,617,503 (GRCm39) D741E probably benign Het
Fam135a C T 1: 24,111,843 (GRCm39) probably null Het
Fam47e C T 5: 92,735,384 (GRCm39) L206F probably damaging Het
Focad G A 4: 88,221,772 (GRCm39) R714H unknown Het
Hace1 T G 10: 45,481,649 (GRCm39) V124G probably damaging Het
Ifit1bl2 T A 19: 34,596,428 (GRCm39) Y396F probably damaging Het
Il22ra2 A G 10: 19,497,826 (GRCm39) I13M probably benign Het
Kif21a A G 15: 90,865,122 (GRCm39) F517L possibly damaging Het
Lrrc4 T C 6: 28,829,762 (GRCm39) T618A probably benign Het
Mdn1 A G 4: 32,691,229 (GRCm39) T952A probably benign Het
Mindy3 A T 2: 12,402,328 (GRCm39) I208K probably damaging Het
Mug1 C A 6: 121,838,179 (GRCm39) H470N possibly damaging Het
Mycbp2 A G 14: 103,450,059 (GRCm39) I1744T probably damaging Het
Nanog A T 6: 122,690,431 (GRCm39) R279W probably damaging Het
Ncoa2 T A 1: 13,244,761 (GRCm39) T646S probably damaging Het
Ndufa5 A G 6: 24,518,724 (GRCm39) *117R probably null Het
Nudt18 A T 14: 70,817,276 (GRCm39) E293D probably benign Het
Or1e22 A G 11: 73,377,426 (GRCm39) S75P probably damaging Het
Or51aa2 A T 7: 103,187,826 (GRCm39) V205E probably damaging Het
Paip1 C T 13: 119,587,306 (GRCm39) T390I possibly damaging Het
Pigg G A 5: 108,486,485 (GRCm39) V713I probably benign Het
Pih1d2 T C 9: 50,529,558 (GRCm39) probably null Het
Ppp2r3d A G 9: 124,442,696 (GRCm38) F17L Het
Ptprk T C 10: 28,342,036 (GRCm39) I481T probably benign Het
Pygo2 T C 3: 89,338,038 (GRCm39) probably null Het
Raet1d T C 10: 22,248,156 (GRCm39) S225P possibly damaging Het
Rnf24 T C 2: 131,164,135 (GRCm39) probably benign Het
Ror1 A G 4: 100,298,687 (GRCm39) S687G probably damaging Het
Rsph9 A G 17: 46,446,013 (GRCm39) S186P probably damaging Het
Sash1 C T 10: 8,605,155 (GRCm39) M1078I probably benign Het
Scd4 C A 19: 44,327,510 (GRCm39) D195E probably benign Het
Spopfm3 C T 3: 94,105,709 (GRCm39) T9I probably damaging Het
Syn3 A G 10: 85,904,940 (GRCm39) C348R probably damaging Het
Uspl1 T C 5: 149,151,827 (GRCm39) F1009S probably benign Het
Vmn1r2 T A 4: 3,172,149 (GRCm39) F23I probably benign Het
Vmn1r257 A G 7: 22,391,229 (GRCm39) S172P probably benign Het
Zfp747l1 A T 7: 126,984,135 (GRCm39) C322* probably null Het
Zfp839 C T 12: 110,835,226 (GRCm39) T827I probably benign Het
Other mutations in Vmn2r-ps158
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01676:Vmn2r-ps158 APN 7 42,674,133 (GRCm39) missense probably damaging 0.97
IGL01753:Vmn2r-ps158 APN 7 42,674,139 (GRCm39) missense probably damaging 1.00
IGL02338:Vmn2r-ps158 APN 7 42,697,160 (GRCm39) missense probably damaging 1.00
IGL02541:Vmn2r-ps158 APN 7 42,673,092 (GRCm39) splice site probably benign
R0751:Vmn2r-ps158 UTSW 7 42,696,833 (GRCm39) missense probably damaging 0.99
R0849:Vmn2r-ps158 UTSW 7 42,674,142 (GRCm39) missense probably damaging 1.00
R1460:Vmn2r-ps158 UTSW 7 42,672,639 (GRCm39) missense probably benign 0.25
R1617:Vmn2r-ps158 UTSW 7 42,673,503 (GRCm39) missense probably benign 0.18
R1962:Vmn2r-ps158 UTSW 7 42,696,824 (GRCm39) missense probably benign 0.00
R1999:Vmn2r-ps158 UTSW 7 42,696,883 (GRCm39) missense probably damaging 1.00
R2022:Vmn2r-ps158 UTSW 7 42,673,454 (GRCm39) missense probably benign
R2434:Vmn2r-ps158 UTSW 7 42,696,881 (GRCm39) missense probably damaging 0.99
R3760:Vmn2r-ps158 UTSW 7 42,673,502 (GRCm39) missense probably benign 0.00
R4562:Vmn2r-ps158 UTSW 7 42,672,986 (GRCm39) nonsense probably null
R4890:Vmn2r-ps158 UTSW 7 42,697,024 (GRCm39) missense probably damaging 1.00
R5221:Vmn2r-ps158 UTSW 7 42,672,684 (GRCm39) missense probably benign 0.31
R5597:Vmn2r-ps158 UTSW 7 42,674,073 (GRCm39) missense probably benign 0.01
R6589:Vmn2r-ps158 UTSW 7 42,673,022 (GRCm39) missense possibly damaging 0.91
R6831:Vmn2r-ps158 UTSW 7 42,673,004 (GRCm39) missense probably damaging 1.00
R6834:Vmn2r-ps158 UTSW 7 42,673,004 (GRCm39) missense probably damaging 1.00
R6910:Vmn2r-ps158 UTSW 7 42,673,475 (GRCm39) missense probably benign 0.01
R6944:Vmn2r-ps158 UTSW 7 42,697,393 (GRCm39) missense possibly damaging 0.95
R7470:Vmn2r-ps158 UTSW 7 42,697,310 (GRCm39) missense probably damaging 1.00
R7553:Vmn2r-ps158 UTSW 7 42,697,447 (GRCm39) missense probably damaging 1.00
R7677:Vmn2r-ps158 UTSW 7 42,674,163 (GRCm39) missense probably damaging 1.00
R8087:Vmn2r-ps158 UTSW 7 42,697,094 (GRCm39) missense probably benign 0.04
R8210:Vmn2r-ps158 UTSW 7 42,673,462 (GRCm39) missense probably benign 0.16
R8379:Vmn2r-ps158 UTSW 7 42,697,270 (GRCm39) missense probably damaging 1.00
R8692:Vmn2r-ps158 UTSW 7 42,697,108 (GRCm39) missense probably benign 0.13
R8917:Vmn2r-ps158 UTSW 7 42,697,433 (GRCm39) missense probably damaging 1.00
R9255:Vmn2r-ps158 UTSW 7 42,673,965 (GRCm39) missense possibly damaging 0.75
R9375:Vmn2r-ps158 UTSW 7 42,673,499 (GRCm39) missense possibly damaging 0.87
R9452:Vmn2r-ps158 UTSW 7 42,697,257 (GRCm39) missense possibly damaging 0.88
R9647:Vmn2r-ps158 UTSW 7 42,697,171 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTACATAACTTCAAGTGCCCATTCC -3'
(R):5'- CCCTGTGAGCCAAAGAAAGG -3'

Sequencing Primer
(F):5'- AACTTCAAGTGCCCATTCCAATTG -3'
(R):5'- TTGAACTCCTGACCTTCGGAAGAG -3'
Posted On 2019-11-12