Incidental Mutation 'R7663:Vmn2r63'
ID |
591707 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r63
|
Ensembl Gene |
ENSMUSG00000090751 |
Gene Name |
vomeronasal 2, receptor 63 |
Synonyms |
EG435975 |
MMRRC Submission |
045738-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.074)
|
Stock # |
R7663 (G1)
|
Quality Score |
157.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
42552675-42583213 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 42576466 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Histidine to Leucine
at position 449
(H449L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000129089
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163803]
|
AlphaFold |
E9Q0K5 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000163803
AA Change: H449L
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
SMART Domains |
Protein: ENSMUSP00000129089 Gene: ENSMUSG00000090751 AA Change: H449L
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
471 |
3.5e-43 |
PFAM |
Pfam:NCD3G
|
514 |
567 |
5.1e-23 |
PFAM |
Pfam:7tm_3
|
600 |
835 |
3.5e-51 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
Validation Efficiency |
99% (68/69) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 74 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1110002E22Rik |
A |
G |
3: 137,771,887 (GRCm39) |
T359A |
probably damaging |
Het |
Abcd4 |
A |
C |
12: 84,652,903 (GRCm39) |
V433G |
probably damaging |
Het |
Acot5 |
C |
A |
12: 84,116,355 (GRCm39) |
R39S |
probably damaging |
Het |
Actl9 |
T |
C |
17: 33,652,443 (GRCm39) |
S168P |
probably damaging |
Het |
Adam15 |
A |
G |
3: 89,253,113 (GRCm39) |
L237P |
probably damaging |
Het |
Ahctf1 |
T |
C |
1: 179,617,879 (GRCm39) |
Q289R |
possibly damaging |
Het |
Arid5b |
C |
T |
10: 67,934,417 (GRCm39) |
G495E |
probably benign |
Het |
Armh1 |
C |
A |
4: 117,070,938 (GRCm39) |
A396S |
probably benign |
Het |
Asah1 |
C |
T |
8: 41,794,664 (GRCm39) |
R385Q |
probably damaging |
Het |
Bicc1 |
T |
C |
10: 70,782,420 (GRCm39) |
T607A |
probably benign |
Het |
Ccdc88a |
T |
C |
11: 29,448,614 (GRCm39) |
|
probably null |
Het |
Cdhr4 |
A |
T |
9: 107,875,971 (GRCm39) |
R750* |
probably null |
Het |
Cep290 |
T |
A |
10: 100,390,398 (GRCm39) |
|
probably null |
Het |
Clca3a1 |
T |
A |
3: 144,442,797 (GRCm39) |
D749V |
probably benign |
Het |
Clcn1 |
C |
T |
6: 42,286,997 (GRCm39) |
P685S |
possibly damaging |
Het |
Clk1 |
A |
G |
1: 58,460,319 (GRCm39) |
S104P |
probably damaging |
Het |
Commd10 |
T |
C |
18: 47,219,323 (GRCm39) |
V172A |
probably benign |
Het |
Cyp2c69 |
A |
T |
19: 39,865,953 (GRCm39) |
C213* |
probably null |
Het |
Dnah14 |
A |
T |
1: 181,579,720 (GRCm39) |
|
probably null |
Het |
Dock2 |
C |
T |
11: 34,611,854 (GRCm39) |
G170R |
probably damaging |
Het |
Fam186a |
T |
G |
15: 99,842,950 (GRCm39) |
H1098P |
probably benign |
Het |
Flt1 |
T |
C |
5: 147,591,930 (GRCm39) |
T511A |
probably benign |
Het |
Fmo1 |
A |
C |
1: 162,663,866 (GRCm39) |
I221S |
possibly damaging |
Het |
Fthl17b |
C |
T |
X: 8,829,043 (GRCm39) |
R9Q |
possibly damaging |
Het |
Fthl17b |
C |
T |
X: 8,829,047 (GRCm39) |
V8M |
possibly damaging |
Het |
Ginm1 |
A |
T |
10: 7,651,126 (GRCm39) |
S93R |
possibly damaging |
Het |
Gm3629 |
A |
C |
14: 17,875,685 (GRCm39) |
|
probably null |
Het |
Gm40460 |
ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
7: 141,794,450 (GRCm39) |
|
probably benign |
Het |
Gys2 |
C |
T |
6: 142,405,211 (GRCm39) |
R192H |
probably damaging |
Het |
H2bw2 |
G |
A |
X: 135,828,471 (GRCm39) |
R120K |
unknown |
Het |
Hectd4 |
C |
A |
5: 121,462,094 (GRCm39) |
A987E |
probably benign |
Het |
Herc2 |
G |
A |
7: 55,786,433 (GRCm39) |
V1593I |
probably benign |
Het |
Ighv14-3 |
T |
C |
12: 114,023,554 (GRCm39) |
T88A |
probably benign |
Het |
Jag2 |
T |
C |
12: 112,877,286 (GRCm39) |
D695G |
probably damaging |
Het |
Kazn |
A |
T |
4: 141,832,209 (GRCm39) |
D663E |
|
Het |
Krt79 |
T |
C |
15: 101,840,278 (GRCm39) |
D306G |
probably damaging |
Het |
Lama1 |
T |
A |
17: 68,087,875 (GRCm39) |
C1498S |
|
Het |
Ldb1 |
T |
C |
19: 46,023,963 (GRCm39) |
Y141C |
probably damaging |
Het |
Lmnb2 |
T |
A |
10: 80,740,573 (GRCm39) |
E336V |
probably damaging |
Het |
Lrp1b |
T |
A |
2: 42,543,047 (GRCm39) |
|
probably benign |
Het |
Mug1 |
C |
A |
6: 121,838,179 (GRCm39) |
H470N |
possibly damaging |
Het |
Mycbp2 |
T |
A |
14: 103,429,045 (GRCm39) |
Y2377F |
probably damaging |
Het |
Neb |
T |
A |
2: 52,120,059 (GRCm39) |
Y721F |
|
Het |
Ntf3 |
A |
G |
6: 126,078,778 (GRCm39) |
S243P |
probably damaging |
Het |
Or4c103 |
G |
C |
2: 88,513,696 (GRCm39) |
P127A |
probably damaging |
Het |
Or52s1 |
T |
C |
7: 102,861,652 (GRCm39) |
M195T |
possibly damaging |
Het |
Or5b121 |
G |
T |
19: 13,507,809 (GRCm39) |
M301I |
probably damaging |
Het |
Pdk1 |
G |
A |
2: 71,705,742 (GRCm39) |
|
probably null |
Het |
Pdzd2 |
A |
G |
15: 12,373,289 (GRCm39) |
V2282A |
probably damaging |
Het |
Piwil1 |
T |
C |
5: 128,824,497 (GRCm39) |
F517L |
probably benign |
Het |
Plch2 |
T |
A |
4: 155,075,619 (GRCm39) |
T738S |
probably damaging |
Het |
Plekhm3 |
G |
A |
1: 64,922,367 (GRCm39) |
R603W |
probably damaging |
Het |
Pltp |
A |
T |
2: 164,698,926 (GRCm39) |
|
probably null |
Het |
Prdm4 |
A |
G |
10: 85,735,145 (GRCm39) |
S666P |
probably damaging |
Het |
Psmb3 |
G |
T |
11: 97,603,318 (GRCm39) |
R177L |
probably damaging |
Het |
Ralgapa2 |
A |
G |
2: 146,260,335 (GRCm39) |
V764A |
probably benign |
Het |
Rel |
T |
C |
11: 23,692,713 (GRCm39) |
D440G |
probably benign |
Het |
Rimoc1 |
T |
C |
15: 4,018,165 (GRCm39) |
Y170C |
probably damaging |
Het |
Rims2 |
T |
A |
15: 39,370,422 (GRCm39) |
V952E |
probably damaging |
Het |
Samd4b |
G |
T |
7: 28,122,925 (GRCm39) |
C44* |
probably null |
Het |
Slamf8 |
C |
A |
1: 172,415,605 (GRCm39) |
V78F |
possibly damaging |
Het |
Slc35a1 |
A |
T |
4: 34,675,493 (GRCm39) |
N111K |
possibly damaging |
Het |
Slc7a5 |
A |
T |
8: 122,614,274 (GRCm39) |
Y264* |
probably null |
Het |
Srsf2 |
T |
C |
11: 116,743,120 (GRCm39) |
S134G |
unknown |
Het |
Stag1 |
T |
A |
9: 100,620,191 (GRCm39) |
M98K |
probably damaging |
Het |
Trib1 |
T |
C |
15: 59,523,562 (GRCm39) |
S199P |
probably damaging |
Het |
Txnip |
T |
C |
3: 96,467,153 (GRCm39) |
S276P |
possibly damaging |
Het |
Vmn1r194 |
C |
T |
13: 22,428,911 (GRCm39) |
T176I |
not run |
Het |
Vmn1r222 |
A |
G |
13: 23,416,601 (GRCm39) |
L204P |
possibly damaging |
Het |
Vmn2r83 |
T |
A |
10: 79,314,956 (GRCm39) |
N401K |
probably damaging |
Het |
Vmn2r87 |
T |
A |
10: 130,308,054 (GRCm39) |
H728L |
probably damaging |
Het |
Zfp69 |
G |
A |
4: 120,792,323 (GRCm39) |
A151V |
probably benign |
Het |
Zfp738 |
A |
G |
13: 67,831,520 (GRCm39) |
|
probably null |
Het |
Zfp974 |
T |
C |
7: 27,611,110 (GRCm39) |
E205G |
possibly damaging |
Het |
|
Other mutations in Vmn2r63 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01399:Vmn2r63
|
APN |
7 |
42,553,543 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01765:Vmn2r63
|
APN |
7 |
42,552,788 (GRCm39) |
missense |
probably benign |
|
IGL02203:Vmn2r63
|
APN |
7 |
42,553,432 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02825:Vmn2r63
|
APN |
7 |
42,576,274 (GRCm39) |
critical splice donor site |
probably null |
|
IGL03155:Vmn2r63
|
APN |
7 |
42,552,878 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03260:Vmn2r63
|
APN |
7 |
42,578,616 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03411:Vmn2r63
|
APN |
7 |
42,577,368 (GRCm39) |
missense |
probably benign |
0.42 |
PIT4280001:Vmn2r63
|
UTSW |
7 |
42,553,409 (GRCm39) |
missense |
probably damaging |
1.00 |
R0066:Vmn2r63
|
UTSW |
7 |
42,576,514 (GRCm39) |
splice site |
probably benign |
|
R0328:Vmn2r63
|
UTSW |
7 |
42,552,699 (GRCm39) |
missense |
probably benign |
0.09 |
R0344:Vmn2r63
|
UTSW |
7 |
42,553,042 (GRCm39) |
missense |
probably damaging |
0.98 |
R0554:Vmn2r63
|
UTSW |
7 |
42,583,129 (GRCm39) |
nonsense |
probably null |
|
R0555:Vmn2r63
|
UTSW |
7 |
42,577,952 (GRCm39) |
nonsense |
probably null |
|
R0685:Vmn2r63
|
UTSW |
7 |
42,577,434 (GRCm39) |
missense |
probably benign |
0.13 |
R0751:Vmn2r63
|
UTSW |
7 |
42,577,459 (GRCm39) |
missense |
probably damaging |
1.00 |
R1349:Vmn2r63
|
UTSW |
7 |
42,578,642 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1372:Vmn2r63
|
UTSW |
7 |
42,578,642 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1416:Vmn2r63
|
UTSW |
7 |
42,577,339 (GRCm39) |
missense |
probably benign |
0.00 |
R1502:Vmn2r63
|
UTSW |
7 |
42,578,015 (GRCm39) |
missense |
possibly damaging |
0.62 |
R1563:Vmn2r63
|
UTSW |
7 |
42,553,550 (GRCm39) |
missense |
probably benign |
0.00 |
R1652:Vmn2r63
|
UTSW |
7 |
42,577,635 (GRCm39) |
missense |
probably benign |
0.32 |
R1693:Vmn2r63
|
UTSW |
7 |
42,577,743 (GRCm39) |
missense |
probably benign |
|
R1698:Vmn2r63
|
UTSW |
7 |
42,583,038 (GRCm39) |
missense |
probably benign |
|
R1753:Vmn2r63
|
UTSW |
7 |
42,577,669 (GRCm39) |
nonsense |
probably null |
|
R2136:Vmn2r63
|
UTSW |
7 |
42,576,297 (GRCm39) |
missense |
probably damaging |
0.99 |
R2175:Vmn2r63
|
UTSW |
7 |
42,583,004 (GRCm39) |
critical splice donor site |
probably null |
|
R2261:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
R2262:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
R2263:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
R3413:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
R3426:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
R3427:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
R3802:Vmn2r63
|
UTSW |
7 |
42,552,829 (GRCm39) |
missense |
probably damaging |
0.99 |
R4319:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
R4321:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
R4323:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
R4346:Vmn2r63
|
UTSW |
7 |
42,577,537 (GRCm39) |
missense |
possibly damaging |
0.67 |
R4568:Vmn2r63
|
UTSW |
7 |
42,583,250 (GRCm39) |
splice site |
probably null |
|
R4649:Vmn2r63
|
UTSW |
7 |
42,553,114 (GRCm39) |
missense |
possibly damaging |
0.79 |
R4653:Vmn2r63
|
UTSW |
7 |
42,553,114 (GRCm39) |
missense |
possibly damaging |
0.79 |
R4679:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
R4734:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
R4741:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
R4748:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
R4806:Vmn2r63
|
UTSW |
7 |
42,576,314 (GRCm39) |
missense |
probably benign |
0.34 |
R4933:Vmn2r63
|
UTSW |
7 |
42,553,402 (GRCm39) |
missense |
probably damaging |
1.00 |
R5198:Vmn2r63
|
UTSW |
7 |
42,553,169 (GRCm39) |
missense |
probably benign |
0.01 |
R5399:Vmn2r63
|
UTSW |
7 |
42,577,701 (GRCm39) |
missense |
probably benign |
|
R5400:Vmn2r63
|
UTSW |
7 |
42,577,635 (GRCm39) |
missense |
probably benign |
0.32 |
R6158:Vmn2r63
|
UTSW |
7 |
42,583,104 (GRCm39) |
missense |
probably damaging |
1.00 |
R6185:Vmn2r63
|
UTSW |
7 |
42,578,435 (GRCm39) |
missense |
probably damaging |
0.98 |
R6267:Vmn2r63
|
UTSW |
7 |
42,578,059 (GRCm39) |
splice site |
probably null |
|
R6362:Vmn2r63
|
UTSW |
7 |
42,552,721 (GRCm39) |
missense |
probably benign |
|
R6706:Vmn2r63
|
UTSW |
7 |
42,578,001 (GRCm39) |
missense |
probably damaging |
1.00 |
R6764:Vmn2r63
|
UTSW |
7 |
42,552,695 (GRCm39) |
missense |
probably damaging |
0.97 |
R7104:Vmn2r63
|
UTSW |
7 |
42,577,959 (GRCm39) |
missense |
possibly damaging |
0.67 |
R7503:Vmn2r63
|
UTSW |
7 |
42,583,014 (GRCm39) |
missense |
probably benign |
0.02 |
R7506:Vmn2r63
|
UTSW |
7 |
42,576,391 (GRCm39) |
missense |
probably damaging |
1.00 |
R7525:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
possibly damaging |
0.52 |
R7658:Vmn2r63
|
UTSW |
7 |
42,574,693 (GRCm39) |
missense |
probably damaging |
1.00 |
R7702:Vmn2r63
|
UTSW |
7 |
42,577,553 (GRCm39) |
missense |
possibly damaging |
0.46 |
R7918:Vmn2r63
|
UTSW |
7 |
42,552,955 (GRCm39) |
missense |
probably damaging |
1.00 |
R8826:Vmn2r63
|
UTSW |
7 |
42,576,441 (GRCm39) |
missense |
probably benign |
0.38 |
R8973:Vmn2r63
|
UTSW |
7 |
42,577,919 (GRCm39) |
missense |
probably benign |
0.19 |
R9024:Vmn2r63
|
UTSW |
7 |
42,577,874 (GRCm39) |
missense |
probably benign |
0.14 |
R9154:Vmn2r63
|
UTSW |
7 |
42,576,413 (GRCm39) |
missense |
probably damaging |
0.96 |
R9731:Vmn2r63
|
UTSW |
7 |
42,553,361 (GRCm39) |
missense |
probably benign |
0.32 |
Z1088:Vmn2r63
|
UTSW |
7 |
42,577,983 (GRCm39) |
missense |
probably benign |
0.09 |
|
Predicted Primers |
PCR Primer
(F):5'- AACTGTGTCGGCCATTGTATC -3'
(R):5'- AGTTGTGGCTAGCTGTTCAAAG -3'
Sequencing Primer
(F):5'- AACTGTGTCGGCCATTGTATCATTTC -3'
(R):5'- TGGCTAGCTGTTCAAAGAATTTTG -3'
|
Posted On |
2019-11-12 |