Incidental Mutation 'R7663:Vmn2r87'
| ID |
591722 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r87
|
| Ensembl Gene |
ENSMUSG00000091511 |
| Gene Name |
vomeronasal 2, receptor 87 |
| Synonyms |
EG625131 |
| MMRRC Submission |
045738-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R7663 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
130307690-130333248 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 130308054 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 728
(H728L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129215
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164227]
|
| AlphaFold |
E9PZX4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164227
AA Change: H728L
PolyPhen 2
Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000129215
Gene: ENSMUSG00000091511
AA Change: H728L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
422 |
1.8e-27 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
1.8e-19 |
PFAM |
|
Pfam:7tm_3
|
595 |
829 |
8.8e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
99% (68/69) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
G |
3: 137,771,887 (GRCm39) |
T359A |
probably damaging |
Het |
| Abcd4 |
A |
C |
12: 84,652,903 (GRCm39) |
V433G |
probably damaging |
Het |
| Acot5 |
C |
A |
12: 84,116,355 (GRCm39) |
R39S |
probably damaging |
Het |
| Actl9 |
T |
C |
17: 33,652,443 (GRCm39) |
S168P |
probably damaging |
Het |
| Adam15 |
A |
G |
3: 89,253,113 (GRCm39) |
L237P |
probably damaging |
Het |
| Ahctf1 |
T |
C |
1: 179,617,879 (GRCm39) |
Q289R |
possibly damaging |
Het |
| Arid5b |
C |
T |
10: 67,934,417 (GRCm39) |
G495E |
probably benign |
Het |
| Armh1 |
C |
A |
4: 117,070,938 (GRCm39) |
A396S |
probably benign |
Het |
| Asah1 |
C |
T |
8: 41,794,664 (GRCm39) |
R385Q |
probably damaging |
Het |
| Bicc1 |
T |
C |
10: 70,782,420 (GRCm39) |
T607A |
probably benign |
Het |
| Ccdc88a |
T |
C |
11: 29,448,614 (GRCm39) |
|
probably null |
Het |
| Cdhr4 |
A |
T |
9: 107,875,971 (GRCm39) |
R750* |
probably null |
Het |
| Cep290 |
T |
A |
10: 100,390,398 (GRCm39) |
|
probably null |
Het |
| Clca3a1 |
T |
A |
3: 144,442,797 (GRCm39) |
D749V |
probably benign |
Het |
| Clcn1 |
C |
T |
6: 42,286,997 (GRCm39) |
P685S |
possibly damaging |
Het |
| Clk1 |
A |
G |
1: 58,460,319 (GRCm39) |
S104P |
probably damaging |
Het |
| Commd10 |
T |
C |
18: 47,219,323 (GRCm39) |
V172A |
probably benign |
Het |
| Cyp2c69 |
A |
T |
19: 39,865,953 (GRCm39) |
C213* |
probably null |
Het |
| Dnah14 |
A |
T |
1: 181,579,720 (GRCm39) |
|
probably null |
Het |
| Dock2 |
C |
T |
11: 34,611,854 (GRCm39) |
G170R |
probably damaging |
Het |
| Fam186a |
T |
G |
15: 99,842,950 (GRCm39) |
H1098P |
probably benign |
Het |
| Flt1 |
T |
C |
5: 147,591,930 (GRCm39) |
T511A |
probably benign |
Het |
| Fmo1 |
A |
C |
1: 162,663,866 (GRCm39) |
I221S |
possibly damaging |
Het |
| Fthl17b |
C |
T |
X: 8,829,043 (GRCm39) |
R9Q |
possibly damaging |
Het |
| Fthl17b |
C |
T |
X: 8,829,047 (GRCm39) |
V8M |
possibly damaging |
Het |
| Ginm1 |
A |
T |
10: 7,651,126 (GRCm39) |
S93R |
possibly damaging |
Het |
| Gm3629 |
A |
C |
14: 17,875,685 (GRCm39) |
|
probably null |
Het |
| Gm40460 |
ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
7: 141,794,450 (GRCm39) |
|
probably benign |
Het |
| Gys2 |
C |
T |
6: 142,405,211 (GRCm39) |
R192H |
probably damaging |
Het |
| H2bw2 |
G |
A |
X: 135,828,471 (GRCm39) |
R120K |
unknown |
Het |
| Hectd4 |
C |
A |
5: 121,462,094 (GRCm39) |
A987E |
probably benign |
Het |
| Herc2 |
G |
A |
7: 55,786,433 (GRCm39) |
V1593I |
probably benign |
Het |
| Ighv14-3 |
T |
C |
12: 114,023,554 (GRCm39) |
T88A |
probably benign |
Het |
| Jag2 |
T |
C |
12: 112,877,286 (GRCm39) |
D695G |
probably damaging |
Het |
| Kazn |
A |
T |
4: 141,832,209 (GRCm39) |
D663E |
|
Het |
| Krt79 |
T |
C |
15: 101,840,278 (GRCm39) |
D306G |
probably damaging |
Het |
| Lama1 |
T |
A |
17: 68,087,875 (GRCm39) |
C1498S |
|
Het |
| Ldb1 |
T |
C |
19: 46,023,963 (GRCm39) |
Y141C |
probably damaging |
Het |
| Lmnb2 |
T |
A |
10: 80,740,573 (GRCm39) |
E336V |
probably damaging |
Het |
| Lrp1b |
T |
A |
2: 42,543,047 (GRCm39) |
|
probably benign |
Het |
| Mug1 |
C |
A |
6: 121,838,179 (GRCm39) |
H470N |
possibly damaging |
Het |
| Mycbp2 |
T |
A |
14: 103,429,045 (GRCm39) |
Y2377F |
probably damaging |
Het |
| Neb |
T |
A |
2: 52,120,059 (GRCm39) |
Y721F |
|
Het |
| Ntf3 |
A |
G |
6: 126,078,778 (GRCm39) |
S243P |
probably damaging |
Het |
| Or4c103 |
G |
C |
2: 88,513,696 (GRCm39) |
P127A |
probably damaging |
Het |
| Or52s1 |
T |
C |
7: 102,861,652 (GRCm39) |
M195T |
possibly damaging |
Het |
| Or5b121 |
G |
T |
19: 13,507,809 (GRCm39) |
M301I |
probably damaging |
Het |
| Pdk1 |
G |
A |
2: 71,705,742 (GRCm39) |
|
probably null |
Het |
| Pdzd2 |
A |
G |
15: 12,373,289 (GRCm39) |
V2282A |
probably damaging |
Het |
| Piwil1 |
T |
C |
5: 128,824,497 (GRCm39) |
F517L |
probably benign |
Het |
| Plch2 |
T |
A |
4: 155,075,619 (GRCm39) |
T738S |
probably damaging |
Het |
| Plekhm3 |
G |
A |
1: 64,922,367 (GRCm39) |
R603W |
probably damaging |
Het |
| Pltp |
A |
T |
2: 164,698,926 (GRCm39) |
|
probably null |
Het |
| Prdm4 |
A |
G |
10: 85,735,145 (GRCm39) |
S666P |
probably damaging |
Het |
| Psmb3 |
G |
T |
11: 97,603,318 (GRCm39) |
R177L |
probably damaging |
Het |
| Ralgapa2 |
A |
G |
2: 146,260,335 (GRCm39) |
V764A |
probably benign |
Het |
| Rel |
T |
C |
11: 23,692,713 (GRCm39) |
D440G |
probably benign |
Het |
| Rimoc1 |
T |
C |
15: 4,018,165 (GRCm39) |
Y170C |
probably damaging |
Het |
| Rims2 |
T |
A |
15: 39,370,422 (GRCm39) |
V952E |
probably damaging |
Het |
| Samd4b |
G |
T |
7: 28,122,925 (GRCm39) |
C44* |
probably null |
Het |
| Slamf8 |
C |
A |
1: 172,415,605 (GRCm39) |
V78F |
possibly damaging |
Het |
| Slc35a1 |
A |
T |
4: 34,675,493 (GRCm39) |
N111K |
possibly damaging |
Het |
| Slc7a5 |
A |
T |
8: 122,614,274 (GRCm39) |
Y264* |
probably null |
Het |
| Srsf2 |
T |
C |
11: 116,743,120 (GRCm39) |
S134G |
unknown |
Het |
| Stag1 |
T |
A |
9: 100,620,191 (GRCm39) |
M98K |
probably damaging |
Het |
| Trib1 |
T |
C |
15: 59,523,562 (GRCm39) |
S199P |
probably damaging |
Het |
| Txnip |
T |
C |
3: 96,467,153 (GRCm39) |
S276P |
possibly damaging |
Het |
| Vmn1r194 |
C |
T |
13: 22,428,911 (GRCm39) |
T176I |
not run |
Het |
| Vmn1r222 |
A |
G |
13: 23,416,601 (GRCm39) |
L204P |
possibly damaging |
Het |
| Vmn2r63 |
T |
A |
7: 42,576,466 (GRCm39) |
H449L |
probably benign |
Het |
| Vmn2r83 |
T |
A |
10: 79,314,956 (GRCm39) |
N401K |
probably damaging |
Het |
| Zfp69 |
G |
A |
4: 120,792,323 (GRCm39) |
A151V |
probably benign |
Het |
| Zfp738 |
A |
G |
13: 67,831,520 (GRCm39) |
|
probably null |
Het |
| Zfp974 |
T |
C |
7: 27,611,110 (GRCm39) |
E205G |
possibly damaging |
Het |
|
| Other mutations in Vmn2r87 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01090:Vmn2r87
|
APN |
10 |
130,333,247 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
IGL01295:Vmn2r87
|
APN |
10 |
130,307,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01411:Vmn2r87
|
APN |
10 |
130,308,429 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01680:Vmn2r87
|
APN |
10 |
130,315,586 (GRCm39) |
nonsense |
probably null |
|
|
IGL01822:Vmn2r87
|
APN |
10 |
130,307,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Vmn2r87
|
APN |
10 |
130,314,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01965:Vmn2r87
|
APN |
10 |
130,314,924 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02562:Vmn2r87
|
APN |
10 |
130,314,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02665:Vmn2r87
|
APN |
10 |
130,333,049 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03202:Vmn2r87
|
APN |
10 |
130,333,091 (GRCm39) |
missense |
probably benign |
|
|
FR4304:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4340:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4342:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4589:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
LCD18:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0344:Vmn2r87
|
UTSW |
10 |
130,315,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0374:Vmn2r87
|
UTSW |
10 |
130,307,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0384:Vmn2r87
|
UTSW |
10 |
130,307,712 (GRCm39) |
missense |
probably benign |
|
|
R1144:Vmn2r87
|
UTSW |
10 |
130,312,098 (GRCm39) |
splice site |
probably benign |
|
|
R1172:Vmn2r87
|
UTSW |
10 |
130,313,453 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1860:Vmn2r87
|
UTSW |
10 |
130,315,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1866:Vmn2r87
|
UTSW |
10 |
130,308,441 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1897:Vmn2r87
|
UTSW |
10 |
130,307,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2360:Vmn2r87
|
UTSW |
10 |
130,315,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2909:Vmn2r87
|
UTSW |
10 |
130,314,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3874:Vmn2r87
|
UTSW |
10 |
130,315,856 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4113:Vmn2r87
|
UTSW |
10 |
130,315,691 (GRCm39) |
missense |
probably benign |
|
|
R4190:Vmn2r87
|
UTSW |
10 |
130,308,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4197:Vmn2r87
|
UTSW |
10 |
130,315,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4201:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4202:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4368:Vmn2r87
|
UTSW |
10 |
130,315,676 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4485:Vmn2r87
|
UTSW |
10 |
130,315,678 (GRCm39) |
nonsense |
probably null |
|
|
R4537:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4590:Vmn2r87
|
UTSW |
10 |
130,315,014 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4752:Vmn2r87
|
UTSW |
10 |
130,314,336 (GRCm39) |
nonsense |
probably null |
|
|
R4873:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4875:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4923:Vmn2r87
|
UTSW |
10 |
130,314,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4970:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Vmn2r87
|
UTSW |
10 |
130,308,298 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5112:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5187:Vmn2r87
|
UTSW |
10 |
130,333,208 (GRCm39) |
missense |
probably null |
0.99 |
|
R5618:Vmn2r87
|
UTSW |
10 |
130,315,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Vmn2r87
|
UTSW |
10 |
130,308,226 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6220:Vmn2r87
|
UTSW |
10 |
130,315,807 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6287:Vmn2r87
|
UTSW |
10 |
130,314,291 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6383:Vmn2r87
|
UTSW |
10 |
130,314,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6576:Vmn2r87
|
UTSW |
10 |
130,314,654 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6742:Vmn2r87
|
UTSW |
10 |
130,308,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7086:Vmn2r87
|
UTSW |
10 |
130,333,178 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7162:Vmn2r87
|
UTSW |
10 |
130,313,416 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7419:Vmn2r87
|
UTSW |
10 |
130,307,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7425:Vmn2r87
|
UTSW |
10 |
130,314,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7443:Vmn2r87
|
UTSW |
10 |
130,308,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7571:Vmn2r87
|
UTSW |
10 |
130,314,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7716:Vmn2r87
|
UTSW |
10 |
130,308,018 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7793:Vmn2r87
|
UTSW |
10 |
130,313,413 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7806:Vmn2r87
|
UTSW |
10 |
130,315,679 (GRCm39) |
missense |
probably benign |
|
|
R7841:Vmn2r87
|
UTSW |
10 |
130,333,095 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8326:Vmn2r87
|
UTSW |
10 |
130,308,180 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8411:Vmn2r87
|
UTSW |
10 |
130,308,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8445:Vmn2r87
|
UTSW |
10 |
130,313,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8540:Vmn2r87
|
UTSW |
10 |
130,314,762 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8892:Vmn2r87
|
UTSW |
10 |
130,308,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9093:Vmn2r87
|
UTSW |
10 |
130,308,165 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9623:Vmn2r87
|
UTSW |
10 |
130,315,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9667:Vmn2r87
|
UTSW |
10 |
130,314,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,312,064 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,308,138 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r87
|
UTSW |
10 |
130,308,183 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Vmn2r87
|
UTSW |
10 |
130,307,713 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAACACCAGCATGCTGAAAG -3'
(R):5'- TCCTGCAGCAGACCACATTTG -3'
Sequencing Primer
(F):5'- CCAGCATGCTGAAAGTTAGGAACTTG -3'
(R):5'- CTGTTTCTACAGTGTTGGCCAAAAC -3'
|
| Posted On |
2019-11-12 |
Incidental Mutation