Mutagenetix > Incidental Mutation

Incidental Mutation 'R7664:Acaca'

591807

Institutional Source

Beutler Lab

Gene Symbol

Acaca

Ensembl Gene

ENSMUSG00000020532

Gene Name

acetyl-Coenzyme A carboxylase alpha

Synonyms

LOC327983, Acac, A530025K05Rik, acetyl-CoA carboxylase, Acc1

MMRRC Submission

045704-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7664 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

84129672-84401651 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 84245349 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 510 (T510I)

Ref Sequence

ENSEMBL: ENSMUSP00000020843 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020843] [ENSMUST00000103201]

AlphaFold

Q5SWU9

Predicted Effect

probably damaging
Transcript: ENSMUST00000020843
AA Change: T510I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000020843
Gene: ENSMUSG00000020532
AA Change: T510I

Domain	Start	End	E-Value	Type
Pfam:CPSase_L_chain	116	236	4.7e-33	PFAM
Pfam:CPSase_L_D2	272	472	2.5e-55	PFAM
Pfam:ATP-grasp	280	443	4.3e-7	PFAM
Pfam:ATP-grasp_4	282	442	1.9e-11	PFAM
Pfam:Dala_Dala_lig_C	284	440	5.4e-7	PFAM
Biotin_carb_C	506	613	3.76e-24	SMART
low complexity region	708	725	N/A	INTRINSIC
Pfam:Biotin_lipoyl	751	817	9.8e-19	PFAM
Pfam:ACC_central	818	1568	2.1e-288	PFAM
Pfam:Carboxyl_trans	1668	2222	1.6e-185	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000103201
AA Change: T510I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000099490
Gene: ENSMUSG00000020532
AA Change: T510I

Domain	Start	End	E-Value	Type
Pfam:CPSase_L_chain	116	236	6.7e-29	PFAM
Pfam:ATP-grasp_4	239	442	2e-15	PFAM
Pfam:CPSase_L_D2	272	472	3.3e-55	PFAM
Pfam:Dala_Dala_lig_C	279	440	3e-7	PFAM
Pfam:ATP-grasp	281	442	1.1e-6	PFAM
Biotin_carb_C	506	613	3.76e-24	SMART
low complexity region	708	725	N/A	INTRINSIC
Pfam:Biotin_lipoyl	751	817	3.7e-18	PFAM
Pfam:ACC_central	818	1568	3.5e-253	PFAM
Pfam:Carboxyl_trans	1668	2222	2.7e-175	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

99% (83/84)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice display embryonic lethality before embryo turning with growth arrest at the egg cylinder stage. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 86 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A430078G23Rik	A	T	8: 3,386,390 (GRCm38)	E228V	probably damaging	Het
Akap12	G	T	10: 4,353,748 (GRCm38)	W291L	probably damaging	Het
Akip1	A	T	7: 109,708,980 (GRCm38)	I152F	probably benign	Het
Alpk2	T	A	18: 65,307,002 (GRCm38)	Y440F	probably benign	Het
Aox3	A	G	1: 58,119,539 (GRCm38)	T90A	probably damaging	Het
B4galnt4	A	G	7: 141,067,713 (GRCm38)	K405E	probably damaging	Het
BC034090	T	C	1: 155,241,631 (GRCm38)	E247G	probably damaging	Het
Camkk2	A	T	5: 122,756,582 (GRCm38)	F216I	unknown	Het
Carm1	A	C	9: 21,586,990 (GRCm38)	K430T	probably benign	Het
Ccdc13	A	G	9: 121,814,213 (GRCm38)	V374A	probably benign	Het
Cdh26	T	A	2: 178,470,042 (GRCm38)	M465K	probably benign	Het
Ceacam10	A	T	7: 24,778,332 (GRCm38)	M91L	probably benign	Het
Chrnb1	T	C	11: 69,787,024 (GRCm38)	T301A	possibly damaging	Het
Clec4a3	A	G	6: 122,966,422 (GRCm38)	D101G	probably benign	Het
Cmss1	G	A	16: 57,317,947 (GRCm38)	P59S	probably benign	Het
Crhr1	T	A	11: 104,169,142 (GRCm38)	F138L	probably benign	Het
Cxcl5	A	T	5: 90,760,031 (GRCm38)	I107F	probably damaging	Het
Cxcr1	A	G	1: 74,192,675 (GRCm38)	S63P	probably damaging	Het
Cxcr5	A	G	9: 44,513,310 (GRCm38)	L350P	probably benign	Het
D5Ertd579e	A	T	5: 36,614,617 (GRCm38)	H811Q	probably benign	Het
Ddx46	T	G	13: 55,659,051 (GRCm38)	I499S	probably damaging	Het
Ddx51	T	G	5: 110,656,919 (GRCm38)		probably null	Het
Dnaja1	C	T	4: 40,724,090 (GRCm38)	P84S	probably benign	Het
Dnajc27	A	G	12: 4,103,132 (GRCm38)	K203E	possibly damaging	Het
Fam107b	T	A	2: 3,570,710 (GRCm38)	C24S	probably damaging	Het
Fancg	T	C	4: 43,010,066 (GRCm38)	K11R	probably benign	Het
Fnip1	T	C	11: 54,466,125 (GRCm38)	L44P	probably damaging	Het
Fthl17b	C	T	X: 8,962,804 (GRCm38)	R9Q	possibly damaging	Het
Fthl17b	C	T	X: 8,962,808 (GRCm38)	V8M	possibly damaging	Het
Heca	A	T	10: 17,902,370 (GRCm38)	L493Q	probably damaging	Het
Hrh2	C	T	13: 54,214,856 (GRCm38)	P284S	probably damaging	Het
Ifnar1	C	G	16: 91,495,194 (GRCm38)	A141G	probably damaging	Het
Igkv6-32	T	A	6: 70,074,298 (GRCm38)	T25S	probably damaging	Het
Inppl1	T	C	7: 101,830,097 (GRCm38)	H525R	probably damaging	Het
Itga2b	A	G	11: 102,460,840 (GRCm38)	L553P	probably damaging	Het
Itgbl1	A	G	14: 123,846,550 (GRCm38)	Y280C	probably damaging	Het
Kap	T	C	6: 133,851,957 (GRCm38)	I54V	probably benign	Het
Kcnh4	G	T	11: 100,750,322 (GRCm38)	L434M	probably damaging	Het
Klhl14	T	C	18: 21,554,649 (GRCm38)	D572G	probably damaging	Het
Klhl41	T	A	2: 69,670,717 (GRCm38)	L174Q	probably damaging	Het
Lrp2	T	G	2: 69,506,732 (GRCm38)	H1232P	probably damaging	Het
Lyar	A	G	5: 38,230,817 (GRCm38)	E229G	probably benign	Het
Mark4	A	T	7: 19,443,226 (GRCm38)	L226Q	probably damaging	Het
Mcm8	A	G	2: 132,843,533 (GRCm38)	K823R	probably damaging	Het
Mfsd6	A	T	1: 52,709,053 (GRCm38)	S218T	probably benign	Het
Mlip	A	T	9: 77,138,546 (GRCm38)	I884N	possibly damaging	Het
Mmrn1	A	G	6: 60,976,705 (GRCm38)	T657A	probably benign	Het
Morc2b	A	G	17: 33,136,402 (GRCm38)	Y799H	probably benign	Het
Muc16	A	T	9: 18,607,722 (GRCm38)	I6304N	probably benign	Het
Mug1	C	A	6: 121,861,220 (GRCm38)	H470N	possibly damaging	Het
Naaladl2	T	C	3: 24,058,139 (GRCm38)	Y593C	probably damaging	Het
Ncor1	T	C	11: 62,398,328 (GRCm38)	E341G	probably damaging	Het
Nrg1	G	T	8: 32,009,141 (GRCm38)		probably null	Het
Nudt3	A	G	17: 27,623,175 (GRCm38)	L4P	probably benign	Het
Odf2l	T	A	3: 145,148,584 (GRCm38)	H493Q	probably benign	Het
Ost4	A	C	5: 30,907,663 (GRCm38)		probably null	Het
Patj	A	T	4: 98,496,950 (GRCm38)	Q840L	possibly damaging	Het
Pcdh20	T	A	14: 88,469,367 (GRCm38)	T166S	probably benign	Het
Pcdhb4	T	A	18: 37,309,240 (GRCm38)	D534E	probably damaging	Het
Pik3ap1	T	C	19: 41,321,630 (GRCm38)	D417G	possibly damaging	Het
Ppwd1	A	T	13: 104,220,290 (GRCm38)	V239E	probably damaging	Het
Prdm9	T	A	17: 15,555,571 (GRCm38)	Y206F	probably damaging	Het
Ranbp6	A	G	19: 29,812,076 (GRCm38)	V292A	possibly damaging	Het
Rgs21	T	A	1: 144,541,249 (GRCm38)	M22L	probably benign	Het
Rnf17	A	T	14: 56,438,878 (GRCm38)	I399F	probably damaging	Het
Rph3a	T	A	5: 120,961,276 (GRCm38)	Q184L	probably benign	Het
Scrn3	T	C	2: 73,319,370 (GRCm38)	Y137H	possibly damaging	Het
Sec14l4	C	A	11: 4,044,178 (GRCm38)	Y342*	probably null	Het
Serpinb11	G	A	1: 107,379,988 (GRCm38)	G383D	probably damaging	Het
Sf3b1	A	G	1: 54,987,467 (GRCm38)	V1261A	probably damaging	Het
Sh3tc2	C	T	18: 62,014,971 (GRCm38)	Q1251*	probably null	Het
Skor1	A	T	9: 63,141,763 (GRCm38)	D845E	probably benign	Het
Slc39a7	A	G	17: 34,029,577 (GRCm38)	L364P	probably damaging	Het
Snrpn	T	C	7: 59,987,491 (GRCm38)	I26V	probably benign	Het
Snx5	A	T	2: 144,258,004 (GRCm38)		probably null	Het
Spag9	T	C	11: 94,102,160 (GRCm38)		probably null	Het
Srrm2	T	C	17: 23,820,981 (GRCm38)	S2200P	probably damaging	Het
Stx11	T	C	10: 12,941,326 (GRCm38)	E218G	probably damaging	Het
Tmem151b	T	C	17: 45,545,935 (GRCm38)	N193S	probably damaging	Het
Tmem87b	A	T	2: 128,849,054 (GRCm38)	D525V	possibly damaging	Het
Ubtfl1	A	T	9: 18,409,486 (GRCm38)	R103S	possibly damaging	Het
Vmn1r196	T	A	13: 22,293,762 (GRCm38)	D190E	probably damaging	Het
Vmn2r67	T	A	7: 85,155,811 (GRCm38)	D31V	probably benign	Het
Zbtb22	T	A	17: 33,918,579 (GRCm38)	M566K	probably benign	Het
Zfp568	A	T	7: 30,022,290 (GRCm38)	H220L	probably benign	Het
Zfp974	A	T	7: 27,910,712 (GRCm38)	S529R	possibly damaging	Het

Other mutations in Acaca

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00544:Acaca	APN	11	84,278,917 (GRCm38)	missense	probably damaging	1.00
IGL01134:Acaca	APN	11	84,251,279 (GRCm38)	missense	probably benign	0.22
IGL01446:Acaca	APN	11	84,260,631 (GRCm38)	missense	probably damaging	1.00
IGL01591:Acaca	APN	11	84,243,320 (GRCm38)	missense	probably damaging	1.00
IGL01663:Acaca	APN	11	84,277,802 (GRCm38)	missense	possibly damaging	0.85
IGL01767:Acaca	APN	11	84,320,542 (GRCm38)	missense	probably benign	0.01
IGL02206:Acaca	APN	11	84,260,747 (GRCm38)	nonsense	probably null
IGL02335:Acaca	APN	11	84,214,258 (GRCm38)	missense	possibly damaging	0.84
IGL02477:Acaca	APN	11	84,307,168 (GRCm38)	splice site	probably benign
IGL02515:Acaca	APN	11	84,262,403 (GRCm38)	missense	probably benign
IGL02651:Acaca	APN	11	84,245,204 (GRCm38)	splice site	probably benign
IGL02805:Acaca	APN	11	84,223,133 (GRCm38)	splice site	probably benign
IGL03328:Acaca	APN	11	84,320,529 (GRCm38)	missense	probably benign	0.00
effervescence	UTSW	11	84,262,474 (GRCm38)	missense	probably benign	0.41
fizz	UTSW	11	84,245,856 (GRCm38)	missense	probably damaging	0.98
greenhouse	UTSW	11	84,338,356 (GRCm38)	missense	probably damaging	1.00
Serene	UTSW	11	84,311,409 (GRCm38)	splice site	probably null
Tranquil	UTSW	11	84,280,461 (GRCm38)	missense	probably damaging	1.00
vitamin	UTSW	11	84,280,435 (GRCm38)	missense	possibly damaging	0.78
ANU05:Acaca	UTSW	11	84,315,852 (GRCm38)	missense	probably damaging	1.00
R0385:Acaca	UTSW	11	84,231,748 (GRCm38)	missense	probably benign	0.01
R0518:Acaca	UTSW	11	84,290,286 (GRCm38)	critical splice acceptor site	probably null
R0536:Acaca	UTSW	11	84,280,516 (GRCm38)	splice site	probably benign
R0962:Acaca	UTSW	11	84,311,303 (GRCm38)	missense	probably damaging	1.00
R0968:Acaca	UTSW	11	84,239,033 (GRCm38)	nonsense	probably null
R1123:Acaca	UTSW	11	84,264,080 (GRCm38)	missense	probably benign	0.09
R1452:Acaca	UTSW	11	84,295,059 (GRCm38)	splice site	probably benign
R1478:Acaca	UTSW	11	84,372,627 (GRCm38)	missense	probably damaging	1.00
R1500:Acaca	UTSW	11	84,293,984 (GRCm38)	missense	probably benign	0.00
R1512:Acaca	UTSW	11	84,195,469 (GRCm38)	missense	probably benign	0.00
R1657:Acaca	UTSW	11	84,264,084 (GRCm38)	missense	probably benign	0.09
R1681:Acaca	UTSW	11	84,226,185 (GRCm38)	missense	probably damaging	1.00
R1682:Acaca	UTSW	11	84,392,217 (GRCm38)	missense	probably benign	0.23
R1688:Acaca	UTSW	11	84,238,896 (GRCm38)	missense	probably damaging	1.00
R1755:Acaca	UTSW	11	84,276,564 (GRCm38)	frame shift	probably null
R1775:Acaca	UTSW	11	84,300,422 (GRCm38)	missense	possibly damaging	0.56
R1793:Acaca	UTSW	11	84,338,393 (GRCm38)	missense	probably damaging	1.00
R1793:Acaca	UTSW	11	84,315,969 (GRCm38)	missense	probably damaging	0.98
R1855:Acaca	UTSW	11	84,371,554 (GRCm38)	missense	probably damaging	0.96
R1881:Acaca	UTSW	11	84,300,471 (GRCm38)	splice site	probably benign
R1881:Acaca	UTSW	11	84,270,387 (GRCm38)	nonsense	probably null
R1989:Acaca	UTSW	11	84,262,529 (GRCm38)	missense	probably damaging	0.98
R2147:Acaca	UTSW	11	84,276,536 (GRCm38)	missense	probably benign	0.03
R2215:Acaca	UTSW	11	84,363,793 (GRCm38)	missense	probably damaging	1.00
R2238:Acaca	UTSW	11	84,391,505 (GRCm38)	splice site	probably benign
R2252:Acaca	UTSW	11	84,371,532 (GRCm38)	missense	probably damaging	0.99
R2316:Acaca	UTSW	11	84,294,983 (GRCm38)	missense	possibly damaging	0.69
R2316:Acaca	UTSW	11	84,264,080 (GRCm38)	missense	probably benign	0.16
R2337:Acaca	UTSW	11	84,257,197 (GRCm38)	missense	possibly damaging	0.93
R2697:Acaca	UTSW	11	84,364,413 (GRCm38)	missense	probably damaging	1.00
R3551:Acaca	UTSW	11	84,261,624 (GRCm38)	missense	probably damaging	1.00
R3552:Acaca	UTSW	11	84,261,624 (GRCm38)	missense	probably damaging	1.00
R3748:Acaca	UTSW	11	84,311,409 (GRCm38)	splice site	probably null
R3844:Acaca	UTSW	11	84,364,413 (GRCm38)	missense	probably damaging	1.00
R3873:Acaca	UTSW	11	84,312,721 (GRCm38)	unclassified	probably benign
R4152:Acaca	UTSW	11	84,292,926 (GRCm38)	missense	possibly damaging	0.88
R4406:Acaca	UTSW	11	84,280,449 (GRCm38)	missense	probably benign	0.35
R4448:Acaca	UTSW	11	84,262,492 (GRCm38)	missense	probably damaging	1.00
R4642:Acaca	UTSW	11	84,280,461 (GRCm38)	missense	probably damaging	1.00
R4696:Acaca	UTSW	11	84,280,435 (GRCm38)	missense	possibly damaging	0.78
R4707:Acaca	UTSW	11	84,312,854 (GRCm38)	missense	probably damaging	0.96
R4710:Acaca	UTSW	11	84,392,337 (GRCm38)	missense	possibly damaging	0.84
R4775:Acaca	UTSW	11	84,243,339 (GRCm38)	missense	probably damaging	1.00
R4821:Acaca	UTSW	11	84,294,987 (GRCm38)	missense	possibly damaging	0.69
R4883:Acaca	UTSW	11	84,251,290 (GRCm38)	missense	probably benign	0.01
R4988:Acaca	UTSW	11	84,263,295 (GRCm38)	missense	probably damaging	1.00
R5034:Acaca	UTSW	11	84,245,264 (GRCm38)	missense	probably benign	0.00
R5255:Acaca	UTSW	11	84,311,307 (GRCm38)	missense	probably damaging	1.00
R5294:Acaca	UTSW	11	84,391,519 (GRCm38)	missense	probably benign	0.01
R5350:Acaca	UTSW	11	84,215,873 (GRCm38)	missense	probably damaging	0.99
R5437:Acaca	UTSW	11	84,346,820 (GRCm38)	splice site	probably null
R5664:Acaca	UTSW	11	84,243,384 (GRCm38)	missense	probably damaging	1.00
R5665:Acaca	UTSW	11	84,245,294 (GRCm38)	nonsense	probably null
R5959:Acaca	UTSW	11	84,215,966 (GRCm38)	missense	probably damaging	1.00
R6011:Acaca	UTSW	11	84,245,744 (GRCm38)	missense	probably benign	0.44
R6027:Acaca	UTSW	11	84,398,177 (GRCm38)	missense	probably benign
R6246:Acaca	UTSW	11	84,315,970 (GRCm38)	missense	probably benign	0.08
R6313:Acaca	UTSW	11	84,292,929 (GRCm38)	missense	probably benign	0.00
R6450:Acaca	UTSW	11	84,280,468 (GRCm38)	missense	probably damaging	0.98
R6623:Acaca	UTSW	11	84,371,499 (GRCm38)	critical splice acceptor site	probably null
R6736:Acaca	UTSW	11	84,238,838 (GRCm38)	missense	probably benign	0.05
R6752:Acaca	UTSW	11	84,195,483 (GRCm38)	missense	probably benign	0.44
R6807:Acaca	UTSW	11	84,391,530 (GRCm38)	missense	probably benign
R6826:Acaca	UTSW	11	84,195,536 (GRCm38)	missense	probably damaging	1.00
R7035:Acaca	UTSW	11	84,238,943 (GRCm38)	missense	probably damaging	1.00
R7078:Acaca	UTSW	11	84,263,312 (GRCm38)	missense	possibly damaging	0.91
R7088:Acaca	UTSW	11	84,278,957 (GRCm38)	critical splice donor site	probably null
R7201:Acaca	UTSW	11	84,262,474 (GRCm38)	missense	probably benign	0.41
R7261:Acaca	UTSW	11	84,368,700 (GRCm38)	missense	probably damaging	1.00
R7399:Acaca	UTSW	11	84,260,679 (GRCm38)	missense	possibly damaging	0.89
R7421:Acaca	UTSW	11	84,363,736 (GRCm38)	missense	possibly damaging	0.64
R7443:Acaca	UTSW	11	84,315,793 (GRCm38)	missense	probably benign	0.02
R7453:Acaca	UTSW	11	84,245,310 (GRCm38)	missense	probably benign
R7471:Acaca	UTSW	11	84,277,782 (GRCm38)	splice site	probably null
R7519:Acaca	UTSW	11	84,245,856 (GRCm38)	missense	probably damaging	0.98
R7537:Acaca	UTSW	11	84,260,634 (GRCm38)	missense	probably damaging	1.00
R7574:Acaca	UTSW	11	84,261,588 (GRCm38)	missense	probably benign
R7633:Acaca	UTSW	11	84,372,639 (GRCm38)	missense	probably benign	0.26
R7643:Acaca	UTSW	11	84,338,356 (GRCm38)	missense	probably damaging	1.00
R7675:Acaca	UTSW	11	84,315,916 (GRCm38)	missense	probably benign	0.04
R7676:Acaca	UTSW	11	84,294,987 (GRCm38)	missense	possibly damaging	0.69
R7729:Acaca	UTSW	11	84,371,513 (GRCm38)	missense	probably damaging	0.98
R7867:Acaca	UTSW	11	84,249,524 (GRCm38)	missense	possibly damaging	0.88
R7898:Acaca	UTSW	11	84,364,449 (GRCm38)	critical splice donor site	probably null
R7909:Acaca	UTSW	11	84,245,235 (GRCm38)	missense	possibly damaging	0.56
R7915:Acaca	UTSW	11	84,276,588 (GRCm38)	missense	probably benign
R7956:Acaca	UTSW	11	84,320,580 (GRCm38)	missense	probably damaging	0.98
R8000:Acaca	UTSW	11	84,392,231 (GRCm38)	missense	possibly damaging	0.88
R8038:Acaca	UTSW	11	84,215,904 (GRCm38)	missense	probably damaging	1.00
R8545:Acaca	UTSW	11	84,345,968 (GRCm38)	missense	probably damaging	1.00
R8722:Acaca	UTSW	11	84,338,457 (GRCm38)	missense	possibly damaging	0.85
R9005:Acaca	UTSW	11	84,371,584 (GRCm38)	missense	probably damaging	0.99
R9130:Acaca	UTSW	11	84,311,319 (GRCm38)	missense	probably damaging	1.00
R9397:Acaca	UTSW	11	84,368,725 (GRCm38)	missense	probably damaging	1.00
R9489:Acaca	UTSW	11	84,293,016 (GRCm38)	missense	probably benign	0.01
R9540:Acaca	UTSW	11	84,243,411 (GRCm38)	missense	probably damaging	1.00
R9593:Acaca	UTSW	11	84,380,513 (GRCm38)	nonsense	probably null
R9605:Acaca	UTSW	11	84,293,016 (GRCm38)	missense	probably benign	0.01
R9634:Acaca	UTSW	11	84,293,990 (GRCm38)	missense	probably benign	0.00
R9720:Acaca	UTSW	11	84,263,357 (GRCm38)	missense	probably damaging	1.00
RF014:Acaca	UTSW	11	84,231,724 (GRCm38)	missense	probably benign	0.01
X0027:Acaca	UTSW	11	84,292,895 (GRCm38)	missense	probably benign	0.01
X0060:Acaca	UTSW	11	84,264,104 (GRCm38)	missense	probably benign
X0067:Acaca	UTSW	11	84,368,737 (GRCm38)	nonsense	probably null
Z1176:Acaca	UTSW	11	84,260,720 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TTGATAGCTCCCCTCTGTTAAGG -3'
(R):5'- CAAATCACGGATGCTTCCTG -3'

Sequencing Primer
(F):5'- GGGACTGTGGAAAGTGACATGTG -3'
(R):5'- AATCACGGATGCTTCCTGAGTGAC -3'

Posted On

2019-11-12