Incidental Mutation 'R7665:Olfr615'
ID 591860
Institutional Source Beutler Lab
Gene Symbol Olfr615
Ensembl Gene ENSMUSG00000073947
Gene Name olfactory receptor 615
Synonyms GA_x6K02T2PBJ9-6284902-6285843, MOR19-2
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R7665 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 103556079-103563798 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 103561316 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 280 (I280F)
Ref Sequence ENSEMBL: ENSMUSP00000148872 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098198] [ENSMUST00000106886] [ENSMUST00000214345] [ENSMUST00000214806] [ENSMUST00000215673] [ENSMUST00000217293]
AlphaFold Q8VGY4
Predicted Effect probably benign
Transcript: ENSMUST00000098198
AA Change: I280F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000095800
Gene: ENSMUSG00000073947
AA Change: I280F

DomainStartEndE-ValueType
Pfam:7tm_4 32 311 2.5e-105 PFAM
Pfam:7TM_GPCR_Srsx 36 253 8.5e-9 PFAM
Pfam:7tm_1 42 293 8.2e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106886
SMART Domains Protein: ENSMUSP00000102499
Gene: ENSMUSG00000047544

DomainStartEndE-ValueType
low complexity region 11 22 N/A INTRINSIC
Pfam:7tm_4 33 311 1.1e-116 PFAM
Pfam:7TM_GPCR_Srsx 37 309 1.2e-6 PFAM
Pfam:7tm_1 43 294 4.3e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214345
AA Change: I280F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000214806
Predicted Effect probably benign
Transcript: ENSMUST00000215673
AA Change: I280F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000217293
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (72/72)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930519G04Rik A G 5: 114,874,323 probably null Het
A830018L16Rik T C 1: 11,972,099 S448P probably damaging Het
Abca4 C T 3: 122,044,490 probably benign Het
Ackr2 A G 9: 121,909,308 M250V probably benign Het
Actn4 A G 7: 28,916,207 I147T probably damaging Het
Adgrv1 C T 13: 81,499,142 S3093N probably damaging Het
Arid5b C T 10: 68,098,587 G495E probably benign Het
Armh1 C A 4: 117,213,741 A396S probably benign Het
Brwd1 G A 16: 96,041,343 T798M probably benign Het
Cdk13 G A 13: 17,772,553 T540I possibly damaging Het
Cdkn1c A G 7: 143,460,634 V25A possibly damaging Het
Col2a1 T C 15: 97,976,700 E1420G unknown Het
Dbf4 G A 5: 8,397,867 P448S probably damaging Het
Dnajb7 T C 15: 81,407,419 N239S probably benign Het
Dnttip1 A G 2: 164,754,141 D102G probably damaging Het
Dpp8 T A 9: 65,078,718 V830D probably damaging Het
Eef1g T C 19: 8,968,289 V29A probably benign Het
Enpp2 T A 15: 54,839,394 Y906F probably damaging Het
Epb41l4a A G 18: 34,006,016 L23P possibly damaging Het
Epp13 G A 7: 6,269,892 probably null Het
Exoc1 T A 5: 76,543,573 M248K probably benign Het
Fam83b T C 9: 76,490,875 Y982C probably damaging Het
Fat4 C T 3: 38,889,178 A740V probably benign Het
Fsip2 T A 2: 82,981,805 S2823T probably benign Het
Gckr T C 5: 31,297,555 Het
Gpr150 A T 13: 76,055,974 V284E probably damaging Het
Grtp1 T G 8: 13,177,103 I344L probably benign Het
Heatr5a T A 12: 51,961,530 N10I probably damaging Het
Herc2 C A 7: 56,153,155 L2109I probably damaging Het
Hs1bp3 T A 12: 8,317,935 D61E probably damaging Het
Ifit1bl1 T A 19: 34,594,883 Y58F probably benign Het
Itfg1 A G 8: 85,764,350 F317L probably benign Het
Itsn1 T C 16: 91,841,603 I764T unknown Het
Med8 A C 4: 118,411,656 probably null Het
Mpeg1 C A 19: 12,463,094 P639T probably damaging Het
Nedd9 A G 13: 41,316,309 L456P probably benign Het
Neo1 A G 9: 58,925,795 S556P probably damaging Het
Nphp3 T A 9: 104,005,393 probably null Het
Nup205 T C 6: 35,177,620 V53A possibly damaging Het
Nvl A T 1: 181,134,944 S154T probably benign Het
Olfr239 G T 17: 33,199,629 G194* probably null Het
Olfr391-ps A T 11: 73,798,961 N265K probably benign Het
Olfr706 A T 7: 106,886,673 V48D possibly damaging Het
Olfr827 T A 10: 130,211,261 probably null Het
Olfr92 A G 17: 37,111,391 M197T probably benign Het
Parvg T C 15: 84,337,801 I243T probably damaging Het
Paxip1 T A 5: 27,765,738 M538L unknown Het
Pgghg G T 7: 140,945,469 D428Y probably damaging Het
Pik3cd C T 4: 149,654,050 V777M possibly damaging Het
Plcl2 A C 17: 50,607,157 K398T probably benign Het
Plxna1 A T 6: 89,324,538 probably null Het
Rbbp6 T C 7: 122,994,686 Y514H possibly damaging Het
Rbbp6 T A 7: 122,990,032 probably null Het
Scin T A 12: 40,069,415 N538I probably damaging Het
Sdcbp A G 4: 6,385,144 D121G probably benign Het
Sgk1 T C 10: 21,996,662 I311T probably damaging Het
Shq1 A C 6: 100,573,756 L407W probably damaging Het
Sipa1 A T 19: 5,651,671 S979T probably benign Het
Slc25a37 G T 14: 69,249,579 T85K probably benign Het
Soga3 T A 10: 29,196,397 Y562N probably damaging Het
Spag9 A T 11: 94,013,654 Q112L probably damaging Het
Spg11 A T 2: 122,066,267 V1686E probably damaging Het
Stap2 A G 17: 55,997,909 V291A probably benign Het
Tnk2 C T 16: 32,680,526 R886C probably damaging Het
Tnrc6c T A 11: 117,720,951 D138E possibly damaging Het
Unc13c A G 9: 73,680,474 S1426P probably benign Het
Vav1 G A 17: 57,297,086 V163M probably damaging Het
Vmn2r67 T A 7: 85,151,988 K247* probably null Het
Zc2hc1c T C 12: 85,296,562 V491A possibly damaging Het
Zfp51 A G 17: 21,463,581 T153A probably benign Het
Zyx A G 6: 42,356,162 E374G probably damaging Het
Other mutations in Olfr615
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00742:Olfr615 APN 7 103561356 missense probably damaging 1.00
IGL01310:Olfr615 APN 7 103560801 missense probably benign
IGL01597:Olfr615 APN 7 103561142 missense possibly damaging 0.79
IGL01725:Olfr615 APN 7 103561075 nonsense probably null
IGL03291:Olfr615 APN 7 103560912 missense possibly damaging 0.93
R0055:Olfr615 UTSW 7 103561037 missense probably damaging 1.00
R0055:Olfr615 UTSW 7 103561037 missense probably damaging 1.00
R0189:Olfr615 UTSW 7 103561082 missense probably benign 0.01
R0254:Olfr615 UTSW 7 103560622 nonsense probably null
R1395:Olfr615 UTSW 7 103561119 missense possibly damaging 0.92
R1781:Olfr615 UTSW 7 103560566 missense probably benign 0.34
R2866:Olfr615 UTSW 7 103560857 missense probably damaging 1.00
R2958:Olfr615 UTSW 7 103561305 missense possibly damaging 0.54
R3922:Olfr615 UTSW 7 103560705 missense probably benign 0.00
R4306:Olfr615 UTSW 7 103561172 nonsense probably null
R4306:Olfr615 UTSW 7 103561173 missense possibly damaging 0.50
R4818:Olfr615 UTSW 7 103560761 missense probably benign 0.07
R4907:Olfr615 UTSW 7 103561034 missense possibly damaging 0.85
R4993:Olfr615 UTSW 7 103561317 missense possibly damaging 0.63
R5461:Olfr615 UTSW 7 103560573 missense probably damaging 1.00
R6225:Olfr615 UTSW 7 103561282 missense probably benign 0.01
R6621:Olfr615 UTSW 7 103560878 missense possibly damaging 0.93
R7174:Olfr615 UTSW 7 103561391 nonsense probably null
R7684:Olfr615 UTSW 7 103561218 missense probably benign 0.01
R8812:Olfr615 UTSW 7 103560609 missense probably benign 0.01
R8934:Olfr615 UTSW 7 103561083 missense probably benign 0.01
R9199:Olfr615 UTSW 7 103560936 missense probably damaging 1.00
R9243:Olfr615 UTSW 7 103560575 missense probably benign
R9276:Olfr615 UTSW 7 103560797 missense probably damaging 1.00
Z1088:Olfr615 UTSW 7 103561059 missense probably benign
Z1088:Olfr615 UTSW 7 103561390 missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- TGATATTTCAAGCAGTTATGGGGATCG -3'
(R):5'- CACTGTTTAGTTAGCAAAGTGCATC -3'

Sequencing Primer
(F):5'- AAGCAGTTATGGGGATCGCTTCTAG -3'
(R):5'- TGTCATGTGTTTATTCATAAAAGCTG -3'
Posted On 2019-11-12