Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00327:Lysmd3'

5920

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lysmd3

Ensembl Gene

ENSMUSG00000035840

Gene Name

LysM, putative peptidoglycan-binding, domain containing 3

Synonyms

1110030H10Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

IGL00327

Quality Score

Status

Chromosome

Chromosomal Location

81657663-81672871 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 81665078 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 22 (L22F)

Ref Sequence

ENSEMBL: ENSMUSP00000038275 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049055] [ENSMUST00000224300] [ENSMUST00000224592]

AlphaFold

Q99LE3

Predicted Effect

probably benign
Transcript: ENSMUST00000049055
AA Change: L22F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000038275
Gene: ENSMUSG00000035840
AA Change: L22F

Domain	Start	End	E-Value	Type
LysM	66	110	4.6e-4	SMART
low complexity region	149	158	N/A	INTRINSIC
transmembrane domain	214	236	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000224300
AA Change: L22F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Predicted Effect

probably benign
Transcript: ENSMUST00000224420

Predicted Effect

probably benign
Transcript: ENSMUST00000224592
AA Change: L22F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atg16l2	A	G	7: 101,300,160	L60S	probably damaging	Het
Aup1	A	G	6: 83,056,409	E267G	probably damaging	Het
Bpi	T	C	2: 158,274,844		probably benign	Het
Brinp2	A	G	1: 158,247,100	Y484H	probably benign	Het
Colq	C	T	14: 31,535,588		probably null	Het
Cubn	T	C	2: 13,427,056	D1242G	possibly damaging	Het
Dclre1c	T	A	2: 3,433,784	L95*	probably null	Het
Fry	C	T	5: 150,340,404	R171*	probably null	Het
Krt23	T	C	11: 99,492,784	E94G	probably damaging	Het
Krt6b	T	G	15: 101,679,832	Q131P	probably benign	Het
Lonp1	A	G	17: 56,619,265	L414P	probably damaging	Het
Lrit2	T	A	14: 37,071,963	M328K	probably benign	Het
Map3k20	A	G	2: 72,412,170	D388G	probably damaging	Het
Mrpl44	C	T	1: 79,781,004	L290F	probably benign	Het
Nell1	A	G	7: 50,120,673	H160R	probably damaging	Het
Nlrc3	T	C	16: 3,955,166	N109S	probably damaging	Het
Prpf40a	T	C	2: 53,150,688	T553A	probably benign	Het
Ptpn23	G	T	9: 110,388,106	T894K	probably benign	Het
Scgb2b27	A	G	7: 34,013,346	C24R	probably damaging	Het
Sipa1l3	G	T	7: 29,354,133	H140N	probably damaging	Het
Slc22a23	T	G	13: 34,305,245	D219A	probably damaging	Het
Slc9a7	T	C	X: 20,138,919	Y557C	probably damaging	Het
Slco1a1	A	T	6: 141,909,125	I600N	probably damaging	Het
Tmx2	T	C	2: 84,673,299	N190S	probably benign	Het
Tpr	T	G	1: 150,423,696		probably benign	Het
Yme1l1	T	C	2: 23,192,500	V501A	probably benign	Het

Other mutations in Lysmd3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00326:Lysmd3	APN	13	81665244	missense	probably damaging	1.00
IGL00813:Lysmd3	APN	13	81665242	missense	probably damaging	1.00
R1509:Lysmd3	UTSW	13	81669271	missense	probably benign	0.11
R2158:Lysmd3	UTSW	13	81669618	missense	probably damaging	1.00
R4170:Lysmd3	UTSW	13	81669410	nonsense	probably null
R4720:Lysmd3	UTSW	13	81669465	missense	possibly damaging	0.81
R5120:Lysmd3	UTSW	13	81669192	missense	probably damaging	1.00
R5728:Lysmd3	UTSW	13	81669261	missense	probably damaging	1.00
R5979:Lysmd3	UTSW	13	81665274	splice site	probably null
R5990:Lysmd3	UTSW	13	81669588	missense	probably damaging	1.00
R8223:Lysmd3	UTSW	13	81669267	missense
R9013:Lysmd3	UTSW	13	81669461	missense	probably damaging	1.00

Posted On

2012-04-20