Incidental Mutation 'R7669:Or6c203'
ID 592054
Institutional Source Beutler Lab
Gene Symbol Or6c203
Ensembl Gene ENSMUSG00000107662
Gene Name olfactory receptor family 6 subfamily C member 203
Synonyms MOR114-3, GA_x6K02T2PULF-10860457-10859522, Olfr772
MMRRC Submission 045741-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R7669 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129009920-129010923 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 129010128 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 254 (F254S)
Ref Sequence ENSEMBL: ENSMUSP00000148854 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169800] [ENSMUST00000214672]
AlphaFold Q8VGC5
Predicted Effect probably damaging
Transcript: ENSMUST00000169800
AA Change: F254S

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000132389
Gene: ENSMUSG00000107662
AA Change: F254S

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.6e-47 PFAM
Pfam:7tm_1 38 287 1.1e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214672
AA Change: F254S

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Meta Mutation Damage Score 0.2154 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 C T 17: 45,831,221 (GRCm39) P930S probably benign Het
Ada T A 2: 163,570,111 (GRCm39) K301* probably null Het
Alb T C 5: 90,611,850 (GRCm39) L93P possibly damaging Het
Aldh1l1 G A 6: 90,547,844 (GRCm39) G435S probably benign Het
Alox12b A T 11: 69,060,167 (GRCm39) I627F probably benign Het
Aloxe3 A G 11: 69,025,946 (GRCm39) I503V probably benign Het
Arhgap29 C T 3: 121,786,461 (GRCm39) A342V probably damaging Het
BC024139 G A 15: 76,004,768 (GRCm39) P636L possibly damaging Het
Bmp6 G T 13: 38,668,896 (GRCm39) R293L probably damaging Het
Cfd G A 10: 79,727,447 (GRCm39) probably null Het
Csmd1 C T 8: 15,967,273 (GRCm39) A3197T probably damaging Het
Flii G A 11: 60,613,490 (GRCm39) L166F probably damaging Het
Fmn1 T A 2: 113,195,822 (GRCm39) N507K unknown Het
Foxe1 C A 4: 46,344,545 (GRCm39) R118S possibly damaging Het
Fras1 T C 5: 96,840,483 (GRCm39) V1646A probably benign Het
Gm14496 A G 2: 181,637,711 (GRCm39) T262A possibly damaging Het
Gpbp1 A T 13: 111,575,658 (GRCm39) S282T probably benign Het
Gria4 A T 9: 4,462,029 (GRCm39) N641K probably damaging Het
Grin2a T G 16: 9,810,327 (GRCm39) N24T probably benign Het
Gstm2 T G 3: 107,892,992 (GRCm39) D40A probably benign Het
Heatr1 T A 13: 12,426,143 (GRCm39) I657N probably benign Het
Kmt2b T C 7: 30,282,656 (GRCm39) E1102G possibly damaging Het
Macroh2a1 T C 13: 56,276,146 (GRCm39) Y39C probably damaging Het
Mgam T A 6: 40,635,944 (GRCm39) N366K probably benign Het
Mier2 A T 10: 79,385,510 (GRCm39) V35E probably damaging Het
Mlxipl T C 5: 135,161,224 (GRCm39) F381S possibly damaging Het
Mroh1 A G 15: 76,336,048 (GRCm39) H1474R possibly damaging Het
Mtrf1l G T 10: 5,765,620 (GRCm39) A239E probably damaging Het
Nbea G T 3: 55,625,200 (GRCm39) A2297E probably damaging Het
Nectin4 A G 1: 171,207,827 (GRCm39) E73G probably benign Het
Neurl1b C G 17: 26,657,720 (GRCm39) H219Q probably benign Het
Nfia G A 4: 97,671,742 (GRCm39) V151I probably damaging Het
Nol6 A G 4: 41,118,717 (GRCm39) L720P probably damaging Het
Or7e165 A G 9: 19,694,839 (GRCm39) N137D possibly damaging Het
Patj A G 4: 98,407,179 (GRCm39) E1054G probably damaging Het
Pcnx1 A G 12: 82,037,325 (GRCm39) D1861G probably damaging Het
Prss12 A G 3: 123,241,045 (GRCm39) T80A probably benign Het
Scart2 A G 7: 139,876,234 (GRCm39) S569G possibly damaging Het
Sgsm1 C A 5: 113,400,890 (GRCm39) R1000L probably damaging Het
Sulf2 T C 2: 165,935,516 (GRCm39) D199G possibly damaging Het
Suox T C 10: 128,506,780 (GRCm39) D416G probably benign Het
Syne1 G A 10: 5,011,531 (GRCm39) T38M probably damaging Het
Tcf7l2 T A 19: 55,912,975 (GRCm39) C421* probably null Het
Tex55 C T 16: 38,648,453 (GRCm39) D219N possibly damaging Het
Traf7 C A 17: 24,732,282 (GRCm39) G143* probably null Het
Trappc12 T C 12: 28,761,957 (GRCm39) I544V probably benign Het
Trmt1 G A 8: 85,424,180 (GRCm39) V434I probably benign Het
Ttc5 T C 14: 51,014,787 (GRCm39) H160R probably benign Het
Xirp2 T A 2: 67,342,521 (GRCm39) H1587Q probably benign Het
Zfp523 C T 17: 28,420,015 (GRCm39) T220M probably damaging Het
Zfp804b A T 5: 6,819,362 (GRCm39) S1234T probably damaging Het
Other mutations in Or6c203
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02512:Or6c203 APN 10 129,010,119 (GRCm39) missense possibly damaging 0.65
IGL03072:Or6c203 APN 10 129,010,358 (GRCm39) missense probably damaging 1.00
IGL03336:Or6c203 APN 10 129,010,098 (GRCm39) missense probably benign 0.00
R1852:Or6c203 UTSW 10 129,010,197 (GRCm39) missense probably benign 0.00
R2496:Or6c203 UTSW 10 129,009,966 (GRCm39) missense probably benign 0.00
R6031:Or6c203 UTSW 10 129,010,224 (GRCm39) missense probably benign 0.14
R6031:Or6c203 UTSW 10 129,010,224 (GRCm39) missense probably benign 0.14
R6168:Or6c203 UTSW 10 129,010,035 (GRCm39) missense probably damaging 1.00
R7454:Or6c203 UTSW 10 129,010,324 (GRCm39) missense probably damaging 1.00
R7905:Or6c203 UTSW 10 129,010,056 (GRCm39) missense probably damaging 0.99
R8307:Or6c203 UTSW 10 129,010,101 (GRCm39) missense probably benign 0.00
R8830:Or6c203 UTSW 10 129,010,715 (GRCm39) nonsense probably null
R9405:Or6c203 UTSW 10 129,010,165 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- GTCAACTGGACCCAGAAGTTTGG -3'
(R):5'- TGGAGCAGACAGTTCTCATCTG -3'

Sequencing Primer
(F):5'- CCAGAAGTTTGGGAAGTTTAATCC -3'
(R):5'- AGCAGACAGTTCTCATCTGTGCTG -3'
Posted On 2019-11-12