Incidental Mutation 'R0239:Depdc5'
| ID |
59211 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Depdc5
|
| Ensembl Gene |
ENSMUSG00000037426 |
| Gene Name |
DEP domain containing 5 |
| Synonyms |
|
| MMRRC Submission |
038477-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0239 (G1)
|
| Quality Score |
223 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
32863701-32994236 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 32943240 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 832
(S832P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000052807
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049780]
[ENSMUST00000087897]
[ENSMUST00000119705]
[ENSMUST00000120902]
[ENSMUST00000124780]
[ENSMUST00000130461]
|
| AlphaFold |
P61460 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000049780
AA Change: S832P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000052807
Gene: ENSMUSG00000037426
AA Change: S832P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3608
|
100 |
382 |
3.7e-64 |
PFAM |
|
low complexity region
|
491 |
508 |
N/A |
INTRINSIC |
|
low complexity region
|
656 |
667 |
N/A |
INTRINSIC |
|
low complexity region
|
690 |
699 |
N/A |
INTRINSIC |
|
low complexity region
|
817 |
827 |
N/A |
INTRINSIC |
|
low complexity region
|
985 |
997 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000087897
AA Change: S841P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000085207
Gene: ENSMUSG00000037426
AA Change: S841P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3608
|
100 |
382 |
2.3e-63 |
PFAM |
|
low complexity region
|
491 |
508 |
N/A |
INTRINSIC |
|
low complexity region
|
656 |
667 |
N/A |
INTRINSIC |
|
low complexity region
|
690 |
699 |
N/A |
INTRINSIC |
|
low complexity region
|
826 |
836 |
N/A |
INTRINSIC |
|
low complexity region
|
994 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1159 |
1175 |
N/A |
INTRINSIC |
|
DEP
|
1184 |
1259 |
2.49e-15 |
SMART |
|
low complexity region
|
1322 |
1335 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000119705
AA Change: S832P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000113862
Gene: ENSMUSG00000037426
AA Change: S832P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3608
|
100 |
382 |
3e-117 |
PFAM |
|
low complexity region
|
491 |
508 |
N/A |
INTRINSIC |
|
low complexity region
|
656 |
667 |
N/A |
INTRINSIC |
|
low complexity region
|
690 |
699 |
N/A |
INTRINSIC |
|
low complexity region
|
817 |
827 |
N/A |
INTRINSIC |
|
low complexity region
|
985 |
997 |
N/A |
INTRINSIC |
|
low complexity region
|
1150 |
1166 |
N/A |
INTRINSIC |
|
DEP
|
1175 |
1250 |
2.49e-15 |
SMART |
|
low complexity region
|
1313 |
1326 |
N/A |
INTRINSIC |
|
low complexity region
|
1511 |
1525 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120902
AA Change: S832P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000113980
Gene: ENSMUSG00000037426
AA Change: S832P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3608
|
100 |
382 |
3.7e-63 |
PFAM |
|
low complexity region
|
491 |
508 |
N/A |
INTRINSIC |
|
low complexity region
|
656 |
667 |
N/A |
INTRINSIC |
|
low complexity region
|
690 |
699 |
N/A |
INTRINSIC |
|
low complexity region
|
817 |
827 |
N/A |
INTRINSIC |
|
low complexity region
|
985 |
997 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1144 |
N/A |
INTRINSIC |
|
DEP
|
1153 |
1228 |
2.49e-15 |
SMART |
|
low complexity region
|
1291 |
1304 |
N/A |
INTRINSIC |
|
low complexity region
|
1489 |
1503 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000124780
AA Change: S194P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000120120
Gene: ENSMUSG00000037426
AA Change: S194P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
179 |
189 |
N/A |
INTRINSIC |
|
low complexity region
|
347 |
359 |
N/A |
INTRINSIC |
|
SCOP:d1fsha_
|
519 |
586 |
1e-13 |
SMART |
|
Blast:DEP
|
537 |
589 |
2e-24 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000130461
|
| SMART Domains |
Protein: ENSMUSP00000118681
Gene: ENSMUSG00000037426
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
70 |
82 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000137169
AA Change: S238P
|
| SMART Domains |
Protein: ENSMUSP00000121089
Gene: ENSMUSG00000037426
AA Change: S238P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
54 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
88 |
97 |
N/A |
INTRINSIC |
|
low complexity region
|
224 |
234 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
404 |
N/A |
INTRINSIC |
|
low complexity region
|
535 |
551 |
N/A |
INTRINSIC |
|
DEP
|
560 |
635 |
2.49e-15 |
SMART |
|
low complexity region
|
698 |
711 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
910 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141812
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000201802
|
| Meta Mutation Damage Score |
0.4344 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 99.0%
- 10x: 97.9%
- 20x: 96.2%
|
| Validation Efficiency |
98% (81/83) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for a conditional allele activated in neurons exhibit reduced body weight, limb grasping, premature death, spontaneous seizure, increased brain size due to neuron hypertrophy and increased PTZ seizure susceptibility. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adra1d |
C |
A |
2: 131,546,214 (GRCm38) |
V474F |
probably benign |
Het |
| Alg8 |
A |
T |
7: 97,383,684 (GRCm38) |
|
probably null |
Het |
| Ash1l |
A |
G |
3: 89,067,222 (GRCm38) |
D2618G |
possibly damaging |
Het |
| Atp6v1c2 |
C |
A |
12: 17,294,675 (GRCm38) |
|
probably null |
Het |
| Cacna1d |
A |
G |
14: 30,123,496 (GRCm38) |
V572A |
probably benign |
Het |
| Camta1 |
A |
G |
4: 151,143,730 (GRCm38) |
W882R |
probably damaging |
Het |
| Cd72 |
A |
G |
4: 43,453,163 (GRCm38) |
V91A |
probably benign |
Het |
| Cdh12 |
T |
C |
15: 21,586,407 (GRCm38) |
W771R |
probably damaging |
Het |
| Cdx2 |
G |
T |
5: 147,303,287 (GRCm38) |
T193K |
probably damaging |
Het |
| Cfap70 |
A |
C |
14: 20,448,605 (GRCm38) |
S5A |
probably benign |
Het |
| Chmp7 |
A |
G |
14: 69,720,997 (GRCm38) |
V241A |
probably damaging |
Het |
| Col4a1 |
C |
T |
8: 11,218,780 (GRCm38) |
|
probably benign |
Het |
| D3Ertd751e |
A |
G |
3: 41,753,878 (GRCm38) |
Y150C |
probably damaging |
Het |
| Dnhd1 |
A |
G |
7: 105,721,531 (GRCm38) |
S4673G |
probably benign |
Het |
| Dock4 |
G |
T |
12: 40,737,540 (GRCm38) |
S818I |
probably damaging |
Het |
| Dysf |
C |
T |
6: 84,064,479 (GRCm38) |
Q156* |
probably null |
Het |
| Espnl |
T |
C |
1: 91,322,287 (GRCm38) |
V52A |
probably damaging |
Het |
| Flcn |
T |
C |
11: 59,801,076 (GRCm38) |
N249S |
probably benign |
Het |
| Gemin6 |
C |
A |
17: 80,225,710 (GRCm38) |
A24D |
probably damaging |
Het |
| Gm5773 |
A |
G |
3: 93,774,032 (GRCm38) |
H337R |
probably benign |
Het |
| Gm9733 |
A |
G |
3: 15,296,601 (GRCm38) |
L163P |
probably damaging |
Het |
| Greb1l |
C |
T |
18: 10,458,567 (GRCm38) |
|
probably benign |
Het |
| Hal |
T |
C |
10: 93,503,482 (GRCm38) |
S478P |
possibly damaging |
Het |
| Hectd1 |
T |
A |
12: 51,769,318 (GRCm38) |
M1324L |
possibly damaging |
Het |
| Hyal5 |
T |
A |
6: 24,876,344 (GRCm38) |
L72Q |
probably damaging |
Het |
| Ift140 |
C |
A |
17: 25,045,523 (GRCm38) |
C557* |
probably null |
Het |
| Ikbkap |
C |
A |
4: 56,784,596 (GRCm38) |
V466L |
probably benign |
Het |
| Il4ra |
T |
C |
7: 125,575,199 (GRCm38) |
|
probably benign |
Het |
| Ipo9 |
A |
G |
1: 135,404,336 (GRCm38) |
|
probably benign |
Het |
| Kbtbd3 |
G |
T |
9: 4,330,144 (GRCm38) |
V173L |
possibly damaging |
Het |
| Kif14 |
A |
G |
1: 136,527,393 (GRCm38) |
E1551G |
probably damaging |
Het |
| Klc1 |
A |
G |
12: 111,785,324 (GRCm38) |
|
probably benign |
Het |
| Krt17 |
G |
A |
11: 100,260,878 (GRCm38) |
R30* |
probably null |
Het |
| Lamb3 |
A |
T |
1: 193,321,053 (GRCm38) |
D100V |
probably damaging |
Het |
| Lrmp |
G |
A |
6: 145,171,978 (GRCm38) |
|
probably benign |
Het |
| Map2 |
A |
G |
1: 66,416,106 (GRCm38) |
D1385G |
probably damaging |
Het |
| Mettl25 |
C |
T |
10: 105,826,525 (GRCm38) |
V195I |
probably damaging |
Het |
| Mfsd7a |
G |
T |
5: 108,444,016 (GRCm38) |
|
probably benign |
Het |
| Micu2 |
G |
A |
14: 57,917,378 (GRCm38) |
|
probably benign |
Het |
| Mrrf |
T |
C |
2: 36,177,281 (GRCm38) |
|
probably benign |
Het |
| Myh8 |
A |
G |
11: 67,301,692 (GRCm38) |
T1466A |
probably benign |
Het |
| Myo3b |
T |
A |
2: 70,105,425 (GRCm38) |
C61S |
probably benign |
Het |
| Nacc2 |
T |
G |
2: 26,062,261 (GRCm38) |
N361T |
probably damaging |
Het |
| Nf1 |
A |
T |
11: 79,418,574 (GRCm38) |
K438M |
possibly damaging |
Het |
| Nipal4 |
A |
G |
11: 46,150,441 (GRCm38) |
V309A |
possibly damaging |
Het |
| Nomo1 |
T |
C |
7: 46,079,594 (GRCm38) |
|
probably null |
Het |
| Nubp2 |
T |
C |
17: 24,884,471 (GRCm38) |
E144G |
probably damaging |
Het |
| Nwd2 |
A |
T |
5: 63,800,124 (GRCm38) |
I266F |
probably benign |
Het |
| Olfr1126 |
T |
C |
2: 87,458,037 (GRCm38) |
F291L |
probably benign |
Het |
| Olfr593 |
G |
A |
7: 103,212,726 (GRCm38) |
V289M |
possibly damaging |
Het |
| Olfr694 |
A |
G |
7: 106,689,255 (GRCm38) |
Y159H |
probably benign |
Het |
| Orc1 |
T |
C |
4: 108,595,646 (GRCm38) |
|
probably null |
Het |
| Otogl |
T |
A |
10: 107,806,696 (GRCm38) |
N1291I |
probably damaging |
Het |
| Pah |
C |
T |
10: 87,567,281 (GRCm38) |
P173S |
possibly damaging |
Het |
| Pga5 |
A |
G |
19: 10,669,453 (GRCm38) |
Y305H |
probably damaging |
Het |
| Plekha4 |
A |
G |
7: 45,532,358 (GRCm38) |
H62R |
probably damaging |
Het |
| Plxnd1 |
G |
T |
6: 115,968,793 (GRCm38) |
D906E |
probably benign |
Het |
| Ppfia4 |
T |
C |
1: 134,329,189 (GRCm38) |
E98G |
possibly damaging |
Het |
| Ptk2 |
A |
T |
15: 73,343,283 (GRCm38) |
|
probably null |
Het |
| Pzp |
C |
T |
6: 128,489,156 (GRCm38) |
|
probably benign |
Het |
| Raet1c |
C |
A |
10: 22,180,862 (GRCm38) |
H112Q |
possibly damaging |
Het |
| Scai |
T |
A |
2: 39,075,042 (GRCm38) |
I597F |
probably benign |
Het |
| Scgb1b2 |
T |
A |
7: 31,291,730 (GRCm38) |
|
probably benign |
Het |
| Sec31b |
G |
A |
19: 44,525,469 (GRCm38) |
|
probably benign |
Het |
| Slc35c2 |
C |
T |
2: 165,280,837 (GRCm38) |
G176S |
probably damaging |
Het |
| Slc35f4 |
A |
T |
14: 49,304,256 (GRCm38) |
I347N |
possibly damaging |
Het |
| Slc52a3 |
T |
C |
2: 152,008,156 (GRCm38) |
*461Q |
probably null |
Het |
| Slc6a1 |
G |
A |
6: 114,302,800 (GRCm38) |
V142I |
probably benign |
Het |
| Tbc1d31 |
C |
A |
15: 57,940,753 (GRCm38) |
T388N |
probably benign |
Het |
| Tmem131 |
T |
C |
1: 36,828,050 (GRCm38) |
|
probably benign |
Het |
| Tmem63c |
T |
C |
12: 87,075,639 (GRCm38) |
W404R |
probably damaging |
Het |
| Tmem79 |
A |
G |
3: 88,333,321 (GRCm38) |
S107P |
probably benign |
Het |
| Trip11 |
C |
T |
12: 101,884,728 (GRCm38) |
E741K |
probably damaging |
Het |
| Trpm5 |
G |
T |
7: 143,082,958 (GRCm38) |
T414N |
probably damaging |
Het |
| Tsnaxip1 |
T |
A |
8: 105,844,488 (GRCm38) |
I660N |
possibly damaging |
Het |
| Ube2q2 |
T |
C |
9: 55,163,007 (GRCm38) |
S78P |
probably damaging |
Het |
| Vac14 |
A |
T |
8: 110,635,375 (GRCm38) |
|
probably null |
Het |
| Vps51 |
G |
T |
19: 6,071,437 (GRCm38) |
S185* |
probably null |
Het |
| Zfp11 |
C |
T |
5: 129,658,238 (GRCm38) |
G53E |
possibly damaging |
Het |
| Zfp532 |
A |
T |
18: 65,682,985 (GRCm38) |
I810F |
possibly damaging |
Het |
| Zfp599 |
C |
T |
9: 22,249,759 (GRCm38) |
C370Y |
probably damaging |
Het |
|
| Other mutations in Depdc5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00861:Depdc5
|
APN |
5 |
32,967,814 (GRCm38) |
splice site |
probably null |
|
|
IGL01019:Depdc5
|
APN |
5 |
32,893,401 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL01067:Depdc5
|
APN |
5 |
32,899,067 (GRCm38) |
splice site |
probably null |
|
|
IGL01405:Depdc5
|
APN |
5 |
32,937,689 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
IGL01577:Depdc5
|
APN |
5 |
32,955,897 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
IGL01633:Depdc5
|
APN |
5 |
32,924,200 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01998:Depdc5
|
APN |
5 |
32,945,151 (GRCm38) |
splice site |
probably benign |
|
|
IGL02025:Depdc5
|
APN |
5 |
32,946,632 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
IGL02167:Depdc5
|
APN |
5 |
32,903,801 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02537:Depdc5
|
APN |
5 |
32,967,787 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02812:Depdc5
|
APN |
5 |
32,893,368 (GRCm38) |
splice site |
probably benign |
|
|
IGL03001:Depdc5
|
APN |
5 |
32,945,090 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
IGL03253:Depdc5
|
APN |
5 |
32,868,813 (GRCm38) |
unclassified |
probably benign |
|
|
alligator
|
UTSW |
5 |
32,964,507 (GRCm38) |
splice site |
probably null |
|
|
lagarto
|
UTSW |
5 |
32,979,508 (GRCm38) |
missense |
probably damaging |
1.00 |
|
sauros
|
UTSW |
5 |
32,986,966 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL02988:Depdc5
|
UTSW |
5 |
32,956,167 (GRCm38) |
splice site |
probably null |
|
|
R0038:Depdc5
|
UTSW |
5 |
32,868,853 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0038:Depdc5
|
UTSW |
5 |
32,868,853 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0153:Depdc5
|
UTSW |
5 |
32,933,937 (GRCm38) |
splice site |
probably benign |
|
|
R0179:Depdc5
|
UTSW |
5 |
32,901,574 (GRCm38) |
unclassified |
probably benign |
|
|
R0212:Depdc5
|
UTSW |
5 |
32,912,242 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0239:Depdc5
|
UTSW |
5 |
32,943,240 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0302:Depdc5
|
UTSW |
5 |
32,904,546 (GRCm38) |
critical splice donor site |
probably benign |
|
|
R0511:Depdc5
|
UTSW |
5 |
32,945,028 (GRCm38) |
nonsense |
probably null |
|
|
R0677:Depdc5
|
UTSW |
5 |
32,901,470 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0884:Depdc5
|
UTSW |
5 |
32,917,978 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R0973:Depdc5
|
UTSW |
5 |
32,986,966 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R1314:Depdc5
|
UTSW |
5 |
32,877,074 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1611:Depdc5
|
UTSW |
5 |
32,990,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1687:Depdc5
|
UTSW |
5 |
32,910,407 (GRCm38) |
critical splice acceptor site |
probably benign |
|
|
R1748:Depdc5
|
UTSW |
5 |
32,917,942 (GRCm38) |
missense |
probably benign |
0.24 |
|
R1903:Depdc5
|
UTSW |
5 |
32,910,407 (GRCm38) |
critical splice acceptor site |
probably benign |
|
|
R1956:Depdc5
|
UTSW |
5 |
32,903,831 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1997:Depdc5
|
UTSW |
5 |
32,901,906 (GRCm38) |
critical splice donor site |
probably null |
|
|
R2079:Depdc5
|
UTSW |
5 |
32,946,674 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R2131:Depdc5
|
UTSW |
5 |
32,990,781 (GRCm38) |
nonsense |
probably null |
|
|
R2291:Depdc5
|
UTSW |
5 |
32,979,402 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2422:Depdc5
|
UTSW |
5 |
32,991,035 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2851:Depdc5
|
UTSW |
5 |
32,924,171 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R2852:Depdc5
|
UTSW |
5 |
32,924,171 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R2937:Depdc5
|
UTSW |
5 |
32,901,621 (GRCm38) |
splice site |
probably null |
|
|
R2938:Depdc5
|
UTSW |
5 |
32,901,621 (GRCm38) |
splice site |
probably null |
|
|
R2974:Depdc5
|
UTSW |
5 |
32,934,017 (GRCm38) |
critical splice donor site |
probably null |
|
|
R3884:Depdc5
|
UTSW |
5 |
32,944,077 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3967:Depdc5
|
UTSW |
5 |
32,944,115 (GRCm38) |
nonsense |
probably null |
|
|
R4118:Depdc5
|
UTSW |
5 |
32,964,635 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4197:Depdc5
|
UTSW |
5 |
32,991,203 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R4407:Depdc5
|
UTSW |
5 |
32,904,534 (GRCm38) |
critical splice donor site |
probably null |
|
|
R4534:Depdc5
|
UTSW |
5 |
32,910,407 (GRCm38) |
critical splice acceptor site |
probably benign |
|
|
R4535:Depdc5
|
UTSW |
5 |
32,910,407 (GRCm38) |
critical splice acceptor site |
probably benign |
|
|
R4538:Depdc5
|
UTSW |
5 |
32,983,946 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4613:Depdc5
|
UTSW |
5 |
32,975,446 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4736:Depdc5
|
UTSW |
5 |
32,975,322 (GRCm38) |
missense |
probably benign |
|
|
R4738:Depdc5
|
UTSW |
5 |
32,975,322 (GRCm38) |
missense |
probably benign |
|
|
R4765:Depdc5
|
UTSW |
5 |
32,937,635 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5021:Depdc5
|
UTSW |
5 |
32,979,414 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5259:Depdc5
|
UTSW |
5 |
32,938,291 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5261:Depdc5
|
UTSW |
5 |
32,938,291 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5541:Depdc5
|
UTSW |
5 |
32,864,629 (GRCm38) |
utr 5 prime |
probably benign |
|
|
R5594:Depdc5
|
UTSW |
5 |
32,901,490 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R5929:Depdc5
|
UTSW |
5 |
32,975,506 (GRCm38) |
nonsense |
probably null |
|
|
R6132:Depdc5
|
UTSW |
5 |
32,910,467 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6146:Depdc5
|
UTSW |
5 |
32,968,731 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6336:Depdc5
|
UTSW |
5 |
32,964,507 (GRCm38) |
splice site |
probably null |
|
|
R6468:Depdc5
|
UTSW |
5 |
32,912,231 (GRCm38) |
missense |
probably benign |
0.02 |
|
R6911:Depdc5
|
UTSW |
5 |
32,924,192 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6969:Depdc5
|
UTSW |
5 |
32,983,860 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7002:Depdc5
|
UTSW |
5 |
32,877,158 (GRCm38) |
splice site |
probably null |
|
|
R7066:Depdc5
|
UTSW |
5 |
32,901,848 (GRCm38) |
missense |
probably benign |
0.08 |
|
R7231:Depdc5
|
UTSW |
5 |
32,901,865 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R7264:Depdc5
|
UTSW |
5 |
32,967,745 (GRCm38) |
missense |
probably benign |
|
|
R7302:Depdc5
|
UTSW |
5 |
32,979,508 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7386:Depdc5
|
UTSW |
5 |
32,927,936 (GRCm38) |
missense |
probably benign |
|
|
R7564:Depdc5
|
UTSW |
5 |
32,901,510 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7636:Depdc5
|
UTSW |
5 |
32,917,983 (GRCm38) |
missense |
probably benign |
|
|
R7795:Depdc5
|
UTSW |
5 |
32,944,103 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7845:Depdc5
|
UTSW |
5 |
32,903,915 (GRCm38) |
splice site |
probably null |
|
|
R8013:Depdc5
|
UTSW |
5 |
32,973,842 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8037:Depdc5
|
UTSW |
5 |
32,959,348 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8038:Depdc5
|
UTSW |
5 |
32,959,348 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8065:Depdc5
|
UTSW |
5 |
32,895,908 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R8067:Depdc5
|
UTSW |
5 |
32,895,908 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R8108:Depdc5
|
UTSW |
5 |
32,945,049 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8112:Depdc5
|
UTSW |
5 |
32,968,706 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R8213:Depdc5
|
UTSW |
5 |
32,937,637 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8382:Depdc5
|
UTSW |
5 |
32,927,898 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8680:Depdc5
|
UTSW |
5 |
32,944,038 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R8743:Depdc5
|
UTSW |
5 |
32,924,243 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8754:Depdc5
|
UTSW |
5 |
32,979,537 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9157:Depdc5
|
UTSW |
5 |
32,945,108 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9364:Depdc5
|
UTSW |
5 |
32,964,732 (GRCm38) |
missense |
probably benign |
|
|
R9441:Depdc5
|
UTSW |
5 |
32,937,698 (GRCm38) |
missense |
probably benign |
0.03 |
|
R9450:Depdc5
|
UTSW |
5 |
32,934,010 (GRCm38) |
missense |
probably benign |
|
|
R9459:Depdc5
|
UTSW |
5 |
32,990,773 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9554:Depdc5
|
UTSW |
5 |
32,964,732 (GRCm38) |
missense |
probably benign |
|
|
R9569:Depdc5
|
UTSW |
5 |
32,867,977 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9647:Depdc5
|
UTSW |
5 |
32,924,223 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9688:Depdc5
|
UTSW |
5 |
32,897,932 (GRCm38) |
nonsense |
probably null |
|
|
X0027:Depdc5
|
UTSW |
5 |
32,904,292 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Depdc5
|
UTSW |
5 |
32,943,282 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
| Predicted Primers |
PCR Primer
(F):5'- GACCAGAAGGTGAAGACTTCCAGC -3'
(R):5'- AATTCAAGATGGTCACCAAGGACGG -3'
Sequencing Primer
(F):5'- GGACCTAGATATGCTCAGGTG -3'
(R):5'- TGGTCACCAAGGACGGTAAAC -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation