Incidental Mutation 'R7671:Olfr1121'
ID 592143
Institutional Source Beutler Lab
Gene Symbol Olfr1121
Ensembl Gene ENSMUSG00000070852
Gene Name olfactory receptor 1121
Synonyms MOR264-18, GA_x6K02T2Q125-48863863-48864807
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R7671 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 87369895-87373469 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87372269 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 246 (T246A)
Ref Sequence ENSEMBL: ENSMUSP00000150120 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062555] [ENSMUST00000213792]
AlphaFold L7MTT1
Predicted Effect probably damaging
Transcript: ENSMUST00000062555
AA Change: T246A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000058201
Gene: ENSMUSG00000070852
AA Change: T246A

Pfam:7tm_4 37 314 3.3e-54 PFAM
Pfam:7tm_1 47 296 3.2e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213792
AA Change: T246A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610009O20Rik T A 18: 38,259,925 (GRCm38) I394N probably damaging Het
4930435E12Rik C T 16: 38,828,091 (GRCm38) D219N possibly damaging Het
4932438A13Rik T C 3: 36,943,231 (GRCm38) F1146L probably damaging Het
4933406M09Rik T C 1: 134,390,062 (GRCm38) C191R probably benign Het
Akap13 C A 7: 75,569,900 (GRCm38) T17K probably damaging Het
Ankrd29 T A 18: 12,260,986 (GRCm38) K257I probably damaging Het
Bicc1 A G 10: 70,957,167 (GRCm38) L219P probably benign Het
Boc C T 16: 44,491,849 (GRCm38) V617M Het
Ccl8 A G 11: 82,115,207 (GRCm38) probably benign Het
Col18a1 A G 10: 77,085,383 (GRCm38) L261P unknown Het
Col5a3 T A 9: 20,775,086 (GRCm38) probably null Het
Cryba4 A C 5: 112,248,173 (GRCm38) probably null Het
Csf2rb A G 15: 78,338,930 (GRCm38) Y114C probably damaging Het
Ctif T C 18: 75,472,016 (GRCm38) D484G probably damaging Het
Ctnnal1 A G 4: 56,837,848 (GRCm38) F261L probably damaging Het
Defb22 A T 2: 152,486,030 (GRCm38) N78K unknown Het
Efr3a G A 15: 65,837,434 (GRCm38) probably null Het
Elp4 G T 2: 105,904,481 (GRCm38) A3E probably damaging Het
Emilin2 A G 17: 71,273,910 (GRCm38) V607A probably benign Het
Epsti1 A G 14: 77,904,490 (GRCm38) Y2C probably damaging Het
Fam81b A C 13: 76,271,293 (GRCm38) L46R probably damaging Het
Fam81b G T 13: 76,271,294 (GRCm38) L46I possibly damaging Het
Fbxo15 T A 18: 84,964,153 (GRCm38) H288Q probably damaging Het
Gabrg1 T A 5: 70,815,980 (GRCm38) N77I probably damaging Het
Ganab A G 19: 8,912,852 (GRCm38) Y715C possibly damaging Het
Hist3h2ba T C 11: 58,949,276 (GRCm38) S113P possibly damaging Het
Iqgap2 T C 13: 95,628,119 (GRCm38) D1539G probably damaging Het
Kcp T C 6: 29,496,517 (GRCm38) N633S probably benign Het
Krt6a C A 15: 101,690,543 (GRCm38) S529I unknown Het
Leo1 A G 9: 75,445,562 (GRCm38) H129R probably benign Het
Lmf1 G A 17: 25,579,349 (GRCm38) V55M possibly damaging Het
Mcm9 A G 10: 53,537,569 (GRCm38) S472P probably benign Het
Med27 T A 2: 29,377,938 (GRCm38) V33D Het
Mup15 C T 4: 61,438,289 (GRCm38) E80K probably benign Het
Myo18a G A 11: 77,859,420 (GRCm38) R199H Het
Nebl T A 2: 17,390,916 (GRCm38) R558* probably null Het
Olfr1252 A T 2: 89,721,259 (GRCm38) I284K probably damaging Het
Olfr1329 A T 4: 118,916,986 (GRCm38) H160Q probably benign Het
Olfr506 T C 7: 108,612,991 (GRCm38) I228T probably damaging Het
Olfr740 G T 14: 50,453,885 (GRCm38) V278L probably benign Het
Olfr815 T C 10: 129,902,353 (GRCm38) D119G probably damaging Het
Olfr890 A T 9: 38,143,440 (GRCm38) M97L probably benign Het
Pde11a A T 2: 76,215,353 (GRCm38) F376I possibly damaging Het
Prima1 A T 12: 103,235,661 (GRCm38) C52S probably damaging Het
Pxn G A 5: 115,548,547 (GRCm38) R366H not run Het
Sgce T C 6: 4,691,564 (GRCm38) Y337C probably damaging Het
Slc25a10 T A 11: 120,495,460 (GRCm38) M130K probably benign Het
Slc29a2 A T 19: 5,024,262 (GRCm38) N5I probably benign Het
Slc35a1 A T 4: 34,673,875 (GRCm38) H150Q Het
Slc5a4a T A 10: 76,147,550 (GRCm38) V7D unknown Het
Stk17b T A 1: 53,766,000 (GRCm38) D134V probably damaging Het
Thbs3 T A 3: 89,216,707 (GRCm38) S36T probably benign Het
Thsd4 A G 9: 60,428,174 (GRCm38) S152P probably benign Het
Tmem67 G T 4: 12,063,698 (GRCm38) H422N probably benign Het
Tram1 C A 1: 13,589,644 (GRCm38) V27F probably damaging Het
Trim14 A G 4: 46,507,238 (GRCm38) V326A possibly damaging Het
Other mutations in Olfr1121
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02534:Olfr1121 APN 2 87,372,254 (GRCm38) missense probably benign
IGL03280:Olfr1121 APN 2 87,372,123 (GRCm38) missense probably damaging 1.00
R0501:Olfr1121 UTSW 2 87,371,552 (GRCm38) missense probably damaging 0.96
R1350:Olfr1121 UTSW 2 87,372,357 (GRCm38) missense probably benign
R1713:Olfr1121 UTSW 2 87,371,946 (GRCm38) missense probably damaging 1.00
R2404:Olfr1121 UTSW 2 87,372,224 (GRCm38) missense probably benign 0.09
R4737:Olfr1121 UTSW 2 87,372,321 (GRCm38) missense probably damaging 0.99
R4825:Olfr1121 UTSW 2 87,372,088 (GRCm38) nonsense probably null
R5109:Olfr1121 UTSW 2 87,371,534 (GRCm38) start codon destroyed probably null 0.04
R5200:Olfr1121 UTSW 2 87,372,102 (GRCm38) missense probably damaging 0.99
R6393:Olfr1121 UTSW 2 87,371,565 (GRCm38) missense probably damaging 1.00
R6658:Olfr1121 UTSW 2 87,372,153 (GRCm38) missense probably benign 0.01
R7011:Olfr1121 UTSW 2 87,372,260 (GRCm38) missense possibly damaging 0.74
R7427:Olfr1121 UTSW 2 87,371,690 (GRCm38) missense probably benign 0.01
R7428:Olfr1121 UTSW 2 87,371,690 (GRCm38) missense probably benign 0.01
R8268:Olfr1121 UTSW 2 87,371,988 (GRCm38) missense probably damaging 0.97
R9015:Olfr1121 UTSW 2 87,372,141 (GRCm38) missense possibly damaging 0.48
R9344:Olfr1121 UTSW 2 87,371,817 (GRCm38) missense possibly damaging 0.89
R9468:Olfr1121 UTSW 2 87,371,772 (GRCm38) missense probably damaging 1.00
R9492:Olfr1121 UTSW 2 87,371,616 (GRCm38) missense probably benign 0.12
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2019-11-12