Incidental Mutation 'R7671:Or11g7'
ID 592179
Institutional Source Beutler Lab
Gene Symbol Or11g7
Ensembl Gene ENSMUSG00000095917
Gene Name olfactory receptor family 11 subfamily G member 7
Synonyms MOR106-4, Olfr740, GA_x6K02T2PMLR-6167145-6168080
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R7671 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 50690511-50693135 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 50691342 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 278 (V278L)
Ref Sequence ENSEMBL: ENSMUSP00000148916 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089838] [ENSMUST00000214792]
AlphaFold E9PV79
Predicted Effect probably benign
Transcript: ENSMUST00000089838
AA Change: V278L

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000087276
Gene: ENSMUSG00000095917
AA Change: V278L

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 2.3e-56 PFAM
Pfam:7tm_1 45 294 1.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214792
AA Change: V278L

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap13 C A 7: 75,219,648 (GRCm39) T17K probably damaging Het
Ankrd29 T A 18: 12,394,043 (GRCm39) K257I probably damaging Het
Bicc1 A G 10: 70,792,997 (GRCm39) L219P probably benign Het
Bltp1 T C 3: 36,997,380 (GRCm39) F1146L probably damaging Het
Boc C T 16: 44,312,212 (GRCm39) V617M Het
Ccl8 A G 11: 82,006,033 (GRCm39) probably benign Het
Col18a1 A G 10: 76,921,217 (GRCm39) L261P unknown Het
Col5a3 T A 9: 20,686,382 (GRCm39) probably null Het
Cryba4 A C 5: 112,396,039 (GRCm39) probably null Het
Csf2rb A G 15: 78,223,130 (GRCm39) Y114C probably damaging Het
Ctif T C 18: 75,605,087 (GRCm39) D484G probably damaging Het
Ctnnal1 A G 4: 56,837,848 (GRCm39) F261L probably damaging Het
Defb22 A T 2: 152,327,950 (GRCm39) N78K unknown Het
Dele1 T A 18: 38,392,978 (GRCm39) I394N probably damaging Het
Efr3a G A 15: 65,709,283 (GRCm39) probably null Het
Elp4 G T 2: 105,734,826 (GRCm39) A3E probably damaging Het
Emilin2 A G 17: 71,580,905 (GRCm39) V607A probably benign Het
Epsti1 A G 14: 78,141,930 (GRCm39) Y2C probably damaging Het
Fam81b A C 13: 76,419,412 (GRCm39) L46R probably damaging Het
Fam81b G T 13: 76,419,413 (GRCm39) L46I possibly damaging Het
Fbxo15 T A 18: 84,982,278 (GRCm39) H288Q probably damaging Het
Gabrg1 T A 5: 70,973,323 (GRCm39) N77I probably damaging Het
Ganab A G 19: 8,890,216 (GRCm39) Y715C possibly damaging Het
H2bc27 T C 11: 58,840,102 (GRCm39) S113P possibly damaging Het
Iqgap2 T C 13: 95,764,627 (GRCm39) D1539G probably damaging Het
Kcp T C 6: 29,496,516 (GRCm39) N633S probably benign Het
Krt6a C A 15: 101,598,978 (GRCm39) S529I unknown Het
Leo1 A G 9: 75,352,844 (GRCm39) H129R probably benign Het
Lmf1 G A 17: 25,798,323 (GRCm39) V55M possibly damaging Het
Mcm9 A G 10: 53,413,665 (GRCm39) S472P probably benign Het
Med27 T A 2: 29,267,950 (GRCm39) V33D Het
Mgat4f T C 1: 134,317,800 (GRCm39) C191R probably benign Het
Mup15 C T 4: 61,356,526 (GRCm39) E80K probably benign Het
Myo18a G A 11: 77,750,246 (GRCm39) R199H Het
Nebl T A 2: 17,395,727 (GRCm39) R558* probably null Het
Or10ak8 A T 4: 118,774,183 (GRCm39) H160Q probably benign Het
Or12e9 A G 2: 87,202,613 (GRCm39) T246A probably damaging Het
Or4a79 A T 2: 89,551,603 (GRCm39) I284K probably damaging Het
Or5p78 T C 7: 108,212,198 (GRCm39) I228T probably damaging Het
Or6c217 T C 10: 129,738,222 (GRCm39) D119G probably damaging Het
Or8b41 A T 9: 38,054,736 (GRCm39) M97L probably benign Het
Pde11a A T 2: 76,045,697 (GRCm39) F376I possibly damaging Het
Prima1 A T 12: 103,201,920 (GRCm39) C52S probably damaging Het
Pxn G A 5: 115,686,606 (GRCm39) R366H not run Het
Sgce T C 6: 4,691,564 (GRCm39) Y337C probably damaging Het
Slc25a10 T A 11: 120,386,286 (GRCm39) M130K probably benign Het
Slc29a2 A T 19: 5,074,290 (GRCm39) N5I probably benign Het
Slc35a1 A T 4: 34,673,875 (GRCm39) H150Q Het
Slc5a4a T A 10: 75,983,384 (GRCm39) V7D unknown Het
Stk17b T A 1: 53,805,159 (GRCm39) D134V probably damaging Het
Tex55 C T 16: 38,648,453 (GRCm39) D219N possibly damaging Het
Thbs3 T A 3: 89,124,014 (GRCm39) S36T probably benign Het
Thsd4 A G 9: 60,335,457 (GRCm39) S152P probably benign Het
Tmem67 G T 4: 12,063,698 (GRCm39) H422N probably benign Het
Tram1 C A 1: 13,659,868 (GRCm39) V27F probably damaging Het
Trim14 A G 4: 46,507,238 (GRCm39) V326A possibly damaging Het
Other mutations in Or11g7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01663:Or11g7 APN 14 50,690,607 (GRCm39) missense probably benign 0.04
IGL02117:Or11g7 APN 14 50,691,399 (GRCm39) missense possibly damaging 0.91
IGL02663:Or11g7 APN 14 50,691,309 (GRCm39) missense probably benign 0.02
IGL02858:Or11g7 APN 14 50,690,507 (GRCm39) utr 5 prime probably benign
IGL02955:Or11g7 APN 14 50,691,442 (GRCm39) missense probably damaging 0.99
IGL03210:Or11g7 APN 14 50,691,440 (GRCm39) missense probably benign 0.10
IGL03249:Or11g7 APN 14 50,690,668 (GRCm39) missense probably damaging 0.98
G1Funyon:Or11g7 UTSW 14 50,691,021 (GRCm39) missense probably benign 0.08
R0946:Or11g7 UTSW 14 50,691,130 (GRCm39) missense probably benign 0.13
R1449:Or11g7 UTSW 14 50,691,378 (GRCm39) missense probably damaging 1.00
R1465:Or11g7 UTSW 14 50,690,634 (GRCm39) missense possibly damaging 0.91
R1465:Or11g7 UTSW 14 50,690,634 (GRCm39) missense possibly damaging 0.91
R1513:Or11g7 UTSW 14 50,691,138 (GRCm39) missense probably benign 0.00
R1908:Or11g7 UTSW 14 50,691,295 (GRCm39) missense probably damaging 0.99
R2422:Or11g7 UTSW 14 50,690,893 (GRCm39) missense probably damaging 1.00
R3406:Or11g7 UTSW 14 50,690,653 (GRCm39) missense probably benign 0.14
R4184:Or11g7 UTSW 14 50,690,827 (GRCm39) missense probably damaging 1.00
R4795:Or11g7 UTSW 14 50,690,874 (GRCm39) missense probably damaging 0.96
R5028:Or11g7 UTSW 14 50,691,196 (GRCm39) missense probably damaging 1.00
R5436:Or11g7 UTSW 14 50,691,184 (GRCm39) missense probably damaging 1.00
R6057:Or11g7 UTSW 14 50,691,201 (GRCm39) nonsense probably null
R6455:Or11g7 UTSW 14 50,691,042 (GRCm39) missense possibly damaging 0.92
R6903:Or11g7 UTSW 14 50,691,412 (GRCm39) missense possibly damaging 0.93
R6998:Or11g7 UTSW 14 50,690,890 (GRCm39) missense probably benign 0.29
R8048:Or11g7 UTSW 14 50,691,373 (GRCm39) missense possibly damaging 0.52
R8301:Or11g7 UTSW 14 50,691,021 (GRCm39) missense probably benign 0.08
X0066:Or11g7 UTSW 14 50,691,115 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCTTATACATTGGTCCTGAGAGCTG -3'
(R):5'- CACTTCTTGGCATCAGCATC -3'

Sequencing Primer
(F):5'- AGCTGTGTTCAGAGTTCCTTCAAGAG -3'
(R):5'- GGCACAATTTAATCATTCTTGTGC -3'
Posted On 2019-11-12