Incidental Mutation 'R7672:Heatr1'
| ID |
592254 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Heatr1
|
| Ensembl Gene |
ENSMUSG00000050244 |
| Gene Name |
HEAT repeat containing 1 |
| Synonyms |
B130016L12Rik |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.971)
|
| Stock # |
R7672 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
12395027-12440289 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 12438664 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Leucine
at position 2140
(Q2140L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000054084
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000059270]
[ENSMUST00000099820]
[ENSMUST00000099821]
[ENSMUST00000124888]
[ENSMUST00000135166]
[ENSMUST00000143693]
[ENSMUST00000144283]
|
| AlphaFold |
G3X9B1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000059270
AA Change: Q2140L
PolyPhen 2
Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000054084
Gene: ENSMUSG00000050244
AA Change: Q2140L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
15 |
N/A |
INTRINSIC |
|
Pfam:U3snoRNP10
|
238 |
354 |
7e-30 |
PFAM |
|
SCOP:d1qbkb_
|
919 |
1795 |
3e-8 |
SMART |
|
low complexity region
|
1805 |
1814 |
N/A |
INTRINSIC |
|
BP28CT
|
1856 |
2009 |
2.25e-77 |
SMART |
|
Blast:BP28CT
|
2015 |
2061 |
2e-15 |
BLAST |
|
coiled coil region
|
2109 |
2137 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099820
|
| SMART Domains |
Protein: ENSMUSP00000097408
Gene: ENSMUSG00000057554
| Domain | Start | End | E-Value | Type |
|---|
|
GLECT
|
16 |
151 |
3.05e-50 |
SMART |
|
Gal-bind_lectin
|
22 |
150 |
7.41e-55 |
SMART |
|
GLECT
|
184 |
316 |
1.38e-48 |
SMART |
|
Gal-bind_lectin
|
190 |
315 |
1.28e-49 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099821
|
| SMART Domains |
Protein: ENSMUSP00000097409
Gene: ENSMUSG00000057554
| Domain | Start | End | E-Value | Type |
|---|
|
GLECT
|
16 |
151 |
3.05e-50 |
SMART |
|
Gal-bind_lectin
|
22 |
150 |
7.41e-55 |
SMART |
|
GLECT
|
184 |
316 |
1.38e-48 |
SMART |
|
Gal-bind_lectin
|
190 |
315 |
1.28e-49 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124888
|
| SMART Domains |
Protein: ENSMUSP00000115094
Gene: ENSMUSG00000057554
| Domain | Start | End | E-Value | Type |
|---|
|
GLECT
|
16 |
151 |
3.05e-50 |
SMART |
|
Gal-bind_lectin
|
22 |
150 |
7.41e-55 |
SMART |
|
GLECT
|
184 |
316 |
1.38e-48 |
SMART |
|
Gal-bind_lectin
|
190 |
315 |
1.28e-49 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135166
|
| SMART Domains |
Protein: ENSMUSP00000120210
Gene: ENSMUSG00000057554
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Gal-bind_lectin
|
1 |
57 |
4e-16 |
PFAM |
|
GLECT
|
91 |
223 |
1.38e-48 |
SMART |
|
Gal-bind_lectin
|
97 |
222 |
1.28e-49 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143693
|
| SMART Domains |
Protein: ENSMUSP00000118925
Gene: ENSMUSG00000057554
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Gal-bind_lectin
|
1 |
57 |
4e-16 |
PFAM |
|
GLECT
|
91 |
223 |
1.38e-48 |
SMART |
|
Gal-bind_lectin
|
97 |
222 |
1.28e-49 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144283
|
| SMART Domains |
Protein: ENSMUSP00000114200
Gene: ENSMUSG00000057554
| Domain | Start | End | E-Value | Type |
|---|
|
GLECT
|
16 |
151 |
3.05e-50 |
SMART |
|
Gal-bind_lectin
|
22 |
150 |
7.41e-55 |
SMART |
|
GLECT
|
193 |
325 |
1.38e-48 |
SMART |
|
Gal-bind_lectin
|
199 |
324 |
1.28e-49 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000222091
AA Change: Q740L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9130023H24Rik |
T |
C |
7: 128,237,019 (GRCm38) |
H134R |
probably damaging |
Het |
| Adcy4 |
A |
G |
14: 55,780,905 (GRCm38) |
M195T |
probably benign |
Het |
| Aktip |
T |
C |
8: 91,129,657 (GRCm38) |
N64S |
possibly damaging |
Het |
| Aldoart1 |
C |
A |
4: 72,852,510 (GRCm38) |
M20I |
probably benign |
Het |
| Alms1 |
T |
C |
6: 85,615,351 (GRCm38) |
L395P |
probably damaging |
Het |
| Ankrd9 |
C |
A |
12: 110,976,746 (GRCm38) |
V252F |
probably benign |
Het |
| Apof |
A |
T |
10: 128,269,016 (GRCm38) |
H13L |
probably benign |
Het |
| Bahcc1 |
T |
C |
11: 120,283,346 (GRCm38) |
F1644S |
possibly damaging |
Het |
| Baz2a |
A |
G |
10: 128,123,857 (GRCm38) |
D1377G |
possibly damaging |
Het |
| Bbox1 |
T |
A |
2: 110,305,449 (GRCm38) |
I62F |
probably damaging |
Het |
| BC028528 |
CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT |
CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT |
3: 95,888,136 (GRCm38) |
|
probably benign |
Het |
| BC028528 |
GTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTG |
GTTCTGTGGTCACTGATTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTG |
3: 95,888,143 (GRCm38) |
|
probably benign |
Het |
| BC028528 |
TCTGTGGTCACTGGT |
TCTGTGGTCACTGGTGCTGTGGTCACTGGT |
3: 95,888,175 (GRCm38) |
|
probably benign |
Het |
| Bcas3 |
C |
T |
11: 85,395,387 (GRCm38) |
R124* |
probably null |
Het |
| Bpnt1 |
T |
C |
1: 185,346,682 (GRCm38) |
V114A |
probably damaging |
Het |
| Ccnd1 |
C |
T |
7: 144,934,056 (GRCm38) |
R228H |
possibly damaging |
Het |
| Cd244a |
T |
C |
1: 171,577,285 (GRCm38) |
V235A |
probably benign |
Het |
| Cramp1 |
C |
T |
17: 24,982,466 (GRCm38) |
E681K |
probably damaging |
Het |
| Crebbp |
C |
T |
16: 4,084,710 (GRCm38) |
A2222T |
probably benign |
Het |
| Cyp1a2 |
T |
A |
9: 57,682,337 (GRCm38) |
T65S |
probably benign |
Het |
| Cyp26b1 |
T |
G |
6: 84,584,369 (GRCm38) |
K104Q |
probably benign |
Het |
| D430041D05Rik |
T |
C |
2: 104,241,236 (GRCm38) |
I556V |
probably benign |
Het |
| Dnase1l2 |
A |
G |
17: 24,442,245 (GRCm38) |
L102P |
probably damaging |
Het |
| Eef1ece2 |
C |
A |
16: 20,638,667 (GRCm38) |
A483E |
probably damaging |
Het |
| Elac1 |
C |
T |
18: 73,738,854 (GRCm38) |
G357S |
probably benign |
Het |
| Enam |
C |
A |
5: 88,503,971 (GRCm38) |
T1113N |
possibly damaging |
Het |
| Eogt |
A |
T |
6: 97,113,909 (GRCm38) |
I423N |
probably damaging |
Het |
| Epc2 |
T |
C |
2: 49,545,819 (GRCm38) |
S612P |
possibly damaging |
Het |
| Fam107b |
T |
C |
2: 3,772,922 (GRCm38) |
V24A |
probably damaging |
Het |
| Fhip2a |
A |
G |
19: 57,385,318 (GRCm38) |
H670R |
possibly damaging |
Het |
| Foxj3 |
C |
T |
4: 119,620,232 (GRCm38) |
P413L |
unknown |
Het |
| Frg1 |
T |
C |
8: 41,417,003 (GRCm38) |
|
probably benign |
Het |
| Fsip2 |
T |
A |
2: 82,990,111 (GRCm38) |
V5396D |
possibly damaging |
Het |
| Hdlbp |
T |
C |
1: 93,437,099 (GRCm38) |
T149A |
possibly damaging |
Het |
| Iqcd |
T |
C |
5: 120,606,816 (GRCm38) |
L403P |
probably damaging |
Het |
| Kifbp |
A |
G |
10: 62,578,073 (GRCm38) |
I102T |
probably benign |
Het |
| Kpna2 |
T |
G |
11: 106,988,963 (GRCm38) |
N505T |
probably benign |
Het |
| Lipo1 |
T |
A |
19: 33,780,385 (GRCm38) |
E228V |
probably benign |
Het |
| Map4k3 |
C |
T |
17: 80,615,071 (GRCm38) |
V474I |
possibly damaging |
Het |
| Mrpl11 |
T |
C |
19: 4,962,396 (GRCm38) |
S2P |
probably damaging |
Het |
| Mug2 |
A |
G |
6: 122,040,719 (GRCm38) |
I472V |
probably benign |
Het |
| Myom1 |
G |
A |
17: 71,084,240 (GRCm38) |
V915M |
possibly damaging |
Het |
| Nedd9 |
A |
T |
13: 41,338,722 (GRCm38) |
I104N |
possibly damaging |
Het |
| Nphp3 |
A |
G |
9: 104,031,960 (GRCm38) |
M790V |
probably benign |
Het |
| Nr3c2 |
C |
T |
8: 76,909,209 (GRCm38) |
P313L |
probably damaging |
Het |
| Obsl1 |
A |
G |
1: 75,492,721 (GRCm38) |
V1192A |
probably benign |
Het |
| Or10j2 |
C |
T |
1: 173,270,873 (GRCm38) |
R233W |
probably benign |
Het |
| Or52e7 |
A |
G |
7: 105,035,543 (GRCm38) |
H115R |
probably damaging |
Het |
| Or5t16 |
T |
C |
2: 86,988,319 (GRCm38) |
I286V |
possibly damaging |
Het |
| Prr5l |
T |
G |
2: 101,734,738 (GRCm38) |
E151A |
probably damaging |
Het |
| Psmb8 |
G |
T |
17: 34,198,430 (GRCm38) |
R11L |
probably benign |
Het |
| Ptprg |
T |
A |
14: 12,211,668 (GRCm38) |
H983Q |
probably benign |
Het |
| Ptprj |
T |
C |
2: 90,460,596 (GRCm38) |
N600D |
possibly damaging |
Het |
| Rasgrp1 |
T |
C |
2: 117,287,943 (GRCm38) |
I522V |
probably damaging |
Het |
| Rc3h1 |
A |
G |
1: 160,950,884 (GRCm38) |
S460G |
probably damaging |
Het |
| Rhot2 |
A |
G |
17: 25,843,105 (GRCm38) |
|
probably null |
Het |
| Sall1 |
T |
C |
8: 89,031,299 (GRCm38) |
T726A |
probably damaging |
Het |
| Samd9l |
G |
A |
6: 3,373,646 (GRCm38) |
T1205I |
probably benign |
Het |
| Sh2b3 |
C |
T |
5: 121,818,759 (GRCm38) |
|
probably null |
Het |
| Slc22a18 |
G |
T |
7: 143,490,820 (GRCm38) |
C170F |
probably damaging |
Het |
| Slc24a1 |
G |
A |
9: 64,947,927 (GRCm38) |
T566I |
unknown |
Het |
| Slc4a5 |
T |
A |
6: 83,260,535 (GRCm38) |
C167S |
probably damaging |
Het |
| Slc8b1 |
T |
G |
5: 120,533,035 (GRCm38) |
V579G |
probably damaging |
Het |
| Snrnp200 |
T |
C |
2: 127,221,902 (GRCm38) |
V667A |
probably damaging |
Het |
| Sp8 |
C |
A |
12: 118,849,335 (GRCm38) |
S308R |
possibly damaging |
Het |
| Srsf9 |
T |
A |
5: 115,330,560 (GRCm38) |
V85E |
probably damaging |
Het |
| Syne1 |
T |
C |
10: 5,218,527 (GRCm38) |
I5285V |
probably benign |
Het |
| Tmem245 |
T |
C |
4: 56,947,069 (GRCm38) |
I115V |
probably benign |
Het |
| Triqk |
A |
G |
4: 12,980,502 (GRCm38) |
D82G |
probably benign |
Het |
| Trmt11 |
A |
T |
10: 30,587,524 (GRCm38) |
S198R |
probably damaging |
Het |
| Ube4b |
C |
T |
4: 149,387,204 (GRCm38) |
R75Q |
probably benign |
Het |
| Ugt3a1 |
C |
T |
15: 9,310,693 (GRCm38) |
Q354* |
probably null |
Het |
| Vmn1r202 |
A |
G |
13: 22,501,680 (GRCm38) |
V189A |
probably benign |
Het |
| Vmn2r26 |
A |
G |
6: 124,039,647 (GRCm38) |
I357V |
probably benign |
Het |
| Wdr6 |
T |
C |
9: 108,573,748 (GRCm38) |
K914R |
probably benign |
Het |
| Zfat |
T |
C |
15: 68,258,686 (GRCm38) |
M1V |
probably null |
Het |
| Zfp207 |
A |
G |
11: 80,389,290 (GRCm38) |
M171V |
probably benign |
Het |
| Zfp568 |
C |
T |
7: 29,997,787 (GRCm38) |
T44I |
probably damaging |
Het |
|
| Other mutations in Heatr1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00666:Heatr1
|
APN |
13 |
12,410,450 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL00863:Heatr1
|
APN |
13 |
12,435,128 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL00899:Heatr1
|
APN |
13 |
12,435,176 (GRCm38) |
missense |
probably benign |
0.31 |
|
IGL01147:Heatr1
|
APN |
13 |
12,437,912 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01317:Heatr1
|
APN |
13 |
12,399,027 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01323:Heatr1
|
APN |
13 |
12,398,938 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
IGL01625:Heatr1
|
APN |
13 |
12,413,528 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01973:Heatr1
|
APN |
13 |
12,429,799 (GRCm38) |
missense |
probably benign |
|
|
IGL02803:Heatr1
|
APN |
13 |
12,433,986 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02830:Heatr1
|
APN |
13 |
12,426,212 (GRCm38) |
missense |
possibly damaging |
0.57 |
|
IGL02956:Heatr1
|
APN |
13 |
12,416,059 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
IGL03000:Heatr1
|
APN |
13 |
12,434,411 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03024:Heatr1
|
APN |
13 |
12,407,509 (GRCm38) |
unclassified |
probably benign |
|
|
IGL03035:Heatr1
|
APN |
13 |
12,413,219 (GRCm38) |
splice site |
probably benign |
|
|
IGL03301:Heatr1
|
APN |
13 |
12,434,205 (GRCm38) |
missense |
probably damaging |
1.00 |
|
hasan
|
UTSW |
13 |
12,417,447 (GRCm38) |
splice site |
probably benign |
|
|
H8562:Heatr1
|
UTSW |
13 |
12,408,713 (GRCm38) |
missense |
probably benign |
0.13 |
|
R0226:Heatr1
|
UTSW |
13 |
12,410,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0571:Heatr1
|
UTSW |
13 |
12,430,240 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0722:Heatr1
|
UTSW |
13 |
12,406,037 (GRCm38) |
missense |
probably benign |
0.14 |
|
R1264:Heatr1
|
UTSW |
13 |
12,424,610 (GRCm38) |
unclassified |
probably benign |
|
|
R1371:Heatr1
|
UTSW |
13 |
12,417,632 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R1388:Heatr1
|
UTSW |
13 |
12,417,447 (GRCm38) |
splice site |
probably benign |
|
|
R1396:Heatr1
|
UTSW |
13 |
12,406,046 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R1519:Heatr1
|
UTSW |
13 |
12,412,159 (GRCm38) |
missense |
probably benign |
|
|
R1689:Heatr1
|
UTSW |
13 |
12,424,625 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1696:Heatr1
|
UTSW |
13 |
12,423,721 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R1756:Heatr1
|
UTSW |
13 |
12,396,460 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1859:Heatr1
|
UTSW |
13 |
12,403,159 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1932:Heatr1
|
UTSW |
13 |
12,435,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1957:Heatr1
|
UTSW |
13 |
12,396,538 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2018:Heatr1
|
UTSW |
13 |
12,414,478 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R2106:Heatr1
|
UTSW |
13 |
12,412,058 (GRCm38) |
missense |
probably benign |
0.03 |
|
R2119:Heatr1
|
UTSW |
13 |
12,432,646 (GRCm38) |
missense |
probably null |
1.00 |
|
R2121:Heatr1
|
UTSW |
13 |
12,403,264 (GRCm38) |
missense |
probably benign |
0.10 |
|
R2122:Heatr1
|
UTSW |
13 |
12,403,264 (GRCm38) |
missense |
probably benign |
0.10 |
|
R2367:Heatr1
|
UTSW |
13 |
12,433,724 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3777:Heatr1
|
UTSW |
13 |
12,413,348 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R3783:Heatr1
|
UTSW |
13 |
12,434,460 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3784:Heatr1
|
UTSW |
13 |
12,434,460 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3786:Heatr1
|
UTSW |
13 |
12,434,460 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3787:Heatr1
|
UTSW |
13 |
12,434,460 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3843:Heatr1
|
UTSW |
13 |
12,435,121 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4533:Heatr1
|
UTSW |
13 |
12,434,511 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4725:Heatr1
|
UTSW |
13 |
12,424,662 (GRCm38) |
nonsense |
probably null |
|
|
R4763:Heatr1
|
UTSW |
13 |
12,430,930 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R4793:Heatr1
|
UTSW |
13 |
12,431,837 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4797:Heatr1
|
UTSW |
13 |
12,412,048 (GRCm38) |
missense |
probably benign |
0.36 |
|
R4798:Heatr1
|
UTSW |
13 |
12,412,048 (GRCm38) |
missense |
probably benign |
0.36 |
|
R4942:Heatr1
|
UTSW |
13 |
12,413,510 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R4952:Heatr1
|
UTSW |
13 |
12,410,599 (GRCm38) |
missense |
probably benign |
0.38 |
|
R4954:Heatr1
|
UTSW |
13 |
12,407,516 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R5370:Heatr1
|
UTSW |
13 |
12,401,522 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5464:Heatr1
|
UTSW |
13 |
12,433,643 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5483:Heatr1
|
UTSW |
13 |
12,398,914 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5497:Heatr1
|
UTSW |
13 |
12,421,064 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R5504:Heatr1
|
UTSW |
13 |
12,406,619 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R5527:Heatr1
|
UTSW |
13 |
12,404,948 (GRCm38) |
missense |
probably benign |
|
|
R5527:Heatr1
|
UTSW |
13 |
12,402,760 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5836:Heatr1
|
UTSW |
13 |
12,408,736 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5916:Heatr1
|
UTSW |
13 |
12,434,471 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6018:Heatr1
|
UTSW |
13 |
12,406,058 (GRCm38) |
missense |
probably benign |
0.26 |
|
R6018:Heatr1
|
UTSW |
13 |
12,404,947 (GRCm38) |
missense |
probably benign |
|
|
R6216:Heatr1
|
UTSW |
13 |
12,432,664 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6396:Heatr1
|
UTSW |
13 |
12,406,097 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R6472:Heatr1
|
UTSW |
13 |
12,434,230 (GRCm38) |
missense |
probably benign |
0.29 |
|
R6922:Heatr1
|
UTSW |
13 |
12,435,075 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7077:Heatr1
|
UTSW |
13 |
12,418,164 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R7297:Heatr1
|
UTSW |
13 |
12,421,060 (GRCm38) |
nonsense |
probably null |
|
|
R7445:Heatr1
|
UTSW |
13 |
12,431,038 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R7669:Heatr1
|
UTSW |
13 |
12,411,262 (GRCm38) |
missense |
probably benign |
0.33 |
|
R7772:Heatr1
|
UTSW |
13 |
12,417,641 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8205:Heatr1
|
UTSW |
13 |
12,416,047 (GRCm38) |
missense |
probably benign |
|
|
R8518:Heatr1
|
UTSW |
13 |
12,410,534 (GRCm38) |
missense |
probably benign |
|
|
R8754:Heatr1
|
UTSW |
13 |
12,413,294 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8874:Heatr1
|
UTSW |
13 |
12,430,912 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8992:Heatr1
|
UTSW |
13 |
12,401,114 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9045:Heatr1
|
UTSW |
13 |
12,413,352 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9077:Heatr1
|
UTSW |
13 |
12,413,366 (GRCm38) |
missense |
probably benign |
|
|
R9183:Heatr1
|
UTSW |
13 |
12,421,385 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9186:Heatr1
|
UTSW |
13 |
12,421,346 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9223:Heatr1
|
UTSW |
13 |
12,404,921 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9242:Heatr1
|
UTSW |
13 |
12,433,925 (GRCm38) |
missense |
probably benign |
|
|
R9267:Heatr1
|
UTSW |
13 |
12,406,608 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9289:Heatr1
|
UTSW |
13 |
12,432,727 (GRCm38) |
missense |
probably benign |
0.13 |
|
R9310:Heatr1
|
UTSW |
13 |
12,438,610 (GRCm38) |
missense |
probably benign |
|
|
R9312:Heatr1
|
UTSW |
13 |
12,431,684 (GRCm38) |
missense |
probably benign |
|
|
R9358:Heatr1
|
UTSW |
13 |
12,418,206 (GRCm38) |
missense |
probably benign |
0.09 |
|
R9385:Heatr1
|
UTSW |
13 |
12,406,542 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9530:Heatr1
|
UTSW |
13 |
12,424,726 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9532:Heatr1
|
UTSW |
13 |
12,414,425 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R9647:Heatr1
|
UTSW |
13 |
12,426,798 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9683:Heatr1
|
UTSW |
13 |
12,434,259 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9695:Heatr1
|
UTSW |
13 |
12,423,743 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF011:Heatr1
|
UTSW |
13 |
12,407,544 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1176:Heatr1
|
UTSW |
13 |
12,399,008 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCAAGAACAAGTACATGCCTG -3'
(R):5'- TTCTGTGGTATCCCAGACAGG -3'
Sequencing Primer
(F):5'- ACAAGTACATGCCTGTGAGG -3'
(R):5'- TCCCAGACAGGCAGGGATTTTG -3'
|
| Posted On |
2019-11-12 |
Incidental Mutation