Incidental Mutation 'R7674:Yipf7'
ID 592361
Institutional Source Beutler Lab
Gene Symbol Yipf7
Ensembl Gene ENSMUSG00000029158
Gene Name Yip1 domain family, member 7
Synonyms Yip1b, 2310016N21Rik
MMRRC Submission 045744-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7674 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 69674013-69699990 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 69676572 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 189 (V189D)
Ref Sequence ENSEMBL: ENSMUSP00000031045 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031045] [ENSMUST00000202423]
AlphaFold Q9JIM5
Predicted Effect probably damaging
Transcript: ENSMUST00000031045
AA Change: V189D

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000031045
Gene: ENSMUSG00000029158
AA Change: V189D

DomainStartEndE-ValueType
Pfam:Yip1 93 253 4.2e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000202423
Meta Mutation Damage Score 0.8183 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (58/58)
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 T A 11: 110,110,123 (GRCm39) I607F probably damaging Het
Abcc4 A T 14: 118,848,899 (GRCm39) D559E probably damaging Het
Abl1 T C 2: 31,579,841 (GRCm39) V8A possibly damaging Het
Alkal1 A T 1: 6,459,712 (GRCm39) Y96F probably damaging Het
Asb3 T A 11: 31,031,435 (GRCm39) C352S possibly damaging Het
B4galnt3 G T 6: 120,192,166 (GRCm39) D523E probably benign Het
Cadps C A 14: 12,411,581 (GRCm38) E1258D probably damaging Het
Carmil2 A T 8: 106,423,918 (GRCm39) Q1257L possibly damaging Het
Cars1 A G 7: 143,140,840 (GRCm39) probably null Het
Ccdc88c G T 12: 100,911,491 (GRCm39) A781E probably benign Het
Ccr10 A T 11: 101,065,475 (GRCm39) D18E probably benign Het
Cdcp1 C A 9: 123,045,071 (GRCm39) probably benign Het
Ces5a C A 8: 94,240,897 (GRCm39) R400L probably damaging Het
Clcn6 C T 4: 148,097,151 (GRCm39) V636M probably damaging Het
Cluh T A 11: 74,558,546 (GRCm39) L1206H probably damaging Het
Cog2 C A 8: 125,264,621 (GRCm39) N333K probably damaging Het
Dnah14 A T 1: 181,535,098 (GRCm39) I2355L probably benign Het
Dok4 T C 8: 95,593,190 (GRCm39) Y165C probably damaging Het
Dpy19l3 A C 7: 35,394,734 (GRCm39) D601E probably damaging Het
Egr3 G A 14: 70,315,526 (GRCm39) probably null Het
Elapor1 T G 3: 108,370,307 (GRCm39) R698S probably damaging Het
Elp1 T C 4: 56,792,075 (GRCm39) Q231R probably damaging Het
Evpl T C 11: 116,113,394 (GRCm39) K1432R probably benign Het
Fbxw8 A T 5: 118,263,036 (GRCm39) C214* probably null Het
Gm45861 A C 8: 28,030,147 (GRCm39) Y821S unknown Het
Gm5519 G C 19: 33,802,428 (GRCm39) G157A probably benign Het
Gys1 T C 7: 45,104,495 (GRCm39) S641P probably damaging Het
Ighv6-6 T A 12: 114,398,837 (GRCm39) I10L probably benign Het
Jmy C T 13: 93,579,107 (GRCm39) R675Q probably damaging Het
Kif14 C T 1: 136,396,558 (GRCm39) T288I probably damaging Het
Kpna3 A T 14: 61,605,086 (GRCm39) N520K probably benign Het
Lonp2 A T 8: 87,392,386 (GRCm39) Q484L probably benign Het
Lrp1b T A 2: 42,542,921 (GRCm39) probably benign Het
Mpeg1 A T 19: 12,438,751 (GRCm39) M70L probably benign Het
Msh3 C A 13: 92,349,011 (GRCm39) V1074L probably benign Het
Muc6 A T 7: 141,224,247 (GRCm39) L1645Q unknown Het
Nipbl C T 15: 8,322,585 (GRCm39) V2609I probably benign Het
Nucks1 C A 1: 131,858,844 (GRCm39) T202N probably benign Het
Or10al3 A G 17: 38,011,573 (GRCm39) N4S probably benign Het
Or4c127 A T 2: 89,833,389 (GRCm39) Y213F probably damaging Het
Or4e2 A G 14: 52,687,899 (GRCm39) T10A probably benign Het
Or5m12 A C 2: 85,734,880 (GRCm39) F173V probably damaging Het
Or8b12i A G 9: 20,082,549 (GRCm39) L106P possibly damaging Het
Plekha2 A G 8: 25,547,314 (GRCm39) S257P probably damaging Het
Pnlip G C 19: 58,663,586 (GRCm39) G187A possibly damaging Het
Pramel22 T A 4: 143,382,175 (GRCm39) K174* probably null Het
Rasgrf2 C T 13: 92,267,914 (GRCm39) S30N possibly damaging Het
Rho G T 6: 115,909,294 (GRCm39) C110F probably damaging Het
Selplg GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT 5: 113,957,756 (GRCm39) probably benign Het
Slc2a12 A G 10: 22,569,893 (GRCm39) D528G probably damaging Het
Sorcs2 G A 5: 36,555,296 (GRCm39) R32C probably damaging Het
Sp110 G A 1: 85,506,813 (GRCm39) R417C probably benign Het
Srp72 A T 5: 77,122,673 (GRCm39) N35Y probably damaging Het
Tm2d2 C A 8: 25,508,280 (GRCm39) Y141* probably null Het
Tor3a G A 1: 156,483,478 (GRCm39) H315Y possibly damaging Het
Usp17la A T 7: 104,510,654 (GRCm39) K420* probably null Het
Vmn2r26 T C 6: 124,016,321 (GRCm39) W262R probably benign Het
Zan T A 5: 137,465,370 (GRCm39) M462L possibly damaging Het
Zc3h18 AGG AG 8: 123,110,295 (GRCm39) probably null Het
Zfp930 A T 8: 69,681,337 (GRCm39) H344L probably damaging Het
Other mutations in Yipf7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01160:Yipf7 APN 5 69,676,660 (GRCm39) missense probably benign 0.13
IGL02829:Yipf7 APN 5 69,698,434 (GRCm39) missense probably benign 0.22
R0581:Yipf7 UTSW 5 69,678,406 (GRCm39) missense probably benign 0.37
R2104:Yipf7 UTSW 5 69,678,462 (GRCm39) missense possibly damaging 0.92
R2697:Yipf7 UTSW 5 69,698,483 (GRCm39) missense possibly damaging 0.79
R4329:Yipf7 UTSW 5 69,678,465 (GRCm39) missense probably damaging 1.00
R4621:Yipf7 UTSW 5 69,676,704 (GRCm39) missense possibly damaging 0.79
R6103:Yipf7 UTSW 5 69,698,405 (GRCm39) missense probably benign
R6652:Yipf7 UTSW 5 69,698,504 (GRCm39) start codon destroyed probably null 1.00
R6823:Yipf7 UTSW 5 69,674,413 (GRCm39) missense probably damaging 1.00
R7796:Yipf7 UTSW 5 69,684,596 (GRCm39) missense possibly damaging 0.85
R8115:Yipf7 UTSW 5 69,684,570 (GRCm39) missense probably benign
R8284:Yipf7 UTSW 5 69,674,539 (GRCm39) missense probably benign 0.25
R8512:Yipf7 UTSW 5 69,674,387 (GRCm39) missense probably benign 0.03
R9646:Yipf7 UTSW 5 69,678,424 (GRCm39) missense probably benign 0.29
Predicted Primers PCR Primer
(F):5'- AGCCAAATTGACCTACTTTCCC -3'
(R):5'- GAATCCTCAGTGACCTGGTG -3'

Sequencing Primer
(F):5'- CCACCCCCGAATATATGTGTAG -3'
(R):5'- AATCCTCAGTGACCTGGTGATGTATC -3'
Posted On 2019-11-12