Incidental Mutation 'R7675:Zfp980'
| ID |
592415 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp980
|
| Ensembl Gene |
ENSMUSG00000058186 |
| Gene Name |
zinc finger protein 980 |
| Synonyms |
Gm13242 |
| MMRRC Submission |
045706-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.380)
|
| Stock # |
R7675 (G1)
|
| Quality Score |
191.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
145397267-145431007 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 145428164 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 298
(Q298*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101364
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105738]
[ENSMUST00000180014]
|
| AlphaFold |
A2A9J5 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000105738
AA Change: Q298*
|
| SMART Domains |
Protein: ENSMUSP00000101364
Gene: ENSMUSG00000058186
AA Change: Q298*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
28 |
90 |
1.46e-16 |
SMART |
|
low complexity region
|
235 |
246 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
251 |
273 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
279 |
301 |
3.49e-5 |
SMART |
|
ZnF_C2H2
|
307 |
329 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
335 |
357 |
5.67e-5 |
SMART |
|
ZnF_C2H2
|
363 |
385 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
391 |
413 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
419 |
441 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
447 |
469 |
1.22e-4 |
SMART |
|
ZnF_C2H2
|
475 |
497 |
5.67e-5 |
SMART |
|
ZnF_C2H2
|
503 |
525 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
531 |
553 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
559 |
581 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
587 |
609 |
1.22e-4 |
SMART |
|
ZnF_C2H2
|
615 |
635 |
1.26e1 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000180014
AA Change: Q298*
|
| SMART Domains |
Protein: ENSMUSP00000137589
Gene: ENSMUSG00000058186
AA Change: Q298*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
28 |
90 |
1.46e-16 |
SMART |
|
low complexity region
|
235 |
246 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
251 |
273 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
279 |
301 |
3.49e-5 |
SMART |
|
ZnF_C2H2
|
307 |
329 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
335 |
357 |
5.67e-5 |
SMART |
|
ZnF_C2H2
|
363 |
385 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
391 |
413 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
419 |
441 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
447 |
469 |
1.22e-4 |
SMART |
|
ZnF_C2H2
|
475 |
497 |
5.67e-5 |
SMART |
|
ZnF_C2H2
|
503 |
525 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
531 |
553 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
559 |
581 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
587 |
609 |
1.22e-4 |
SMART |
|
ZnF_C2H2
|
615 |
635 |
1.26e1 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
97% (28/29) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2010109A12Rik |
T |
C |
5: 93,361,233 (GRCm39) |
S96P |
unknown |
Het |
| Acaca |
A |
G |
11: 84,206,742 (GRCm39) |
E1534G |
probably benign |
Het |
| Adam7 |
A |
T |
14: 68,737,302 (GRCm39) |
D773E |
probably benign |
Het |
| Cacna1s |
T |
A |
1: 136,038,612 (GRCm39) |
I1398N |
probably damaging |
Het |
| Calu |
C |
T |
6: 29,356,516 (GRCm39) |
T14I |
probably benign |
Het |
| Casp8 |
A |
G |
1: 58,863,106 (GRCm39) |
D2G |
possibly damaging |
Het |
| Cldn1 |
T |
C |
16: 26,190,261 (GRCm39) |
N39S |
probably benign |
Het |
| Clspn |
T |
C |
4: 126,460,113 (GRCm39) |
S447P |
probably benign |
Het |
| Eef2k |
A |
G |
7: 120,457,727 (GRCm39) |
T29A |
probably benign |
Het |
| Gm5519 |
G |
C |
19: 33,802,428 (GRCm39) |
G157A |
probably benign |
Het |
| Gucy2c |
A |
G |
6: 136,693,030 (GRCm39) |
V723A |
possibly damaging |
Het |
| Ighv1-69 |
A |
T |
12: 115,587,209 (GRCm39) |
W3R |
probably damaging |
Het |
| Inava |
G |
T |
1: 136,143,741 (GRCm39) |
A565E |
probably benign |
Het |
| Krtap16-1 |
A |
G |
11: 99,876,259 (GRCm39) |
C382R |
possibly damaging |
Het |
| Lrrc8a |
G |
A |
2: 30,145,680 (GRCm39) |
D165N |
probably damaging |
Het |
| Mideas |
G |
T |
12: 84,220,574 (GRCm39) |
P127T |
probably damaging |
Het |
| Naaladl2 |
T |
A |
3: 24,605,816 (GRCm39) |
M148L |
probably benign |
Het |
| Nphp3 |
A |
T |
9: 103,893,287 (GRCm39) |
E424D |
probably benign |
Het |
| Prpf40a |
T |
C |
2: 53,035,648 (GRCm39) |
K714R |
possibly damaging |
Het |
| Ptpn23 |
A |
T |
9: 110,216,094 (GRCm39) |
L1254* |
probably null |
Het |
| Sap30l |
A |
G |
11: 57,700,867 (GRCm39) |
K174E |
probably damaging |
Het |
| Serpinb9d |
C |
T |
13: 33,386,759 (GRCm39) |
Q276* |
probably null |
Het |
| Sp140l2 |
C |
T |
1: 85,224,736 (GRCm39) |
M266I |
probably benign |
Het |
| Spata31f3 |
TCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGTCATTCAACACTTTGG |
TCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGTCATTCAACACTTTGG |
4: 42,871,823 (GRCm39) |
|
probably benign |
Het |
| Tex14 |
A |
G |
11: 87,400,504 (GRCm39) |
D432G |
probably damaging |
Het |
| Tmsb10b |
A |
T |
7: 24,561,784 (GRCm39) |
T28S |
probably benign |
Het |
| Unc119 |
G |
A |
11: 78,234,423 (GRCm39) |
G11R |
probably damaging |
Het |
| Usp36 |
A |
G |
11: 118,154,522 (GRCm39) |
V965A |
probably benign |
Het |
| Vmn2r4 |
A |
T |
3: 64,322,657 (GRCm39) |
Y21N |
probably benign |
Het |
| Zbtb38 |
G |
T |
9: 96,567,594 (GRCm39) |
D1163E |
probably benign |
Het |
| Zfp62 |
A |
G |
11: 49,106,847 (GRCm39) |
I313V |
possibly damaging |
Het |
|
| Other mutations in Zfp980 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00828:Zfp980
|
APN |
4 |
145,428,561 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0164:Zfp980
|
UTSW |
4 |
145,428,567 (GRCm39) |
missense |
probably benign |
|
|
R0164:Zfp980
|
UTSW |
4 |
145,428,567 (GRCm39) |
missense |
probably benign |
|
|
R1186:Zfp980
|
UTSW |
4 |
145,428,653 (GRCm39) |
missense |
probably benign |
|
|
R1761:Zfp980
|
UTSW |
4 |
145,428,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3726:Zfp980
|
UTSW |
4 |
145,428,653 (GRCm39) |
missense |
probably benign |
|
|
R4049:Zfp980
|
UTSW |
4 |
145,429,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4467:Zfp980
|
UTSW |
4 |
145,428,653 (GRCm39) |
missense |
probably benign |
|
|
R4610:Zfp980
|
UTSW |
4 |
145,428,653 (GRCm39) |
missense |
probably benign |
|
|
R4622:Zfp980
|
UTSW |
4 |
145,428,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4873:Zfp980
|
UTSW |
4 |
145,428,653 (GRCm39) |
missense |
probably benign |
|
|
R5008:Zfp980
|
UTSW |
4 |
145,428,653 (GRCm39) |
missense |
probably benign |
|
|
R5027:Zfp980
|
UTSW |
4 |
145,428,653 (GRCm39) |
missense |
probably benign |
|
|
R5497:Zfp980
|
UTSW |
4 |
145,428,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5995:Zfp980
|
UTSW |
4 |
145,428,479 (GRCm39) |
nonsense |
probably null |
|
|
R6125:Zfp980
|
UTSW |
4 |
145,429,208 (GRCm39) |
makesense |
probably null |
|
|
R7353:Zfp980
|
UTSW |
4 |
145,428,714 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7939:Zfp980
|
UTSW |
4 |
145,428,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8833:Zfp980
|
UTSW |
4 |
145,427,596 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9122:Zfp980
|
UTSW |
4 |
145,428,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9165:Zfp980
|
UTSW |
4 |
145,428,024 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9361:Zfp980
|
UTSW |
4 |
145,427,999 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9469:Zfp980
|
UTSW |
4 |
145,427,687 (GRCm39) |
missense |
probably benign |
0.14 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCAAGGAACCCACATAGAGAAG -3'
(R):5'- TGGTACGGTTTCTCTCCTGT -3'
Sequencing Primer
(F):5'- GTGAAATGAGCACTTACACTTGTGG -3'
(R):5'- CTCCTGTATGAATTCTCTGATGAAC -3'
|
| Posted On |
2019-11-12 |
Incidental Mutation