Incidental Mutation 'R7675:Tmsb10b'
ID 592419
Institutional Source Beutler Lab
Gene Symbol Tmsb10b
Ensembl Gene ENSMUSG00000091955
Gene Name thymosin beta 10b
Synonyms Gm9844
MMRRC Submission 045706-MU
Accession Numbers
Essential gene? Not available question?
Stock # R7675 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 24561628-24562103 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 24561784 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 28 (T28S)
Ref Sequence ENSEMBL: ENSMUSP00000137210 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079306] [ENSMUST00000122995] [ENSMUST00000170837]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000079306
SMART Domains Protein: ENSMUSP00000078287
Gene: ENSMUSG00000062732

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:UPAR_LY6 142 233 7.5e-23 PFAM
low complexity region 237 244 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000122995
SMART Domains Protein: ENSMUSP00000122913
Gene: ENSMUSG00000062732

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000170837
AA Change: T28S

PolyPhen 2 Score 0.373 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 97% (28/29)
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010109A12Rik T C 5: 93,361,233 (GRCm39) S96P unknown Het
Acaca A G 11: 84,206,742 (GRCm39) E1534G probably benign Het
Adam7 A T 14: 68,737,302 (GRCm39) D773E probably benign Het
Cacna1s T A 1: 136,038,612 (GRCm39) I1398N probably damaging Het
Calu C T 6: 29,356,516 (GRCm39) T14I probably benign Het
Casp8 A G 1: 58,863,106 (GRCm39) D2G possibly damaging Het
Cldn1 T C 16: 26,190,261 (GRCm39) N39S probably benign Het
Clspn T C 4: 126,460,113 (GRCm39) S447P probably benign Het
Eef2k A G 7: 120,457,727 (GRCm39) T29A probably benign Het
Gm5519 G C 19: 33,802,428 (GRCm39) G157A probably benign Het
Gucy2c A G 6: 136,693,030 (GRCm39) V723A possibly damaging Het
Ighv1-69 A T 12: 115,587,209 (GRCm39) W3R probably damaging Het
Inava G T 1: 136,143,741 (GRCm39) A565E probably benign Het
Krtap16-1 A G 11: 99,876,259 (GRCm39) C382R possibly damaging Het
Lrrc8a G A 2: 30,145,680 (GRCm39) D165N probably damaging Het
Mideas G T 12: 84,220,574 (GRCm39) P127T probably damaging Het
Naaladl2 T A 3: 24,605,816 (GRCm39) M148L probably benign Het
Nphp3 A T 9: 103,893,287 (GRCm39) E424D probably benign Het
Prpf40a T C 2: 53,035,648 (GRCm39) K714R possibly damaging Het
Ptpn23 A T 9: 110,216,094 (GRCm39) L1254* probably null Het
Sap30l A G 11: 57,700,867 (GRCm39) K174E probably damaging Het
Serpinb9d C T 13: 33,386,759 (GRCm39) Q276* probably null Het
Sp140l2 C T 1: 85,224,736 (GRCm39) M266I probably benign Het
Spata31f3 TCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGTCATTCAACACTTTGG TCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGTCATTCAACACTTTGG 4: 42,871,823 (GRCm39) probably benign Het
Tex14 A G 11: 87,400,504 (GRCm39) D432G probably damaging Het
Unc119 G A 11: 78,234,423 (GRCm39) G11R probably damaging Het
Usp36 A G 11: 118,154,522 (GRCm39) V965A probably benign Het
Vmn2r4 A T 3: 64,322,657 (GRCm39) Y21N probably benign Het
Zbtb38 G T 9: 96,567,594 (GRCm39) D1163E probably benign Het
Zfp62 A G 11: 49,106,847 (GRCm39) I313V possibly damaging Het
Zfp980 C T 4: 145,428,164 (GRCm39) Q298* probably null Het
Other mutations in Tmsb10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1909:Tmsb10b UTSW 7 24,561,731 (GRCm39) missense possibly damaging 0.50
R8240:Tmsb10b UTSW 7 24,561,805 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGAACTGCCTTGAGAATTTTCCC -3'
(R):5'- GGGTTTCACAGTGCAGCTTG -3'

Sequencing Primer
(F):5'- ATTTTACCATCAAGGGCATGATTAGG -3'
(R):5'- GTGGCTCGCGTCCATCTTG -3'
Posted On 2019-11-12