Incidental Mutation 'R7677:Txndc11'
ID 592535
Institutional Source Beutler Lab
Gene Symbol Txndc11
Ensembl Gene ENSMUSG00000022498
Gene Name thioredoxin domain containing 11
Synonyms 2810408E11Rik, EF-hand binding protein 1, EFP1, Txdc11
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R7677 (G1)
Quality Score 110.467
Status Not validated
Chromosome 16
Chromosomal Location 10892775-10952514 bp(-) (GRCm39)
Type of Mutation small deletion (1 aa in frame mutation)
DNA Base Change (assembly) CCCGCCGCCGCCGCCGC to CCCGCCGCCGCCGC at 10952338 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000114777 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037633] [ENSMUST00000038424] [ENSMUST00000118362] [ENSMUST00000118679] [ENSMUST00000145225] [ENSMUST00000147884] [ENSMUST00000155221]
AlphaFold Q8K2W3
Predicted Effect probably benign
Transcript: ENSMUST00000037633
SMART Domains Protein: ENSMUSP00000041308
Gene: ENSMUSG00000037965

DomainStartEndE-ValueType
PDB:2DBA|A 26 157 9e-7 PDB
Blast:TPR 43 76 1e-7 BLAST
SCOP:d1ihga1 46 169 1e-11 SMART
Blast:TPR 124 156 9e-9 BLAST
low complexity region 308 319 N/A INTRINSIC
low complexity region 380 398 N/A INTRINSIC
ZnF_C2H2 443 467 1.83e2 SMART
ZnF_C3H1 630 654 1.57e1 SMART
ZnF_C3H1 770 795 8.81e0 SMART
ZnF_C2H2 856 880 1.62e0 SMART
ZnF_C3H1 902 926 1.76e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000038424
SMART Domains Protein: ENSMUSP00000041113
Gene: ENSMUSG00000022498

DomainStartEndE-ValueType
low complexity region 2 42 N/A INTRINSIC
low complexity region 61 76 N/A INTRINSIC
low complexity region 92 103 N/A INTRINSIC
Pfam:Thioredoxin 107 208 5.8e-11 PFAM
Pfam:Thioredoxin 660 756 1e-11 PFAM
coiled coil region 793 830 N/A INTRINSIC
low complexity region 927 936 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000118362
SMART Domains Protein: ENSMUSP00000113432
Gene: ENSMUSG00000022498

DomainStartEndE-ValueType
low complexity region 2 42 N/A INTRINSIC
low complexity region 61 76 N/A INTRINSIC
low complexity region 92 103 N/A INTRINSIC
Pfam:Thioredoxin 107 208 2.5e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000118679
SMART Domains Protein: ENSMUSP00000112601
Gene: ENSMUSG00000022498

DomainStartEndE-ValueType
low complexity region 2 42 N/A INTRINSIC
low complexity region 61 76 N/A INTRINSIC
low complexity region 92 103 N/A INTRINSIC
Pfam:Thioredoxin 107 208 4.5e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138282
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143121
Predicted Effect probably benign
Transcript: ENSMUST00000145225
SMART Domains Protein: ENSMUSP00000116563
Gene: ENSMUSG00000022498

DomainStartEndE-ValueType
low complexity region 2 42 N/A INTRINSIC
low complexity region 61 76 N/A INTRINSIC
low complexity region 92 103 N/A INTRINSIC
Pfam:Thioredoxin 107 208 5.2e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000147884
SMART Domains Protein: ENSMUSP00000117426
Gene: ENSMUSG00000022498

DomainStartEndE-ValueType
low complexity region 2 42 N/A INTRINSIC
low complexity region 61 76 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000155221
SMART Domains Protein: ENSMUSP00000114777
Gene: ENSMUSG00000022498

DomainStartEndE-ValueType
low complexity region 2 42 N/A INTRINSIC
low complexity region 61 76 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,248,349 (GRCm39) R2699* probably null Het
Adra2a G A 19: 54,035,375 (GRCm39) V244M probably damaging Het
Apba2 A G 7: 64,344,845 (GRCm39) S12G probably benign Het
Arhgap20 T A 9: 51,751,698 (GRCm39) M383K probably damaging Het
Armc12 T C 17: 28,756,865 (GRCm39) V210A probably benign Het
Ash1l A T 3: 88,950,500 (GRCm39) H2131L probably damaging Het
Atg5 T C 10: 44,223,035 (GRCm39) L219P probably damaging Het
Atp2c2 A T 8: 120,474,915 (GRCm39) M507L probably benign Het
Atr T A 9: 95,767,515 (GRCm39) L1191I probably damaging Het
B4galt5 T C 2: 167,146,998 (GRCm39) T279A probably damaging Het
Bglap2 T C 3: 88,285,280 (GRCm39) E62G probably damaging Het
Card6 A G 15: 5,127,926 (GRCm39) S1157P unknown Het
Ccdc17 T C 4: 116,454,962 (GRCm39) probably null Het
Cdc6 T A 11: 98,810,191 (GRCm39) L500* probably null Het
Dst G T 1: 34,208,403 (GRCm39) probably null Het
Fbxw7 C T 3: 84,811,373 (GRCm39) T166I Het
Fer1l6 T C 15: 58,474,139 (GRCm39) V955A probably benign Het
Fezf2 T C 14: 12,344,941 (GRCm38) E82G probably benign Het
Flii T C 11: 60,610,971 (GRCm39) D486G probably damaging Het
Fndc3a T C 14: 72,804,854 (GRCm39) T476A probably benign Het
Gbp3 C T 3: 142,266,264 (GRCm39) probably benign Het
Hebp2 T C 10: 18,421,547 (GRCm39) probably benign Het
Hhipl2 T A 1: 183,204,951 (GRCm39) M88K possibly damaging Het
Hip1 A G 5: 135,459,171 (GRCm39) C605R probably benign Het
Hoxd13 T C 2: 74,498,909 (GRCm39) S86P probably benign Het
Hspa12a G T 19: 58,849,317 (GRCm39) A2E probably benign Het
Il1rl1 A C 1: 40,485,864 (GRCm39) *338C probably null Het
Lrrc37a G T 11: 103,390,464 (GRCm39) P1654T probably benign Het
Mybpc3 A T 2: 90,959,376 (GRCm39) D704V probably benign Het
Napsa A T 7: 44,231,130 (GRCm39) K120* probably null Het
Nat3 A C 8: 68,000,139 (GRCm39) Y6S probably damaging Het
Negr1 C T 3: 156,774,823 (GRCm39) Q180* probably null Het
Nynrin T A 14: 56,107,693 (GRCm39) D933E probably benign Het
Or10al3 T A 17: 38,011,957 (GRCm39) I132K probably damaging Het
Or10c1 A T 17: 37,522,386 (GRCm39) Y119* probably null Het
Or2l5 G A 16: 19,333,678 (GRCm39) A236V probably benign Het
Or6k2 A T 1: 173,986,614 (GRCm39) I92F probably damaging Het
Or8b1c T A 9: 38,384,831 (GRCm39) S263T possibly damaging Het
Or8c16 T A 9: 38,130,324 (GRCm39) N65K probably damaging Het
Or9s23 C T 1: 92,500,983 (GRCm39) T30I not run Het
Pbx1 A T 1: 168,030,995 (GRCm39) F208I probably damaging Het
Pcdha11 T C 18: 37,144,605 (GRCm39) V232A probably damaging Het
Pcsk5 A G 19: 17,558,593 (GRCm39) Y605H possibly damaging Het
Pde3a T A 6: 141,195,983 (GRCm39) L223Q probably damaging Het
Peg10 CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG CCACATCAGGATCCACATCAGGATGCACATCAG 6: 4,756,398 (GRCm39) probably benign Het
Pitpnm2 G A 5: 124,261,632 (GRCm39) R977C probably damaging Het
Pkdrej A C 15: 85,699,788 (GRCm39) D2049E probably benign Het
Psmd6 T C 14: 14,120,837 (GRCm38) D16G probably benign Het
Pth2r C A 1: 65,427,605 (GRCm39) T426N probably benign Het
Ralgapa1 G T 12: 55,705,928 (GRCm39) L1865M probably damaging Het
Ryr3 T A 2: 112,664,245 (GRCm39) Q1702L probably benign Het
Sars2 A G 7: 28,446,176 (GRCm39) Y135C probably benign Het
Sdha G A 13: 74,481,172 (GRCm39) R345* probably null Het
Selp A T 1: 163,961,525 (GRCm39) S413C probably damaging Het
Sirt2 G A 7: 28,484,835 (GRCm39) C221Y probably damaging Het
Skic2 A T 17: 35,067,140 (GRCm39) S100T probably benign Het
Socs7 C A 11: 97,280,468 (GRCm39) Q566K probably benign Het
Spdye4c G A 2: 128,436,056 (GRCm39) V151M probably benign Het
Srcap A G 7: 127,158,980 (GRCm39) D2952G unknown Het
Srd5a2 A T 17: 74,354,749 (GRCm39) L25Q probably damaging Het
Srrt A T 5: 137,298,410 (GRCm39) V254D probably damaging Het
Tap2 T C 17: 34,424,494 (GRCm39) F76L probably benign Het
Tdpoz4 T A 3: 93,704,815 (GRCm39) *371R probably null Het
Tm9sf3 A T 19: 41,209,743 (GRCm39) F441I probably damaging Het
Tmem259 C T 10: 79,814,414 (GRCm39) R314Q probably damaging Het
Trim28 G T 7: 12,762,040 (GRCm39) R312L possibly damaging Het
Tsc1 A G 2: 28,562,829 (GRCm39) T393A probably benign Het
Ube2v2 T C 16: 15,398,964 (GRCm39) T42A probably benign Het
Vmn2r-ps158 A C 7: 42,674,163 (GRCm39) H414P probably damaging Het
Zfp609 A T 9: 65,604,456 (GRCm39) S1342R possibly damaging Het
Zg16 A T 7: 126,649,763 (GRCm39) V66E probably damaging Het
Other mutations in Txndc11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00562:Txndc11 APN 16 10,922,496 (GRCm39) missense probably damaging 0.96
IGL00563:Txndc11 APN 16 10,922,496 (GRCm39) missense probably damaging 0.96
IGL02576:Txndc11 APN 16 10,892,881 (GRCm39) unclassified probably benign
IGL03070:Txndc11 APN 16 10,893,151 (GRCm39) missense probably damaging 0.97
P0047:Txndc11 UTSW 16 10,909,661 (GRCm39) splice site probably benign
R0091:Txndc11 UTSW 16 10,905,968 (GRCm39) missense probably benign
R0448:Txndc11 UTSW 16 10,909,625 (GRCm39) missense probably damaging 0.99
R0796:Txndc11 UTSW 16 10,952,338 (GRCm39) small deletion probably benign
R0960:Txndc11 UTSW 16 10,909,453 (GRCm39) missense probably benign 0.28
R1184:Txndc11 UTSW 16 10,946,364 (GRCm39) missense probably benign 0.03
R1327:Txndc11 UTSW 16 10,934,678 (GRCm39) missense possibly damaging 0.86
R1441:Txndc11 UTSW 16 10,952,414 (GRCm39) start gained probably benign
R1515:Txndc11 UTSW 16 10,892,926 (GRCm39) missense probably damaging 0.98
R1699:Txndc11 UTSW 16 10,905,639 (GRCm39) critical splice donor site probably null
R1709:Txndc11 UTSW 16 10,946,565 (GRCm39) nonsense probably null
R1850:Txndc11 UTSW 16 10,906,268 (GRCm39) missense probably damaging 0.98
R2026:Txndc11 UTSW 16 10,952,338 (GRCm39) small deletion probably benign
R3433:Txndc11 UTSW 16 10,906,052 (GRCm39) missense probably benign
R4468:Txndc11 UTSW 16 10,893,087 (GRCm39) missense probably benign 0.01
R4469:Txndc11 UTSW 16 10,893,087 (GRCm39) missense probably benign 0.01
R4652:Txndc11 UTSW 16 10,892,986 (GRCm39) missense probably benign
R4675:Txndc11 UTSW 16 10,902,745 (GRCm39) missense possibly damaging 0.65
R4697:Txndc11 UTSW 16 10,902,178 (GRCm39) missense probably damaging 0.99
R4907:Txndc11 UTSW 16 10,906,398 (GRCm39) missense probably benign 0.17
R5205:Txndc11 UTSW 16 10,946,529 (GRCm39) missense probably damaging 0.98
R5273:Txndc11 UTSW 16 10,946,487 (GRCm39) missense probably benign 0.07
R5865:Txndc11 UTSW 16 10,940,552 (GRCm39) missense probably damaging 1.00
R5873:Txndc11 UTSW 16 10,893,069 (GRCm39) missense probably damaging 1.00
R5941:Txndc11 UTSW 16 10,892,935 (GRCm39) missense probably benign 0.04
R6360:Txndc11 UTSW 16 10,902,656 (GRCm39) missense probably damaging 1.00
R6894:Txndc11 UTSW 16 10,906,009 (GRCm39) missense probably damaging 1.00
R7285:Txndc11 UTSW 16 10,902,163 (GRCm39) missense probably damaging 0.98
R7334:Txndc11 UTSW 16 10,946,425 (GRCm39) missense probably damaging 1.00
R7502:Txndc11 UTSW 16 10,905,742 (GRCm39) missense probably benign 0.08
R7660:Txndc11 UTSW 16 10,905,793 (GRCm39) missense probably damaging 1.00
R7683:Txndc11 UTSW 16 10,902,099 (GRCm39) missense probably damaging 1.00
R8315:Txndc11 UTSW 16 10,893,465 (GRCm39) missense possibly damaging 0.70
R9395:Txndc11 UTSW 16 10,902,683 (GRCm39) missense probably benign 0.03
R9406:Txndc11 UTSW 16 10,893,498 (GRCm39) missense probably benign 0.45
R9494:Txndc11 UTSW 16 10,952,156 (GRCm39) missense probably damaging 1.00
X0020:Txndc11 UTSW 16 10,902,082 (GRCm39) missense possibly damaging 0.46
Predicted Primers PCR Primer
(F):5'- AGCCTCACCTGCAAGTGAAC -3'
(R):5'- CTTGAGTGACTGCAAGCCTG -3'

Sequencing Primer
(F):5'- AGTGAACTTGAGGGCGAAG -3'
(R):5'- TGCGCAGAGTCGCTACAAG -3'
Posted On 2019-11-12