Incidental Mutation 'R7679:Cdh13'
ID 592645
Institutional Source Beutler Lab
Gene Symbol Cdh13
Ensembl Gene ENSMUSG00000031841
Gene Name cadherin 13
Synonyms T-cadherin, 4932416G01Rik, Tcad
MMRRC Submission 045707-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7679 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 119010472-120051660 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 119963658 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 413 (I413V)
Ref Sequence ENSEMBL: ENSMUSP00000113527 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117160]
AlphaFold Q9WTR5
PDB Structure Crystal Structure of mouse T-cadherin EC1 EC2 [X-RAY DIFFRACTION]
Crystal structure of mouse T-cadherin EC1 [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000117160
AA Change: I413V

PolyPhen 2 Score 0.288 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000113527
Gene: ENSMUSG00000031841
AA Change: I413V

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Cadherin_pro 26 112 1.04e-17 SMART
CA 160 243 1.49e-18 SMART
CA 267 361 1.84e-23 SMART
CA 383 476 8.75e-16 SMART
CA 499 583 2.36e-21 SMART
CA 604 687 5.93e-2 SMART
low complexity region 695 714 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is highly expressed in the vasculature including endothelial cells, smooth muscle cells and pericytes, where the encoded protein binds to adiponectin and has been implicated in the modulation of angiogenesis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased retinal neovascularization and increased adiponectin levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap11 A C 14: 78,752,256 (GRCm39) Y206D Het
Atm A T 9: 53,353,797 (GRCm39) I2906N probably damaging Het
B4galnt4 T C 7: 140,647,678 (GRCm39) V422A probably benign Het
Bod1l TTCAGGGATC TTC 5: 41,977,986 (GRCm39) probably null Het
Ccar2 G A 14: 70,376,684 (GRCm39) Q887* probably null Het
Cfap54 A G 10: 92,803,374 (GRCm39) V1556A probably benign Het
Chchd7 A T 4: 3,941,297 (GRCm39) N14Y probably damaging Het
Col24a1 C A 3: 145,105,110 (GRCm39) T824N possibly damaging Het
Col6a3 A T 1: 90,739,473 (GRCm39) Y859N possibly damaging Het
Dnaaf5 C T 5: 139,136,392 (GRCm39) P131S unknown Het
Erh T C 12: 80,684,345 (GRCm39) N44S probably benign Het
Esm1 T A 13: 113,346,646 (GRCm39) D90E probably damaging Het
Fbxo44 A G 4: 148,238,089 (GRCm39) F213L probably benign Het
Flnc A G 6: 29,456,789 (GRCm39) T2262A probably benign Het
Fmo9 T C 1: 166,495,058 (GRCm39) Q281R probably benign Het
Gdpgp1 G T 7: 79,888,324 (GRCm39) E118D probably benign Het
Gnas A T 2: 174,126,624 (GRCm39) Q53L probably damaging Het
Gpr142 G A 11: 114,697,533 (GRCm39) V360M possibly damaging Het
Grn A G 11: 102,323,895 (GRCm39) D46G probably benign Het
H2-T10 A G 17: 36,430,216 (GRCm39) F242L not run Het
Hgsnat T C 8: 26,444,665 (GRCm39) T428A probably damaging Het
Hoxa9 A G 6: 52,201,288 (GRCm39) I251T probably damaging Het
Inpp5f C T 7: 128,296,247 (GRCm39) T866I possibly damaging Het
Itgb1 T A 8: 129,446,929 (GRCm39) N481K probably damaging Het
Leng9 C A 7: 4,152,659 (GRCm39) D6Y probably benign Het
Lox A C 18: 52,658,178 (GRCm39) F332V possibly damaging Het
Lrp1 G T 10: 127,424,297 (GRCm39) Y796* probably null Het
Lrrc32 G A 7: 98,148,894 (GRCm39) G558D possibly damaging Het
Lrrk2 A G 15: 91,610,389 (GRCm39) E707G possibly damaging Het
Matn4 A G 2: 164,231,578 (GRCm39) *625R probably null Het
Mcur1 T A 13: 43,697,959 (GRCm39) K314* probably null Het
Med1 G C 11: 98,046,887 (GRCm39) P1303R unknown Het
Mgam T C 6: 40,619,980 (GRCm39) L23P probably damaging Het
Muc6 G C 7: 141,217,659 (GRCm39) P2338R probably damaging Het
Nfatc1 T C 18: 80,651,205 (GRCm39) I936V probably benign Het
Nol11 T C 11: 107,064,142 (GRCm39) S557G probably benign Het
Palb2 A G 7: 121,727,237 (GRCm39) I211T probably benign Het
Pard3 T C 8: 128,098,327 (GRCm39) V456A probably benign Het
Pax2 G A 19: 44,749,376 (GRCm39) V40M probably damaging Het
Pik3cb T C 9: 98,970,660 (GRCm39) K344E probably benign Het
Pik3r3 T A 4: 116,113,392 (GRCm39) M45K probably benign Het
Plat G T 8: 23,262,248 (GRCm39) G91W probably damaging Het
Pot1a A G 6: 25,771,633 (GRCm39) V196A probably benign Het
Prkdc T A 16: 15,649,183 (GRCm39) I3719N probably damaging Het
Psg16 G A 7: 16,827,685 (GRCm39) G123S probably damaging Het
Psme4 A G 11: 30,828,425 (GRCm39) D1815G probably damaging Het
Rpe65 C T 3: 159,310,030 (GRCm39) T101I probably damaging Het
Rpp25l A C 4: 41,712,326 (GRCm39) C150G unknown Het
Saxo4 T C 19: 10,459,618 (GRCm39) T30A probably damaging Het
Serpina1b A T 12: 103,696,774 (GRCm39) W212R probably damaging Het
Slc9a3 G A 13: 74,308,395 (GRCm39) R466H possibly damaging Het
Sned1 T C 1: 93,163,760 (GRCm39) L17P unknown Het
Speg C T 1: 75,382,959 (GRCm39) T1056I probably damaging Het
Tada1 T C 1: 166,219,540 (GRCm39) F281L probably benign Het
Tbcd G A 11: 121,494,534 (GRCm39) V1032I probably benign Het
Tlr3 A T 8: 45,852,088 (GRCm39) S270T probably benign Het
Txndc15 G T 13: 55,873,621 (GRCm39) R327L probably damaging Het
Zfp169 G C 13: 48,651,859 (GRCm39) L66V probably damaging Het
Zfp442 G T 2: 150,252,917 (GRCm39) Y45* probably null Het
Zzef1 A G 11: 72,784,104 (GRCm39) D2003G probably benign Het
Other mutations in Cdh13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00539:Cdh13 APN 8 120,039,245 (GRCm39) missense possibly damaging 0.87
IGL00659:Cdh13 APN 8 120,039,406 (GRCm39) missense probably damaging 1.00
IGL01662:Cdh13 APN 8 119,401,916 (GRCm39) missense probably damaging 0.99
IGL01719:Cdh13 APN 8 119,401,927 (GRCm39) missense probably benign 0.01
IGL02148:Cdh13 APN 8 119,925,697 (GRCm39) missense probably damaging 1.00
IGL02157:Cdh13 APN 8 119,232,410 (GRCm39) missense possibly damaging 0.68
IGL02188:Cdh13 APN 8 119,578,500 (GRCm39) missense probably benign 0.08
IGL02490:Cdh13 APN 8 119,822,062 (GRCm39) missense probably damaging 1.00
IGL02851:Cdh13 APN 8 119,401,897 (GRCm39) missense probably benign 0.32
IGL02958:Cdh13 APN 8 120,039,460 (GRCm39) missense possibly damaging 0.90
IGL03085:Cdh13 APN 8 120,015,463 (GRCm39) missense probably damaging 1.00
IGL03230:Cdh13 APN 8 119,969,056 (GRCm39) missense probably damaging 1.00
IGL03280:Cdh13 APN 8 120,040,873 (GRCm39) missense probably damaging 1.00
K3955:Cdh13 UTSW 8 119,401,843 (GRCm39) missense probably damaging 0.99
P0038:Cdh13 UTSW 8 119,401,843 (GRCm39) missense probably damaging 0.99
R0398:Cdh13 UTSW 8 120,040,786 (GRCm39) missense probably damaging 1.00
R2156:Cdh13 UTSW 8 119,963,703 (GRCm39) missense probably damaging 1.00
R3415:Cdh13 UTSW 8 119,401,946 (GRCm39) missense probably benign 0.35
R4243:Cdh13 UTSW 8 119,968,996 (GRCm39) missense probably damaging 1.00
R4839:Cdh13 UTSW 8 119,578,587 (GRCm39) nonsense probably null
R4851:Cdh13 UTSW 8 119,484,129 (GRCm39) missense possibly damaging 0.75
R5129:Cdh13 UTSW 8 119,821,954 (GRCm39) missense probably damaging 1.00
R5453:Cdh13 UTSW 8 119,925,706 (GRCm39) missense probably damaging 1.00
R5607:Cdh13 UTSW 8 119,484,213 (GRCm39) missense probably benign
R5608:Cdh13 UTSW 8 119,484,213 (GRCm39) missense probably benign
R5610:Cdh13 UTSW 8 119,578,462 (GRCm39) missense possibly damaging 0.95
R6035:Cdh13 UTSW 8 119,232,437 (GRCm39) missense probably benign 0.03
R6035:Cdh13 UTSW 8 119,232,437 (GRCm39) missense probably benign 0.03
R6556:Cdh13 UTSW 8 119,694,926 (GRCm39) missense probably damaging 0.99
R7124:Cdh13 UTSW 8 119,694,912 (GRCm39) missense probably damaging 1.00
R7349:Cdh13 UTSW 8 119,969,097 (GRCm39) missense probably damaging 0.97
R7418:Cdh13 UTSW 8 120,039,264 (GRCm39) missense probably damaging 1.00
R7807:Cdh13 UTSW 8 119,010,594 (GRCm39) start codon destroyed probably null 0.77
R8777:Cdh13 UTSW 8 119,963,706 (GRCm39) critical splice donor site probably null
R8777-TAIL:Cdh13 UTSW 8 119,963,706 (GRCm39) critical splice donor site probably null
R9175:Cdh13 UTSW 8 119,968,968 (GRCm39) missense probably damaging 1.00
R9481:Cdh13 UTSW 8 119,963,676 (GRCm39) missense
X0025:Cdh13 UTSW 8 119,232,418 (GRCm39) missense probably benign 0.28
Predicted Primers PCR Primer
(F):5'- AGTACGCTGACTATGGCCAC -3'
(R):5'- TTCCCTGCCTTAGAAGCAAACAG -3'

Sequencing Primer
(F):5'- GACTATGGCCACCTGCTTTG -3'
(R):5'- TCTACCAGAATGCTCGAATCAGGG -3'
Posted On 2019-11-12