Incidental Mutation 'R7681:Ogfr'
ID 592741
Institutional Source Beutler Lab
Gene Symbol Ogfr
Ensembl Gene ENSMUSG00000049401
Gene Name opioid growth factor receptor
Synonyms 2010013E17Rik
MMRRC Submission 045747-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.526) question?
Stock # R7681 (G1)
Quality Score 214.458
Status Not validated
Chromosome 2
Chromosomal Location 180231200-180237630 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG to GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG at 180237059 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000128718 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029087] [ENSMUST00000103059] [ENSMUST00000132527]
AlphaFold Q99PG2
Predicted Effect probably benign
Transcript: ENSMUST00000029087
SMART Domains Protein: ENSMUSP00000029087
Gene: ENSMUSG00000049401

DomainStartEndE-ValueType
low complexity region 7 40 N/A INTRINSIC
Pfam:OGFr_N 76 283 2.3e-111 PFAM
low complexity region 358 369 N/A INTRINSIC
internal_repeat_1 459 483 4.08e-5 PROSPERO
internal_repeat_1 576 600 4.08e-5 PROSPERO
Predicted Effect probably benign
Transcript: ENSMUST00000103059
SMART Domains Protein: ENSMUSP00000099348
Gene: ENSMUSG00000027570

DomainStartEndE-ValueType
Pfam:Collagen 21 80 7.7e-12 PFAM
Pfam:Collagen 58 114 4.2e-9 PFAM
low complexity region 126 162 N/A INTRINSIC
Pfam:Collagen 174 236 4.1e-12 PFAM
Pfam:Collagen 213 292 8e-9 PFAM
internal_repeat_1 315 366 1.58e-12 PROSPERO
internal_repeat_2 360 382 2.94e-6 PROSPERO
low complexity region 384 396 N/A INTRINSIC
Pfam:Collagen 456 518 1.8e-11 PFAM
Pfam:Collagen 545 606 3.8e-11 PFAM
low complexity region 635 656 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000132527
SMART Domains Protein: ENSMUSP00000128718
Gene: ENSMUSG00000027570

DomainStartEndE-ValueType
Pfam:Collagen 21 80 7.9e-12 PFAM
Pfam:Collagen 58 114 4.3e-9 PFAM
Pfam:Collagen 109 166 4.5e-8 PFAM
Pfam:Collagen 174 236 4.2e-12 PFAM
Pfam:Collagen 213 292 8.2e-9 PFAM
internal_repeat_1 315 366 1.58e-12 PROSPERO
internal_repeat_2 360 382 2.94e-6 PROSPERO
low complexity region 384 396 N/A INTRINSIC
Pfam:Collagen 402 474 8.2e-8 PFAM
Pfam:Collagen 456 518 1.8e-11 PFAM
Pfam:Collagen 545 606 3.9e-11 PFAM
Pfam:Collagen 603 662 2.5e-8 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 97% (58/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b C T 5: 8,899,619 (GRCm39) A963V probably benign Het
Agbl1 T C 7: 76,094,649 (GRCm39) V760A unknown Het
Akap13 T C 7: 75,378,544 (GRCm39) F347L possibly damaging Het
Anapc5 A T 5: 122,940,202 (GRCm39) F356L probably benign Het
Bmp6 A G 13: 38,530,171 (GRCm39) H88R probably damaging Het
Cblb C A 16: 52,025,001 (GRCm39) S921R probably damaging Het
Ccs T A 19: 4,882,858 (GRCm39) probably null Het
Cyp20a1 A G 1: 60,392,192 (GRCm39) T83A probably benign Het
Defa25 T A 8: 21,574,535 (GRCm39) D26E probably benign Het
Dmwd T A 7: 18,815,007 (GRCm39) N552K probably benign Het
Dnah17 C T 11: 117,916,012 (GRCm39) V4297M probably damaging Het
Fam135a A T 1: 24,106,996 (GRCm39) S47R probably benign Het
Fbxo41 A T 6: 85,455,461 (GRCm39) C574* probably null Het
Fgb T C 3: 82,957,139 (GRCm39) probably benign Het
Fgfr1 C T 8: 26,045,677 (GRCm39) T82I probably damaging Het
Fhod3 T A 18: 25,123,095 (GRCm39) L262M probably damaging Het
Galnt16 A T 12: 80,637,413 (GRCm39) Q380L probably damaging Het
Glp2r C T 11: 67,600,505 (GRCm39) G448D probably benign Het
Gnb4 C A 3: 32,641,902 (GRCm39) A242S possibly damaging Het
Golim4 T C 3: 75,794,331 (GRCm39) probably null Het
Grik2 G T 10: 49,120,476 (GRCm39) N604K probably damaging Het
Hnf1b T G 11: 83,779,972 (GRCm39) I435S probably damaging Het
Hoxa11 C T 6: 52,222,099 (GRCm39) G201S probably benign Het
Hpse A G 5: 100,839,257 (GRCm39) S364P possibly damaging Het
Kif16b A T 2: 142,598,046 (GRCm39) N525K probably damaging Het
Kif1a A T 1: 92,982,666 (GRCm39) C704S probably benign Het
Limk2 A G 11: 3,303,354 (GRCm39) S322P probably damaging Het
Lrp1b A T 2: 40,765,011 (GRCm39) C2938* probably null Het
Malrd1 A G 2: 16,222,913 (GRCm39) R2071G unknown Het
Man2a2 T A 7: 80,001,497 (GRCm39) I1137F possibly damaging Het
Map2k6 C T 11: 110,388,729 (GRCm39) R224* probably null Het
Map3k4 G A 17: 12,537,430 (GRCm39) P29L unknown Het
Morn5 A T 2: 35,947,156 (GRCm39) N145Y possibly damaging Het
Muc20 T C 16: 32,613,989 (GRCm39) T463A probably benign Het
Myh10 C T 11: 68,662,762 (GRCm39) T642I probably damaging Het
Myh14 C A 7: 44,273,572 (GRCm39) R1362L possibly damaging Het
Nup88 C A 11: 70,860,711 (GRCm39) V23L probably benign Het
Or13p8 A G 4: 118,583,761 (GRCm39) I106V probably benign Het
Or4c116 A C 2: 88,941,935 (GRCm39) V307G probably benign Het
Or5p56 T C 7: 107,590,355 (GRCm39) M261T possibly damaging Het
Pabpn1 T C 14: 55,135,499 (GRCm39) Y299H probably damaging Het
Pak4 T C 7: 28,259,655 (GRCm39) E514G probably damaging Het
Ppp1r12b A C 1: 134,793,673 (GRCm39) S564A probably benign Het
Psmc2 T C 5: 22,008,272 (GRCm39) probably null Het
Psme4 A G 11: 30,741,975 (GRCm39) Y146C possibly damaging Het
Rb1cc1 A G 1: 6,310,547 (GRCm39) D315G probably damaging Het
Rilpl1 A G 5: 124,668,976 (GRCm39) V24A possibly damaging Het
Rtel1 A T 2: 180,964,187 (GRCm39) H62L probably damaging Het
Ruvbl1 G A 6: 88,444,635 (GRCm39) probably null Het
Scn5a A G 9: 119,359,043 (GRCm39) V668A probably benign Het
Slc22a6 G A 19: 8,603,493 (GRCm39) G519E probably benign Het
Slc43a2 T A 11: 75,454,499 (GRCm39) I348N probably benign Het
Slc6a16 T A 7: 44,910,338 (GRCm39) L347Q probably damaging Het
Smg6 T A 11: 74,822,531 (GRCm39) L658H probably damaging Het
Spata31e4 C T 13: 50,856,290 (GRCm39) P643S possibly damaging Het
Spidr C A 16: 15,713,488 (GRCm39) G832W probably damaging Het
Ssrp1 G A 2: 84,876,092 (GRCm39) G616E probably benign Het
Sult1b1 G A 5: 87,678,495 (GRCm39) L110F probably damaging Het
Tfec T A 6: 16,834,235 (GRCm39) H224L probably benign Het
Ttn C T 2: 76,539,295 (GRCm39) E34564K probably benign Het
Washc2 A G 6: 116,237,618 (GRCm39) D1285G probably damaging Het
Zfp870 T C 17: 33,101,664 (GRCm39) E555G probably benign Het
Other mutations in Ogfr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00480:Ogfr APN 2 180,235,355 (GRCm39) unclassified probably benign
IGL02437:Ogfr APN 2 180,231,329 (GRCm39) missense possibly damaging 0.72
IGL02602:Ogfr APN 2 180,237,230 (GRCm39) missense possibly damaging 0.85
IGL02609:Ogfr APN 2 180,234,308 (GRCm39) splice site probably benign
IGL03297:Ogfr APN 2 180,236,200 (GRCm39) missense possibly damaging 0.93
BB017:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
PIT4812001:Ogfr UTSW 2 180,237,304 (GRCm39) missense possibly damaging 0.93
R0085:Ogfr UTSW 2 180,232,830 (GRCm39) splice site probably null
R0398:Ogfr UTSW 2 180,235,492 (GRCm39) missense probably damaging 0.99
R1313:Ogfr UTSW 2 180,236,423 (GRCm39) missense probably benign
R1313:Ogfr UTSW 2 180,236,423 (GRCm39) missense probably benign
R1468:Ogfr UTSW 2 180,236,543 (GRCm39) missense probably damaging 1.00
R1468:Ogfr UTSW 2 180,236,543 (GRCm39) missense probably damaging 1.00
R4747:Ogfr UTSW 2 180,236,216 (GRCm39) missense probably damaging 0.99
R4902:Ogfr UTSW 2 180,235,518 (GRCm39) unclassified probably benign
R5422:Ogfr UTSW 2 180,237,068 (GRCm39) missense probably benign 0.02
R5422:Ogfr UTSW 2 180,237,067 (GRCm39) missense possibly damaging 0.63
R5860:Ogfr UTSW 2 180,234,285 (GRCm39) missense probably damaging 1.00
R5988:Ogfr UTSW 2 180,236,026 (GRCm39) missense probably damaging 1.00
R6015:Ogfr UTSW 2 180,236,467 (GRCm39) missense probably damaging 1.00
R6558:Ogfr UTSW 2 180,237,197 (GRCm39) missense possibly damaging 0.93
R6721:Ogfr UTSW 2 180,237,221 (GRCm39) missense possibly damaging 0.70
R7111:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R7201:Ogfr UTSW 2 180,236,887 (GRCm39) unclassified probably benign
R7217:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R7243:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R7387:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R7563:Ogfr UTSW 2 180,234,300 (GRCm39) critical splice donor site probably null
R7844:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R7845:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R7848:Ogfr UTSW 2 180,234,226 (GRCm39) missense probably damaging 1.00
R7930:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R7985:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R8011:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8039:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8045:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R8094:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8339:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8464:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R8555:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8557:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8688:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R8703:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8856:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8886:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R8956:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R9098:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R9198:Ogfr UTSW 2 180,232,850 (GRCm39) critical splice donor site probably null
R9227:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R9244:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R9340:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R9352:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R9440:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R9462:Ogfr UTSW 2 180,236,850 (GRCm39) unclassified probably benign
R9514:Ogfr UTSW 2 180,235,417 (GRCm39) missense possibly damaging 0.61
R9612:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
R9661:Ogfr UTSW 2 180,233,431 (GRCm39) missense probably damaging 1.00
R9782:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
RF022:Ogfr UTSW 2 180,237,059 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- GTGTCCTGAGTCCCAAAAGG -3'
(R):5'- AGTGTCAGAGTCAGGATCCTCC -3'

Sequencing Primer
(F):5'- GACCCCAAAAGCCAGGTGG -3'
(R):5'- AGAGTCAGGATCCTCCCCCAG -3'
Posted On 2019-11-12