Incidental Mutation 'R7682:Vmn2r11'
ID |
592815 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r11
|
Ensembl Gene |
ENSMUSG00000091450 |
Gene Name |
vomeronasal 2, receptor 11 |
Synonyms |
EG384219 |
MMRRC Submission |
045748-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.073)
|
Stock # |
R7682 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
5 |
Chromosomal Location |
109194739-109207318 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to C
at 109195481 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Glycine
at position 615
(V615G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000133218
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164875]
|
AlphaFold |
E9Q4X4 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000164875
AA Change: V615G
PolyPhen 2
Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
|
SMART Domains |
Protein: ENSMUSP00000133218 Gene: ENSMUSG00000091450 AA Change: V615G
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
167 |
475 |
1.6e-29 |
PFAM |
Pfam:NCD3G
|
520 |
574 |
9.1e-19 |
PFAM |
Pfam:7tm_3
|
607 |
842 |
4.6e-55 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
Validation Efficiency |
100% (62/62) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 64 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2310034C09Rik |
T |
A |
16: 88,556,373 (GRCm39) |
S196T |
probably benign |
Het |
Abcc5 |
T |
C |
16: 20,186,803 (GRCm39) |
D977G |
probably damaging |
Het |
Acot2 |
T |
C |
12: 84,034,698 (GRCm39) |
V8A |
probably benign |
Het |
Adamts9 |
T |
A |
6: 92,857,679 (GRCm39) |
I870F |
possibly damaging |
Het |
Adgrl3 |
G |
A |
5: 81,942,407 (GRCm39) |
V1414I |
probably damaging |
Het |
Aggf1 |
T |
C |
13: 95,504,934 (GRCm39) |
K275R |
probably benign |
Het |
Alpk1 |
T |
C |
3: 127,466,195 (GRCm39) |
I1104V |
possibly damaging |
Het |
Angptl7 |
A |
T |
4: 148,582,539 (GRCm39) |
I119N |
probably damaging |
Het |
Ank3 |
A |
T |
10: 69,824,065 (GRCm39) |
E129D |
possibly damaging |
Het |
Brca2 |
T |
A |
5: 150,466,618 (GRCm39) |
H2127Q |
probably benign |
Het |
Brd4 |
A |
G |
17: 32,420,134 (GRCm39) |
F1008S |
unknown |
Het |
Car2 |
T |
C |
3: 14,953,025 (GRCm39) |
S56P |
probably damaging |
Het |
Casp3 |
A |
G |
8: 47,085,420 (GRCm39) |
Y41C |
probably benign |
Het |
Ces4a |
A |
T |
8: 105,873,297 (GRCm39) |
T381S |
probably benign |
Het |
Clstn1 |
A |
G |
4: 149,710,558 (GRCm39) |
T77A |
possibly damaging |
Het |
Cul7 |
G |
T |
17: 46,966,521 (GRCm39) |
V615L |
probably benign |
Het |
Dnpep |
A |
G |
1: 75,293,384 (GRCm39) |
F24L |
probably damaging |
Het |
Efcab3 |
T |
A |
11: 104,855,174 (GRCm39) |
|
probably null |
Het |
Emsy |
G |
A |
7: 98,239,905 (GRCm39) |
R1263W |
probably damaging |
Het |
Fam124b |
A |
T |
1: 80,191,282 (GRCm39) |
C34S |
possibly damaging |
Het |
Fan1 |
C |
A |
7: 64,022,512 (GRCm39) |
G247V |
probably benign |
Het |
Fbxl9 |
C |
A |
8: 106,041,916 (GRCm39) |
R304L |
possibly damaging |
Het |
Glipr1l3 |
T |
G |
10: 111,977,777 (GRCm39) |
H218P |
probably benign |
Het |
Gm14305 |
T |
A |
2: 176,412,703 (GRCm39) |
S198R |
probably benign |
Het |
Gm14326 |
T |
C |
2: 177,590,274 (GRCm39) |
Y29C |
probably damaging |
Het |
Gm45713 |
C |
T |
7: 44,783,426 (GRCm39) |
V147I |
probably benign |
Het |
Gpr149 |
C |
T |
3: 62,438,160 (GRCm39) |
D666N |
probably damaging |
Het |
Gpr183 |
A |
G |
14: 122,192,152 (GRCm39) |
I123T |
possibly damaging |
Het |
Il7r |
A |
T |
15: 9,513,013 (GRCm39) |
H165Q |
probably damaging |
Het |
Krt73 |
A |
G |
15: 101,710,480 (GRCm39) |
F85L |
probably benign |
Het |
Lrrc8d |
A |
G |
5: 105,960,657 (GRCm39) |
T356A |
probably damaging |
Het |
Marco |
A |
G |
1: 120,421,771 (GRCm39) |
|
probably null |
Het |
Mettl14 |
T |
A |
3: 123,177,253 (GRCm39) |
E49D |
possibly damaging |
Het |
Mrap |
T |
A |
16: 90,546,110 (GRCm39) |
|
probably null |
Het |
Mrps34 |
C |
T |
17: 25,114,852 (GRCm39) |
A152V |
probably benign |
Het |
Nfasc |
T |
A |
1: 132,501,511 (GRCm39) |
Y1163F |
unknown |
Het |
Nfic |
T |
C |
10: 81,256,334 (GRCm39) |
D110G |
probably damaging |
Het |
Nip7 |
T |
C |
8: 107,783,751 (GRCm39) |
V28A |
possibly damaging |
Het |
Odam |
T |
C |
5: 88,040,287 (GRCm39) |
F251S |
possibly damaging |
Het |
Olfm5 |
T |
A |
7: 103,810,979 (GRCm39) |
Q53L |
probably null |
Het |
P2ry13 |
T |
G |
3: 59,117,545 (GRCm39) |
M78L |
probably benign |
Het |
Pacs1 |
T |
C |
19: 5,202,727 (GRCm39) |
E385G |
probably damaging |
Het |
Pip5k1b |
C |
T |
19: 24,337,343 (GRCm39) |
G315D |
probably damaging |
Het |
Pla2g4a |
C |
A |
1: 149,762,022 (GRCm39) |
R145L |
probably damaging |
Het |
Pramel26 |
A |
G |
4: 143,537,290 (GRCm39) |
L347S |
probably benign |
Het |
Rars1 |
T |
C |
11: 35,719,579 (GRCm39) |
Q81R |
probably benign |
Het |
Rassf7 |
A |
G |
7: 140,797,847 (GRCm39) |
N296D |
probably damaging |
Het |
Rcsd1 |
C |
T |
1: 165,485,262 (GRCm39) |
A94T |
probably benign |
Het |
Rgs8 |
T |
C |
1: 153,566,668 (GRCm39) |
F73S |
probably damaging |
Het |
Rilpl2 |
A |
C |
5: 124,616,043 (GRCm39) |
Y36D |
probably damaging |
Het |
Rpl10l |
A |
G |
12: 66,331,004 (GRCm39) |
V43A |
probably benign |
Het |
Sesn2 |
T |
C |
4: 132,224,200 (GRCm39) |
I403V |
probably damaging |
Het |
Slc10a4 |
C |
T |
5: 73,164,453 (GRCm39) |
S15L |
unknown |
Het |
Slc7a5 |
T |
C |
8: 122,633,879 (GRCm39) |
Y156C |
probably damaging |
Het |
Spata18 |
A |
G |
5: 73,826,008 (GRCm39) |
H105R |
|
Het |
Specc1l |
A |
G |
10: 75,081,636 (GRCm39) |
D344G |
probably damaging |
Het |
Syne1 |
A |
G |
10: 5,112,461 (GRCm39) |
V415A |
probably benign |
Het |
Thbs4 |
T |
G |
13: 92,912,070 (GRCm39) |
D220A |
probably benign |
Het |
Tmco5 |
T |
C |
2: 116,716,752 (GRCm39) |
S152P |
probably benign |
Het |
Tmem35b |
A |
T |
4: 127,022,734 (GRCm39) |
D125V |
probably damaging |
Het |
Trim17 |
A |
G |
11: 58,857,634 (GRCm39) |
E155G |
possibly damaging |
Het |
Vmn2r88 |
A |
T |
14: 51,655,906 (GRCm39) |
Q705L |
|
Het |
Vmn2r93 |
A |
G |
17: 18,525,583 (GRCm39) |
R414G |
probably benign |
Het |
Xirp2 |
T |
C |
2: 67,339,193 (GRCm39) |
L478P |
probably damaging |
Het |
|
Other mutations in Vmn2r11 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00925:Vmn2r11
|
APN |
5 |
109,194,885 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01677:Vmn2r11
|
APN |
5 |
109,201,823 (GRCm39) |
missense |
possibly damaging |
0.50 |
IGL02048:Vmn2r11
|
APN |
5 |
109,202,658 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02559:Vmn2r11
|
APN |
5 |
109,200,046 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02879:Vmn2r11
|
APN |
5 |
109,201,704 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL03084:Vmn2r11
|
APN |
5 |
109,207,209 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03163:Vmn2r11
|
APN |
5 |
109,201,692 (GRCm39) |
missense |
probably benign |
0.41 |
IGL03289:Vmn2r11
|
APN |
5 |
109,196,788 (GRCm39) |
splice site |
probably benign |
|
IGL03294:Vmn2r11
|
APN |
5 |
109,201,935 (GRCm39) |
missense |
probably benign |
0.22 |
R0233:Vmn2r11
|
UTSW |
5 |
109,201,968 (GRCm39) |
missense |
probably benign |
0.16 |
R0233:Vmn2r11
|
UTSW |
5 |
109,201,968 (GRCm39) |
missense |
probably benign |
0.16 |
R0421:Vmn2r11
|
UTSW |
5 |
109,207,294 (GRCm39) |
missense |
probably benign |
0.00 |
R0549:Vmn2r11
|
UTSW |
5 |
109,199,963 (GRCm39) |
missense |
possibly damaging |
0.80 |
R0628:Vmn2r11
|
UTSW |
5 |
109,195,597 (GRCm39) |
missense |
possibly damaging |
0.88 |
R1523:Vmn2r11
|
UTSW |
5 |
109,201,707 (GRCm39) |
missense |
probably benign |
0.25 |
R1660:Vmn2r11
|
UTSW |
5 |
109,201,724 (GRCm39) |
missense |
possibly damaging |
0.79 |
R1827:Vmn2r11
|
UTSW |
5 |
109,199,938 (GRCm39) |
missense |
probably benign |
0.01 |
R1913:Vmn2r11
|
UTSW |
5 |
109,202,654 (GRCm39) |
missense |
probably benign |
|
R2260:Vmn2r11
|
UTSW |
5 |
109,201,657 (GRCm39) |
nonsense |
probably null |
|
R2400:Vmn2r11
|
UTSW |
5 |
109,199,928 (GRCm39) |
missense |
probably benign |
0.03 |
R3933:Vmn2r11
|
UTSW |
5 |
109,201,260 (GRCm39) |
missense |
probably damaging |
0.97 |
R4091:Vmn2r11
|
UTSW |
5 |
109,202,616 (GRCm39) |
critical splice donor site |
probably null |
|
R4624:Vmn2r11
|
UTSW |
5 |
109,200,101 (GRCm39) |
missense |
probably damaging |
0.99 |
R4762:Vmn2r11
|
UTSW |
5 |
109,195,436 (GRCm39) |
missense |
probably damaging |
1.00 |
R5256:Vmn2r11
|
UTSW |
5 |
109,202,658 (GRCm39) |
missense |
probably benign |
0.26 |
R5370:Vmn2r11
|
UTSW |
5 |
109,195,421 (GRCm39) |
missense |
probably damaging |
1.00 |
R5419:Vmn2r11
|
UTSW |
5 |
109,207,224 (GRCm39) |
missense |
possibly damaging |
0.55 |
R5516:Vmn2r11
|
UTSW |
5 |
109,195,032 (GRCm39) |
missense |
probably damaging |
0.98 |
R5643:Vmn2r11
|
UTSW |
5 |
109,194,869 (GRCm39) |
missense |
probably damaging |
1.00 |
R5671:Vmn2r11
|
UTSW |
5 |
109,202,772 (GRCm39) |
missense |
probably benign |
0.03 |
R5679:Vmn2r11
|
UTSW |
5 |
109,202,708 (GRCm39) |
missense |
probably benign |
0.00 |
R5739:Vmn2r11
|
UTSW |
5 |
109,207,114 (GRCm39) |
critical splice donor site |
probably null |
|
R5746:Vmn2r11
|
UTSW |
5 |
109,201,560 (GRCm39) |
missense |
probably benign |
0.41 |
R5995:Vmn2r11
|
UTSW |
5 |
109,194,921 (GRCm39) |
missense |
probably damaging |
1.00 |
R6147:Vmn2r11
|
UTSW |
5 |
109,202,700 (GRCm39) |
missense |
probably benign |
0.04 |
R6220:Vmn2r11
|
UTSW |
5 |
109,201,434 (GRCm39) |
missense |
probably benign |
0.09 |
R6374:Vmn2r11
|
UTSW |
5 |
109,201,679 (GRCm39) |
missense |
possibly damaging |
0.65 |
R6491:Vmn2r11
|
UTSW |
5 |
109,196,800 (GRCm39) |
missense |
possibly damaging |
0.95 |
R6804:Vmn2r11
|
UTSW |
5 |
109,201,350 (GRCm39) |
missense |
probably damaging |
1.00 |
R6814:Vmn2r11
|
UTSW |
5 |
109,194,976 (GRCm39) |
missense |
possibly damaging |
0.81 |
R6872:Vmn2r11
|
UTSW |
5 |
109,194,976 (GRCm39) |
missense |
possibly damaging |
0.81 |
R7014:Vmn2r11
|
UTSW |
5 |
109,201,289 (GRCm39) |
missense |
probably damaging |
1.00 |
R7041:Vmn2r11
|
UTSW |
5 |
109,202,816 (GRCm39) |
missense |
probably damaging |
1.00 |
R7043:Vmn2r11
|
UTSW |
5 |
109,200,098 (GRCm39) |
missense |
probably benign |
0.00 |
R7050:Vmn2r11
|
UTSW |
5 |
109,202,657 (GRCm39) |
missense |
probably benign |
0.05 |
R7184:Vmn2r11
|
UTSW |
5 |
109,201,281 (GRCm39) |
missense |
probably damaging |
1.00 |
R7388:Vmn2r11
|
UTSW |
5 |
109,202,742 (GRCm39) |
missense |
probably benign |
0.05 |
R7477:Vmn2r11
|
UTSW |
5 |
109,207,214 (GRCm39) |
missense |
possibly damaging |
0.67 |
R7524:Vmn2r11
|
UTSW |
5 |
109,201,848 (GRCm39) |
missense |
probably benign |
0.01 |
R7715:Vmn2r11
|
UTSW |
5 |
109,195,307 (GRCm39) |
missense |
probably damaging |
0.99 |
R7869:Vmn2r11
|
UTSW |
5 |
109,199,986 (GRCm39) |
missense |
probably damaging |
1.00 |
R8094:Vmn2r11
|
UTSW |
5 |
109,201,626 (GRCm39) |
missense |
probably damaging |
1.00 |
R8277:Vmn2r11
|
UTSW |
5 |
109,202,833 (GRCm39) |
missense |
probably benign |
0.00 |
R8506:Vmn2r11
|
UTSW |
5 |
109,207,270 (GRCm39) |
missense |
probably benign |
0.00 |
R8676:Vmn2r11
|
UTSW |
5 |
109,201,626 (GRCm39) |
missense |
probably damaging |
1.00 |
R8701:Vmn2r11
|
UTSW |
5 |
109,195,556 (GRCm39) |
missense |
probably damaging |
1.00 |
R8749:Vmn2r11
|
UTSW |
5 |
109,195,319 (GRCm39) |
missense |
probably damaging |
0.97 |
R9046:Vmn2r11
|
UTSW |
5 |
109,202,850 (GRCm39) |
missense |
probably benign |
0.00 |
R9138:Vmn2r11
|
UTSW |
5 |
109,201,904 (GRCm39) |
missense |
probably damaging |
1.00 |
R9267:Vmn2r11
|
UTSW |
5 |
109,199,929 (GRCm39) |
missense |
possibly damaging |
0.93 |
R9306:Vmn2r11
|
UTSW |
5 |
109,196,831 (GRCm39) |
missense |
probably damaging |
1.00 |
R9384:Vmn2r11
|
UTSW |
5 |
109,201,266 (GRCm39) |
missense |
probably damaging |
1.00 |
R9443:Vmn2r11
|
UTSW |
5 |
109,195,159 (GRCm39) |
nonsense |
probably null |
|
R9520:Vmn2r11
|
UTSW |
5 |
109,201,455 (GRCm39) |
missense |
probably benign |
0.35 |
R9596:Vmn2r11
|
UTSW |
5 |
109,201,563 (GRCm39) |
missense |
possibly damaging |
0.67 |
R9677:Vmn2r11
|
UTSW |
5 |
109,201,332 (GRCm39) |
missense |
|
|
|
Predicted Primers |
PCR Primer
(F):5'- GCTTGAAAGCCATGAGCACAG -3'
(R):5'- TCTTTGCCAGCAGATATGGAAC -3'
Sequencing Primer
(F):5'- ACACTGTAGAAATAGCCACTGTG -3'
(R):5'- AACAGTGTGTGAGGTGTCCAG -3'
|
Posted On |
2019-11-12 |