Incidental Mutation 'R7682:Vmn2r93'
ID 592846
Institutional Source Beutler Lab
Gene Symbol Vmn2r93
Ensembl Gene ENSMUSG00000079698
Gene Name vomeronasal 2, receptor 93
Synonyms EG627132
MMRRC Submission 045748-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R7682 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 18518543-18546703 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 18525583 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 414 (R414G)
Ref Sequence ENSEMBL: ENSMUSP00000078200 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079206] [ENSMUST00000231879] [ENSMUST00000231938]
AlphaFold L7N1Z9
Predicted Effect probably benign
Transcript: ENSMUST00000079206
AA Change: R414G

PolyPhen 2 Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000078200
Gene: ENSMUSG00000079698
AA Change: R414G

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 453 5.9e-40 PFAM
Pfam:NCD3G 509 562 2.6e-21 PFAM
Pfam:7tm_3 594 830 1.5e-50 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231879
AA Change: R414G

PolyPhen 2 Score 0.079 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000231938
AA Change: R414G

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (62/62)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310034C09Rik T A 16: 88,556,373 (GRCm39) S196T probably benign Het
Abcc5 T C 16: 20,186,803 (GRCm39) D977G probably damaging Het
Acot2 T C 12: 84,034,698 (GRCm39) V8A probably benign Het
Adamts9 T A 6: 92,857,679 (GRCm39) I870F possibly damaging Het
Adgrl3 G A 5: 81,942,407 (GRCm39) V1414I probably damaging Het
Aggf1 T C 13: 95,504,934 (GRCm39) K275R probably benign Het
Alpk1 T C 3: 127,466,195 (GRCm39) I1104V possibly damaging Het
Angptl7 A T 4: 148,582,539 (GRCm39) I119N probably damaging Het
Ank3 A T 10: 69,824,065 (GRCm39) E129D possibly damaging Het
Brca2 T A 5: 150,466,618 (GRCm39) H2127Q probably benign Het
Brd4 A G 17: 32,420,134 (GRCm39) F1008S unknown Het
Car2 T C 3: 14,953,025 (GRCm39) S56P probably damaging Het
Casp3 A G 8: 47,085,420 (GRCm39) Y41C probably benign Het
Ces4a A T 8: 105,873,297 (GRCm39) T381S probably benign Het
Clstn1 A G 4: 149,710,558 (GRCm39) T77A possibly damaging Het
Cul7 G T 17: 46,966,521 (GRCm39) V615L probably benign Het
Dnpep A G 1: 75,293,384 (GRCm39) F24L probably damaging Het
Efcab3 T A 11: 104,855,174 (GRCm39) probably null Het
Emsy G A 7: 98,239,905 (GRCm39) R1263W probably damaging Het
Fam124b A T 1: 80,191,282 (GRCm39) C34S possibly damaging Het
Fan1 C A 7: 64,022,512 (GRCm39) G247V probably benign Het
Fbxl9 C A 8: 106,041,916 (GRCm39) R304L possibly damaging Het
Glipr1l3 T G 10: 111,977,777 (GRCm39) H218P probably benign Het
Gm14305 T A 2: 176,412,703 (GRCm39) S198R probably benign Het
Gm14326 T C 2: 177,590,274 (GRCm39) Y29C probably damaging Het
Gm45713 C T 7: 44,783,426 (GRCm39) V147I probably benign Het
Gpr149 C T 3: 62,438,160 (GRCm39) D666N probably damaging Het
Gpr183 A G 14: 122,192,152 (GRCm39) I123T possibly damaging Het
Il7r A T 15: 9,513,013 (GRCm39) H165Q probably damaging Het
Krt73 A G 15: 101,710,480 (GRCm39) F85L probably benign Het
Lrrc8d A G 5: 105,960,657 (GRCm39) T356A probably damaging Het
Marco A G 1: 120,421,771 (GRCm39) probably null Het
Mettl14 T A 3: 123,177,253 (GRCm39) E49D possibly damaging Het
Mrap T A 16: 90,546,110 (GRCm39) probably null Het
Mrps34 C T 17: 25,114,852 (GRCm39) A152V probably benign Het
Nfasc T A 1: 132,501,511 (GRCm39) Y1163F unknown Het
Nfic T C 10: 81,256,334 (GRCm39) D110G probably damaging Het
Nip7 T C 8: 107,783,751 (GRCm39) V28A possibly damaging Het
Odam T C 5: 88,040,287 (GRCm39) F251S possibly damaging Het
Olfm5 T A 7: 103,810,979 (GRCm39) Q53L probably null Het
P2ry13 T G 3: 59,117,545 (GRCm39) M78L probably benign Het
Pacs1 T C 19: 5,202,727 (GRCm39) E385G probably damaging Het
Pip5k1b C T 19: 24,337,343 (GRCm39) G315D probably damaging Het
Pla2g4a C A 1: 149,762,022 (GRCm39) R145L probably damaging Het
Pramel26 A G 4: 143,537,290 (GRCm39) L347S probably benign Het
Rars1 T C 11: 35,719,579 (GRCm39) Q81R probably benign Het
Rassf7 A G 7: 140,797,847 (GRCm39) N296D probably damaging Het
Rcsd1 C T 1: 165,485,262 (GRCm39) A94T probably benign Het
Rgs8 T C 1: 153,566,668 (GRCm39) F73S probably damaging Het
Rilpl2 A C 5: 124,616,043 (GRCm39) Y36D probably damaging Het
Rpl10l A G 12: 66,331,004 (GRCm39) V43A probably benign Het
Sesn2 T C 4: 132,224,200 (GRCm39) I403V probably damaging Het
Slc10a4 C T 5: 73,164,453 (GRCm39) S15L unknown Het
Slc7a5 T C 8: 122,633,879 (GRCm39) Y156C probably damaging Het
Spata18 A G 5: 73,826,008 (GRCm39) H105R Het
Specc1l A G 10: 75,081,636 (GRCm39) D344G probably damaging Het
Syne1 A G 10: 5,112,461 (GRCm39) V415A probably benign Het
Thbs4 T G 13: 92,912,070 (GRCm39) D220A probably benign Het
Tmco5 T C 2: 116,716,752 (GRCm39) S152P probably benign Het
Tmem35b A T 4: 127,022,734 (GRCm39) D125V probably damaging Het
Trim17 A G 11: 58,857,634 (GRCm39) E155G possibly damaging Het
Vmn2r11 A C 5: 109,195,481 (GRCm39) V615G probably benign Het
Vmn2r88 A T 14: 51,655,906 (GRCm39) Q705L Het
Xirp2 T C 2: 67,339,193 (GRCm39) L478P probably damaging Het
Other mutations in Vmn2r93
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00743:Vmn2r93 APN 17 18,546,504 (GRCm39) missense probably damaging 1.00
IGL01326:Vmn2r93 APN 17 18,536,906 (GRCm39) missense possibly damaging 0.92
IGL01328:Vmn2r93 APN 17 18,545,819 (GRCm39) missense probably benign 0.00
IGL01360:Vmn2r93 APN 17 18,525,510 (GRCm39) missense possibly damaging 0.71
IGL01382:Vmn2r93 APN 17 18,533,578 (GRCm39) nonsense probably null
IGL01463:Vmn2r93 APN 17 18,525,150 (GRCm39) missense probably damaging 1.00
IGL02057:Vmn2r93 APN 17 18,546,032 (GRCm39) missense probably damaging 1.00
IGL02257:Vmn2r93 APN 17 18,545,770 (GRCm39) unclassified probably benign
IGL02686:Vmn2r93 APN 17 18,533,526 (GRCm39) missense possibly damaging 0.89
IGL02720:Vmn2r93 APN 17 18,525,296 (GRCm39) missense probably damaging 1.00
IGL03328:Vmn2r93 APN 17 18,525,220 (GRCm39) missense probably damaging 1.00
PIT4576001:Vmn2r93 UTSW 17 18,533,473 (GRCm39) missense probably benign
R0067:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R0067:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R0240:Vmn2r93 UTSW 17 18,525,061 (GRCm39) missense probably benign 0.00
R0240:Vmn2r93 UTSW 17 18,525,061 (GRCm39) missense probably benign 0.00
R0488:Vmn2r93 UTSW 17 18,546,311 (GRCm39) missense probably damaging 1.00
R0667:Vmn2r93 UTSW 17 18,546,503 (GRCm39) missense probably damaging 1.00
R0668:Vmn2r93 UTSW 17 18,518,667 (GRCm39) missense probably benign 0.00
R0850:Vmn2r93 UTSW 17 18,525,279 (GRCm39) missense possibly damaging 0.93
R0924:Vmn2r93 UTSW 17 18,524,443 (GRCm39) missense probably benign
R0947:Vmn2r93 UTSW 17 18,524,343 (GRCm39) missense probably benign 0.06
R1124:Vmn2r93 UTSW 17 18,518,710 (GRCm39) missense probably benign 0.00
R1584:Vmn2r93 UTSW 17 18,525,413 (GRCm39) missense possibly damaging 0.84
R1943:Vmn2r93 UTSW 17 18,546,063 (GRCm39) missense probably benign 0.04
R2012:Vmn2r93 UTSW 17 18,536,840 (GRCm39) missense probably benign 0.01
R2018:Vmn2r93 UTSW 17 18,546,324 (GRCm39) missense probably damaging 1.00
R2196:Vmn2r93 UTSW 17 18,525,428 (GRCm39) missense probably damaging 1.00
R2373:Vmn2r93 UTSW 17 18,518,665 (GRCm39) missense probably benign
R2864:Vmn2r93 UTSW 17 18,546,323 (GRCm39) missense probably damaging 1.00
R4276:Vmn2r93 UTSW 17 18,525,092 (GRCm39) missense possibly damaging 0.47
R4446:Vmn2r93 UTSW 17 18,524,312 (GRCm39) missense possibly damaging 0.93
R4537:Vmn2r93 UTSW 17 18,525,194 (GRCm39) missense possibly damaging 0.86
R4674:Vmn2r93 UTSW 17 18,525,255 (GRCm39) missense probably benign 0.34
R4726:Vmn2r93 UTSW 17 18,536,960 (GRCm39) missense probably damaging 1.00
R4936:Vmn2r93 UTSW 17 18,524,327 (GRCm39) missense possibly damaging 0.95
R4984:Vmn2r93 UTSW 17 18,533,389 (GRCm39) splice site probably null
R5111:Vmn2r93 UTSW 17 18,546,326 (GRCm39) missense probably damaging 0.99
R5749:Vmn2r93 UTSW 17 18,518,546 (GRCm39) missense probably benign 0.06
R5918:Vmn2r93 UTSW 17 18,546,030 (GRCm39) missense probably damaging 1.00
R5921:Vmn2r93 UTSW 17 18,546,030 (GRCm39) missense probably damaging 1.00
R6091:Vmn2r93 UTSW 17 18,545,958 (GRCm39) missense probably benign 0.06
R6283:Vmn2r93 UTSW 17 18,524,366 (GRCm39) missense probably benign 0.02
R6680:Vmn2r93 UTSW 17 18,536,920 (GRCm39) nonsense probably null
R6876:Vmn2r93 UTSW 17 18,525,450 (GRCm39) missense probably benign 0.00
R6963:Vmn2r93 UTSW 17 18,536,849 (GRCm39) missense probably damaging 1.00
R6996:Vmn2r93 UTSW 17 18,524,903 (GRCm39) missense probably damaging 1.00
R7027:Vmn2r93 UTSW 17 18,533,548 (GRCm39) missense probably benign 0.01
R7034:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R7036:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R7246:Vmn2r93 UTSW 17 18,546,012 (GRCm39) missense possibly damaging 0.89
R7258:Vmn2r93 UTSW 17 18,525,403 (GRCm39) missense probably benign 0.32
R7323:Vmn2r93 UTSW 17 18,533,497 (GRCm39) nonsense probably null
R7325:Vmn2r93 UTSW 17 18,524,249 (GRCm39) missense probably benign 0.01
R7390:Vmn2r93 UTSW 17 18,525,329 (GRCm39) missense probably damaging 1.00
R7427:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R7428:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R7448:Vmn2r93 UTSW 17 18,546,248 (GRCm39) missense probably benign 0.19
R7453:Vmn2r93 UTSW 17 18,533,580 (GRCm39) missense probably benign 0.10
R7562:Vmn2r93 UTSW 17 18,518,731 (GRCm39) missense probably benign 0.01
R7662:Vmn2r93 UTSW 17 18,525,631 (GRCm39) missense probably benign 0.00
R7704:Vmn2r93 UTSW 17 18,536,910 (GRCm39) missense probably benign 0.01
R7772:Vmn2r93 UTSW 17 18,533,482 (GRCm39) missense probably damaging 0.99
R7957:Vmn2r93 UTSW 17 18,545,954 (GRCm39) nonsense probably null
R8276:Vmn2r93 UTSW 17 18,525,649 (GRCm39) critical splice donor site probably null
R8290:Vmn2r93 UTSW 17 18,524,291 (GRCm39) missense probably damaging 1.00
R8362:Vmn2r93 UTSW 17 18,546,353 (GRCm39) missense probably benign 0.02
R8376:Vmn2r93 UTSW 17 18,525,230 (GRCm39) missense probably damaging 1.00
R8870:Vmn2r93 UTSW 17 18,525,320 (GRCm39) missense possibly damaging 0.91
R8925:Vmn2r93 UTSW 17 18,546,500 (GRCm39) missense probably damaging 0.99
R8927:Vmn2r93 UTSW 17 18,546,500 (GRCm39) missense probably damaging 0.99
R8954:Vmn2r93 UTSW 17 18,546,252 (GRCm39) missense probably damaging 0.99
R9038:Vmn2r93 UTSW 17 18,524,471 (GRCm39) missense probably benign
R9131:Vmn2r93 UTSW 17 18,546,143 (GRCm39) missense probably damaging 0.99
R9205:Vmn2r93 UTSW 17 18,524,281 (GRCm39) missense probably damaging 1.00
R9530:Vmn2r93 UTSW 17 18,518,562 (GRCm39) missense probably damaging 0.96
Z1088:Vmn2r93 UTSW 17 18,546,665 (GRCm39) missense probably damaging 1.00
Z1177:Vmn2r93 UTSW 17 18,525,600 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCACCATTACAGGGAGAATTCTG -3'
(R):5'- GCGATTGTGGCCAAAATAAACTG -3'

Sequencing Primer
(F):5'- GTTGTGGTATTACTTCTTCAAATGC -3'
(R):5'- CTGCCATGGAAAGAACAC -3'
Posted On 2019-11-12