Incidental Mutation 'R7684:Zfp609'
ID 592948
Institutional Source Beutler Lab
Gene Symbol Zfp609
Ensembl Gene ENSMUSG00000040524
Gene Name zinc finger protein 609
Synonyms
MMRRC Submission 067780-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.620) question?
Stock # R7684 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 65599673-65734846 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 65638362 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 290 (N290S)
Ref Sequence ENSEMBL: ENSMUSP00000124089 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159109]
AlphaFold Q8BZ47
Predicted Effect possibly damaging
Transcript: ENSMUST00000159109
AA Change: N290S

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000124089
Gene: ENSMUSG00000040524
AA Change: N290S

DomainStartEndE-ValueType
low complexity region 83 101 N/A INTRINSIC
low complexity region 125 139 N/A INTRINSIC
low complexity region 155 176 N/A INTRINSIC
low complexity region 259 269 N/A INTRINSIC
low complexity region 365 376 N/A INTRINSIC
low complexity region 386 405 N/A INTRINSIC
ZnF_C2H2 495 520 2.14e0 SMART
low complexity region 629 638 N/A INTRINSIC
low complexity region 657 667 N/A INTRINSIC
low complexity region 724 738 N/A INTRINSIC
low complexity region 1000 1020 N/A INTRINSIC
low complexity region 1210 1219 N/A INTRINSIC
low complexity region 1257 1273 N/A INTRINSIC
low complexity region 1329 1348 N/A INTRINSIC
Meta Mutation Damage Score 0.1050 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (73/73)
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik A T 13: 77,760,659 (GRCm39) K1239* probably null Het
Abhd6 T C 14: 8,039,807 (GRCm38) F60S probably damaging Het
Adam6b G A 12: 113,455,196 (GRCm39) W671* probably null Het
Ankrd36 A G 11: 5,520,113 (GRCm39) T63A possibly damaging Het
Arhgef16 A G 4: 154,366,285 (GRCm39) V494A possibly damaging Het
Arhgef7 T A 8: 11,869,663 (GRCm39) M659K probably benign Het
Cacna1h A G 17: 25,608,346 (GRCm39) Y854H probably damaging Het
Chd3 A T 11: 69,248,692 (GRCm39) F780I possibly damaging Het
Cldn8 A G 16: 88,359,335 (GRCm39) Y197H probably damaging Het
Cpne8 A T 15: 90,533,450 (GRCm39) D58E probably damaging Het
Cul9 T G 17: 46,820,815 (GRCm39) Y1954S probably damaging Het
Cyp4a10 T A 4: 115,375,549 (GRCm39) F11I probably benign Het
Cysrt1 A T 2: 25,129,094 (GRCm39) C139* probably null Het
Dnajc16 A G 4: 141,501,879 (GRCm39) V317A probably benign Het
Dnmt3a T C 12: 3,947,340 (GRCm39) V437A probably benign Het
Dok5 T C 2: 170,683,344 (GRCm39) C202R probably damaging Het
Dusp11 T A 6: 85,927,542 (GRCm39) R164S probably damaging Het
Dysf T C 6: 84,077,117 (GRCm39) S648P probably benign Het
Egfem1 A T 3: 29,744,334 (GRCm39) R581S probably damaging Het
Enpep A G 3: 129,115,094 (GRCm39) F226S probably damaging Het
Ep400 A G 5: 110,845,218 (GRCm39) I1541T unknown Het
Exd1 A G 2: 119,350,684 (GRCm39) S526P probably damaging Het
Fam118a A G 15: 84,942,982 (GRCm39) E337G possibly damaging Het
Fam20b T C 1: 156,518,215 (GRCm39) N193S probably benign Het
Fat3 A G 9: 15,899,564 (GRCm39) probably null Het
Flg2 T C 3: 93,126,956 (GRCm39) V1956A unknown Het
Fzd10 A G 5: 128,678,480 (GRCm39) I67V possibly damaging Het
Gckr A T 5: 31,465,141 (GRCm39) D370V probably damaging Het
Gm8797 A T 3: 5,816,148 (GRCm39) Q62L probably benign Het
H6pd G T 4: 150,080,519 (GRCm39) Q109K probably benign Het
Higd1a T C 9: 121,679,322 (GRCm39) K55R possibly damaging Het
Il1b C T 2: 129,209,277 (GRCm39) V118I probably benign Het
Insr T C 8: 3,219,753 (GRCm39) N923S possibly damaging Het
Krit1 A G 5: 3,880,723 (GRCm39) I561V possibly damaging Het
Lamc2 T C 1: 153,002,771 (GRCm39) D1070G probably null Het
Lpcat2 T A 8: 93,635,823 (GRCm39) D408E possibly damaging Het
Mst1r T A 9: 107,788,762 (GRCm39) F427Y probably benign Het
Mtx1 A T 3: 89,117,739 (GRCm39) I258K possibly damaging Het
Nckap5 T C 1: 125,954,594 (GRCm39) T653A probably benign Het
Npas3 A T 12: 54,115,609 (GRCm39) N844Y probably damaging Het
Nrg3 A T 14: 39,194,522 (GRCm39) L79Q probably damaging Het
Nsmce1 C A 7: 125,070,348 (GRCm39) K154N probably damaging Het
Oard1 T C 17: 48,723,726 (GRCm39) L124P probably damaging Het
Or10ag57 T C 2: 87,218,372 (GRCm39) S108P probably damaging Het
Or10ak13 T C 4: 118,639,471 (GRCm39) M104V probably benign Het
Or51a10 G A 7: 103,698,667 (GRCm39) T298I probably damaging Het
Or51ah3 T C 7: 103,210,425 (GRCm39) F247S probably benign Het
Ovgp1 A T 3: 105,887,272 (GRCm39) T223S probably damaging Het
Pik3c2a A T 7: 115,987,312 (GRCm39) Y536* probably null Het
Plekho2 A T 9: 65,466,816 (GRCm39) probably null Het
Prelid3b T C 2: 174,310,210 (GRCm39) probably null Het
Rftn1 G T 17: 50,354,408 (GRCm39) A318D probably damaging Het
Rxfp1 T A 3: 79,578,214 (GRCm39) N159I possibly damaging Het
Sfmbt1 A G 14: 30,532,311 (GRCm39) Q557R probably damaging Het
Slc22a18 G T 7: 143,044,577 (GRCm39) V177L probably benign Het
Slc22a8 A G 19: 8,587,294 (GRCm39) I451M probably benign Het
Slc39a12 T C 2: 14,454,670 (GRCm39) S563P probably damaging Het
Snx20 T C 8: 89,353,863 (GRCm39) D289G probably benign Het
Sptb A G 12: 76,658,969 (GRCm39) Y1189H probably benign Het
Tbc1d1 T A 5: 64,473,829 (GRCm39) M784K probably benign Het
Tbkbp1 T C 11: 97,038,559 (GRCm39) probably benign Het
Tfap2b G C 1: 19,284,511 (GRCm39) D140H probably damaging Het
Thy1 G A 9: 43,957,855 (GRCm39) G13D unknown Het
Ticam1 A G 17: 56,576,984 (GRCm39) S704P unknown Het
Tmem151b A G 17: 45,857,929 (GRCm39) Y106H probably damaging Het
Trappc8 T C 18: 20,996,559 (GRCm39) N452S probably benign Het
Ttc9c A G 19: 8,789,128 (GRCm39) Y166H probably damaging Het
Txndc16 A G 14: 45,385,325 (GRCm39) V556A possibly damaging Het
Tyrp1 C A 4: 80,758,862 (GRCm39) S245Y probably damaging Het
Urb1 A T 16: 90,583,006 (GRCm39) L621* probably null Het
Wdr72 A T 9: 74,054,292 (GRCm39) T224S probably damaging Het
Zc3h18 T G 8: 123,134,165 (GRCm39) S544A unknown Het
Zfp462 T A 4: 55,008,908 (GRCm39) N291K probably benign Het
Zfp979 A T 4: 147,697,799 (GRCm39) H303Q probably damaging Het
Other mutations in Zfp609
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00956:Zfp609 APN 9 65,610,045 (GRCm39) missense probably benign 0.18
IGL01688:Zfp609 APN 9 65,611,307 (GRCm39) missense probably benign
IGL01718:Zfp609 APN 9 65,609,682 (GRCm39) nonsense probably null
IGL01860:Zfp609 APN 9 65,610,116 (GRCm39) missense possibly damaging 0.82
IGL02441:Zfp609 APN 9 65,610,611 (GRCm39) missense possibly damaging 0.92
IGL02490:Zfp609 APN 9 65,611,250 (GRCm39) missense possibly damaging 0.92
IGL02614:Zfp609 APN 9 65,610,072 (GRCm39) missense probably damaging 0.96
IGL02794:Zfp609 APN 9 65,611,602 (GRCm39) missense possibly damaging 0.83
IGL02959:Zfp609 APN 9 65,610,675 (GRCm39) missense probably benign
IGL02967:Zfp609 APN 9 65,604,901 (GRCm39) missense possibly damaging 0.83
IGL03036:Zfp609 APN 9 65,609,927 (GRCm39) missense possibly damaging 0.89
IGL03182:Zfp609 APN 9 65,608,287 (GRCm39) missense probably benign 0.02
H8441:Zfp609 UTSW 9 65,702,169 (GRCm39) missense possibly damaging 0.82
R0304:Zfp609 UTSW 9 65,608,470 (GRCm39) missense possibly damaging 0.89
R0487:Zfp609 UTSW 9 65,609,916 (GRCm39) missense unknown
R0505:Zfp609 UTSW 9 65,610,744 (GRCm39) missense possibly damaging 0.92
R0684:Zfp609 UTSW 9 65,638,483 (GRCm39) missense probably benign 0.01
R1480:Zfp609 UTSW 9 65,610,593 (GRCm39) missense possibly damaging 0.82
R1507:Zfp609 UTSW 9 65,702,059 (GRCm39) missense possibly damaging 0.92
R1579:Zfp609 UTSW 9 65,611,754 (GRCm39) missense possibly damaging 0.90
R1655:Zfp609 UTSW 9 65,610,836 (GRCm39) missense possibly damaging 0.46
R1692:Zfp609 UTSW 9 65,702,593 (GRCm39) missense probably damaging 0.98
R1701:Zfp609 UTSW 9 65,638,282 (GRCm39) missense probably benign 0.05
R1735:Zfp609 UTSW 9 65,610,374 (GRCm39) nonsense probably null
R1883:Zfp609 UTSW 9 65,702,040 (GRCm39) missense probably benign
R1970:Zfp609 UTSW 9 65,702,559 (GRCm39) missense probably damaging 0.96
R2059:Zfp609 UTSW 9 65,611,716 (GRCm39) missense possibly damaging 0.83
R2302:Zfp609 UTSW 9 65,702,179 (GRCm39) missense possibly damaging 0.66
R3404:Zfp609 UTSW 9 65,608,454 (GRCm39) missense possibly damaging 0.68
R3405:Zfp609 UTSW 9 65,608,454 (GRCm39) missense possibly damaging 0.68
R4514:Zfp609 UTSW 9 65,610,977 (GRCm39) missense possibly damaging 0.46
R4533:Zfp609 UTSW 9 65,610,890 (GRCm39) missense probably benign 0.00
R5043:Zfp609 UTSW 9 65,608,109 (GRCm39) missense probably damaging 0.97
R5499:Zfp609 UTSW 9 65,610,137 (GRCm39) missense probably benign 0.00
R7081:Zfp609 UTSW 9 65,609,723 (GRCm39) missense possibly damaging 0.46
R7514:Zfp609 UTSW 9 65,613,418 (GRCm39) missense probably benign 0.05
R7677:Zfp609 UTSW 9 65,604,456 (GRCm39) missense possibly damaging 0.61
R8229:Zfp609 UTSW 9 65,610,782 (GRCm39) missense possibly damaging 0.66
R8266:Zfp609 UTSW 9 65,610,996 (GRCm39) missense possibly damaging 0.66
R8278:Zfp609 UTSW 9 65,604,804 (GRCm39) missense possibly damaging 0.90
R8934:Zfp609 UTSW 9 65,610,561 (GRCm39) missense possibly damaging 0.90
R8938:Zfp609 UTSW 9 65,610,561 (GRCm39) missense possibly damaging 0.90
R8940:Zfp609 UTSW 9 65,610,561 (GRCm39) missense possibly damaging 0.90
R8986:Zfp609 UTSW 9 65,610,561 (GRCm39) missense possibly damaging 0.90
R9267:Zfp609 UTSW 9 65,608,328 (GRCm39) missense possibly damaging 0.90
R9456:Zfp609 UTSW 9 65,611,125 (GRCm39) missense
R9561:Zfp609 UTSW 9 65,604,512 (GRCm39) nonsense probably null
X0028:Zfp609 UTSW 9 65,604,362 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- AATACTCTTATGGGTGCTTGGC -3'
(R):5'- AGAAAGCAGTATGTCCTCTAATGG -3'

Sequencing Primer
(F):5'- TGCTTGGCAGTGTTCCC -3'
(R):5'- AAGCAGTATGTCCTCTAATGGTCTTC -3'
Posted On 2019-11-12