Incidental Mutation 'R7685:Spg11'
| ID |
592984 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Spg11
|
| Ensembl Gene |
ENSMUSG00000033396 |
| Gene Name |
SPG11, spatacsin vesicle trafficking associated |
| Synonyms |
6030465E24Rik, C530005A01Rik, spastic paraplegia 11 |
| MMRRC Submission |
045750-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.144)
|
| Stock # |
R7685 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
121884001-121948867 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 121899361 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Phenylalanine
at position 1575
(V1575F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000037543
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000036450]
|
| AlphaFold |
Q3UHA3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000036450
AA Change: V1575F
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000037543
Gene: ENSMUSG00000033396
AA Change: V1575F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
254 |
276 |
N/A |
INTRINSIC |
|
low complexity region
|
945 |
958 |
N/A |
INTRINSIC |
|
low complexity region
|
1250 |
1264 |
N/A |
INTRINSIC |
|
low complexity region
|
1305 |
1313 |
N/A |
INTRINSIC |
|
low complexity region
|
1673 |
1684 |
N/A |
INTRINSIC |
|
low complexity region
|
1772 |
1784 |
N/A |
INTRINSIC |
|
Pfam:Spatacsin_C
|
2082 |
2374 |
1.1e-105 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
99% (79/80) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
PHENOTYPE: Mice homozygous for a knock-out allele develop a progressive spastic and ataxic gait disorder and show loss of cortical motoneurons and Purkinje cells, a reduced number of lysosomes available for fusion with autophagosomes in degenerating neurons, and accumulation of autolysosome-derived material. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(10) : Gene trapped(10)
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcg3 |
A |
G |
5: 105,116,081 (GRCm39) |
L251S |
probably damaging |
Het |
| Acsbg1 |
C |
T |
9: 54,535,843 (GRCm39) |
S53N |
unknown |
Het |
| Adamts18 |
A |
G |
8: 114,439,855 (GRCm39) |
C913R |
probably damaging |
Het |
| Adck5 |
C |
A |
15: 76,479,588 (GRCm39) |
Y524* |
probably null |
Het |
| Adgrv1 |
G |
T |
13: 81,251,443 (GRCm39) |
Q6225K |
possibly damaging |
Het |
| Ahr |
T |
C |
12: 35,554,016 (GRCm39) |
N701S |
probably damaging |
Het |
| Apc |
T |
C |
18: 34,447,261 (GRCm39) |
C1386R |
probably damaging |
Het |
| Bbs1 |
A |
G |
19: 4,956,182 (GRCm39) |
S38P |
probably benign |
Het |
| Celsr1 |
G |
T |
15: 85,862,933 (GRCm39) |
C1366* |
probably null |
Het |
| Cep290 |
A |
C |
10: 100,375,919 (GRCm39) |
H1424P |
probably benign |
Het |
| Clcn3 |
C |
T |
8: 61,386,119 (GRCm39) |
R311K |
possibly damaging |
Het |
| Crat |
C |
T |
2: 30,294,577 (GRCm39) |
R497Q |
probably benign |
Het |
| Dhx9 |
A |
G |
1: 153,334,152 (GRCm39) |
Y1002H |
probably damaging |
Het |
| Dnah8 |
C |
T |
17: 30,876,947 (GRCm39) |
T533I |
probably damaging |
Het |
| Ermard |
T |
C |
17: 15,279,724 (GRCm39) |
S505P |
probably benign |
Het |
| Fbxw17 |
G |
A |
13: 50,579,680 (GRCm39) |
D166N |
probably damaging |
Het |
| Fmo3 |
T |
C |
1: 162,785,901 (GRCm39) |
K363R |
possibly damaging |
Het |
| Frey1 |
C |
A |
2: 92,213,817 (GRCm39) |
P68Q |
probably damaging |
Het |
| Gadd45gip1 |
A |
T |
8: 85,558,980 (GRCm39) |
R21W |
probably damaging |
Het |
| Galnt4 |
A |
G |
10: 98,945,826 (GRCm39) |
N517S |
probably benign |
Het |
| Ganc |
T |
A |
2: 120,264,273 (GRCm39) |
W409R |
probably damaging |
Het |
| Glrx3 |
T |
C |
7: 137,060,920 (GRCm39) |
S185P |
probably damaging |
Het |
| Gm49368 |
T |
C |
7: 127,712,414 (GRCm39) |
S853P |
probably damaging |
Het |
| Gtf3c2 |
A |
C |
5: 31,325,611 (GRCm39) |
L443V |
probably damaging |
Het |
| Gxylt2 |
A |
T |
6: 100,781,489 (GRCm39) |
Q388L |
probably benign |
Het |
| Hcar2 |
C |
T |
5: 124,003,396 (GRCm39) |
V36M |
possibly damaging |
Het |
| Ifit3b |
A |
T |
19: 34,589,955 (GRCm39) |
D377V |
possibly damaging |
Het |
| Ints5 |
A |
G |
19: 8,874,168 (GRCm39) |
D709G |
probably benign |
Het |
| Lyst |
A |
G |
13: 13,844,450 (GRCm39) |
E1880G |
probably benign |
Het |
| Mep1a |
C |
T |
17: 43,790,065 (GRCm39) |
S428N |
probably benign |
Het |
| Mllt6 |
T |
C |
11: 97,567,790 (GRCm39) |
L739P |
probably damaging |
Het |
| Mlst8 |
T |
C |
17: 24,695,031 (GRCm39) |
Y284C |
probably damaging |
Het |
| Mmel1 |
T |
C |
4: 154,956,111 (GRCm39) |
M1T |
probably null |
Het |
| Muc5ac |
C |
T |
7: 141,363,120 (GRCm39) |
P2144S |
unknown |
Het |
| Myh4 |
T |
C |
11: 67,131,756 (GRCm39) |
V72A |
probably benign |
Het |
| Naa15 |
T |
A |
3: 51,377,395 (GRCm39) |
|
probably null |
Het |
| Nlrc5 |
A |
G |
8: 95,248,028 (GRCm39) |
|
probably null |
Het |
| Nme8 |
T |
A |
13: 19,835,145 (GRCm39) |
M514L |
probably benign |
Het |
| Nudt9 |
C |
A |
5: 104,194,946 (GRCm39) |
S14* |
probably null |
Het |
| Optn |
G |
A |
2: 5,059,461 (GRCm39) |
T19I |
probably benign |
Het |
| Or11h23 |
A |
T |
14: 50,948,215 (GRCm39) |
I143F |
possibly damaging |
Het |
| Or13a24 |
T |
C |
7: 140,154,159 (GRCm39) |
F31S |
probably damaging |
Het |
| Osbpl8 |
T |
A |
10: 111,112,370 (GRCm39) |
L495* |
probably null |
Het |
| Panx2 |
T |
C |
15: 88,951,973 (GRCm39) |
S147P |
possibly damaging |
Het |
| Pclo |
T |
A |
5: 14,730,630 (GRCm39) |
V3044D |
unknown |
Het |
| Pcnt |
T |
C |
10: 76,258,642 (GRCm39) |
K608E |
probably benign |
Het |
| Pde7a |
T |
A |
3: 19,281,909 (GRCm39) |
N447I |
probably damaging |
Het |
| Peli2 |
G |
T |
14: 48,517,491 (GRCm39) |
C186F |
not run |
Het |
| Pgm5 |
A |
G |
19: 24,705,215 (GRCm39) |
F433L |
probably benign |
Het |
| Plce1 |
G |
A |
19: 38,736,877 (GRCm39) |
V1588I |
probably benign |
Het |
| Plin4 |
T |
A |
17: 56,409,413 (GRCm39) |
H1295L |
probably benign |
Het |
| Poli |
T |
C |
18: 70,658,590 (GRCm39) |
E134G |
probably benign |
Het |
| Pramel11 |
T |
A |
4: 143,624,371 (GRCm39) |
D42V |
probably benign |
Het |
| Ptprq |
T |
A |
10: 107,479,839 (GRCm39) |
I1144F |
probably damaging |
Het |
| Ptprz1 |
A |
T |
6: 23,024,977 (GRCm39) |
T1738S |
probably damaging |
Het |
| Pxdc1 |
A |
G |
13: 34,836,267 (GRCm39) |
L51P |
probably damaging |
Het |
| Rabepk |
C |
T |
2: 34,669,308 (GRCm39) |
G362S |
probably damaging |
Het |
| Rftn1 |
G |
T |
17: 50,354,408 (GRCm39) |
A318D |
probably damaging |
Het |
| Rhd |
T |
A |
4: 134,611,820 (GRCm39) |
|
probably null |
Het |
| Rpp14 |
T |
C |
14: 8,090,453 (GRCm38) |
S126P |
probably damaging |
Het |
| Scn7a |
C |
T |
2: 66,506,536 (GRCm39) |
C1451Y |
probably damaging |
Het |
| Sdr39u1 |
G |
A |
14: 56,135,191 (GRCm39) |
R251* |
probably null |
Het |
| Sephs2 |
G |
T |
7: 126,872,506 (GRCm39) |
P196T |
possibly damaging |
Het |
| Slc22a16 |
T |
C |
10: 40,450,085 (GRCm39) |
Y195H |
possibly damaging |
Het |
| Sqle |
C |
T |
15: 59,187,890 (GRCm39) |
S66L |
probably benign |
Het |
| Tas2r124 |
T |
G |
6: 132,732,056 (GRCm39) |
W122G |
probably damaging |
Het |
| Tex52 |
A |
T |
6: 128,361,921 (GRCm39) |
|
probably null |
Het |
| Thoc1 |
T |
A |
18: 9,993,454 (GRCm39) |
C604* |
probably null |
Het |
| Tmc3 |
T |
C |
7: 83,246,666 (GRCm39) |
S136P |
probably damaging |
Het |
| Tmem212 |
T |
A |
3: 27,950,462 (GRCm39) |
T11S |
probably benign |
Het |
| Ubn2 |
A |
G |
6: 38,468,727 (GRCm39) |
N1147S |
probably benign |
Het |
| Uggt2 |
A |
G |
14: 119,312,759 (GRCm39) |
I350T |
probably damaging |
Het |
| Ust |
A |
T |
10: 8,083,339 (GRCm39) |
Y346N |
probably damaging |
Het |
| Vwa8 |
A |
G |
14: 79,335,740 (GRCm39) |
T1399A |
probably benign |
Het |
| Zc3h18 |
G |
A |
8: 123,140,615 (GRCm39) |
R850Q |
unknown |
Het |
| Zfp800 |
C |
A |
6: 28,244,193 (GRCm39) |
K257N |
probably damaging |
Het |
| Zfp985 |
T |
A |
4: 147,667,331 (GRCm39) |
D66E |
probably benign |
Het |
|
| Other mutations in Spg11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00426:Spg11
|
APN |
2 |
121,896,041 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00495:Spg11
|
APN |
2 |
121,924,937 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL00757:Spg11
|
APN |
2 |
121,901,440 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01304:Spg11
|
APN |
2 |
121,902,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01355:Spg11
|
APN |
2 |
121,943,637 (GRCm39) |
missense |
probably benign |
|
|
IGL01626:Spg11
|
APN |
2 |
121,891,452 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01739:Spg11
|
APN |
2 |
121,945,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Spg11
|
APN |
2 |
121,918,705 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02129:Spg11
|
APN |
2 |
121,926,167 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02178:Spg11
|
APN |
2 |
121,927,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02199:Spg11
|
APN |
2 |
121,890,034 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02212:Spg11
|
APN |
2 |
121,938,638 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL02605:Spg11
|
APN |
2 |
121,922,741 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02635:Spg11
|
APN |
2 |
121,943,549 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02743:Spg11
|
APN |
2 |
121,889,988 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02822:Spg11
|
APN |
2 |
121,905,015 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02992:Spg11
|
APN |
2 |
121,888,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03010:Spg11
|
APN |
2 |
121,918,801 (GRCm39) |
missense |
probably damaging |
0.96 |
|
3-1:Spg11
|
UTSW |
2 |
121,917,371 (GRCm39) |
missense |
probably damaging |
0.98 |
|
PIT4354001:Spg11
|
UTSW |
2 |
121,918,666 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0131:Spg11
|
UTSW |
2 |
121,901,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0206:Spg11
|
UTSW |
2 |
121,886,177 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0208:Spg11
|
UTSW |
2 |
121,886,177 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0302:Spg11
|
UTSW |
2 |
121,922,668 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0347:Spg11
|
UTSW |
2 |
121,927,850 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0357:Spg11
|
UTSW |
2 |
121,896,713 (GRCm39) |
splice site |
probably benign |
|
|
R0372:Spg11
|
UTSW |
2 |
121,889,928 (GRCm39) |
frame shift |
probably null |
|
|
R0715:Spg11
|
UTSW |
2 |
121,915,464 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0927:Spg11
|
UTSW |
2 |
121,924,968 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1163:Spg11
|
UTSW |
2 |
121,901,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1534:Spg11
|
UTSW |
2 |
121,922,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1555:Spg11
|
UTSW |
2 |
121,927,858 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1569:Spg11
|
UTSW |
2 |
121,932,187 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1840:Spg11
|
UTSW |
2 |
121,932,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1929:Spg11
|
UTSW |
2 |
121,890,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2265:Spg11
|
UTSW |
2 |
121,938,788 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2303:Spg11
|
UTSW |
2 |
121,899,318 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2510:Spg11
|
UTSW |
2 |
121,905,791 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2760:Spg11
|
UTSW |
2 |
121,927,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2918:Spg11
|
UTSW |
2 |
121,905,782 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3195:Spg11
|
UTSW |
2 |
121,913,879 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3423:Spg11
|
UTSW |
2 |
121,901,534 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4353:Spg11
|
UTSW |
2 |
121,943,675 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4407:Spg11
|
UTSW |
2 |
121,905,813 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4644:Spg11
|
UTSW |
2 |
121,891,510 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4663:Spg11
|
UTSW |
2 |
121,928,580 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4684:Spg11
|
UTSW |
2 |
121,895,557 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Spg11
|
UTSW |
2 |
121,895,963 (GRCm39) |
nonsense |
probably null |
|
|
R4810:Spg11
|
UTSW |
2 |
121,890,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4829:Spg11
|
UTSW |
2 |
121,938,936 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5089:Spg11
|
UTSW |
2 |
121,945,198 (GRCm39) |
nonsense |
probably null |
|
|
R5362:Spg11
|
UTSW |
2 |
121,891,481 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5684:Spg11
|
UTSW |
2 |
121,923,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5899:Spg11
|
UTSW |
2 |
121,928,680 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5923:Spg11
|
UTSW |
2 |
121,923,959 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6052:Spg11
|
UTSW |
2 |
121,927,837 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6111:Spg11
|
UTSW |
2 |
121,923,963 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6174:Spg11
|
UTSW |
2 |
121,917,286 (GRCm39) |
splice site |
probably null |
|
|
R6226:Spg11
|
UTSW |
2 |
121,918,743 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6336:Spg11
|
UTSW |
2 |
121,943,440 (GRCm39) |
splice site |
probably null |
|
|
R6480:Spg11
|
UTSW |
2 |
121,922,786 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6494:Spg11
|
UTSW |
2 |
121,943,706 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6582:Spg11
|
UTSW |
2 |
121,922,773 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6714:Spg11
|
UTSW |
2 |
121,926,212 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6791:Spg11
|
UTSW |
2 |
121,923,924 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6836:Spg11
|
UTSW |
2 |
121,890,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6928:Spg11
|
UTSW |
2 |
121,900,385 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7179:Spg11
|
UTSW |
2 |
121,932,270 (GRCm39) |
splice site |
probably null |
|
|
R7229:Spg11
|
UTSW |
2 |
121,938,585 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7337:Spg11
|
UTSW |
2 |
121,915,474 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7338:Spg11
|
UTSW |
2 |
121,885,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7351:Spg11
|
UTSW |
2 |
121,900,412 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7378:Spg11
|
UTSW |
2 |
121,888,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7448:Spg11
|
UTSW |
2 |
121,924,026 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7505:Spg11
|
UTSW |
2 |
121,905,832 (GRCm39) |
nonsense |
probably null |
|
|
R7665:Spg11
|
UTSW |
2 |
121,896,748 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7779:Spg11
|
UTSW |
2 |
121,901,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7947:Spg11
|
UTSW |
2 |
121,922,803 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7958:Spg11
|
UTSW |
2 |
121,923,426 (GRCm39) |
splice site |
probably null |
|
|
R8024:Spg11
|
UTSW |
2 |
121,927,802 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8033:Spg11
|
UTSW |
2 |
121,917,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8069:Spg11
|
UTSW |
2 |
121,943,637 (GRCm39) |
missense |
probably benign |
|
|
R8121:Spg11
|
UTSW |
2 |
121,900,348 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8252:Spg11
|
UTSW |
2 |
121,918,820 (GRCm39) |
splice site |
probably benign |
|
|
R8358:Spg11
|
UTSW |
2 |
121,910,739 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8362:Spg11
|
UTSW |
2 |
121,948,842 (GRCm39) |
missense |
unknown |
|
|
R8385:Spg11
|
UTSW |
2 |
121,927,802 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8406:Spg11
|
UTSW |
2 |
121,923,923 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8480:Spg11
|
UTSW |
2 |
121,943,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8810:Spg11
|
UTSW |
2 |
121,901,425 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8883:Spg11
|
UTSW |
2 |
121,943,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8968:Spg11
|
UTSW |
2 |
121,922,687 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9008:Spg11
|
UTSW |
2 |
121,900,413 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9059:Spg11
|
UTSW |
2 |
121,918,788 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9296:Spg11
|
UTSW |
2 |
121,945,175 (GRCm39) |
missense |
probably benign |
0.34 |
|
R9333:Spg11
|
UTSW |
2 |
121,932,244 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9657:Spg11
|
UTSW |
2 |
121,910,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Spg11
|
UTSW |
2 |
121,938,965 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Spg11
|
UTSW |
2 |
121,903,466 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAACTTGGCAGCAGCTTCAG -3'
(R):5'- AAGCCTTGGGAATGTTCGGG -3'
Sequencing Primer
(F):5'- TTGGCAGCAGCTTCAGAATAAAACTG -3'
(R):5'- CCGTTAAAGATGGTTGTGAGCCAC -3'
|
| Posted On |
2019-11-12 |
Incidental Mutation