Incidental Mutation 'R7686:Xkr6'
ID 593117
Institutional Source Beutler Lab
Gene Symbol Xkr6
Ensembl Gene ENSMUSG00000035067
Gene Name X-linked Kx blood group related 6
Synonyms
MMRRC Submission 045751-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R7686 (G1)
Quality Score 168.009
Status Not validated
Chromosome 14
Chromosomal Location 63843952-64058258 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 63844295 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 106 (T106M)
Ref Sequence ENSEMBL: ENSMUSP00000113708 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000119973]
AlphaFold E9Q6C8
Predicted Effect possibly damaging
Transcript: ENSMUST00000119973
AA Change: T106M

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000113708
Gene: ENSMUSG00000035067
AA Change: T106M

DomainStartEndE-ValueType
low complexity region 25 51 N/A INTRINSIC
Pfam:XK-related 127 498 1.1e-125 PFAM
low complexity region 627 638 N/A INTRINSIC
Predicted Effect
SMART Domains Protein: ENSMUSP00000134975
Gene: ENSMUSG00000035067
AA Change: T57M

DomainStartEndE-ValueType
Pfam:XK-related 79 207 1.8e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000177500
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (78/78)
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadl A T 1: 66,887,557 (GRCm39) probably null Het
Adgrg5 A T 8: 95,664,430 (GRCm39) I347F Het
Agmo T C 12: 37,469,973 (GRCm39) V431A probably benign Het
Arl14epl A G 18: 47,065,523 (GRCm39) D96G probably damaging Het
Asxl1 C T 2: 153,233,534 (GRCm39) S113F probably damaging Het
Axdnd1 A T 1: 156,223,034 (GRCm39) C81* probably null Het
Bloc1s3 C T 7: 19,241,531 (GRCm39) probably benign Het
Bmper C G 9: 23,310,840 (GRCm39) L425V probably benign Het
Bok A T 1: 93,622,822 (GRCm39) T194S probably benign Het
Bpifa5 A T 2: 154,007,432 (GRCm39) I125L probably benign Het
Brcc3dc T C 10: 108,535,301 (GRCm39) E218G probably damaging Het
Brd10 A T 19: 29,694,870 (GRCm39) I1541N probably benign Het
Brpf3 T C 17: 29,025,908 (GRCm39) I327T probably damaging Het
Camk1 T A 6: 113,313,158 (GRCm39) N297Y probably damaging Het
Catsper2 C T 2: 121,227,937 (GRCm39) probably null Het
Ccdc171 A T 4: 83,575,556 (GRCm39) N480I unknown Het
Cd83 A G 13: 43,938,848 (GRCm39) M22V probably benign Het
Col1a2 A G 6: 4,518,964 (GRCm39) D243G unknown Het
Crat C T 2: 30,294,577 (GRCm39) R497Q probably benign Het
Ctla4 A T 1: 60,951,752 (GRCm39) T94S probably benign Het
Cyp2b19 T C 7: 26,461,768 (GRCm39) F196S probably damaging Het
Dhx32 A T 7: 133,361,430 (GRCm39) M1K probably null Het
Epha3 T A 16: 63,593,651 (GRCm39) I146F probably damaging Het
Erbb2 T A 11: 98,326,399 (GRCm39) S1008T probably benign Het
Esp34 A G 17: 38,870,534 (GRCm39) R143G possibly damaging Het
Fam135b T C 15: 71,335,233 (GRCm39) K654E possibly damaging Het
Fgr T C 4: 132,725,324 (GRCm39) M343T probably benign Het
Fibcd1 T G 2: 31,723,880 (GRCm39) D253A probably damaging Het
Foxk1 C T 5: 142,387,625 (GRCm39) S116L probably damaging Het
Gimap8 G A 6: 48,633,006 (GRCm39) G275E probably damaging Het
Glp1r T C 17: 31,144,633 (GRCm39) Y269H probably damaging Het
H2ac20 T C 3: 96,127,886 (GRCm39) E92G probably damaging Het
Lbr A G 1: 181,645,086 (GRCm39) F522S probably damaging Het
Lca5 T C 9: 83,277,292 (GRCm39) N684S probably benign Het
Leng8 C A 7: 4,146,504 (GRCm39) S372* probably null Het
Lrp2 A G 2: 69,319,581 (GRCm39) Y1981H probably damaging Het
Lrrc37a T G 11: 103,389,062 (GRCm39) Q2121P unknown Het
Lrrn2 A G 1: 132,866,332 (GRCm39) T466A probably benign Het
Map3k19 A T 1: 127,749,985 (GRCm39) L1122* probably null Het
Mfsd6 T C 1: 52,701,554 (GRCm39) E632G probably benign Het
Mfsd6l C T 11: 68,448,052 (GRCm39) A301V probably benign Het
Mro A T 18: 74,010,510 (GRCm39) M197L probably benign Het
Ncam2 A T 16: 81,418,342 (GRCm39) E799V probably damaging Het
Nek9 A T 12: 85,350,433 (GRCm39) D880E probably benign Het
Ntng1 T A 3: 109,842,330 (GRCm39) I148L possibly damaging Het
Or1ad6 A G 11: 50,860,582 (GRCm39) T246A possibly damaging Het
Or5ac23 T A 16: 59,149,379 (GRCm39) R164S probably damaging Het
P2ry13 C T 3: 59,117,439 (GRCm39) G113D probably damaging Het
Pnpt1 A T 11: 29,107,070 (GRCm39) T687S probably damaging Het
Pou2af1 T C 9: 51,149,486 (GRCm39) Y193H probably damaging Het
Ppp1r14c T A 10: 3,413,396 (GRCm39) I143N probably damaging Het
Ppp1r16a A T 15: 76,578,783 (GRCm39) S496C probably benign Het
Prdm12 G A 2: 31,530,229 (GRCm39) R40Q probably damaging Het
Rabepk C T 2: 34,669,308 (GRCm39) G362S probably damaging Het
Rftn1 G T 17: 50,354,408 (GRCm39) A318D probably damaging Het
Rnf26rt A T 6: 76,474,013 (GRCm39) L201H probably damaging Het
Robo2 C A 16: 73,755,293 (GRCm39) V743F probably damaging Het
Scart1 T A 7: 139,802,116 (GRCm39) C148* probably null Het
Scart2 A G 7: 139,828,965 (GRCm39) N208S probably benign Het
Smg1 A T 7: 117,767,081 (GRCm39) Y1804N unknown Het
Ssh2 A G 11: 77,316,150 (GRCm39) E257G possibly damaging Het
Stoml3 T C 3: 53,410,589 (GRCm39) I101T probably damaging Het
Stxbp5 T C 10: 9,645,154 (GRCm39) D950G probably damaging Het
Syt10 T C 15: 89,698,360 (GRCm39) D328G probably damaging Het
Taf3 T C 2: 9,956,299 (GRCm39) K623E probably damaging Het
Tas2r134 T A 2: 51,518,255 (GRCm39) S245T possibly damaging Het
Tfap2b G C 1: 19,284,511 (GRCm39) D140H probably damaging Het
Tjp3 C T 10: 81,113,885 (GRCm39) V458I probably benign Het
Tnpo3 G T 6: 29,562,899 (GRCm39) S606* probably null Het
Tram1l1 T C 3: 124,114,959 (GRCm39) F40L probably benign Het
Ttc29 A T 8: 79,119,759 (GRCm39) T464S probably benign Het
Txndc9 A T 1: 38,026,849 (GRCm39) M192K probably benign Het
Urb2 C A 8: 124,771,911 (GRCm39) A1444E probably benign Het
Uty G A Y: 1,158,075 (GRCm39) T657I possibly damaging Het
Vmn1r1 A T 1: 181,985,590 (GRCm39) V25D probably damaging Het
Vmn2r65 A T 7: 84,589,744 (GRCm39) I724N probably damaging Het
Zc3h18 G A 8: 123,140,615 (GRCm39) R850Q unknown Het
Zfp341 A G 2: 154,466,781 (GRCm39) E50G probably damaging Het
Zfp62 C A 11: 49,107,985 (GRCm39) A692E probably damaging Het
Other mutations in Xkr6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00335:Xkr6 APN 14 64,056,664 (GRCm39) missense probably damaging 0.96
IGL01419:Xkr6 APN 14 64,056,325 (GRCm39) missense probably benign 0.39
IGL01450:Xkr6 APN 14 64,035,664 (GRCm39) missense probably damaging 0.98
IGL02010:Xkr6 APN 14 64,056,653 (GRCm39) missense probably benign 0.39
IGL02352:Xkr6 APN 14 64,057,156 (GRCm39) missense unknown
IGL02359:Xkr6 APN 14 64,057,156 (GRCm39) missense unknown
R0148:Xkr6 UTSW 14 64,056,998 (GRCm39) missense unknown
R0521:Xkr6 UTSW 14 64,056,871 (GRCm39) missense probably benign 0.28
R1555:Xkr6 UTSW 14 64,056,374 (GRCm39) missense unknown
R1619:Xkr6 UTSW 14 64,056,766 (GRCm39) missense probably benign 0.39
R1874:Xkr6 UTSW 14 64,035,745 (GRCm39) missense unknown
R2864:Xkr6 UTSW 14 64,057,205 (GRCm39) missense unknown
R2960:Xkr6 UTSW 14 63,844,586 (GRCm39) missense possibly damaging 0.71
R3014:Xkr6 UTSW 14 64,056,793 (GRCm39) missense unknown
R4888:Xkr6 UTSW 14 64,056,953 (GRCm39) missense unknown
R5019:Xkr6 UTSW 14 64,056,515 (GRCm39) missense unknown
R5193:Xkr6 UTSW 14 64,056,356 (GRCm39) missense possibly damaging 0.92
R5354:Xkr6 UTSW 14 64,056,353 (GRCm39) missense possibly damaging 0.48
R5485:Xkr6 UTSW 14 64,056,833 (GRCm39) missense unknown
R5825:Xkr6 UTSW 14 64,056,481 (GRCm39) missense probably benign 0.39
R5885:Xkr6 UTSW 14 63,844,360 (GRCm39) missense probably damaging 0.99
R6074:Xkr6 UTSW 14 63,844,519 (GRCm39) missense possibly damaging 0.67
R6861:Xkr6 UTSW 14 64,057,093 (GRCm39) missense probably benign 0.39
R7289:Xkr6 UTSW 14 64,035,748 (GRCm39) missense unknown
R7477:Xkr6 UTSW 14 63,844,129 (GRCm39) missense possibly damaging 0.84
R7525:Xkr6 UTSW 14 64,056,610 (GRCm39) missense probably benign 0.39
R7528:Xkr6 UTSW 14 64,056,610 (GRCm39) missense probably benign 0.39
R7529:Xkr6 UTSW 14 64,056,610 (GRCm39) missense probably benign 0.39
R7646:Xkr6 UTSW 14 63,844,423 (GRCm39) missense probably damaging 0.99
R7697:Xkr6 UTSW 14 63,844,628 (GRCm39) missense probably damaging 0.99
R8331:Xkr6 UTSW 14 64,056,392 (GRCm39) missense unknown
R8702:Xkr6 UTSW 14 64,057,103 (GRCm39) missense unknown
R9169:Xkr6 UTSW 14 63,844,067 (GRCm39) missense possibly damaging 0.83
Z1176:Xkr6 UTSW 14 63,844,394 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- TCAAGATGGCGGCGAAATC -3'
(R):5'- TGTAGTCCTGCACGAACCAG -3'

Sequencing Primer
(F):5'- AGCTGCACAACCTGGACGAG -3'
(R):5'- CTGCACGAACCAGCGGAAG -3'
Posted On 2019-11-12